Strain Name:
C57BL/6J-MtgxR8246Btlr/Mmmh
Stock Number:
067852-MU
Citation ID:
RRID:MMRRC_067852-MU
Other Names:
R8246 (G1)
Major Collection:

Strain Information

Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Anln
Name: anillin, actin binding protein
Synonyms: Scraps, 2900037I21Rik, 1110037A17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68743
VEGA: 9
Homologene: 41281
Eif3a
Name: eukaryotic translation initiation factor 3, subunit A
Synonyms: Eif3, Eif3s10, Csma, A830012B05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13669
VEGA: 19
HGNC: HGNC:3271
Homologene: 2779
Mdn1
Name: midasin AAA ATPase 1
Synonyms: D4Abb1e, LOC213784, 4833432B22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Fhip1b
Name: FHF complex subunit HOOK interacting protein 1B
Synonyms: Fam160a2, 4632419K20Rik, 6530415H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74349
Homologene: 75329
Sqstm1
Name: sequestosome 1
Synonyms: Osi, STAP, OSF-6, A170, p62
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18412
Homologene: 31202
Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
Synonyms: 2810411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66313
Homologene: 41490
Nol8
Name: nucleolar protein 8
Synonyms: D13Ertd548e, 5730412B09Rik, 4921532D18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70930
VEGA: 13
Homologene: 41210
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231386
Homologene: 15796
Stard8
Name: StAR related lipid transfer domain containing 8
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 236920
Homologene: 22837
Unc13b
Name: unc-13 homolog B
Synonyms: Unc13h2, Munc13-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: D430029O09Rik, Polydom, 1110021D17Rik, 4833413O10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: sba, 1700096C21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209012
Homologene: 41205
Kif6
Name: kinesin family member 6
Synonyms: D130004B10Rik, D130084M03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319991
Homologene: 35308
Rmdn2
Name: regulator of microtubule dynamics 2
Synonyms: Fam82a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381110
VEGA: 17
Homologene: 71930
Elapor2
Name: endosome-lysosome associated apoptosis and autophagy regulator family member 2
Synonyms: 9330182L06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231014
Homologene: 27396
Dnm3
Name: dynamin 3
Synonyms: 9630020E24Rik, B230343F03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Alpk3
Name: alpha-kinase 3
Synonyms: Midori
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 116904
Homologene: 10813
Tecrl
Name: trans-2,3-enoyl-CoA reductase-like
Synonyms: D330017N19Rik, Srd5a2l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243078
Homologene: 27549
Or4f57
Name: olfactory receptor family 4 subfamily F member 57
Synonyms: Olfr1308, MOR245-22, GA_x6K02T2Q125-73008844-73007882
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258258
Homologene: 45797
Tmem184c
Name: transmembrane protein 184C
Synonyms: Tmem34, 8430433H16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234463
Homologene: 32403
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212326
Homologene: 27540
Or11g2
Name: olfactory receptor family 11 subfamily G member 2
Synonyms: GA_x6K02T2PMLR-6326342-6327313, MOR106-13P, Olfr744
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 257884
Homologene: 128063
Fyn
Name: Fyn proto-oncogene
Synonyms: Src Kinase p59
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14360
HGNC: HGNC:4037
Homologene: 48068
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Ccdc42
Name: coiled-coil domain containing 42
Synonyms: A530001H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276920
Homologene: 44902
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: 1700030F18Rik, LOC380973
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Sorcs2
Name: sortilin-related VPS10 domain containing receptor 2
