Strain Name:
C57BL/6J-MtgxR8313Btlr/Mmmh
Stock Number:
067797-MU
Citation ID:
RRID:MMRRC_067797-MU
Other Names:
R8313 (G1)
Major Collection:

Strain Information

Prkaca
Name: protein kinase, cAMP dependent, catalytic, alpha
Synonyms: Cs, C alpha, PKA, Pkaca
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18747
HGNC: HGNC:9380
Homologene: 121574
Vcp
Name: valosin containing protein
Synonyms: CDC48, p97, p97/VCP, AAA ATPase p97
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269523
Homologene: 5168
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Efemp1
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216616
HGNC: HGNC:3218
Homologene: 3028
Mdk
Name: midkine
Synonyms: MK, Mek
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17242
HGNC: HGNC:6972
Homologene: 1792
Fbxo22
Name: F-box protein 22
Synonyms: 1600016C16Rik, 0610033L19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71999
Homologene: 12433
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, 3110054G10Rik, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Dab2ip
Name: disabled 2 interacting protein
Synonyms: 2310011D08Rik, AIP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69601
Homologene: 13058
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Pkm
Name: pyruvate kinase, muscle
Synonyms: Pk-3, Pk-2, Pk3, Pkm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18746
VEGA: 9
HGNC: HGNC:9021
Homologene: 37650
Chaf1a
Name: chromatin assembly factor 1, subunit A
Synonyms: CAF-1, p150
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27221
VEGA: 17
HGNC: HGNC:1910
Homologene: 4003
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: MmRad24, 9430035O09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Prkab2
Name: protein kinase, AMP-activated, beta 2 non-catalytic subunit
Synonyms: 5730553K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 108097
HGNC: HGNC:9379
Homologene: 38046
Bcar1
Name: breast cancer anti-estrogen resistance 1
Synonyms: p130Cas, Cas, Crkas
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12927
HGNC: HGNC:971
Homologene: 7674
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Mphosph8
Name: M-phase phosphoprotein 8
Synonyms: 1500035L22Rik, 4930548G07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75339
Homologene: 11380
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Exosc7
Name: exosome component 7
Synonyms: 2610002K22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66446
Homologene: 8994
Mxra7
Name: matrix-remodelling associated 7
Synonyms: E130302J09Rik, 1810057P16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67622
HGNC: HGNC:7541
Homologene: 137378
Atl2
Name: atlastin GTPase 2
Synonyms: Aip-2, 2010110I21Rik, Arl6ip2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56298
VEGA: 17
Homologene: 56949
Noc3l
Name: NOC3 like DNA replication regulator
Synonyms: Fad24
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57753
VEGA: 19
Homologene: 39642
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: NHE4, D730009J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110895
Homologene: 72232
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Trak2
Name: trafficking protein, kinesin binding 2
Synonyms: GRIF-1, CALS-C, OIP98, GRIF1, 4733401O11Rik, Als2cr3, 2900022D04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70827
Homologene: 22861
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237465
Homologene: 52182
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Tmem175
Name: transmembrane protein 175
Synonyms: 3010001K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72392
Homologene: 12461
Vmn1r231
Name: vomeronasal 1 receptor 231
Synonyms: V1re7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171230
Vmn1r208
Name: vomeronasal 1 receptor 208
Synonyms: V1rh9, Vmn1r208-ps
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171252
Homologene: 110880
Prmt8
Name: protein arginine N-methyltransferase 8
Synonyms: Hrmt1l3, Hrmt1l4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381813
HGNC: HGNC:5188
Homologene: 76124
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Itga1
Name: integrin alpha 1
Synonyms: CD49A, Vla1, E130012M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Zfp108
Name: zinc finger protein 108
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54678
Homologene: 117959
Bpifa6
Name: BPI fold containing family A, member 6
Synonyms: Gm5840
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545477
Homologene: 129594
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Vstm2a
Name: V-set and transmembrane domain containing 2A
Synonyms: 9330184N17Rik, Vstm2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211739
Homologene: 17123
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Tmem237
Name: transmembrane protein 237
Synonyms: LOC381259, Als2cr4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381259
Homologene: 17570
Vmn1r80
Name: vomeronasal 1 receptor 80
Synonyms: V1rg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171238
Or8c10
Name: olfactory receptor family 8 subfamily C member 10
Synonyms: GA_x6K02T2MYUG-19447-18473, MOR170-14, Olfr899, Olfr250, MOR170-8, GA_x6K02T2PVTD-32060891-32061865
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404312
