Strain Name:
C57BL/6J-MtgxR8507Btlr/Mmmh
Stock Number:
067843-MU
Citation ID:
RRID:MMRRC_067843-MU
Other Names:
R8507 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Whi, GENA 60, GENA 47, Gena 52, Cyn, Cycn, Dz, WBE1, Edy, Flo, Lda, Mt, Obt, Todo, A730019I05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: DARPP-32, Darpp32
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972
Ndrg4
Name: N-myc downstream regulated gene 4
Synonyms: SMAP-8, Ndr4, Ndr1-rs, D8Bwg1337e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234593
Homologene: 23228
Htr3b
Name: 5-hydroxytryptamine (serotonin) receptor 3B
Synonyms: 5-HT3 receptor subunit B, 5-HT3B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57014
VEGA: 9
HGNC: HGNC:5298
Homologene: 38131
Ncam2
Name: neural cell adhesion molecule 2
Synonyms: RNCAM, Ncam-2, Ocam, R4B12 antigen
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Agpat5
Name: 1-acylglycerol-3-phosphate O-acyltransferase 5
Synonyms: 1110013A05Rik, D8Ertd319e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52123
Homologene: 10153
Spidr
Name: scaffolding protein involved in DNA repair
Synonyms: 2310008H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224008
VEGA: 16
Homologene: 51693
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alphaII-spectrin, 2610027H02Rik, Spna-2, alpha-fodrin, Spna2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Plxnd1
Name: plexin D1
Synonyms: b2b1863Clo, 6230425C21Rik, b2b553Clo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Alfy, Bchs, Ggtb3, Bwf1, D5Ertd66e, 2610509D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Reps1
Name: RalBP1 associated Eps domain containing protein
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19707
Homologene: 7515
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: 2900001A12Rik, ANCO-2, GAC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106585
Homologene: 9059
Kdsr
Name: 3-ketodihydrosphingosine reductase
Synonyms: 6330410P18Rik, 9430079B08Rik, Fvt1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70750
HGNC: HGNC:4021
Homologene: 1539
Znrf1
Name: zinc and ring finger 1
Synonyms: nin283, Zrfp1, Rnf42, B830022L21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170737
Homologene: 41858
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, CS1, CS-1, SPAG13, KRAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Tbc1d15
Name: TBC1 domain family, member 15
Synonyms: Ly6dl, 4432405K22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66687
VEGA: 10
Homologene: 11249
Ric8b
Name: RIC8 guanine nucleotide exchange factor B
Synonyms: Ric-8b, Ric-8
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237422
VEGA: 10
Homologene: 23080
Fas
Name: Fas cell surface death receptor
Synonyms: Tnfrsf6, APO-1, CD95, TNFR6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14102
VEGA: 19
Homologene: 27
Snapc1
Name: small nuclear RNA activating complex, polypeptide 1
Synonyms: 9630050P21Rik, 2700033G17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75627
VEGA: 12
Homologene: 2317
Gas8
Name: growth arrest specific 8
Synonyms: Gas11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104346
HGNC: HGNC:4166
Homologene: 1135
Malt1
Name: MALT1 paracaspase
Synonyms: paracaspase, Pcasp1, D430033E09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240354
HGNC: HGNC:6819
Homologene: 4938
Hey1
Name: hairy/enhancer-of-split related with YRPW motif 1
Synonyms: CHF2, Herp2, Hesr1, hesr-1, bHLHb31, HRT1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15213
HGNC: HGNC:4880
Homologene: 7756
Anxa6
Name: annexin A6
Synonyms: Annexin VI, Camb, Anx6, Cabm, AnxVI
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11749
HGNC: HGNC:544
Homologene: 55558
Cdk12
Name: cyclin dependent kinase 12
Synonyms: Crkrs, D11Ertd752e, 1810022J16Rik, Crk7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69131
Homologene: 128632
Septin10
Name: septin 10
Synonyms: 9430099J10Rik, 4921515A04Rik, Sept10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103080
VEGA: 10
Homologene: 27035
