Strain Name:
C57BL/6J-MtgxR8311Btlr/Mmmh
Stock Number:
067796-MU
Citation ID:
RRID:MMRRC_067796-MU
Other Names:
R8311 (G1)
Major Collection:

Strain Information

Gga3
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 3
Synonyms: C230037M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 260302
Homologene: 121703
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: Tkr, TrkA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: Rpo2-1, 220kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Ccdc91
Name: coiled-coil domain containing 91
Synonyms: 1810060J02Rik, 1700086G08Rik, p56
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67015
Homologene: 10131
Bnc2
Name: basonuclin zinc finger protein 2
Synonyms: 5031434M05Rik, 8430420F16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242509
Homologene: 18243
Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Synonyms: PHAS-I, 4e-bp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13685
HGNC: HGNC:3288
Homologene: 3021
Tonsl
Name: tonsoku-like, DNA repair protein
Synonyms: Nfkbil2, 2810439M11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72749
HGNC: HGNC:7801
Homologene: 22754
Wdr37
Name: WD repeat domain 37
Synonyms: 4933417A01Rik, 3110035P10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 207615
Homologene: 40914
Dmxl2
Name: Dmx-like 2
Synonyms: 6430411K14Rik, E130119P06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Rtn1
Name: reticulon 1
Synonyms: Rtn1-a, 4930441F12Rik, Rtn1-b, Rtn1-c, Nsp, 0710005K15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104001
Homologene: 49654
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, C330002D13Rik, Coh1, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Hmgb1
Name: high mobility group box 1
Synonyms: DEF, p30, SBP-1, amphoterin, HMG-1, Hmg1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15289
HGNC: HGNC:4983
Homologene: 135819
Yars2
Name: tyrosyl-tRNA synthetase 2 (mitochondrial)
Synonyms: 2210023C10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70120
Homologene: 7097
Eng
Name: endoglin
Synonyms: CD105, Endo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13805
HGNC: HGNC:3349
Homologene: 92
Copb2
Name: COPI coat complex subunit beta 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50797
HGNC: HGNC:2232
Homologene: 3499
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76967
Homologene: 8839
Metap2
Name: methionine aminopeptidase 2
Synonyms: 4930584B20Rik, p67, eIF-2-associated p67, A930035J23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56307
Homologene: 4981
Ppp4r2
Name: protein phosphatase 4, regulatory subunit 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232314
Homologene: 17953
Serpind1
Name: serine (or cysteine) peptidase inhibitor, clade D, member 1
Synonyms: heparin cofactor II, HC II, Hcf2, HCII
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15160
HGNC: HGNC:4838
Homologene: 36018
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: D030022P06Rik, F630004O05Rik, B930091H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Sirpa
Name: signal-regulatory protein alpha
Synonyms: Ptpns1, Idd13.2, SIRP, CD172a, P84, SHPS-1, Bit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19261
HGNC: HGNC:9662
Homologene: 7246
Nlrc4
Name: NLR family, CARD domain containing 4
Synonyms: 9530011P19Rik, Ipaf, Card12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268973
VEGA: 17
Homologene: 10924
Zc3h12a
Name: zinc finger CCCH type containing 12A
Synonyms: Mcpip1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230738
Homologene: 11824
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227644
Homologene: 2321
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: basilin, FOAP-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Eps8l1
Name: EPS8-like 1
Synonyms: 4632407K17Rik, EPS8R1, 2310051G19Rik, DRC3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67425
Homologene: 15767
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20849
Homologene: 20679
Ptchd3
Name: patched domain containing 3
Synonyms: 4930451E13Rik, 4933440L20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74675
Homologene: 111041
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Spata31g1
Name: SPATA31 subfamily G member 1
Synonyms: 1700022I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67317
Homologene: 52406
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Orp1, mG145, Rp1h, oxygen-regulated protein 1, Dcdc3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241263
Homologene: 19381
Tmem216
Name: transmembrane protein 216
Synonyms: 4921533J23Rik, 1110017C22Rik, 2810441K11Rik, A930021F15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68642
Homologene: 9541
Rchy1
Name: ring finger and CHY zinc finger domain containing 1
Synonyms: Pirh2, 6720407C15Rik, Zfp363, PRO1996