VEGA: 9
Homologene: 74151
Rita1
Name: RBPJ interacting and tubulin associated 1
Synonyms: 1110008J03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100764
Homologene: 12585
Zfp938
Name: zinc finger protein 938
Synonyms: B230315N10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237411
Homologene: 135924
Epx
Name: eosinophil peroxidase
Synonyms: EPO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13861
HGNC: HGNC:3423
Homologene: 20144
Senp5
Name: SUMO/sentrin specific peptidase 5
Synonyms: A730063F07Rik, 6230429P13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320213
Homologene: 17647
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74772
Homologene: 56940
Ch25h
Name: cholesterol 25-hydroxylase
Synonyms: m25OH
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12642
VEGA: 19
HGNC: HGNC:1907
Homologene: 2942
Gpr33
Name: G protein-coupled receptor 33
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14762
HGNC: HGNC:4489
Homologene: 7345
Or7a39
Name: olfactory receptor family 7 subfamily A member 39
Synonyms: GA_x6K02T2QGN0-2932609-2931677, MOR139-6, Olfr1355
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257734
Homologene: 136441
Gpr20
Name: G protein-coupled receptor 20
Synonyms: A430106B11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239530
HGNC: HGNC:4475
Homologene: 3870
Rogdi
Name: rogdi homolog
Synonyms: 0610011C19Rik, Lzf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66049
Homologene: 11605
Gm8267
Name: predicted gene 8267
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 666744
Homologene: 115686
Eif1ad3
Name: eukaryotic translation initiation factor 1A domain containing 3
Synonyms: Gm2016
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039042
Homologene: 103865
Or5h24
Name: olfactory receptor family 5 subfamily H member 24, pseudogene 1
Synonyms: GA_x54KRFPKG5P-55327126-55326203, MOR183-11_p, Olfr192
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 404309
Homologene: 131129
Lysmd2
Name: LysM, putative peptidoglycan-binding, domain containing 2
Synonyms: 2210402C18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70082
VEGA: 9
Homologene: 12347
Fam150b
Name:
Type: Gene
Species: Mouse
Chromosome: 12
Foxr1
Name: forkhead box R1
Synonyms: LOC382074, Foxn5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382074
VEGA: 9
Homologene: 19844
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 40,580,360 bp
  • G to A, chromosome 1 at 46,175,296 bp
  • A to T, chromosome 1 at 58,921,147 bp
  • A to T, chromosome 1 at 59,108,078 bp
  • T to C, chromosome 2 at 35,727,428 bp
  • A to G, chromosome 2 at 69,945,134 bp
  • T to C, chromosome 2 at 91,930,833 bp
  • T to A, chromosome 2 at 153,989,258 bp
  • G to T, chromosome 3 at 97,663,595 bp
  • T to C, chromosome 4 at 42,988,728 bp
  • G to A, chromosome 4 at 49,665,599 bp
  • G to A, chromosome 4 at 126,910,969 bp
  • G to A, chromosome 4 at 141,002,735 bp
  • A to G, chromosome 5 at 89,046,263 bp
  • T to A, chromosome 5 at 108,643,209 bp
  • A to G, chromosome 5 at 112,875,179 bp
  • G to T, chromosome 5 at 120,609,651 bp
  • A to G, chromosome 6 at 127,689,850 bp
  • T to C, chromosome 7 at 12,193,067 bp
  • A to C, chromosome 7 at 24,260,662 bp
  • A to G, chromosome 7 at 28,086,344 bp
  • A to T, chromosome 7 at 41,872,528 bp
  • A to G, chromosome 7 at 119,951,152 bp
  • T to A, chromosome 7 at 123,170,713 bp
  • A to T, chromosome 8 at 83,990,522 bp
  • A to T, chromosome 8 at 111,713,638 bp
  • A to C, chromosome 9 at 18,525,147 bp
  • T to A, chromosome 9 at 38,368,050 bp
  • A to G, chromosome 9 at 44,436,054 bp
  • T to A, chromosome 9 at 55,221,060 bp
  • G to T, chromosome 9 at 59,668,619 bp
  • A to T, chromosome 9 at 75,625,758 bp
  • A to T, chromosome 9 at 122,853,630 bp
  • T to C, chromosome 9 at 123,127,877 bp
  • C to T, chromosome 10 at 78,879,336 bp
  • T to G, chromosome 10 at 82,225,588 bp
  • T to A, chromosome 10 at 88,439,209 bp
  • T to C, chromosome 10 at 93,563,249 bp
  • T to A, chromosome 11 at 16,281,898 bp
  • A to G, chromosome 11 at 28,910,691 bp
  • C to T, chromosome 11 at 87,872,731 bp
  • T to C, chromosome 11 at 116,804,550 bp
  • T to A, chromosome 12 at 25,004,111 bp
  • G to T, chromosome 12 at 30,884,851 bp
  • A to G, chromosome 12 at 52,024,124 bp
  • A to T, chromosome 12 at 87,876,994 bp
  • G to C, chromosome 13 at 22,772,777 bp
  • T to C, chromosome 13 at 100,624,566 bp
  • T to A, chromosome 13 at 114,966,584 bp
  • A to T, chromosome 14 at 44,724,058 bp
  • AC to A, chromosome 14 at 56,678,605 bp
  • A to G, chromosome 15 at 73,696,312 bp
  • C to A, chromosome 16 at 5,013,449 bp
  • T to C, chromosome 16 at 31,989,299 bp
  • A to T, chromosome 16 at 32,753,423 bp
  • C to A, chromosome 16 at 49,120,018 bp
  • C to T, chromosome 16 at 59,098,641 bp
  • C to T, chromosome 17 at 20,890,027 bp
  • C to A, chromosome 17 at 56,044,109 bp
  • A to G, chromosome 17 at 67,750,520 bp
  • C to T, chromosome 17 at 79,852,604 bp
  • A to C, chromosome 19 at 34,474,738 bp
  • A to G, chromosome 19 at 38,795,810 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8313 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067797-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.