Pcdh17
Name: protocadherin 17
Synonyms: C030033F14Rik, LOC219228
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Peg10
Name: paternally expressed 10
Synonyms: Rtl2, MEF3L, MyEF-3, Mar2, MyEF-3 like, Edr, HB-1, Mart2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Barx2
Name: BarH-like homeobox 2
Synonyms: Barx2b, 2310006E12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12023
HGNC: HGNC:956
Homologene: 2715
Zfp830
Name: zinc finger protein 830
Synonyms: Omcg1, Ccdc16, 2410003C20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66983
Homologene: 41655
Tspear
Name: thrombospondin type laminin G domain and EAR repeats
Synonyms: C330046G03Rik, ORF65
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 252974
HGNC: HGNC:1268
Homologene: 36972
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, PTPL1, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, Dnahc14, LOC381311, A230079K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
BC024139
Name: cDNA sequence BC024139
Synonyms: 6230424I18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271278
Homologene: 129974
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Trpm5
Name: transient receptor potential cation channel, subfamily M, member 5
Synonyms: Mtr1, 9430099A16Rik, Ltrpc5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56843
Homologene: 22818
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546981
Homologene: 115466
Spn
Name: sialophorin
Synonyms: Galgp, leukosialin, 3E8 antigen, A630014B01Rik, Cd43, Ly48, Ly-48
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20737
Homologene: 36108
Myo1f
Name: myosin IF
Synonyms: C330006B10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17916
HGNC: HGNC:7600
Homologene: 56276
Itgal
Name: integrin alpha L
Synonyms: Ly-21, Cd11a, LFA-1, Ly-15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: mSlo1, Slo, 5730414M22Rik, BK channel alpha subunit, BKCa, MaxiK, Slo1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Fmnl1
Name: formin-like 1
Synonyms: formin-related gene in leukocytes, 8030453N10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57778
HGNC: HGNC:1212
Homologene: 135620
Or1j15
Name: olfactory receptor family 1 subfamily J member 15
Synonyms: GA_x6K02T2NLDC-33262744-33263673, MOR136-12, Olfr344
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258621
Or4f7
Name: olfactory receptor family 4 subfamily F member 7
Synonyms: Olfr1303, MOR245-7, GA_x6K02T2Q125-72882187-72881249, MOR245-7, Olfr276, GA_x6K02T2N82Q-3465-3764, MOR245-28_p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258397
Homologene: 88429
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Mymk
Name: myomaker, myoblast fusion factor
Synonyms: 1110002H13Rik, Tmem8c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66139
Homologene: 11925
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: D130067I03Rik, 1700074E13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Adam7
Name: a disintegrin and metallopeptidase domain 7
Synonyms: EAP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11500
HGNC: HGNC:214
Homologene: 2830
Or5h22
Name: olfactory receptor family 5 subfamily H member 22
Synonyms: MOR183-4, GA_x54KRFPKG5P-55303207-55302284, Olfr190
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258392
Homologene: 131129
Cc2d1a
Name: coiled-coil and C2 domain containing 1A
Synonyms: Tape, Freud-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212139
Homologene: 23040
Plscr4
Name: phospholipid scramblase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235527
Homologene: 23217
Pak1ip1
Name: PAK1 interacting protein 1
Synonyms: Gdpd1, 5830431I15Rik, p21-activated protein kinase-interacting protein 1, 5930415H02Rik, PIP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68083
Homologene: 39574
Dyrk2
Name: dual-specificity tyrosine phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Kcnip4
Name: Kv channel interacting protein 4
Synonyms: KChIP4a, Calp250
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80334
Homologene: 23528
