Strain Name:
C57BL/6J-MtgxR7720Btlr/Mmmh
Stock Number:
067892-MU
Citation ID:
RRID:MMRRC_067892-MU
Other Names:
R7720 (G1)
Major Collection:

Strain Information

Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Ese1, EHSH1, Intersectin-L, Eh domain, SH3 domain regulator of endocytosis 1, Sh3p17
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Gluralpha4, Glur4, spkw1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: Depdc2, 6230420N16Rik, C030045D06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Mrps27
Name: mitochondrial ribosomal protein S27
Synonyms: 2610028H14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218506
VEGA: 13
Homologene: 41006
Kif1b
Name: kinesin family member 1B
Synonyms: N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, A530096N05Rik, Kif1b alpha, Kif1b beta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: RPTPgamma, 5430405N12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Lman2
Name: lectin, mannose-binding 2
Synonyms: VIP36, GP36B, 1300009F09Rik, 1110003H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66890
VEGA: 13
Homologene: 4962
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Card6
Name: caspase recruitment domain family, member 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239319
Homologene: 13067
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, 2600013A04Rik, D230004I22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
Synonyms: CnA, PP2B alpha 1, PP2BA alpha, Caln, 2900074D19Rik, CN, Calna
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19055
HGNC: HGNC:9314
Homologene: 55497
Mrpl10
Name: mitochondrial ribosomal protein L10
Synonyms: MRP-L8, 0610040E02Rik, Rpml8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107732
Homologene: 41665
Tbl2
Name: transducin (beta)-like 2
Synonyms: WS-bTRP, C76179
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27368
Homologene: 8260
Hapstr1
Name: HUWE1 associated protein modifying stress responses
Synonyms: 1810013L24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69053
VEGA: 16
Homologene: 105712
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Hmcn1
Name: hemicentin 1
Synonyms: EG545370, LOC240793
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: Ltbp1L, b2b1000Clo, 9430031G15Rik, LTBP-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Hs2st1
Name: heparan sulfate 2-O-sulfotransferase 1
Synonyms: Hs2st
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23908
HGNC: HGNC:5193
Homologene: 8025
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Gsdme
Name: gasdermin E
Synonyms: 4932441K13Rik, Dfna5h, Fin15, 2310037D07Rik, Dfna5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54722
HGNC: HGNC:2810
Homologene: 3242
Wipi1
Name: WD repeat domain, phosphoinositide interacting 1
Synonyms: 4930533H01Rik, D11Ertd498e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52639
Homologene: 117983
Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms: p110alpha, 6330412C24Rik, caPI3K
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18706
HGNC: HGNC:8975
Homologene: 21249
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Sirpb1c
Name: signal-regulatory protein beta 1C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100038947
Homologene: 82993
Nol4
Name: nucleolar protein 4
Synonyms: LOC383304, 4930568N03Rik, 1700013J13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240753
Homologene: 135779
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20419
Homologene: 32123
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: Pynod, 6430548I20Rik, Nalp10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244202
Homologene: 18468
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mor1, Mar, Mart1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Semp2l1
Name: SUMO/sentrin specific peptidase 2-like 1
Synonyms: Gm5415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 408191
Homologene: 130042
F11
Name: coagulation factor XI
Synonyms: Cf11, plasma thromboplastin antecedent, 1600027G01Rik, FXI
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Fam124b
Name: family with sequence similarity 124, member B
Synonyms: A830043J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241128
Homologene: 65263
Pfpl
Name: pore forming protein-like
Synonyms: Epcs5, Epcs50
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56093
VEGA: 19
Homologene: 130704
Hgd
Name: homogentisate 1, 2-dioxygenase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15233
HGNC: HGNC:4892
Homologene: 156
Prss50
Name: serine protease 50
