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Strain Name:
C57BL/6J-MtgxR8358Btlr/Mmmh
Stock Number:
067871-MU
Citation ID:
RRID:MMRRC_067871-MU
Other Names:
R8358 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108096
Homologene: 56603
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: A330076K04Rik, 1100001C18Rik, 2500002E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70097
Homologene: 69182
Csnk1a1
Name: casein kinase 1, alpha 1
Synonyms: 4632404G05Rik, 2610208K14Rik, 5430427P18Rik, CK1a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93687
HGNC: HGNC:2451
Homologene: 111694
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Resf1
Name: retroelement silencing factor 1
Synonyms: GET, 2810474O19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67246
Homologene: 19251
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,452,129 bp
  • T to A, chromosome 1 at 75,553,715 bp
  • T to C, chromosome 1 at 87,981,048 bp
  • C to T, chromosome 2 at 13,325,160 bp
  • T to A, chromosome 2 at 71,530,308 bp
  • T to C, chromosome 2 at 84,950,516 bp
  • C to T, chromosome 2 at 89,752,079 bp
  • T to C, chromosome 2 at 122,080,258 bp
  • G to A, chromosome 3 at 30,699,783 bp
  • A to T, chromosome 3 at 58,637,028 bp
  • T to A, chromosome 3 at 88,245,218 bp
  • T to C, chromosome 3 at 100,927,318 bp
  • G to T, chromosome 4 at 8,839,529 bp
  • A to G, chromosome 4 at 100,959,471 bp
  • A to T, chromosome 4 at 118,916,526 bp
  • T to G, chromosome 4 at 146,124,773 bp
  • A to G, chromosome 5 at 31,136,994 bp
  • A to T, chromosome 5 at 35,974,486 bp
  • T to A, chromosome 5 at 114,937,406 bp
  • T to C, chromosome 6 at 42,912,042 bp
  • A to G, chromosome 6 at 142,262,685 bp
  • C to T, chromosome 6 at 149,326,578 bp
  • T to G, chromosome 7 at 11,670,383 bp
  • T to C, chromosome 7 at 18,614,597 bp
  • T to A, chromosome 7 at 44,140,761 bp
  • T to C, chromosome 7 at 135,700,126 bp
  • A to G, chromosome 9 at 39,599,355 bp
  • T to A, chromosome 9 at 105,397,056 bp
  • C to A, chromosome 10 at 8,729,981 bp
  • T to C, chromosome 10 at 115,404,293 bp
  • T to C, chromosome 10 at 116,048,275 bp
  • T to C, chromosome 11 at 4,205,837 bp
  • T to A, chromosome 11 at 67,652,908 bp
  • T to A, chromosome 11 at 121,160,519 bp
  • T to C, chromosome 13 at 13,359,344 bp
  • A to G, chromosome 13 at 38,192,481 bp
  • G to A, chromosome 13 at 98,725,774 bp
  • C to A, chromosome 14 at 60,971,185 bp
  • T to A, chromosome 15 at 57,244,847 bp
  • C to T, chromosome 15 at 76,347,997 bp
  • T to C, chromosome 15 at 88,811,300 bp
  • T to C, chromosome 16 at 20,549,046 bp
  • A to G, chromosome 16 at 29,348,987 bp
  • T to A, chromosome 17 at 6,023,805 bp
  • T to A, chromosome 17 at 23,553,374 bp
  • T to C, chromosome 17 at 36,017,337 bp
  • G to T, chromosome 18 at 59,048,809 bp
  • A to G, chromosome 18 at 61,580,539 bp
  • G to A, chromosome 18 at 75,565,044 bp
  • T to C, chromosome 19 at 13,585,400 bp
  • T to A, chromosome 19 at 60,563,235 bp
  • C to T, chromosome X at 105,996,895 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8358 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067871-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.