Zfp456
Name: zinc finger protein 456
Synonyms: Rslcan-13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408065
Homologene: 110878
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Plat
Name: plasminogen activator, tissue
Synonyms: t-PA, tPA, D8Ertd2e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Sgms1
Name: sphingomyelin synthase 1
Synonyms: Tmem23, SMS1alpha2, SMS1beta, SMS1gamma, 9530058O11Rik, SMS1, SMS1alpha1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208449
Homologene: 27040
Epn3
Name: epsin 3
Synonyms: 2310022G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71889
Homologene: 56791
Nps
Name: neuropeptide S
Synonyms: ENSMUSG00000073804
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043254
Homologene: 106066
Or2ak4
Name: olfactory receptor family 2 subfamily AK member 4
Synonyms: MOR285-3P, Olfr316, GA_x6K02T2NKPP-648708-647788, MOR285-6_p
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258064
Homologene: 133825
Pcdhgc5
Name: protocadherin gamma subfamily C, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93708
HGNC: HGNC:8718
Homologene: 110933
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 106,743,670 bp
  • T to A, chromosome 1 at 129,678,053 bp
  • T to A, chromosome 1 at 181,641,414 bp
  • A to G, chromosome 2 at 27,062,700 bp
  • G to A, chromosome 2 at 30,026,584 bp
  • T to C, chromosome 2 at 36,569,431 bp
  • T to C, chromosome 2 at 41,408,375 bp
  • A to G, chromosome 2 at 79,644,864 bp
  • T to C, chromosome 2 at 111,814,706 bp
  • G to C, chromosome 3 at 8,664,776 bp
  • A to G, chromosome 3 at 19,971,029 bp
  • A to G, chromosome 4 at 8,858,675 bp
  • T to G, chromosome 5 at 48,482,655 bp
  • G to T, chromosome 5 at 101,872,901 bp
  • A to G, chromosome 5 at 103,557,949 bp
  • C to CTCA, chromosome 6 at 4,756,453 bp
  • A to T, chromosome 6 at 115,966,905 bp
  • A to T, chromosome 7 at 86,148,477 bp
  • C to T, chromosome 7 at 127,136,556 bp
  • C to T, chromosome 7 at 127,329,435 bp
  • C to T, chromosome 7 at 135,272,350 bp
  • T to A, chromosome 7 at 143,078,313 bp
  • G to A, chromosome 8 at 18,878,027 bp
  • G to T, chromosome 8 at 22,772,232 bp
  • T to C, chromosome 8 at 84,134,976 bp
  • A to G, chromosome 8 at 95,678,347 bp
  • G to A, chromosome 8 at 111,537,210 bp
  • T to C, chromosome 8 at 123,531,038 bp
  • A to T, chromosome 9 at 31,859,013 bp
  • C to A, chromosome 9 at 48,964,877 bp
  • C to T, chromosome 9 at 92,490,790 bp
  • T to C, chromosome 10 at 18,094,470 bp
  • A to T, chromosome 10 at 59,177,003 bp
  • C to A, chromosome 10 at 77,875,064 bp
  • T to C, chromosome 10 at 84,980,175 bp
  • A to G, chromosome 10 at 115,202,502 bp
  • G to T, chromosome 10 at 118,860,662 bp
  • C to T, chromosome 11 at 55,013,870 bp
  • C to T, chromosome 11 at 58,758,159 bp
  • A to G, chromosome 11 at 82,764,703 bp
  • A to T, chromosome 11 at 94,493,776 bp
  • A to G, chromosome 11 at 98,250,285 bp
  • G to T, chromosome 11 at 98,355,484 bp
  • A to T, chromosome 11 at 103,194,033 bp
  • C to A, chromosome 12 at 73,964,732 bp
  • G to A, chromosome 13 at 41,009,294 bp
  • A to T, chromosome 13 at 67,366,989 bp
  • G to T, chromosome 14 at 23,591,638 bp
  • A to G, chromosome 14 at 68,526,324 bp
  • G to A, chromosome 14 at 84,445,944 bp
  • A to C, chromosome 15 at 4,949,090 bp
  • T to A, chromosome 15 at 8,147,560 bp
  • T to C, chromosome 15 at 76,120,133 bp
  • A to G, chromosome 16 at 15,968,676 bp
  • A to G, chromosome 16 at 37,948,236 bp
  • C to T, chromosome 16 at 59,074,880 bp
  • C to A, chromosome 16 at 81,512,979 bp
  • T to A, chromosome 17 at 20,462,933 bp
  • T to A, chromosome 17 at 33,598,018 bp
  • T to A, chromosome 17 at 65,986,909 bp
  • G to T, chromosome 18 at 37,819,892 bp
  • T to A, chromosome 18 at 65,470,523 bp
  • A to T, chromosome 19 at 32,159,709 bp
  • C to T, chromosome 19 at 34,327,226 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8507 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067843-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.