Strain Name:
C57BL/6J-MtgxR8428Btlr/Mmmh
Stock Number:
067822-MU
Citation ID:
RRID:MMRRC_067822-MU
Other Names:
R8428 (G1)
Major Collection:

Strain Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: OREBP, nfatz, TonEBP, B130038B15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CDO, CAM-related/down-regulated by oncogenes
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 6720481N21Rik, AIP4, C230047C07Rik, 8030492O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16396
Homologene: 88442
Fzr1
Name: fizzy and cell division cycle 20 related 1
Synonyms: Cdh1, Fyr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56371
Homologene: 9444
Syt4
Name: synaptotagmin IV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20983
VEGA: 18
Homologene: 7559
Get4
Name: golgi to ER traffic protein 4
Synonyms: 1110007L15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67604
Homologene: 41080
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Ppa2
Name: pyrophosphatase (inorganic) 2
Synonyms: Sid6306, 1110013G13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74776
Homologene: 134244
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: 2810017C20Rik, E130319N12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215351
Homologene: 9196
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: KMT6, Enx1h, Enx-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Fbxw8
Name: F-box and WD-40 domain protein 8
Synonyms: FBW6, FBXO29, FBW8, 4930438M06Rik, Fbx29
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231672
Homologene: 17731
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117599
Homologene: 50463
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2810413I22Rik, 6030449K19Rik, 2410152H17Rik, 2900036C23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: 6330404E13Rik, 3110005L17Rik, MSK1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Ndc1
Name: NDC1 transmembrane nucleoporin
Synonyms: Tmem48, 2810475A17Rik, sks
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72787
Homologene: 41224
Nop14
Name: NOP14 nucleolar protein
Synonyms: 2610033H07Rik, Nol14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75416
Homologene: 41773
Exd1
Name: exonuclease 3'-5' domain containing 1
Synonyms: Exdl1, 4932702D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241624
Homologene: 17627
Ccdc117
Name: coiled-coil domain containing 117
Synonyms: 1110004K02Rik, 1700026O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104479
Homologene: 15886
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Zfp277
Name: zinc finger protein 277
Synonyms: 2410017E24Rik, NIRF4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 246196
VEGA: 12
Homologene: 11087
Micu3
Name: mitochondrial calcium uptake family, member 3
Synonyms: Efha2, 2900075B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78506
Homologene: 15058
Sf3b2
Name: splicing factor 3b, subunit 2
Synonyms: 145kDa, SF3b150, SF3b145, SAP145, SF3b1, B230398H18Rik, 2810441F20Rik, 2610311M13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319322
VEGA: 19
Homologene: 6678
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: C130042M06Rik, Stra14, DEC1, Stra13, CR8, Bhlhb2, Sharp2, cytokine response gene 8, Clast5, eip1 (E47 interaction protein 1)
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: CaT2, ECaC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Slc39a5
Name: solute carrier family 39 (metal ion transporter), member 5
Synonyms: Zip5, 2010205A06Rik, 1810013D05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72002
VEGA: 10
Homologene: 57083
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Tgm5
Name: transglutaminase 5
Synonyms: 2310007C07Rik, TGx
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74176
Homologene: 20899
Or51k1
Name: olfactory receptor family 51 subfamily K member 1
Synonyms: GA_x6K02T2PBJ9-6747143-6746193, MOR12-1, Olfr639
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259088
Homologene: 17497
Hoxa7
Name: homeobox A7
Synonyms: Hox-1.1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15404
HGNC: HGNC:5108
Homologene: 56001
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76376
Homologene: 10669
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: ANG1, 3110041O18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73166
Homologene: 68305
Slc13a4
Name: solute carrier family 13 (sodium/sulfate symporters), member 4
Synonyms: 9630060C05Rik, SUT-1, SUT1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243755
Homologene: 69125
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Mgat4b
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103534
HGNC: HGNC:7048
Homologene: 8611
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1, Mtap1a, 6330416M19Rik, Mtap-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Upk1a
Name: uroplakin 1A
Synonyms: 1110031P12Rik, Upk1, Tspan21
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109637
Homologene: 21383
Tmem268
Name: transmembrane protein 268
Synonyms: 6330416G13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230279
Homologene: 17005
Kif26b
Name: kinesin family member 26B
Synonyms: D230039L06Rik, N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Rbm17
Name: RNA binding motif protein 17
Synonyms: 2700027J02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76938
Homologene: 13162
Ifi44
Name: interferon-induced protein 44
