Strain Name:
C57BL/6J-MtgxR8497Btlr/Mmmh
Stock Number:
067939-MU
Citation ID:
RRID:MMRRC_067939-MU
Other Names:
R8497 (G1)
Major Collection:

Strain Information

Utp23
Name: UTP23 small subunit processome component
Synonyms: D530033C11Rik, 1700010I21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78581
Homologene: 41789
Cnot6
Name: CCR4-NOT transcription complex, subunit 6
Synonyms: A230103N10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104625
Homologene: 69187
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1454Clo, b2b1752Clo, Nphp6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Nfx1
Name: nuclear transcription factor, X-box binding 1
Synonyms: Tex42, 1300017N15Rik, TEG-42, 3000003M19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74164
HGNC: HGNC:7803
Homologene: 1875
Skp2
Name: S-phase kinase-associated protein 2
Synonyms: FBXL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27401
Homologene: 55942
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, 6430585N13Rik, LOC381139
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240476
Homologene: 86402
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: 8030453L17Rik, KMT2H, chromatin remodeling factor, E430018P19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rinp, Rip1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19766
Homologene: 2820
Prelid1
Name: PRELI domain containing 1
Synonyms: 2610524G07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66494
VEGA: 13
Homologene: 40859
Bdkrb1
Name: bradykinin receptor, beta 1
Synonyms: kinin B1, B1R
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12061
HGNC: HGNC:1029
Homologene: 570
Fhip1b
Name: FHF complex subunit HOOK interacting protein 1B
Synonyms: Fam160a2, 6530415H11Rik, 4632419K20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74349
Homologene: 75329
Tcf20
Name: transcription factor 20
Synonyms: 2810438H08Rik, SPBP, stromelysin 1 PDGF responsive element binding protein
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: adenomatosis polyposis coli, Min, CC1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Cdc34
Name: cell division cycle 34
Synonyms: UBE2R1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216150
VEGA: 10
HGNC: HGNC:1734
Homologene: 55815
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Prkg1
Name: protein kinase, cGMP-dependent, type I
Synonyms: Prkgr1b, Prkg1b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19091
HGNC: HGNC:9414
Homologene: 55964
Cat
Name: catalase
Synonyms: Cas1, Cs-1, Cas-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12359
HGNC: HGNC:1516
Homologene: 55514
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Afm
Name: afamin
Synonyms: Alf, alpha albumin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Nalcn
Name: sodium leak channel, non-selective
Synonyms: Vgcnl1, A530023G15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Hs2st1
Name: heparan sulfate 2-O-sulfotransferase 1
Synonyms: Hs2st
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23908
HGNC: HGNC:5193
Homologene: 8025
Il5ra
Name: interleukin 5 receptor, alpha
Synonyms: CD125, Il5r, CDw125, IL-5 receptor alpha chain
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16192
HGNC: HGNC:6017
Homologene: 473
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627743
Homologene: 129680
Mat1a
Name: methionine adenosyltransferase 1A
Synonyms: MATA1, SAMS, MAT, SAMS1, Ams, AdoMet
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11720
VEGA: 14
HGNC: HGNC:6903
Homologene: 68057
Bphl
Name: biphenyl hydrolase like
Synonyms: 2010012D11Rik, 5730533B08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68021
VEGA: 13
HGNC: HGNC:1094
Homologene: 55812
Or2y17
Name: olfactory receptor family 2 subfamily Y member 17
Synonyms: MOR256-2, GA_x6K02T2QP88-6094111-6093176, Olfr1390
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259068
Itgav
Name: integrin alpha V
Synonyms: vitronectin receptor alpha polypeptide (VNRA), 1110004F14Rik, alphav-integrin, 2610028E01Rik, CD51, D430040G12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16410
HGNC: HGNC:6150
Homologene: 20510
Pcdhb14
Name: protocadherin beta 14
Synonyms: Pcdhb17, 2210006M07Rik, PcdhbN
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93885
Homologene: 70876
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76265
Homologene: 35476
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: Ccdc129, D530004J12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232016
Homologene: 52344
Pdss2
Name: prenyl (solanesyl) diphosphate synthase, subunit 2
Synonyms: PLMP, mDLP1, kd, 5430420P03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71365
Homologene: 56885
A1cf
Name: APOBEC1 complementation factor
Synonyms: apobec-1 complementation factor, 1810073H04Rik, ACF
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69865
VEGA: 19
Homologene: 16363
Lrrcc1
Name: leucine rich repeat and coiled-coil domain containing 1
Synonyms: 4932441F23Rik, 1200008A14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71710
