Strain Name:
C57BL/6J-MtgxR7274Btlr/Mmmh
Stock Number:
067851-MU
Citation ID:
RRID:MMRRC_067851-MU
Other Names:
R7274 (G1)
Major Collection:

Strain Information

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Crym
Name: crystallin, mu
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12971
HGNC: HGNC:2418
Homologene: 1424
1190005I06Rik
Name: RIKEN cDNA 1190005I06 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68918
Homologene: 18858
Ssc4d
Name: scavenger receptor cysteine rich family, 4 domains
Synonyms: C330016E03Rik, Srcrb4d
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109267
Homologene: 34137
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 9130422G05Rik, 1810054D07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69863
Homologene: 25228
Klhdc4
Name: kelch domain containing 4
Synonyms: G430025P05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234825
Homologene: 69234
Sptlc2
Name: serine palmitoyltransferase, long chain base subunit 2
Synonyms: LCB2, Spt2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20773
Homologene: 21610
Tsc22d1
Name: TSC22 domain family, member 1
Synonyms: TSC-22, Egr5, Tgfb1i4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21807
Homologene: 7573
Sec24a
Name: SEC24 homolog A, COPII coat complex component
Synonyms: 9430090N21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77371
Homologene: 70131
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: mRPA1, RPA194, 194kDa, 3010014K16Rik, Rpo1-4, 2900087K15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20019
Homologene: 7033
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Zfp30
Name: zinc finger protein 30
Synonyms: Zfp-30, 2610306P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22693
Homologene: 84799
Pgm3
Name: phosphoglucomutase 3
Synonyms: Pgm-3, GlcNAc-P mutase, 2810473H05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109785
HGNC: HGNC:8907
Homologene: 9205
Chrna2
Name: cholinergic receptor nicotinic alpha 2 subunit
Synonyms: Acra-2, Acra2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110902
HGNC: HGNC:1956
Homologene: 20193
Tjp1
Name: tight junction protein 1
Synonyms: ZO-1, ZO1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21872
Homologene: 2445
Lifr
Name: LIF receptor alpha
Synonyms: soluble differentiation-stimulating factor receptor, A230075M04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Ighmbp2
Name: immunoglobulin mu DNA binding protein 2
Synonyms: Catf1, AEP, sma, Smbp2, Smubp2, p110 subunit, RIPE3b1, Smbp-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Alg12
Name: ALG12 alpha-1,6-mannosyltransferase
Synonyms: mannosyltransferase, ECM39
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223774
Homologene: 36269
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: Trrp7, LTRPC2, TRPC7, 9830168K16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Zp2
Name: zona pellucida glycoprotein 2
Synonyms: Zp-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22787
Homologene: 48194
Pkp2
Name: plakophilin 2
Synonyms: 1200012P04Rik, 1200008D14Rik, Pkp2l
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67451
HGNC: HGNC:9024
Homologene: 3364
Cat
Name: catalase
Synonyms: Cs-1, Cas-1, Cas1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12359
HGNC: HGNC:1516
Homologene: 55514
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: 1810045E08Rik, MCCalpha, MCCA, 2310058B18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Spats2l
Name: spermatogenesis associated, serine-rich 2-like
Synonyms: A230104H11Rik, 2810022L02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67198
Homologene: 56711
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: PDE5A1, Pde5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: D-LTCC, Cchl1a, Cchl1a2, Cacnl1a2, 8430418G19Rik, Cav1.3alpha1, C79217
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Fancd2os
Name: Fancd2 opposite strand
Synonyms: 4931417G12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70979
Homologene: 45456
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Cdh17
Name: cadherin 17
Synonyms: HPT-1, BILL-cadherin, LI-cadherin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Trim60
Name: tripartite motif-containing 60
Synonyms: 2czf45, Rnf33
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234329
Homologene: 51876
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NR2A, NMDAR2A, GluRepsilon1, GluN2A
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Nubpl
Name: nucleotide binding protein-like
Synonyms: 2410170E07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76826
Homologene: 11854
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Cog2
Name: component of oligomeric golgi complex 2
Synonyms: 1190002B08Rik, 2700012E02Rik, Cog2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76332
HGNC: HGNC:6546
Homologene: 7206
C1qtnf4
Name: C1q and tumor necrosis factor related protein 4
Synonyms: 0710001E10Rik, CTRP4, 9430004J15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67445
Homologene: 12134
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Irf5
Name: interferon regulatory factor 5
Synonyms: mirf5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27056
HGNC: HGNC:6120
Homologene: 8088
Or8h10
Name: olfactory receptor family 8 subfamily H member 10
