Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8461Btlr/Mmmh
Stock Number:
067837-MU
Citation ID:
RRID:MMRRC_067837-MU
Other Names:
R8461 (G1)
Major Collection:

Strain Information

Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Synonyms: Atpa-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11928
HGNC: HGNC:799
Homologene: 564
Trim13
Name: tripartite motif-containing 13
Synonyms: 3110001L12Rik, LEU5, Rfp2, RNF77
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66597
VEGA: 14
HGNC: HGNC:9976
Homologene: 4234
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, Alpha-MPP, 4933435E07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: RAB5 effector protein, neurocrescin, rabaptin-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Nup93
Name: nucleoporin 93
Synonyms: 2410008G02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71805
Homologene: 40971
Rev1
Name: REV1, DNA directed polymerase
Synonyms: REV1, 1110027I23Rik, Rev1l
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56210
Homologene: 32309
Sec23ip
Name: Sec23 interacting protein
Synonyms: D7Ertd373e, p125
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207352
Homologene: 38288
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 36,794,821 bp
  • G to T, chromosome 1 at 38,083,787 bp
  • G to A, chromosome 1 at 66,944,835 bp
  • G to A, chromosome 1 at 78,817,716 bp
  • T to C, chromosome 1 at 136,073,702 bp
  • T to C, chromosome 2 at 23,321,517 bp
  • G to A, chromosome 2 at 25,365,410 bp
  • A to G, chromosome 2 at 26,293,802 bp
  • G to C, chromosome 2 at 26,395,034 bp
  • A to G, chromosome 2 at 58,780,056 bp
  • A to G, chromosome 2 at 76,781,093 bp
  • G to A, chromosome 2 at 86,657,546 bp
  • A to G, chromosome 2 at 104,167,935 bp
  • T to A, chromosome 3 at 101,589,089 bp
  • T to C, chromosome 3 at 158,058,734 bp
  • T to C, chromosome 4 at 103,255,515 bp
  • T to C, chromosome 4 at 141,070,220 bp
  • T to A, chromosome 5 at 28,387,972 bp
  • T to C, chromosome 5 at 38,201,109 bp
  • T to A, chromosome 5 at 96,213,787 bp
  • T to C, chromosome 5 at 137,290,320 bp
  • A to T, chromosome 6 at 89,893,719 bp
  • A to T, chromosome 6 at 143,035,076 bp
  • T to C, chromosome 7 at 29,705,319 bp
  • T to C, chromosome 7 at 35,627,486 bp
  • T to C, chromosome 7 at 87,317,271 bp
  • T to C, chromosome 7 at 100,371,805 bp
  • G to T, chromosome 7 at 100,998,688 bp
  • T to C, chromosome 7 at 120,436,695 bp
  • T to A, chromosome 7 at 128,772,202 bp
  • G to A, chromosome 8 at 18,986,370 bp
  • G to T, chromosome 8 at 69,707,655 bp
  • T to C, chromosome 8 at 94,281,335 bp
  • A to T, chromosome 8 at 125,944,622 bp
  • T to A, chromosome 9 at 38,378,481 bp
  • A to G, chromosome 10 at 5,061,463 bp
  • T to C, chromosome 10 at 58,476,394 bp
  • T to C, chromosome 11 at 69,050,901 bp
  • T to A, chromosome 11 at 70,884,855 bp
  • T to A, chromosome 11 at 73,395,156 bp
  • T to C, chromosome 11 at 76,244,332 bp
  • T to C, chromosome 11 at 89,048,993 bp
  • T to C, chromosome 11 at 96,955,913 bp
  • T to G, chromosome 11 at 101,044,574 bp
  • T to C, chromosome 11 at 120,348,184 bp
  • T to C, chromosome 12 at 117,714,109 bp
  • A to G, chromosome 13 at 119,368,502 bp
  • T to C, chromosome 14 at 31,305,958 bp
  • T to C, chromosome 14 at 61,605,472 bp
  • T to C, chromosome 14 at 73,518,028 bp
  • A to T, chromosome 15 at 65,923,874 bp
  • A to T, chromosome 15 at 89,387,621 bp
  • A to T, chromosome 15 at 101,646,217 bp
  • G to T, chromosome 17 at 48,090,329 bp
  • A to G, chromosome 18 at 16,650,465 bp
  • T to C, chromosome 18 at 69,465,430 bp
  • T to C, chromosome X at 73,759,497 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8461 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067837-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.