Strain Name:
C57BL/6J-MtgxR8059Btlr/Mmmh
Stock Number:
067894-MU
Citation ID:
RRID:MMRRC_067894-MU
Other Names:
R8059 (G1)
Major Collection:

Strain Information

Pax3
Name: paired box 3
Synonyms: Pax-3, Splchl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18505
HGNC: HGNC:8617
Homologene: 22494
Lrrn3
Name: leucine rich repeat protein 3, neuronal
Synonyms: NLRR-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16981
VEGA: 12
Homologene: 36315
Slc17a6
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: VGLUT2, 2900073D12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140919
Homologene: 121617
Mtmr7
Name: myotubularin related protein 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54384
HGNC: HGNC:7454
Homologene: 99732
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: Aprin, AS3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Maco1
Name: macoilin 1
Synonyms: 9230118A01Rik, Tmem57, 1110007C24Rik, C61
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66146
Homologene: 14449
Cers2
Name: ceramide synthase 2
Synonyms: CerS2, Trh3, 0610013I17Rik, Lass2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76893
Homologene: 39581
Rgs3
Name: regulator of G-protein signaling 3
Synonyms: C2PA-RGS3, PDZ-RGS3, RGS3S, C2pa, 4930506N09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50780
HGNC: HGNC:9999
Homologene: 32440
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, D16Ertd95e, Gm15797
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF kappaB1, p50, NF-kappaB p50, p50/p105, NF-kappaB, nuclear factor kappaB p50, p50 subunit of NF kappaB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 3110050K21Rik, 2600010B19Rik, 4930570G11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Sp1
Name: trans-acting transcription factor 1
Synonyms: Sp1-1, 1110003E12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20683
Homologene: 8276
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, b2b327Clo, opm
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: 2610301F02Rik, ENSMUSG00000075261, CAMDI
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545428
Homologene: 52149
Slc18a2
Name: solute carrier family 18 (vesicular monoamine), member 2
Synonyms: 1110037L13Rik, Vmat2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 214084
VEGA: 19
Homologene: 2298
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: LOC380777, skNAC
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Slc39a8
Name: solute carrier family 39 (metal ion transporter), member 8
Synonyms: ZIP8, 4933419D20Rik, BIGM103
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67547
Homologene: 11155
Hspd1
Name: heat shock protein 1 (chaperonin)
Synonyms: Hsp60
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15510
HGNC: HGNC:5261
Homologene: 1626
Plod1
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Synonyms: lysyl hydroxylase 1, LH1, 2410042F05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18822
HGNC: HGNC:9081
Homologene: 256
Adam19
Name: ADAM metallopeptidase domain 19
Synonyms: Mltnb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11492
HGNC: HGNC:197
Homologene: 74925
Nop2
Name: NOP2 nucleolar protein
Synonyms: 120kDa, Nol1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110109
HGNC: HGNC:7867
Homologene: 135865
Per1
Name: period circadian clock 1
Synonyms: Hftm, m-rigui, mPer1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18626
HGNC: HGNC:8845
Homologene: 1966
Psmc6
Name: proteasome (prosome, macropain) 26S subunit, ATPase, 6
Synonyms: 2300001E01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67089
VEGA: 14
HGNC: HGNC:9553
Homologene: 100630
Rtraf
Name: RNA transcription, translation and transport factor
Synonyms: 2700060E02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68045
VEGA: 14
Homologene: 9355
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Dnai3
Name: dynein axonemal intermediate chain 3
Synonyms: 4931433A13Rik, IC140, Ida7, Wdr63
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242253
Homologene: 44922
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, ihj, Spna1, erythroid
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Kctd19
Name: potassium channel tetramerisation domain containing 19
Synonyms: 4922504H04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 279499
Homologene: 18630
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Or6d14
Name: olfactory receptor family 6 subfamily D member 14
Synonyms: MOR119-1, Olfr214, GA_x54KRFPKN04-58190962-58191900
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258754
Homologene: 133694
Vrtn
Name: vertebrae development associated
Synonyms: 7420416P09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 432677
VEGA: 12
Homologene: 41236
Oaz2
Name: ornithine decarboxylase antizyme 2
Synonyms: antizyme 2, AZ-2, Oaz2-ps, Sez15, AZ2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18247
HGNC: HGNC:8096
Homologene: 31094
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110893
Homologene: 62645
Nek11
Name: NIMA (never in mitosis gene a)-related expressed kinase 11
Synonyms: 4932416N14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208583
Homologene: 57008
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Chl1
Name: cell adhesion molecule L1-like
Synonyms: CALL, A530023M13Rik, close homolog of L1, LICAM2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Dnm3