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68098
Homologene: 22894
Itgav
Name: integrin alpha V
Synonyms: 2610028E01Rik, vitronectin receptor alpha polypeptide (VNRA), alphav-integrin, CD51, 1110004F14Rik, D430040G12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 435845
Homologene: 78847
Or10ak7
Name: olfactory receptor family 10 subfamily AK member 7
Synonyms: MOR259-1, MOR259-1, MOR259-13, Olfr1328, Olfr1519, GA_x6K02T2QD9B-18602750-18603691
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258394
Homologene: 121524
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216188
Homologene: 51942
Apol9a
Name: apolipoprotein L 9a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223672
VEGA: 15
Homologene: 77567
Ykt6
Name: YKT6 v-SNARE homolog (S. cerevisiae)
Synonyms: 1810013M05Rik, 0610042I15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56418
Homologene: 4778
Efhb
Name: EF hand domain family, member B
Synonyms: 4921525D22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211482
VEGA: 17
Homologene: 16982
Kcna1
Name: potassium voltage-gated channel, shaker-related subfamily, member 1
Synonyms: Kv1.1, mouse brain potassium channel protein-1, Shak, mceph, Mk-1, MBK1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16485
HGNC: HGNC:6218
Homologene: 183
Cyp4a14
Name: cytochrome P450, family 4, subfamily a, polypeptide 14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13119
Homologene: 134697
Vmn1r26
Name: vomeronasal 1 receptor 26
Synonyms: V1rc17
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171190
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106648
Homologene: 80199
Tmem37
Name: transmembrane protein 37
Synonyms: Pr1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170706
Homologene: 10447
Mak16
Name: MAK16 homolog
Synonyms: 2600016B03Rik, Rbm13
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67920
Homologene: 5296
Rmdn1
Name: regulator of microtubule dynamics 1
Synonyms: 6430576D04Rik, 2410005O16Rik, Fam82b, 5033415E11Rik, 5730501K14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66302
Homologene: 41093
Or10w3
Name: olfactory receptor family 10 subfamily W member 3
Synonyms: MOR266-3, Olfr1493, GA_x6K02T2RE5P-4059239-4060188
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258735
1700007B14Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 4,348,349 bp
  • A to T, chromosome 1 at 52,102,916 bp
  • C to T, chromosome 1 at 120,068,252 bp
  • A to G, chromosome 2 at 21,368,890 bp
  • A to T, chromosome 2 at 26,378,534 bp
  • A to G, chromosome 2 at 32,678,993 bp
  • T to A, chromosome 2 at 83,765,777 bp
  • T to C, chromosome 2 at 129,616,223 bp
  • T to A, chromosome 3 at 87,781,563 bp
  • T to C, chromosome 4 at 19,575,329 bp
  • T to C, chromosome 4 at 42,973,169 bp
  • A to T, chromosome 4 at 84,276,345 bp
  • A to G, chromosome 4 at 115,491,078 bp
  • A to C, chromosome 4 at 118,934,150 bp
  • A to C, chromosome 4 at 125,126,995 bp
  • T to G, chromosome 5 at 86,235,553 bp
  • T to C, chromosome 5 at 91,951,903 bp
  • A to G, chromosome 5 at 149,050,617 bp
  • T to C, chromosome 6 at 58,008,533 bp
  • T to C, chromosome 6 at 100,866,382 bp
  • T to A, chromosome 6 at 126,642,292 bp
  • A to G, chromosome 6 at 147,535,616 bp
  • T to C, chromosome 7 at 3,736,483 bp
  • A to G, chromosome 7 at 4,471,818 bp
  • T to C, chromosome 7 at 127,557,797 bp
  • T to A, chromosome 8 at 27,275,096 bp
  • T to C, chromosome 8 at 31,168,669 bp
  • T to A, chromosome 8 at 75,753,490 bp
  • A to T, chromosome 9 at 54,446,933 bp
  • G to T, chromosome 9 at 98,568,019 bp
  • T to A, chromosome 10 at 83,490,615 bp
  • C to T, chromosome 10 at 93,861,522 bp
  • T to A, chromosome 11 at 5,962,366 bp
  • T to C, chromosome 11 at 33,276,126 bp
  • T to C, chromosome 11 at 65,989,818 bp
  • T to C, chromosome 11 at 69,737,456 bp
  • C to T, chromosome 11 at 103,503,421 bp
  • A to T, chromosome 11 at 115,587,008 bp
  • A to G, chromosome 11 at 121,836,473 bp
  • A to G, chromosome 12 at 71,138,041 bp
  • T to C, chromosome 12 at 72,304,064 bp
  • T to C, chromosome 13 at 8,853,573 bp
  • T to C, chromosome 13 at 48,933,957 bp
  • T to A, chromosome 15 at 35,886,954 bp
  • C to T, chromosome 15 at 76,633,263 bp
  • T to C, chromosome 15 at 77,405,020 bp
  • T to C, chromosome 15 at 82,063,239 bp
  • T to C, chromosome 16 at 16,307,283 bp
  • G to A, chromosome 16 at 17,342,866 bp
  • C to T, chromosome 16 at 20,591,222 bp
  • A to T, chromosome 17 at 32,697,940 bp
  • A to G, chromosome 17 at 53,413,461 bp
  • C to G, chromosome 17 at 71,255,146 bp
  • G to A, chromosome 17 at 74,446,545 bp
  • A to T, chromosome 19 at 10,551,827 bp
  • A to G, chromosome 19 at 13,726,671 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8311 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067796-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.