Strain Name:
C57BL/6J-MtgxR8485Btlr/Mmmh
Stock Number:
067928-MU
Citation ID:
RRID:MMRRC_067928-MU
Other Names:
R8485 (G1)
Major Collection:

Strain Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1-D, NFATp, NFAT1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Phb1
Name: prohibitin 1
Synonyms: Phb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18673
HGNC: HGNC:8912
Homologene: 1980
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, 1700008J19Rik, Ankycorbin, Norpeg
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Cacng7
Name: calcium channel, voltage-dependent, gamma subunit 7
Synonyms: TARP gamma 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81904
Homologene: 12895
Nphs1
Name: nephrosis 1, nephrin
Synonyms: nephrin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54631
HGNC: HGNC:7908
Homologene: 20974
Cwc27
Name: CWC27 spliceosome-associated protein
Synonyms: NY-CO-10, Sdccag10, 3110009E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67285
Homologene: 21192
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330177
Homologene: 83279
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: 2900001A12Rik, ANCO-2, GAC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106585
Homologene: 9059
Gpa33
Name: glycoprotein A33 transmembrane
Synonyms: A33 antigen, 2010310L10Rik, 2210401D16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59290
HGNC: HGNC:4445
Homologene: 4245
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20336
Homologene: 40654
Gpi1
Name: glucose-6-phosphate isomerase 1
Synonyms: Gpi-1s, Gpi-1t, Gpi-1, autocrine motility factor, AMF, NK, Gpi1-t, maturation factor, Org, neuroleukin, NK/GPI, Gpi-1r, MF, Gpi1-s, Gpi1-r
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14751
HGNC: HGNC:4458
Homologene: 145
Zc3h11a
Name: zinc finger CCCH type containing 11A
Synonyms: G630041M05Rik, 1110003F06Rik, 5730454B08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70579
Homologene: 8888
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: Nkcc1, mBSC2, sodium/potassium/chloride cotransporters, sy-ns
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Rapgef1
Name: Rap guanine nucleotide exchange factor (GEF) 1
Synonyms: Grf2, 4932418O06Rik, C3G
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107746
HGNC: HGNC:4568
Homologene: 50501
Zfp512
Name: zinc finger protein 512
Synonyms: 2500002M11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269639
Homologene: 13026
Kctd2
Name: potassium channel tetramerisation domain containing 2
Synonyms: 2310012I15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70382
Homologene: 82389
Nsd2
Name: nuclear receptor binding SET domain protein 2
Synonyms: 9430010A17Rik, 5830445G22Rik, Whsc1, D030027O06Rik, C130020C13Rik, D930023B08Rik, Whsc1l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107823
Homologene: 26175
Flii
Name: flightless I actin binding protein
Synonyms: Fliih, 3632430F08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Acp6
Name: acid phosphatase 6, lysophosphatidic
Synonyms: ACPL1, 5730559A09Rik, mPACPL1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66659
Homologene: 41128
Glb1l2
Name: galactosidase, beta 1-like 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244757
Homologene: 71790
Rrbp1
Name: ribosome binding protein 1
Synonyms: ES/130, 1700087N07Rik, mRRp47, mRRp41, mRRp15a, 5730465C04Rik, mRRp15b, mRRp16.8, mRRp10, mRRp5.4, mRRp2, mRRp1.8, p180, mRRp0
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 81910
Homologene: 68138
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
L1td1
Name: LINE-1 type transposase domain containing 1
Synonyms: ECAT11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381591
Homologene: 135709
Pak2
Name: p21 (RAC1) activated kinase 2
Synonyms: D16Ertd269e, PAK-2, 5330420P17Rik, A130002K10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224105
HGNC: HGNC:8591
Homologene: 99711
Slc7a8
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Synonyms: LAT2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50934
VEGA: 14
Homologene: 8166
Mycbpap
Name: MYCBP associated protein
Synonyms: AMAP-1, 4932408B01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104601
Homologene: 49982
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: mRib72-1, myoclonin1, 1700029F22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Stk32a
Name: serine/threonine kinase 32A
Synonyms: YANK1, A930015B13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269019
VEGA: 18
Homologene: 65357
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Or8b37
Name: olfactory receptor family 8 subfamily B member 37
Synonyms: MOR162-13, MOR162-11P, Olfr1550-ps1, Olfr884, GA_x6K02T2PVTD-31726544-31727473, MOR162-9P, MOR162-11P
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257996
Homologene: 79400
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Ankrd2
Name: ankyrin repeat domain 2
