Strain Name:
C57BL/6J-MtgxR8474Btlr/Mmmh
Stock Number:
067918-MU
Citation ID:
RRID:MMRRC_067918-MU
Other Names:
R8474 (G1)
Major Collection:

Strain Information

Qki
Name: quaking, KH domain containing RNA binding
Synonyms: l(17)-1Wis, QkI, l17Wis1, 1110003F05Rik, Qk
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19317
VEGA: 17
Homologene: 11059
Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, 2310047O13Rik, Fam188a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Pcif1
Name: phosphorylated CTD interacting factor 1
Synonyms: 2310022K11Rik, F730014I05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228866
Homologene: 11134
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Cyt28, Gpr56
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Gse1
Name: genetic suppressor element 1, coiled-coil protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382034
Homologene: 40964
Impact
Name: impact, RWD domain protein
Synonyms: E430016J11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16210
VEGA: 18
Homologene: 5490
Ccdc191
Name: coiled-coil domain containing 191
Synonyms: 2610015P09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212153
Homologene: 19484
Eif3a
Name: eukaryotic translation initiation factor 3, subunit A
Synonyms: Csma, Eif3, A830012B05Rik, Eif3s10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13669
VEGA: 19
HGNC: HGNC:3271
Homologene: 2779
Crot
Name: carnitine O-octanoyltransferase
Synonyms: 1200003H03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74114
HGNC: HGNC:2366
Homologene: 10899
Myo1d
Name: myosin ID
Synonyms: 9930104H07Rik, D11Ertd9e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Bcam
Name: basal cell adhesion molecule
Synonyms: B-CAM, 1200005K12Rik, Lu
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57278
HGNC: HGNC:6722
Homologene: 21149
Cbln1
Name: cerebellin 1 precursor protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12404
HGNC: HGNC:1543
Homologene: 74520
Ptger1
Name: prostaglandin E receptor 1 (subtype EP1)
Synonyms: EP1, Ptgerep1, 42kDa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19216
HGNC: HGNC:9593
Homologene: 738
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, D230004I22Rik, 2600013A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p67MBP, p160MBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Runx2
Name: runt related transcription factor 2
Synonyms: AML3, polyomavirus enhancer binding factor 2 (PEBP2), SL3-3 enhancer factor 1, PEBP2 alpha A, PEBP2aA, Osf2, Cbfa1, Pebpa2a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Nudcd2
Name: NudC domain containing 2
Synonyms: 2700047N05Rik, D11Ertd603e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52653
Homologene: 12094
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: Ftsh, ATP-dependent metalloprotease FtsH1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27377
Homologene: 31996
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1154Clo, b2b1134Clo, b2b1537Clo, b2b1565Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103199
VEGA: 10
Homologene: 6713
Bcat2
Name: branched chain aminotransferase 2, mitochondrial
Synonyms: Eca40, Bcat-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12036
HGNC: HGNC:977
Homologene: 81684
Enpep
Name: glutamyl aminopeptidase
Synonyms: Bp-1/6C3, APA, Ly-51, Ly51, 6030431M22Rik, aminopeptidase-A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Slc5a8
Name: solute carrier family 5 (iodide transporter), member 8
Synonyms: SMCT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216225
VEGA: 10
Homologene: 64832
Or4f62
Name: olfactory receptor family 4 subfamily F member 62
Synonyms: GA_x6K02T2Q125-73202172-73203134, MOR245-16, Olfr1318
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258022
Homologene: 134079
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Sis
Name: sucrase isomaltase
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Akip1
Name: A kinase interacting protein 1
Synonyms: ICRFP703N2430Q5.6, D7H11orf17, BCA3, ORF27, ICRFP703B1614Q5.6, D930014E17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57373
HGNC: HGNC:1170
Homologene: 10765
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Gramd1b
Name: GRAM domain containing 1B
Synonyms: A930008A22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235283
Homologene: 18223
Ifi207
Name: interferon activated gene 207
Synonyms: AI607873, Pyhin-A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226691
HGNC: HGNC:5395
Homologene: 115929
Sppl2c
Name: signal peptide peptidase 2C
Synonyms: 4933407P14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237958
Homologene: 18491
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Cmah
Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase
Synonyms: CMP-NeuAc hydroxylase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12763
HGNC: HGNC:2098
Homologene: 7269
Atg2a
Name: autophagy related 2A
Synonyms: 1810013C15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329015
Homologene: 86985
Or5b101
Name: olfactory receptor family 5 subfamily B member 101
Synonyms: GA_x6K02T2RE5P-3357666-3356743, MOR202-6, Olfr1453
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258695
HGNC: HGNC:8324
Homologene: 120159
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74362
Homologene: 52601
