Strain Name:
C57BL/6J-MtgxR8337Btlr/Mmmh
Stock Number:
067800-MU
Citation ID:
RRID:MMRRC_067800-MU
Other Names:
R8337 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: B430219L04Rik, mMTMH1, 4833411B01Rik, SBF2, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Itk
Name: IL2 inducible T cell kinase
Synonyms: Emt, Tcsk, Tsk
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16428
HGNC: HGNC:6171
Homologene: 4051
Cep97
Name: centrosomal protein 97
Synonyms: 4932439K18Rik, 2810403B08Rik, Lrriq2, E130116N02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74201
Homologene: 11579
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, C030018K18Rik, Pdzgef2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Sec23ip
Name: Sec23 interacting protein
Synonyms: D7Ertd373e, p125
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207352
Homologene: 38288
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Strn3
Name: striatin, calmodulin binding protein 3
Synonyms: SG2NA
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94186
VEGA: 12
Homologene: 82078
Ntng2
Name: netrin G2
Synonyms: Lmnt2, 2610016D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 171171
Homologene: 13053
Ifnar1
Name: interferon (alpha and beta) receptor 1
Synonyms: Ifar, IFN-alpha/betaR, Ifrc
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15975
HGNC: HGNC:5432
Homologene: 524
Chrna2
Name: cholinergic receptor nicotinic alpha 2 subunit
Synonyms: Acra2, Acra-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110902
HGNC: HGNC:1956
Homologene: 20193
Angptl7
Name: angiopoietin-like 7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 654812
Homologene: 133923
Hhipl2
Name: hedgehog interacting protein-like 2
Synonyms: 4930507C10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78772
Homologene: 11690
Metap1d
Name: methionyl aminopeptidase type 1D (mitochondrial)
Synonyms: Metapl1, 2310066F24Rik, 3110033D18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66559
Homologene: 11987
Cab39l
Name: calcium binding protein 39-like
Synonyms: 1500031K13Rik, 2810425O13Rik, 4930520C08Rik, MO2L
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69008
VEGA: 14
Homologene: 69422
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Cxxc1
Name: CXXC finger protein 1
Synonyms: 5830420C16Rik, Cgbp, Cfp1, 2410002I16Rik, PHF18, CXXC finger 1 (PHD domain)
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74322
VEGA: 18
Homologene: 32221
Shisa4
Name: shisa family member 4
Synonyms: Tmem58, 9330132O05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77552
Homologene: 18428
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: wmfl, Flk-2, Flk2, Flt-3, CD135
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Cmtr1
Name: cap methyltransferase 1
Synonyms: Ftsjd2, 1300018I05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74157
Homologene: 9003
Clec4b1
Name: C-type lectin domain family 4, member b1
Synonyms: DCAR, 1810046I24Rik, DCARbeta, mDcar2, 1810046I24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69810
Homologene: 130350
Clvs2
Name: clavesin 2
Synonyms: Rlbp1l2, A330019N05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215890
Homologene: 27894
Ckap4
Name: cytoskeleton-associated protein 4
Synonyms: 5630400A09Rik, CLIMP-63, P63
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216197
VEGA: 10
Homologene: 4970
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG667069, EG620718
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Taf5l
Name: TATA-box binding protein associated factor 5 like
Synonyms: 1110005N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102162
Homologene: 8676
Tnn
Name: tenascin N
Synonyms: tenascin-W, Tnw
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Ankrd34c
Name: ankyrin repeat domain 34C
Synonyms: B230218L05Rik, LOC330998
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330998
Homologene: 19814
Or8b57
Name: olfactory receptor family 8 subfamily B member 57
Synonyms: Olfr983, GA_x6K02T2PVTD-33790948-33790013, MOR162-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258824
VEGA: 9
Homologene: 121547
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: Kif16a, E230025N21Rik, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Cdsn
Name: corneodesmosin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 386463
HGNC: HGNC:1802
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: ENSMUSG00000073143, A630082K20Rik, Jhdm1d, Kdm7a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 338523
Homologene: 25281
Acod1
Name: aconitate decarboxylase 1
Synonyms: Irg1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16365
Homologene: 35405
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Slc28a2b
Name: solute carrier family 28 member 2b
Synonyms: Gm14085
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381417
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
BC028528
Name: cDNA sequence BC028528
Synonyms: L259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229600
Homologene: 49773
Tfb2m
Name: transcription factor B2, mitochondrial
Synonyms: Hkp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15278
Homologene: 7362
Or51q1
Name: olfactory receptor family 51 subfamily Q member 1
Synonyms: MOR5-2, GA_x6K02T2PBJ9-6713641-6714588, Olfr635
