Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8475Btlr/Mmmh
Stock Number:
067919-MU
Citation ID:
RRID:MMRRC_067919-MU
Other Names:
R8475 (G1)
Major Collection:

Strain Information

Tbx21
Name: T-box 21
Synonyms: Tblym, TBT1, T-bet, Tbet
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57765
Homologene: 8353
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Nudt3
Name: nudix hydrolase 3
Synonyms: diphosphoinositol polyphosphate phosphohydrolase, Dipp, 1110011B09Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56409
HGNC: HGNC:8050
Homologene: 31400
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: Bmn, 2410030O07Rik, B930014J03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Depdc7
Name: DEP domain containing 7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211896
Homologene: 16386
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: D130075K09Rik, lectomedin 3, LEC3, 5430402I23Rik, Lphn3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Sephs1
Name: selenophosphate synthetase 1
Synonyms: SPS1, 1110046B24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109079
Homologene: 56558
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Parn
Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms: DAN, 1200003I18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74108
VEGA: 16
HGNC: HGNC:8609
Homologene: 31098
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Dbf4
Name: DBF4 zinc finger
Synonyms: Ask
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27214
Homologene: 40892
Pygo2
Name: pygopus 2
Synonyms: 1190004M21Rik, mpygo2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68911
Homologene: 44519
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Mrpl10
Name: mitochondrial ribosomal protein L10
Synonyms: MRP-L8, Rpml8, 0610040E02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107732
Homologene: 41665
Slc12a9
Name: solute carrier family 12 (potassium/chloride transporters), member 9
Synonyms: CIP1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83704
Homologene: 5429
Klf16
Name: Kruppel-like transcription factor 16
Synonyms: BTEB4, DRRF
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 118445
Homologene: 136123
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Gngt1
Name: guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
Synonyms: G(y)1, Gng1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14699
HGNC: HGNC:4411
Homologene: 7738
1700123K08Rik
Name: RIKEN cDNA 1700123K08 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76658
Homologene: 86127
Eogt
Name: EGF domain specific O-linked N-acetylglucosamine transferase
Synonyms: A130022J15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101351
Homologene: 65276
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: mr-gef, D030051B22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Fshr
Name: follicle stimulating hormone receptor
Synonyms: follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14309
VEGA: 17
HGNC: HGNC:3969
Homologene: 117
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: PFK-2/FBPase-2 gene B, 4930568D07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Masp1
Name: MBL associated serine protease 1
Synonyms: Crarf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
Als2cl
Name: ALS2 C-terminal like
Synonyms: mRn.49018, D930044G19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235633
Homologene: 17152
Or52h7
Name: olfactory receptor family 52 subfamily H member 7
Synonyms: GA_x6K02T2PBJ9-7191524-7192471, MOR31-8, Olfr652
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259050
Homologene: 17477
Akt1
Name: thymoma viral proto-oncogene 1
Synonyms: PKB/Akt, Akt, PKBalpha, PKB
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11651
HGNC: HGNC:391
Homologene: 3785
Or1q1
Name: olfactory receptor family 1 subfamily Q member 1
Synonyms: GA_x6K02T2NLDC-33688556-33689482, MOR138-3, Olfr357
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258616
HGNC: HGNC:8223
Homologene: 17320
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Or14c39
Name: olfactory receptor family 14 subfamily C member 39
Synonyms: GA_x6K02T2NHDJ-9425121-9424195, MOR220-2, Olfr292
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258613
Homologene: 115526
Amn
Name: amnionless
Synonyms: 5033428N14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 93835
VEGA: 12
Homologene: 12804
Oxnad1