Name: dynamin 3
Synonyms: 9630020E24Rik, B230343F03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: Gnn, BC030307
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103220
VEGA: 10
Homologene: 52968
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: C130044A18Rik, Phlppl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244650
Homologene: 71015
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27405
HGNC: HGNC:74
Homologene: 86845
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Pabpc2
Name: poly(A) binding protein, cytoplasmic 2
Synonyms: Pabp2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18459
Homologene: 56509
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: 1190004A11Rik, LOC215798, DREG, Gpr126
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215798
Homologene: 10724
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Vmn1r233
Name: vomeronasal 1 receptor 233
Synonyms: V1rf5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171236
Homologene: 128343
Or5p57
Name: olfactory receptor family 5 subfamily P member 57
Synonyms: MOR204-32, GA_x6K02T2PBJ9-10395807-10394869, Olfr480
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56861
Homologene: 72039
Man2b2
Name: mannosidase 2, alpha B2
Synonyms: 135 kDa alpha-D-mannosidase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17160
Homologene: 7411
Or8k23
Name: olfactory receptor family 8 subfamily K member 23
Synonyms: MOR186-2, GA_x6K02T2Q125-47827833-47826892, Olfr1056
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259020
Homologene: 27328
Defb30
Name: defensin beta 30
Synonyms: 2410125J01Rik, 4930449O14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73670
Homologene: 86862
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433586
Homologene: 41284
Mapk10
Name: mitogen-activated protein kinase 10
Synonyms: JNK3, p493F12, C230008H04Rik, Serk2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26414
HGNC: HGNC:6872
Homologene: 56439
Trpv6
Name: transient receptor potential cation channel, subfamily V, member 6
Synonyms: Ecac2, CaT1, Cac, CAT
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64177
Homologene: 56812
Entpd2
Name: ectonucleoside triphosphate diphosphohydrolase 2
Synonyms: NTPDase2, Cd39l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12496
HGNC: HGNC:3364
Homologene: 20333
Kcnj4
Name: potassium inwardly-rectifying channel, subfamily J, member 4
Synonyms: IRK3, Kir 2.3, MB-IRK3, Kcnf2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16520
VEGA: 15
HGNC: HGNC:6265
Homologene: 3653
Trav21-dv12
Name: T cell receptor alpha variable 21-DV12
Synonyms: Gm13892
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100101940
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 55,081,724 bp
  • T to C, chromosome 1 at 78,103,366 bp
  • A to G, chromosome 1 at 162,084,139 bp
  • A to G, chromosome 1 at 174,218,370 bp
  • G to T, chromosome 2 at 25,398,084 bp
  • A to C, chromosome 2 at 77,044,751 bp
  • A to G, chromosome 2 at 86,355,962 bp
  • A to G, chromosome 3 at 51,856,689 bp
  • A to G, chromosome 3 at 95,322,671 bp
  • C to T, chromosome 3 at 135,593,852 bp
  • G to T, chromosome 3 at 135,826,586 bp
  • C to G, chromosome 3 at 146,046,673 bp
  • T to C, chromosome 4 at 62,602,977 bp
  • A to T, chromosome 4 at 134,828,048 bp
  • A to T, chromosome 4 at 147,928,484 bp
  • A to G, chromosome 5 at 36,816,160 bp
  • G to T, chromosome 5 at 102,966,612 bp
  • A to T, chromosome 5 at 104,953,082 bp
  • G to T, chromosome 5 at 150,807,835 bp
  • T to G, chromosome 6 at 41,624,586 bp
  • T to A, chromosome 6 at 103,674,987 bp
  • C to T, chromosome 6 at 116,556,473 bp
  • T to C, chromosome 6 at 125,140,812 bp
  • T to A, chromosome 7 at 51,645,044 bp
  • T to C, chromosome 7 at 108,066,016 bp
  • C to T, chromosome 8 at 40,581,522 bp
  • T to G, chromosome 8 at 105,396,351 bp
  • T to A, chromosome 8 at 109,895,557 bp
  • C to T, chromosome 9 at 65,689,143 bp
  • T to C, chromosome 9 at 105,162,974 bp
  • G to T, chromosome 10 at 14,469,050 bp
  • T to C, chromosome 10 at 38,966,061 bp
  • T to C, chromosome 10 at 39,843,495 bp
  • A to G, chromosome 10 at 86,712,978 bp
  • C to T, chromosome 10 at 128,040,503 bp
  • T to A, chromosome 11 at 9,373,279 bp
  • G to A, chromosome 11 at 46,136,466 bp
  • G to A, chromosome 11 at 69,106,483 bp
  • T to C, chromosome 12 at 41,454,217 bp
  • T to A, chromosome 12 at 51,790,378 bp
  • C to T, chromosome 12 at 81,202,258 bp
  • T to C, chromosome 12 at 84,649,916 bp
  • T to C, chromosome 14 at 19,822,563 bp
  • G to A, chromosome 14 at 31,160,241 bp
  • A to T, chromosome 14 at 45,340,803 bp
  • C to A, chromosome 14 at 53,876,721 bp
  • A to G, chromosome 14 at 63,035,934 bp
  • C to G, chromosome 14 at 75,327,810 bp
  • C to T, chromosome 15 at 34,345,335 bp
  • T to C, chromosome 15 at 79,484,802 bp
  • T to G, chromosome 15 at 102,407,902 bp
  • T to C, chromosome 15 at 103,493,287 bp
  • T to C, chromosome 16 at 18,912,151 bp
  • T to C, chromosome 17 at 20,994,436 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • A to T, chromosome 18 at 39,774,822 bp
  • A to T, chromosome 19 at 15,981,512 bp
  • A to T, chromosome 19 at 59,284,140 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8059 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067894-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.