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259122
Homologene: 133592
Or51b17
Name: olfactory receptor family 51 subfamily B member 17
Synonyms: MOR1-2, Olfr64, GA_x6K02T2PBJ9-6648196-6649143, 5'[b]2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18366
Homologene: 56593
Frs3
Name: fibroblast growth factor receptor substrate 3
Synonyms: Frs2beta, 4930417B13Rik, SNT2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 107971
Homologene: 4845
Marchf1
Name: membrane associated ring-CH-type finger 1
Synonyms: 2900024D24Rik, March1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72925
Homologene: 113749
Pla2g12a
Name: phospholipase A2, group XIIA
Synonyms: Rossy, mGXII-1, Pla2g12, GXII, 2310004B05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66350
Homologene: 11328
Dtx3l
Name: deltex 3-like, E3 ubiquitin ligase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209200
Homologene: 51375
Prlhr
Name: prolactin releasing hormone receptor
Synonyms: Gpr10, PrRPR, GR3, LOC226278
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226278
VEGA: 19
HGNC: HGNC:4464
Homologene: 3134
Gsdmd
Name: gasdermin D
Synonyms: DF5L, Gsdmdc1, Dfna5l, M2-4, 1810036L03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69146
VEGA: 15
Homologene: 12299
Tox3
Name: TOX high mobility group box family member 3
Synonyms: 500-9, Tnrc9, CAGF9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244579
Homologene: 18257
Mrps25
Name: mitochondrial ribosomal protein S25
Synonyms: Rpms25, 2810429N01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64658
Homologene: 11207
Mfsd8
Name: major facilitator superfamily domain containing 8
Synonyms: Cln7, 2810423E13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72175
Homologene: 115814
Abhd14b
Name: abhydrolase domain containing 14b
Synonyms: 1810013B01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76491
Homologene: 9125
Tfec
Name: transcription factor EC
Synonyms: TFEC, Tcfec, bHLHe34
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21426
Homologene: 32148
Mucl3
Name: mucin like 3
Synonyms: LOC268949, Dpcr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268949
Homologene: 133813
Krtap13-20
Name: keratin associated protein 13-20
Synonyms: 2310034C09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117172
Homologene: 114409
Wdr97
Name: WD repeat domain 97
Synonyms: Gm35339
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 102638882
Homologene: 131539
Ighv1-34
Name: immunoglobulin heavy variable 1-34
Synonyms: Gm16735
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 628614
Gm6882
Name: predicted gene 6882
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628475
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 135,373,169 bp
  • C to T, chromosome 1 at 160,118,483 bp
  • T to A, chromosome 1 at 179,542,349 bp
  • C to A, chromosome 1 at 183,428,632 bp
  • C to A, chromosome 2 at 29,248,038 bp
  • T to C, chromosome 2 at 71,515,638 bp
  • T to A, chromosome 2 at 120,679,825 bp
  • C to T, chromosome 2 at 122,525,136 bp
  • T to A, chromosome 2 at 158,450,272 bp
  • G to A, chromosome 3 at 40,835,193 bp
  • A to T, chromosome 3 at 64,556,105 bp
  • A to G, chromosome 3 at 95,884,986 bp
  • A to G, chromosome 3 at 129,878,816 bp
  • T to C, chromosome 4 at 148,497,284 bp
  • A to G, chromosome 5 at 147,332,888 bp
  • T to C, chromosome 6 at 16,845,423 bp
  • T to C, chromosome 6 at 39,145,527 bp
  • T to C, chromosome 6 at 92,175,764 bp
  • A to G, chromosome 6 at 123,065,963 bp
  • A to G, chromosome 7 at 19,196,236 bp
  • G to A, chromosome 7 at 21,427,634 bp
  • C to T, chromosome 7 at 103,893,049 bp
  • A to C, chromosome 7 at 103,979,374 bp
  • T to C, chromosome 7 at 110,441,462 bp
  • C to A, chromosome 7 at 128,764,025 bp
  • T to C, chromosome 8 at 66,418,989 bp
  • T to C, chromosome 8 at 90,347,879 bp
  • T to C, chromosome 8 at 123,998,102 bp
  • T to C, chromosome 9 at 40,092,399 bp
  • T to A, chromosome 9 at 89,729,898 bp
  • T to A, chromosome 9 at 106,450,041 bp
  • CGGGG to CGGGGG, chromosome 9 at 108,841,272 bp
  • A to T, chromosome 10 at 33,528,488 bp
  • A to G, chromosome 10 at 79,148,873 bp
  • A to G, chromosome 10 at 84,528,596 bp
  • A to G, chromosome 10 at 127,088,325 bp
  • T to C, chromosome 11 at 46,342,395 bp
  • T to A, chromosome 11 at 54,631,301 bp
  • T to C, chromosome 12 at 51,661,172 bp
  • A to T, chromosome 12 at 114,851,319 bp
  • T to C, chromosome 14 at 59,539,191 bp
  • G to T, chromosome 14 at 66,149,568 bp
  • C to T, chromosome 14 at 103,049,344 bp
  • C to T, chromosome 15 at 75,864,421 bp
  • T to C, chromosome 15 at 76,361,484 bp
  • T to A, chromosome 16 at 35,933,703 bp
  • A to T, chromosome 16 at 55,915,031 bp
  • T to C, chromosome 16 at 88,759,263 bp
  • C to A, chromosome 16 at 91,505,336 bp
  • G to A, chromosome 17 at 29,674,177 bp
  • T to C, chromosome 17 at 35,555,518 bp
  • T to C, chromosome 17 at 35,637,594 bp
  • T to A, chromosome 17 at 47,703,852 bp
  • T to A, chromosome 18 at 74,220,839 bp
  • A to G, chromosome 19 at 60,467,846 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8337 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067800-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.