Name: oxidoreductase NAD-binding domain containing 1
Synonyms: 2410002F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218885
Homologene: 16303
Or9m2
Name: olfactory receptor family 9 subfamily M member 2
Synonyms: GA_x6K02T2Q125-49480812-49481753, MOR173-3, Olfr1158
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258639
Spmip4
Name: sperm microtubule inner protein 4
Synonyms: 4921507P07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70821
Homologene: 69433
Adamts14
Name: ADAM metallopeptidase with thrombospondin type 1 motif 14
Synonyms: TS14, Adamts-14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237360
Homologene: 16383
Adh6a
Name: alcohol dehydrogenase 6A (class V)
Synonyms: 1810009C16Rik, Adh5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69117
Homologene: 66291
Or4a81
Name: olfactory receptor family 4 subfamily A member 81
Synonyms: GA_x6K02T2Q125-51230155-51229211, MOR231-13, Olfr1254
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258468
Homologene: 103784
Klk5
Name: kallikrein related-peptidase 5
Synonyms: 1110030O19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68668
HGNC: HGNC:6366
Homologene: 75000
Mtfmt
Name: mitochondrial methionyl-tRNA formyltransferase
Synonyms: 2310020P08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69606
Homologene: 12320
Zpbp
Name: zona pellucida binding protein
Synonyms: Sp38, 4930486K01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53604
Homologene: 5092
Lipi
Name: lipase, member I
Synonyms: D930038D03Rik, lpd1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320355
Homologene: 77864
Pjvk
Name: pejvakin
Synonyms: LOC381375, pejvakin, Dfnb59
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381375
Homologene: 19773
Nectin4
Name: nectin cell adhesion molecule 4
Synonyms: nectin 4, Prr4, 1200017F15Rik, Pvrl4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71740
Homologene: 32744
Grxcr1
Name: glutaredoxin, cysteine rich 1
Synonyms: tde, pi
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433899
Homologene: 42423
Pcdha12
Name: protocadherin alpha 12
Synonyms: Cnr5, Crnr5, Pcdha13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192164
HGNC: HGNC:8667
Homologene: 135870
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 66,414,005 bp
  • G to C, chromosome 1 at 130,697,079 bp
  • C to T, chromosome 1 at 171,384,712 bp
  • T to A, chromosome 2 at 4,889,010 bp
  • G to A, chromosome 2 at 36,997,054 bp
  • T to C, chromosome 2 at 76,650,557 bp
  • T to C, chromosome 2 at 87,990,192 bp
  • T to C, chromosome 2 at 89,789,242 bp
  • G to A, chromosome 2 at 104,721,969 bp
  • T to G, chromosome 2 at 156,522,230 bp
  • A to G, chromosome 3 at 89,433,390 bp
  • G to A, chromosome 3 at 135,511,812 bp
  • T to C, chromosome 3 at 138,325,218 bp
  • A to G, chromosome 5 at 8,398,664 bp
  • T to C, chromosome 5 at 68,166,141 bp
  • T to C, chromosome 5 at 81,724,129 bp
  • T to C, chromosome 5 at 109,339,207 bp
  • A to T, chromosome 5 at 112,873,556 bp
  • C to A, chromosome 5 at 137,315,475 bp
  • G to A, chromosome 5 at 138,562,926 bp
  • C to A, chromosome 6 at 3,994,262 bp
  • A to G, chromosome 6 at 50,589,127 bp
  • A to T, chromosome 6 at 97,145,366 bp
  • A to G, chromosome 7 at 43,850,780 bp
  • A to C, chromosome 7 at 86,695,153 bp
  • A to G, chromosome 7 at 104,564,859 bp
  • A to G, chromosome 9 at 62,744,045 bp
  • C to A, chromosome 9 at 65,452,187 bp
  • C to G, chromosome 9 at 110,886,416 bp
  • C to T, chromosome 10 at 27,101,373 bp
  • T to C, chromosome 10 at 61,202,887 bp
  • A to G, chromosome 10 at 80,576,885 bp
  • T to C, chromosome 11 at 11,415,203 bp
  • A to T, chromosome 11 at 97,047,435 bp
  • A to T, chromosome 11 at 97,099,982 bp
  • T to A, chromosome 12 at 111,275,385 bp
  • A to G, chromosome 12 at 112,658,429 bp
  • A to C, chromosome 12 at 117,718,230 bp
  • A to G, chromosome 14 at 32,101,293 bp
  • C to A, chromosome 14 at 50,841,255 bp
  • A to G, chromosome 15 at 12,150,369 bp
  • A to G, chromosome 16 at 13,607,249 bp
  • C to A, chromosome 16 at 23,452,531 bp
  • T to A, chromosome 16 at 75,573,974 bp
  • A to G, chromosome 17 at 27,580,802 bp
  • A to T, chromosome 17 at 88,986,028 bp
  • T to C, chromosome 18 at 37,021,083 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8475 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067919-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.