Homologene: 12559
Cyth3
Name: cytohesin 3
Synonyms: cytohesin 3, Pscd3, Grp1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19159
HGNC: HGNC:9504
Homologene: 3116
Neu3
Name: neuraminidase 3
Synonyms: membrane sialidase, ganglioside sialidase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50877
HGNC: HGNC:7760
Homologene: 4847
Ffar1
Name: free fatty acid receptor 1
Synonyms: Gpr40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233081
HGNC: HGNC:4498
Homologene: 3876
Or5b104
Name: olfactory receptor family 5 subfamily B member 104
Synonyms: MOR202-20, Olfr1457, GA_x6K02T2RE5P-3423041-3422097
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258568
HGNC: HGNC:8324
Homologene: 133676
Or2a14
Name: olfactory receptor family 2 subfamily A member 14
Synonyms: GA_x6K02T2P3E9-4404793-4403861, Olfr438, GA_x6K02T08UK8-1-481, Olfr237-ps1, Olfr237, MOR261-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258648
Homologene: 88438
Or4f14
Name: olfactory receptor family 4 subfamily F member 14
Synonyms: GA_x6K02T2Q125-72954873-72953935, MOR245-15, Olfr1306
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258023
Homologene: 128383
H2-M10.5
Name: histocompatibility 2, M region locus 10.5
Synonyms: 6.9H
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224761
Homologene: 117973
Mtss2
Name: MTSS I-BAR domain containing 2
Synonyms: Mtss1l, ABBA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244654
Homologene: 70926
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: Gm11133, Pgc-1alpha, A830037N07Rik, Pgc-1alphaa, Pgc1, Pgco1, PPAR Gamma Coactivator-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
Rnft1
Name: ring finger protein, transmembrane 1
Synonyms: 0610013E23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76892
Homologene: 41110
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73246
Homologene: 37125
Spopfm2
Name: speckle-type BTB/POZ protein family member 2
Synonyms: Gm10696
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043188
Homologene: 128308
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: 1700013B16Rik, Fam75d3, Fam75d1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Gpr17
Name: G protein-coupled receptor 17
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 574402
HGNC: HGNC:4471
Homologene: 83191
Psmb5
Name: proteasome (prosome, macropain) subunit, beta type 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19173
VEGA: 14
HGNC: HGNC:9542
Homologene: 55690
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 150,580,239 bp
  • T to C, chromosome 2 at 31,423,345 bp
  • T to A, chromosome 2 at 83,785,461 bp
  • C to G, chromosome 2 at 103,456,876 bp
  • T to A, chromosome 2 at 111,912,619 bp
  • A to G, chromosome 3 at 14,539,984 bp
  • G to T, chromosome 3 at 89,007,644 bp
  • T to A, chromosome 3 at 94,175,812 bp
  • T to G, chromosome 3 at 144,434,691 bp
  • A to G, chromosome 4 at 40,976,968 bp
  • G to A, chromosome 4 at 118,388,321 bp
  • A to G, chromosome 5 at 51,490,228 bp
  • A to T, chromosome 5 at 90,551,343 bp
  • A to G, chromosome 5 at 90,631,532 bp
  • A to C, chromosome 5 at 143,692,573 bp
  • T to C, chromosome 6 at 23,355,919 bp
  • T to C, chromosome 6 at 43,153,884 bp
  • A to T, chromosome 6 at 55,898,194 bp
  • G to A, chromosome 6 at 106,738,105 bp
  • T to G, chromosome 7 at 30,860,909 bp
  • A to T, chromosome 7 at 99,823,135 bp
  • G to T, chromosome 7 at 105,381,189 bp
  • C to T, chromosome 7 at 105,758,961 bp
  • T to C, chromosome 8 at 110,738,590 bp
  • TG to TGG, chromosome 9 at 7,465,083 bp
  • A to C, chromosome 10 at 43,413,525 bp
  • G to T, chromosome 10 at 79,685,011 bp
  • A to G, chromosome 10 at 100,551,458 bp
  • G to A, chromosome 11 at 49,340,894 bp
  • A to T, chromosome 11 at 49,675,364 bp
  • A to T, chromosome 11 at 86,495,306 bp
  • T to C, chromosome 11 at 115,822,584 bp
  • C to T, chromosome 12 at 105,604,204 bp
  • T to C, chromosome 13 at 34,027,951 bp
  • A to G, chromosome 13 at 34,037,723 bp
  • A to G, chromosome 13 at 55,323,020 bp
  • T to C, chromosome 13 at 59,701,174 bp
  • C to T, chromosome 14 at 32,966,399 bp
  • C to T, chromosome 14 at 41,121,894 bp
  • A to G, chromosome 14 at 54,614,380 bp
  • G to A, chromosome 14 at 61,192,253 bp
  • A to G, chromosome 14 at 123,515,359 bp
  • A to T, chromosome 15 at 9,127,884 bp
  • C to T, chromosome 15 at 51,882,218 bp
  • A to G, chromosome 15 at 82,855,951 bp
  • T to C, chromosome 17 at 20,234,872 bp
  • A to C, chromosome 17 at 36,773,837 bp
  • A to G, chromosome 18 at 31,947,120 bp
  • G to A, chromosome 18 at 34,313,030 bp
  • A to T, chromosome 18 at 37,449,296 bp
  • T to C, chromosome 18 at 84,559,896 bp
  • T to C, chromosome 19 at 13,095,343 bp
  • C to A, chromosome 19 at 31,302,309 bp
  • C to T, chromosome 19 at 31,945,850 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8497 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067939-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.