Synonyms: VPS10 domain receptor protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81840
Homologene: 56899
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Pax5
Name: paired box 5
Synonyms: EBB-1, Pax-5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18507
HGNC: HGNC:8619
Homologene: 56419
Dok5
Name: docking protein 5
Synonyms: 2700055C10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76829
Homologene: 10195
Vps16
Name: VSP16 CORVET/HOPS core subunit
Synonyms: 1810074M16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80743
Homologene: 7116
Mrgprb3
Name: MAS-related GPR, member B3
Synonyms: MrgB3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404238
Homologene: 138632
Dtwd2
Name: DTW domain containing 2
Synonyms: 1190002H09Rik, 8030470C17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68857
Homologene: 79701
Rpusd4
Name: RNA pseudouridylate synthase domain containing 4
Synonyms: 2410001E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71989
Homologene: 32794
Tinf2
Name: Terf1 (TRF1)-interacting nuclear factor 2
Synonyms: D14Wsu146e, TIN2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 28113
VEGA: 14
Homologene: 8264
Klrh1
Name: killer cell lectin-like receptor subfamily H, member 1
Synonyms: Gm156, LOC232415
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232415
Homologene: 16395
Krtap12-22
Name: keratin associated protein 12-22
Synonyms: Gm10024
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100009614
VEGA: 10
Homologene: 135713
Gpr157
Name: G protein-coupled receptor 157
Synonyms: F730108M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269604
Homologene: 18573
Borcs6
Name: BLOC-1 related complex subunit 6
Synonyms: 2310047M10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71923
Homologene: 41183
Mcub
Name: mitochondrial calcium uniporter dominant negative beta subunit
Synonyms: Ccdc109b, 9030408N13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66815
Homologene: 23056
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 162,307,917 bp
  • T to C, chromosome 2 at 111,960,138 bp
  • G to C, chromosome 2 at 130,438,873 bp
  • A to G, chromosome 2 at 170,800,893 bp
  • A to G, chromosome 3 at 19,975,022 bp
  • C to A, chromosome 3 at 129,915,165 bp
  • C to T, chromosome 4 at 32,657,284 bp
  • T to C, chromosome 4 at 43,175,954 bp
  • T to C, chromosome 4 at 44,570,027 bp
  • A to T, chromosome 4 at 58,091,889 bp
  • C to T, chromosome 4 at 150,102,296 bp
  • T to C, chromosome 5 at 9,446,966 bp
  • G to A, chromosome 5 at 36,062,588 bp
  • T to C, chromosome 5 at 83,279,309 bp
  • C to T, chromosome 5 at 86,817,322 bp
  • G to A, chromosome 5 at 111,233,341 bp
  • A to G, chromosome 6 at 129,775,376 bp
  • T to G, chromosome 7 at 48,643,520 bp
  • C to A, chromosome 7 at 81,092,776 bp
  • T to C, chromosome 7 at 105,389,660 bp
  • T to C, chromosome 8 at 45,381,618 bp
  • A to T, chromosome 8 at 77,610,185 bp
  • A to C, chromosome 9 at 22,350,955 bp
  • A to G, chromosome 9 at 35,272,580 bp
  • T to C, chromosome 9 at 121,156,875 bp
  • T to A, chromosome 10 at 39,529,529 bp
  • T to A, chromosome 10 at 77,711,535 bp
  • T to C, chromosome 11 at 50,210,561 bp
  • C to A, chromosome 11 at 68,587,296 bp
  • C to T, chromosome 11 at 69,060,551 bp
  • T to C, chromosome 11 at 106,831,044 bp
  • T to G, chromosome 13 at 49,655,248 bp
  • A to G, chromosome 14 at 50,618,384 bp
  • T to C, chromosome 14 at 55,679,585 bp
  • G to T, chromosome 14 at 103,155,204 bp
  • A to T, chromosome 15 at 89,533,346 bp
  • T to A, chromosome 15 at 99,940,547 bp
  • C to T, chromosome 17 at 49,758,514 bp
  • T to A, chromosome 17 at 79,672,537 bp
  • A to T, chromosome 18 at 49,698,425 bp
  • A to G, chromosome 18 at 77,363,546 bp
  • T to C, chromosome 19 at 60,779,368 bp
  • C to T, chromosome X at 99,065,964 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8246 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067852-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.