Synonyms: Tsp50
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235631
Homologene: 8314
Ccdc202
Name: coiled-coil domain containing 202
Synonyms: 4921530L21Rik, Spertl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66732
VEGA: 14
Homologene: 41645
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Vps16
Name: VSP16 CORVET/HOPS core subunit
Synonyms: 1810074M16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80743
Homologene: 7116
Or5h25
Name: olfactory receptor family 5 subfamily H member 25
Synonyms: Olfr193, MOR113-7P, MOR183-7P, Olfr1540-ps1, MOR113-7P, GA_x54KRFPKG5P-55338697-55337768
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 257972
Homologene: 128162
Shfl
Name: shiftless antiviral inhibitor of ribosomal frameshifting
Synonyms: A230050P20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319278
Homologene: 10165
Garin2
Name: golgi associated RAB2 interactor 2
Synonyms: 4921509E07Rik, Fam71d, 4930516C23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70897
Homologene: 49887
Ctsw
Name: cathepsin W
Synonyms: lymphopain
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13041
VEGA: 19
HGNC: HGNC:2546
Homologene: 37471
Vstm5
Name: V-set and transmembrane domain containing 5
Synonyms: 2200002K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69137
VEGA: 9
Homologene: 45982
Oasl1
Name: 2'-5' oligoadenylate synthetase-like 1
Synonyms: 7530414C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231655
HGNC: HGNC:8090
Homologene: 2769
Gipr
Name: gastric inhibitory polypeptide receptor
Synonyms: LOC232937, LOC381853, glucose-dependent insulinotropic polypeptide receptor
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381853
HGNC: HGNC:4271
Homologene: 20081
Or2d3c
Name: olfactory receptor family 2 subfamily D member 3C
Synonyms: MOR260-7, Olfr709, GA_x6K02T2PBJ9-9307730-9306814
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258146
Pcdhga2
Name: protocadherin gamma subfamily A, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93710
HGNC: HGNC:8700
Homologene: 69262
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 11,181,937 bp
  • T to G, chromosome 1 at 30,829,857 bp
  • T to C, chromosome 1 at 32,546,097 bp
  • A to G, chromosome 1 at 80,200,257 bp
  • T to C, chromosome 1 at 133,293,707 bp
  • C to A, chromosome 1 at 150,429,532 bp
  • T to A, chromosome 1 at 150,646,709 bp
  • C to T, chromosome 2 at 130,441,703 bp
  • T to A, chromosome 3 at 15,832,072 bp
  • C to G, chromosome 3 at 32,436,218 bp
  • T to A, chromosome 3 at 136,890,489 bp
  • T to C, chromosome 3 at 144,454,022 bp
  • A to G, chromosome 4 at 149,182,355 bp
  • G to A, chromosome 5 at 114,929,921 bp
  • G to C, chromosome 5 at 135,159,475 bp
  • G to A, chromosome 6 at 22,222,431 bp
  • C to T, chromosome 6 at 50,229,308 bp
  • T to A, chromosome 7 at 8,483,461 bp
  • T to C, chromosome 7 at 19,162,959 bp
  • C to A, chromosome 7 at 106,927,411 bp
  • A to G, chromosome 7 at 108,924,488 bp
  • G to C, chromosome 7 at 141,809,303 bp
  • A to C, chromosome 8 at 4,748,720 bp
  • A to T, chromosome 8 at 15,931,108 bp
  • T to C, chromosome 8 at 45,252,090 bp
  • A to T, chromosome 9 at 4,464,288 bp
  • A to T, chromosome 9 at 15,239,356 bp
  • C to T, chromosome 9 at 20,868,859 bp
  • A to G, chromosome 9 at 21,399,537 bp
  • T to C, chromosome 9 at 53,522,239 bp
  • T to C, chromosome 9 at 110,861,335 bp
  • G to A, chromosome 10 at 123,032,588 bp
  • A to G, chromosome 10 at 127,091,088 bp
  • T to G, chromosome 11 at 97,047,537 bp
  • G to T, chromosome 11 at 109,582,423 bp
  • T to C, chromosome 12 at 40,806,975 bp
  • T to C, chromosome 12 at 78,712,133 bp
  • T to C, chromosome 12 at 109,594,430 bp
  • A to T, chromosome 13 at 55,353,077 bp
  • A to T, chromosome 13 at 99,401,330 bp
  • A to G, chromosome 14 at 12,211,703 bp
  • A to G, chromosome 14 at 95,882,112 bp
  • G to T, chromosome 15 at 5,098,423 bp
  • T to A, chromosome 16 at 8,843,102 bp
  • T to A, chromosome 16 at 37,593,435 bp
  • T to C, chromosome 16 at 59,109,771 bp
  • C to A, chromosome 16 at 73,897,015 bp
  • G to A, chromosome 16 at 91,868,083 bp
  • A to T, chromosome 17 at 75,385,124 bp
  • A to T, chromosome 18 at 23,040,023 bp
  • A to G, chromosome 18 at 37,669,940 bp
  • A to G, chromosome 18 at 43,571,908 bp
  • T to C, chromosome 19 at 5,467,044 bp
  • C to T, chromosome 19 at 12,429,174 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7720 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067892-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.