Strain Name:
C57BL/6J-MtgxR8488Btlr/Mmmh
Stock Number:
067931-MU
Citation ID:
RRID:MMRRC_067931-MU
Other Names:
R8488 (G1)
Major Collection:

Strain Information

Gstt2
Name: glutathione S-transferase, theta 2
Synonyms: mGSTT2, Yrs
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14872
VEGA: 10
Homologene: 37358
Anapc5
Name: anaphase-promoting complex subunit 5
Synonyms: 2510006G12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59008
Homologene: 41118
Trip13
Name: thyroid hormone receptor interactor 13
Synonyms: 2410002G23Rik, D13Ertd328e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69716
Homologene: 3125
Gls
Name: glutaminase
Synonyms: B230365M23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14660
HGNC: HGNC:4331
Homologene: 22726
Sec23b
Name: SEC23 homolog B, COPII coat complex component
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27054
Homologene: 74571
Clint1
Name: clathrin interactor 1
Synonyms: Epn4, C530049I24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216705
Homologene: 133740
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 386750
Homologene: 8955
Cenpe
Name: centromere protein E
Synonyms: N-7 kinesin, CENP-E, 312kDa, Kif10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Pold3
Name: polymerase (DNA-directed), delta 3, accessory subunit
Synonyms: P68, P66, 2410142G14Rik, C85233, GC12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67967
Homologene: 38202
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: Idh-2, IDPm
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76131
Homologene: 9834
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: GlcT-1, Epcs21, Ugcgl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22234
Homologene: 37763
Gm10800
Name: predicted gene 10800
Type: Gene
Species: Mouse
Chromosome: 2
Arhgef15
Name: Rho guanine nucleotide exchange factor 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 442801
Homologene: 18345
Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
Synonyms: Gabrb-2, C030021G16Rik, C030002O17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Pnp2
Name: purine-nucleoside phosphorylase 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667034
HGNC: HGNC:7892
Homologene: 227
Crxos
Name: cone-rod homeobox, opposite strand
Synonyms: Egam1, Crxos1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546024
Homologene: 136482
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: C130044A18Rik, Phlppl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244650
Homologene: 71015
Tex48
Name: testis expressed 48
Synonyms: 1700018C11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75524
Homologene: 87066
Hck
Name: hemopoietic cell kinase
Synonyms: Hck-1, Bmk
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15162
HGNC: HGNC:4840
Homologene: 20489
Prr5
Name: proline rich 5 (renal)
Synonyms: C030017C09Rik, Protor-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109270
Homologene: 17132
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: SLC21A20, PRO2176, OATP4C1, OATP-M1, OATP-H, C330017E21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227394
Homologene: 62654
Or3a1
Name: olfactory receptor family 3 subfamily A member 1
Synonyms: GA_x6K02T2P1NL-4467421-4466474, MOR255-5, Olfr410
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258702
Homologene: 68262
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
BC005624
Name: cDNA sequence BC005624
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227707
Homologene: 9551
Slc6a17
Name: solute carrier family 6 (neurotransmitter transporter), member 17
Synonyms: D130012J15Rik, NTT4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229706
Homologene: 27775
Dpysl2
Name: dihydropyrimidinase-like 2
Synonyms: Ulip2, Crmp2, TOAD-64, DRP2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12934
HGNC: HGNC:3014
Homologene: 74392
Dtd2
Name: D-tyrosyl-tRNA deacylase 2
Synonyms: 4930578F06Rik, B830049N13Rik, 6530401N04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328092
Homologene: 12634
Appl2
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Synonyms: Dip3b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216190
Homologene: 10046
Actg1
Name: actin, gamma, cytoplasmic 1
Synonyms: E51, Actl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11465
HGNC: HGNC:144
Homologene: 74402
Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106648
Homologene: 80199
Srcin1
Name: SRC kinase signaling inhibitor 1
Synonyms: P140, p140Cap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56013
Homologene: 10324
Gjb5
Name: gap junction protein, beta 5
Synonyms: Cnx31.1, connexin 31.1, Gjb-5, Cx31.1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14622
HGNC: HGNC:4287
Homologene: 3858
Or6c3b
Name: olfactory receptor family 6 subfamily C member 3B
Synonyms: GA_x6K02T2PULF-11370664-11369738, MOR111-3, Olfr803
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258547
Homologene: 105153
Cd200l2
Name: CD200 molecule like 2
Synonyms: Gm17783, iSEC2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100047671
VEGA: 16
Homologene: 86707
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,199,853 bp
  • T to C, chromosome 1 at 96,832,011 bp
  • T to C, chromosome 2 at 30,981,845 bp
  • AAGAAAACTGAAAATCAT to A, chromosome 2 at 98,667,034 bp
  • T to A, chromosome 2 at 144,582,063 bp
  • A to G, chromosome 2 at 153,124,210 bp
  • C to T, chromosome 3 at 59,320,010 bp
  • T to G, chromosome 3 at 73,051,187 bp
  • A to G, chromosome 3 at 107,477,258 bp
  • T to A, chromosome 3 at 135,259,241 bp
  • A to G, chromosome 3 at 159,523,875 bp
  • T to A, chromosome 4 at 59,213,896 bp
  • C to T, chromosome 4 at 63,611,923 bp
  • C to A, chromosome 4 at 127,356,285 bp
  • A to G, chromosome 5 at 122,817,970 bp
  • A to T, chromosome 6 at 48,594,018 bp
  • A to G, chromosome 6 at 125,980,170 bp
  • T to C, chromosome 7 at 15,903,700 bp
  • GGTCCCAG to GG, chromosome 7 at 80,098,329 bp
  • T to C, chromosome 7 at 100,089,731 bp
  • A to T, chromosome 8 at 109,913,570 bp
  • T to A, chromosome 10 at 75,831,989 bp
  • T to C, chromosome 10 at 83,611,002 bp
  • C to T, chromosome 10 at 127,560,487 bp
  • T to A, chromosome 10 at 129,691,474 bp
  • A to T, chromosome 11 at 42,626,664 bp
  • T to G, chromosome 11 at 45,890,630 bp
  • T to A, chromosome 11 at 68,947,670 bp
  • C to T, chromosome 11 at 74,335,106 bp
  • T to C, chromosome 11 at 97,525,860 bp
  • A to G, chromosome 11 at 120,347,691 bp
  • A to G, chromosome 12 at 51,999,561 bp
  • C to T, chromosome 12 at 75,965,772 bp
  • A to T, chromosome 13 at 73,932,913 bp
  • A to G, chromosome 14 at 50,964,379 bp
  • T to C, chromosome 14 at 66,829,401 bp
  • C to T, chromosome 15 at 84,693,804 bp
  • C to A, chromosome 16 at 29,417,836 bp
  • A to G, chromosome 16 at 45,528,471 bp
  • A to G, chromosome 17 at 32,701,974 bp
  • A to G, chromosome 18 at 20,601,374 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8488 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067931-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.