Tmc3
Name: transmembrane channel-like gene family 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233424
Homologene: 45588
Tsks
Name: testis-specific serine kinase substrate
Synonyms: clone 4, Tssks1, Tsks, Stk22s1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22116
Homologene: 7984
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, 4632415N18Rik, 4930463G05Rik, D19Ertd652e, Wdr96
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Mark1
Name: MAP/microtubule affinity regulating kinase 1
Synonyms: Emk3, B930025N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226778
HGNC: HGNC:6896
Homologene: 49552
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 3110007G05Rik, 1700084G18Rik, 2310039H16Rik, B130050I23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 213027
Homologene: 134635
Pebp4
Name: phosphatidylethanolamine binding protein 4
Synonyms: 1700051A02Rik, 1700081D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73523
VEGA: 14
Homologene: 51650
Hoxa9
Name: homeobox A9
Synonyms: D6a9, Hox-1.7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15405
HGNC: HGNC:5109
Homologene: 7766
Arhgef39
Name: Rho guanine nucleotide exchange factor 39
Synonyms: E130306D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230098
Homologene: 19225
Stxbp6
Name: syntaxin binding protein 6 (amisyn)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217517
Homologene: 8579
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667373
Homologene: 78213
Clca1
Name: chloride channel accessory 1
Synonyms: gob-5, gob5, Clca3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 435916
Homologene: 135826
Or8g2b
Name: olfactory receptor family 8 subfamily G member 2B
Synonyms: GA_x6K02T2PVTD-33539896-33540819, MOR171-13, Olfr971
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258607
VEGA: 9
Homologene: 133635
Bcl2l14
Name: BCL2 like 14
Synonyms: 4933405K19Rik, 9030625M01Rik, 4930452K23Rik, Bcl-G
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66813
Homologene: 49840
Ephx3
Name: epoxide hydrolase 3
Synonyms: 2310063B19Rik, Abhd9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71932
Homologene: 69386
Cd70
Name: CD70 antigen
Synonyms: Ki-24 antigen, CD27LG, Tnfsf7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21948
VEGA: 17
Homologene: 956
Wdr54
Name: WD repeat domain 54
Synonyms: 1700030E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75659
Homologene: 11382
Tmem258
Name: transmembrane protein 258
Synonyms: 1810006K21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69038
HGNC: HGNC:1164
Homologene: 40931
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,169,185 bp
  • G to A, chromosome 1 at 173,729,039 bp
  • A to G, chromosome 1 at 184,919,586 bp
  • T to C, chromosome 2 at 12,400,028 bp
  • T to A, chromosome 2 at 23,162,572 bp
  • T to C, chromosome 2 at 112,155,975 bp
  • C to G, chromosome 2 at 146,424,830 bp
  • A to T, chromosome 2 at 164,888,352 bp
  • A to T, chromosome 3 at 72,929,397 bp
  • A to T, chromosome 3 at 100,027,270 bp
  • C to T, chromosome 3 at 129,319,427 bp
  • T to A, chromosome 3 at 145,005,031 bp
  • A to G, chromosome 4 at 43,498,015 bp
  • A to G, chromosome 5 at 8,993,518 bp
  • C to A, chromosome 5 at 146,104,677 bp
  • A to G, chromosome 6 at 52,225,526 bp
  • T to C, chromosome 6 at 83,153,004 bp
  • T to C, chromosome 6 at 123,704,640 bp
  • T to C, chromosome 6 at 134,423,757 bp
  • A to T, chromosome 7 at 19,760,400 bp
  • A to T, chromosome 7 at 44,950,839 bp
  • A to G, chromosome 7 at 45,587,651 bp
  • G to A, chromosome 7 at 83,609,914 bp
  • T to A, chromosome 7 at 109,707,490 bp
  • T to C, chromosome 8 at 4,210,784 bp
  • C to T, chromosome 8 at 83,668,638 bp
  • C to T, chromosome 8 at 87,472,045 bp
  • C to G, chromosome 8 at 95,003,308 bp
  • C to T, chromosome 8 at 120,568,384 bp
  • A to G, chromosome 9 at 21,465,720 bp
  • T to A, chromosome 9 at 39,839,752 bp
  • A to G, chromosome 9 at 40,375,911 bp
  • A to T, chromosome 10 at 41,232,174 bp
  • A to G, chromosome 10 at 88,921,690 bp
  • A to G, chromosome 10 at 127,539,703 bp
  • C to T, chromosome 11 at 40,734,023 bp
  • A to G, chromosome 11 at 72,447,737 bp
  • A to G, chromosome 11 at 80,670,919 bp
  • A to G, chromosome 11 at 104,188,137 bp
  • A to C, chromosome 12 at 44,902,921 bp
  • A to T, chromosome 13 at 24,417,367 bp
  • A to T, chromosome 13 at 70,604,447 bp
  • T to A, chromosome 14 at 69,847,687 bp
  • A to G, chromosome 15 at 28,247,832 bp
  • A to T, chromosome 15 at 64,704,789 bp
  • G to T, chromosome 16 at 43,889,899 bp
  • C to T, chromosome 16 at 73,948,262 bp
  • A to T, chromosome 17 at 10,318,818 bp
  • A to G, chromosome 17 at 32,188,245 bp
  • A to G, chromosome 17 at 44,608,260 bp
  • C to T, chromosome 17 at 57,149,468 bp
  • T to C, chromosome 18 at 12,974,741 bp
  • A to C, chromosome 18 at 74,770,340 bp
  • T to C, chromosome 19 at 6,251,403 bp
  • T to C, chromosome 19 at 10,207,186 bp
  • A to G, chromosome 19 at 13,027,993 bp
  • A to G, chromosome 19 at 34,594,862 bp
  • G to A, chromosome 19 at 47,897,924 bp
  • A to T, chromosome 19 at 60,779,491 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8474 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067918-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.