Synonyms: mArpp, Arpp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56642
VEGA: 19
HGNC: HGNC:495
Homologene: 10568
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Cbfa2t3
Name: CBFA2/RUNX1 translocation partner 3
Synonyms: ETO-2, MTGR2, Eto2, A630044F12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12398
HGNC: HGNC:1537
Homologene: 74543
Irag2
Name: inositol 1,4,5-triphosphate receptor associated 2
Synonyms: D6Int5, Jaw1, Lrmp, D6Int7, D6Int8, D6Int4, D6Int3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16970
HGNC: HGNC:6690
Homologene: 4483
Ercc2
Name: excision repair cross-complementing rodent repair deficiency, complementation group 2
Synonyms: Mhdarco15, XPD, Ercc-2, RCO015
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13871
HGNC: HGNC:3434
Homologene: 344
Cdh15
Name: cadherin 15
Synonyms: M cadherin, Mcad, Cdh14
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Or10ag60
Name: olfactory receptor family 10 subfamily AG member 60
Synonyms: MOR264-4, GA_x6K02T2Q125-49112575-49113519, Olfr1130
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258835
Homologene: 133705
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Btnl10
Name: butyrophilin-like 10
Synonyms: Butr1, BUTR-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192194
Homologene: 138184
Rdm1
Name: RAD52 motif 1
Synonyms: Rad52b, 2410008M22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66599
Homologene: 11992
Arhgap18
Name: Rho GTPase activating protein 18
Synonyms: 4833419J07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73910
Homologene: 14135
Plat
Name: plasminogen activator, tissue
Synonyms: tPA, D8Ertd2e, t-PA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Ugdh
Name: UDP-glucose dehydrogenase
Synonyms: Udpgdh
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22235
Homologene: 2520
Fbxl22
Name: F-box and leucine-rich repeat protein 22
Synonyms: 1110004B15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74165
VEGA: 9
Homologene: 35275
Aspdh
Name: aspartate dehydrogenase domain containing
Synonyms: 0610012D14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68352
Homologene: 41692
Gm49368
Name: predicted gene, 49368
Type: Gene
Species: Mouse
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,523,033 bp
  • T to C, chromosome 1 at 20,960,236 bp
  • A to C, chromosome 1 at 46,680,792 bp
  • A to C, chromosome 1 at 51,779,601 bp
  • T to A, chromosome 1 at 133,625,895 bp
  • T to A, chromosome 1 at 166,164,692 bp
  • T to C, chromosome 2 at 19,293,134 bp
  • T to C, chromosome 2 at 29,710,174 bp
  • T to A, chromosome 2 at 32,212,093 bp
  • A to T, chromosome 2 at 87,608,257 bp
  • T to A, chromosome 2 at 110,667,855 bp
  • A to G, chromosome 2 at 143,955,013 bp
  • A to C, chromosome 2 at 168,590,092 bp
  • T to A, chromosome 3 at 79,481,537 bp
  • A to G, chromosome 3 at 97,158,986 bp
  • C to T, chromosome 4 at 98,737,674 bp
  • C to T, chromosome 5 at 31,480,057 bp
  • A to T, chromosome 5 at 33,882,845 bp
  • T to C, chromosome 5 at 65,427,559 bp
  • G to A, chromosome 5 at 117,251,077 bp
  • T to A, chromosome 6 at 33,921,501 bp
  • A to T, chromosome 6 at 145,171,674 bp
  • A to G, chromosome 7 at 3,366,025 bp
  • G to A, chromosome 7 at 19,388,240 bp
  • A to G, chromosome 7 at 30,466,173 bp
  • A to T, chromosome 7 at 34,219,252 bp
  • G to T, chromosome 7 at 44,467,669 bp
  • C to T, chromosome 7 at 128,112,439 bp
  • G to T, chromosome 8 at 22,772,232 bp
  • C to A, chromosome 8 at 122,630,778 bp
  • T to C, chromosome 8 at 122,857,366 bp
  • G to A, chromosome 9 at 26,767,740 bp
  • T to A, chromosome 9 at 38,047,957 bp
  • C to T, chromosome 9 at 66,514,567 bp
  • T to G, chromosome 9 at 119,128,591 bp
  • T to C, chromosome 10 at 26,846,108 bp
  • G to A, chromosome 10 at 127,558,650 bp
  • G to T, chromosome 11 at 58,920,316 bp
  • G to T, chromosome 11 at 60,716,237 bp
  • A to G, chromosome 11 at 94,511,708 bp
  • T to C, chromosome 11 at 94,514,533 bp
  • A to G, chromosome 11 at 95,675,229 bp
  • G to A, chromosome 11 at 101,627,990 bp
  • G to T, chromosome 11 at 115,429,608 bp
  • T to C, chromosome 13 at 70,738,675 bp
  • T to C, chromosome 13 at 95,660,151 bp
  • G to T, chromosome 13 at 104,804,264 bp
  • C to A, chromosome 13 at 104,804,268 bp
  • G to A, chromosome 14 at 12,439,872 bp
  • T to A, chromosome 14 at 54,724,807 bp
  • A to G, chromosome 15 at 10,575,036 bp
  • A to G, chromosome 15 at 44,560,400 bp
  • A to C, chromosome 15 at 74,548,304 bp
  • G to A, chromosome 16 at 32,052,265 bp
  • C to T, chromosome 17 at 65,983,716 bp
  • T to C, chromosome 18 at 5,064,566 bp
  • T to A, chromosome 18 at 43,243,010 bp
  • T to C, chromosome 18 at 57,941,146 bp
  • G to A, chromosome 19 at 42,041,945 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8485 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067928-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.