Synonyms: GA_x6K02T2Q125-48465387-48464422, MOR206-4, Olfr1100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258587
Homologene: 34954
Kdr
Name: kinase insert domain protein receptor
Synonyms: VEGF receptor-2, VEGFR-2, vascular endothelial growth factor receptor- 2, VEGFR2, Flk-1, Flk1, orv
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16542
HGNC: HGNC:6307
Homologene: 55639
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21881
Homologene: 68154
Eif4a3l1
Name: eukaryotic translation initiation factor 4A3 like 1
Synonyms: Gm8994, B020013A22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 668137
Kif19a
Name: kinesin family member 19A
Synonyms: N-8 kinesin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 286942
Homologene: 17709
Rassf8
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms: mHoj-1, 5133400D11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71323
Homologene: 5219
Mia2
Name: MIA SH3 domain ER export factor 2
Synonyms: MEA6, Mgea, D12Bwg0579e, Mgea6, Ctage5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 338320
Homologene: 137655
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Cpa6
Name: carboxypeptidase A6
Synonyms: 9030616D13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329093
Homologene: 75130
Or4n4b
Name: olfactory receptor family 4 subfamily N member 4B
Synonyms: GA_x6K02T2PMLR-5992342-5991416, MOR241-2, Olfr733
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258657
Homologene: 128266
Epdr1
Name: ependymin related 1
Synonyms: MERP-1, MERP2, Ucc1, MERP-2, Epdr1, Epdr2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105298
VEGA: 13
Homologene: 9714
Rab3gap1
Name: RAB3 GTPase activating protein subunit 1
Synonyms: 1700003B17Rik, 4732493F09Rik, p130
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226407
Homologene: 45617
Bcl11a
Name: BCL11 transcription factor A
Synonyms: mouse myeloid leukemia gene, COUP-TF interacting protein 1, CTIP1, Evi9, 2810047E18Rik, D930021L15Rik, Evi9c, Evi9b, Evi9a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14025
Homologene: 11284
Fbxo16
Name: F-box protein 16
Synonyms: Fbx16
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50759
VEGA: 14
Homologene: 9273
Mecr
Name: mitochondrial trans-2-enoyl-CoA reductase
Synonyms: Nrbf1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26922
Homologene: 5362
Hypk
Name: huntingtin interacting protein K
Synonyms: 2310003F16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67693
Homologene: 9498
Gm4131
Name: predicted gene 4131
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100042960
Homologene: 132023
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 10,409,299 bp
  • C to A, chromosome 1 at 57,879,513 bp
  • T to C, chromosome 1 at 71,628,113 bp
  • T to A, chromosome 1 at 127,927,512 bp
  • C to T, chromosome 2 at 76,723,588 bp
  • A to G, chromosome 2 at 86,978,523 bp
  • T to C, chromosome 2 at 90,889,541 bp
  • T to C, chromosome 2 at 103,476,890 bp
  • A to G, chromosome 2 at 121,454,324 bp
  • A to T, chromosome 3 at 35,989,856 bp
  • A to T, chromosome 3 at 122,855,246 bp
  • C to T, chromosome 4 at 11,783,174 bp
  • T to A, chromosome 4 at 32,725,944 bp
  • T to C, chromosome 4 at 83,261,851 bp
  • C to A, chromosome 4 at 131,853,778 bp
  • A to T, chromosome 5 at 75,964,700 bp
  • T to C, chromosome 5 at 135,967,956 bp
  • A to G, chromosome 6 at 29,534,040 bp
  • T to A, chromosome 6 at 71,920,516 bp
  • G to A, chromosome 6 at 113,597,890 bp
  • A to G, chromosome 6 at 136,329,398 bp
  • T to C, chromosome 6 at 145,815,569 bp
  • C to A, chromosome 7 at 29,792,618 bp
  • A to G, chromosome 7 at 65,527,652 bp
  • A to G, chromosome 7 at 120,132,391 bp
  • T to A, chromosome 7 at 120,190,519 bp
  • T to C, chromosome 8 at 61,940,108 bp
  • T to A, chromosome 8 at 65,000,481 bp
  • T to C, chromosome 8 at 120,611,266 bp
  • T to C, chromosome 8 at 121,799,658 bp
  • T to G, chromosome 8 at 124,535,519 bp
  • A to G, chromosome 9 at 86,562,597 bp
  • A to T, chromosome 10 at 27,119,980 bp
  • A to T, chromosome 10 at 39,092,299 bp
  • T to C, chromosome 10 at 77,923,555 bp
  • T to A, chromosome 10 at 115,452,505 bp
  • T to C, chromosome 11 at 24,163,985 bp
  • A to T, chromosome 11 at 51,707,255 bp
  • C to T, chromosome 11 at 59,133,227 bp
  • C to T, chromosome 11 at 60,705,986 bp
  • G to T, chromosome 11 at 114,765,455 bp
  • A to G, chromosome 12 at 52,132,420 bp
  • A to G, chromosome 12 at 59,108,119 bp
  • A to T, chromosome 12 at 87,341,606 bp
  • A to T, chromosome 13 at 19,593,288 bp
  • T to A, chromosome 14 at 30,142,643 bp
  • T to A, chromosome 14 at 30,569,145 bp
  • T to A, chromosome 14 at 50,298,422 bp
  • T to A, chromosome 14 at 61,214,081 bp
  • T to A, chromosome 14 at 62,466,852 bp
  • C to A, chromosome 14 at 65,321,267 bp
  • A to G, chromosome 14 at 66,149,226 bp
  • T to C, chromosome 14 at 76,416,714 bp
  • T to A, chromosome 15 at 7,167,059 bp
  • A to T, chromosome 15 at 80,376,822 bp
  • G to A, chromosome 15 at 88,806,707 bp
  • G to A, chromosome 15 at 89,102,970 bp
  • T to C, chromosome 16 at 9,579,122 bp
  • T to C, chromosome 16 at 16,246,929 bp
  • A to G, chromosome 17 at 25,378,837 bp
  • A to G, chromosome 19 at 3,264,951 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7274 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067851-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.