Synonyms: p44, A430056A10Rik, MTAP44
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99899
Homologene: 4683
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383258
Homologene: 129687
Prss50
Name: serine protease 50
Synonyms: Tsp50
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235631
Homologene: 8314
Thoc5
Name: THO complex 5
Synonyms: 1700060C24Rik, Fmip, PK1.3, A430085L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107829
Homologene: 37836
Vmn2r76
Name: vomeronasal 2, receptor 76
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 675969
Homologene: 104330
Dpysl5
Name: dihydropyrimidinase-like 5
Synonyms: CRMP-5, Crmp5, CRAM
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 65254
Homologene: 41347
Gnat3
Name: G protein subunit alpha transducin 3
Synonyms: Ggust, alpha-gustducin, Gtn
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242851
Homologene: 24284
Fam161b
Name: family with sequence similarity 161, member B
Synonyms: 9830169C18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217705
Homologene: 17581
Txnrd2
Name: thioredoxin reductase 2
Synonyms: TGR, TR beta, ESTM573010, TR3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26462
Homologene: 4701
Ccdc17
Name: coiled-coil domain containing 17
Synonyms: 1100001F07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 622665
Homologene: 77410
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: LOC382816, Dlgh2, B230218P12Rik, A330103J02Rik, PSD93, Gm21505, Chapsyn-110, B330007M19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Cbx8
Name: chromobox 8
Synonyms: polycomb 3, Pc3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 30951
Homologene: 32199
Prokr1
Name: prokineticin receptor 1
Synonyms: Pkr1, Gpr73, EG-VEGFR1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58182
HGNC: HGNC:4524
Homologene: 10968
Hand2
Name: heart and neural crest derivatives expressed 2
Synonyms: dHAND, bHLHa26, Thing2, Ehand2, Hed
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15111
HGNC: HGNC:4808
Homologene: 32092
Fmc1
Name: formation of mitochondrial complex V assembly factor 1
Synonyms: 1110001J03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66117
Homologene: 41627
Gm32742
Name: predicted gene, 32742
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102635385
Homologene: 132734
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,672,376 bp
  • T to A, chromosome 1 at 53,472,953 bp
  • C to T, chromosome 1 at 100,383,585 bp
  • C to T, chromosome 1 at 135,967,782 bp
  • C to A, chromosome 1 at 150,414,813 bp
  • T to C, chromosome 1 at 178,917,358 bp
  • T to C, chromosome 2 at 11,600,630 bp
  • A to T, chromosome 2 at 76,754,430 bp
  • G to T, chromosome 2 at 119,538,867 bp
  • A to G, chromosome 2 at 121,048,875 bp
  • A to T, chromosome 2 at 121,304,937 bp
  • A to G, chromosome 2 at 155,168,707 bp
  • G to T, chromosome 3 at 87,997,098 bp
  • A to G, chromosome 3 at 133,348,143 bp
  • G to A, chromosome 3 at 151,739,341 bp
  • T to A, chromosome 4 at 63,577,904 bp
  • A to G, chromosome 4 at 87,227,100 bp
  • A to G, chromosome 4 at 107,368,820 bp
  • A to T, chromosome 4 at 116,599,626 bp
  • G to A, chromosome 5 at 18,015,314 bp
  • A to G, chromosome 5 at 30,745,467 bp
  • G to A, chromosome 5 at 34,641,440 bp
  • C to A, chromosome 5 at 118,077,698 bp
  • T to G, chromosome 5 at 139,265,638 bp
  • A to T, chromosome 6 at 29,450,850 bp
  • A to T, chromosome 6 at 35,268,879 bp
  • A to T, chromosome 6 at 38,539,180 bp
  • G to T, chromosome 6 at 41,653,248 bp
  • T to A, chromosome 6 at 47,545,811 bp
  • A to T, chromosome 6 at 52,218,013 bp
  • T to A, chromosome 6 at 73,074,651 bp
  • T to C, chromosome 6 at 87,588,774 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • A to G, chromosome 6 at 136,727,894 bp
  • G to A, chromosome 7 at 3,895,258 bp
  • A to G, chromosome 7 at 30,603,618 bp
  • T to A, chromosome 7 at 86,225,271 bp
  • T to C, chromosome 7 at 91,091,032 bp
  • G to T, chromosome 7 at 104,012,425 bp
  • T to A, chromosome 7 at 122,112,001 bp
  • G to A, chromosome 8 at 40,308,164 bp
  • A to G, chromosome 8 at 57,322,426 bp
  • T to A, chromosome 8 at 107,368,520 bp
  • T to C, chromosome 9 at 35,491,867 bp
  • A to G, chromosome 9 at 45,742,586 bp
  • G to A, chromosome 9 at 51,144,375 bp
  • G to T, chromosome 9 at 80,118,512 bp
  • C to T, chromosome 9 at 110,858,060 bp
  • A to G, chromosome 10 at 81,371,108 bp
  • A to G, chromosome 10 at 107,798,736 bp
  • T to C, chromosome 10 at 120,091,617 bp
  • A to G, chromosome 10 at 127,087,306 bp
  • T to A, chromosome 10 at 128,397,015 bp
  • A to G, chromosome 11 at 4,926,115 bp
  • A to T, chromosome 11 at 5,534,350 bp
  • G to T, chromosome 11 at 50,230,685 bp
  • A to T, chromosome 11 at 60,496,415 bp
  • C to A, chromosome 11 at 119,038,928 bp
  • T to C, chromosome 12 at 40,329,578 bp
  • C to T, chromosome 12 at 84,357,595 bp
  • G to A, chromosome 12 at 100,575,241 bp
  • T to C, chromosome 16 at 18,456,298 bp
  • T to C, chromosome 16 at 56,179,028 bp
  • A to G, chromosome 17 at 55,608,642 bp
  • A to G, chromosome 18 at 31,444,019 bp
  • C to T, chromosome 19 at 5,287,214 bp
  • C to T, chromosome 19 at 6,063,044 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8428 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067822-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.