Strain Name:
C57BL/6J-MtgxR8503Btlr/Mmmh
Stock Number:
067943-MU
Citation ID:
RRID:MMRRC_067943-MU
Other Names:
R8503 (G1)
Major Collection:

Strain Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Gldc
Name: glycine decarboxylase
Synonyms: D19Wsu57e, b2b2679Clo, D030049L12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Prdm16
Name: PR domain containing 16
Synonyms: line 27, csp1, 5730557K01Rik, Mel1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70673
Homologene: 11139
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: A330076K04Rik, 1100001C18Rik, 2500002E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70097
Homologene: 69182
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: Aprin, AS3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: ABIN1, A20-binding inhibitor of NF-kappa B activation, VAN, Nef
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57783
Homologene: 31355
Rpa2
Name: replication protein A2
Synonyms: 30-kDa protein, Rf-A2, RPA34
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19891
Homologene: 37712
R3hdm2
Name: R3H domain containing 2
Synonyms: 1300003K24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71750
Homologene: 8954
Tubb3
Name: tubulin, beta 3 class III
Synonyms: 3200002H15Rik, betaIII-tubulin, Tuj1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22152
Homologene: 68503
Casp12
Name: caspase 12
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12364
Homologene: 7654
Sp3
Name: trans-acting transcription factor 3
Synonyms: D130027J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20687
Homologene: 7952
Hoxd10
Name: homeobox D10
Synonyms: Hox-5.3, Hox-4.5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15430
HGNC: HGNC:5133
Homologene: 1619
Fam151a
Name: family with sequence simliarity 151, member A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230579
Homologene: 17143
Ampd2
Name: adenosine monophosphate deaminase 2
Synonyms: 1200014F01Rik, Ampd-2, m4521Dajl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109674
HGNC: HGNC:469
Homologene: 2979
Kif3b
Name: kinesin family member 3B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16569
HGNC: HGNC:6320
Homologene: 55849
Nipal3
Name: NIPA-like domain containing 3
Synonyms: 9130020G22Rik, Npal3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74552
Homologene: 10722
Pom121
Name: nuclear pore membrane protein 121
Synonyms: 2610027A18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107939
Homologene: 70878
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98432
Homologene: 11015
Pcdh12
Name: protocadherin 12
Synonyms: vascular endothelial cadherin-2, VE-cadherin-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53601
HGNC: HGNC:8657
Homologene: 9574
Sycp2l
Name: synaptonemal complex protein 2-like
Synonyms: EG621792, Gm40956, LOC218175
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 637277
Homologene: 52882
Nlgn1
Name: neuroligin 1
Synonyms: NL1, Nlg1, 6330415N05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192167
Homologene: 56690
Bpifa3
Name: BPI fold containing family A, member 3
Synonyms: 1700058C13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73388
Homologene: 52268
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Wdpcp
Name: WD repeat containing planar cell polarity effector
Synonyms: homoloc-13, AV249152
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216560
Homologene: 9299
Tsbp1
Name: testis expressed basic protein 1
Synonyms: BC051142
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 407788
Homologene: 128168
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Ubtd2
Name: ubiquitin domain containing 2
Synonyms: 9630054F20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327900
Homologene: 15484
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 9030605H24Rik, 5930426O13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NMDAR2A, GluN2A, GluRepsilon1, NR2A
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Synonyms: 2700043D08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108037
VEGA: 10
Homologene: 133984
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382018
Homologene: 11279
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Nuggc
Name: nuclear GTPase, germinal center associated
Synonyms: SLIP-GC, LOC239151, Gm600
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100503545
Homologene: 72641
Lhpp
Name: phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Synonyms: 2310007H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76429
Homologene: 41469
Or6c211
Name: olfactory receptor family 6 subfamily C member 211
Synonyms: GA_x6K02T2PULF-11349138-11348182, MOR110-10, Olfr801
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258282
Homologene: 138306
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49Q, Ly49q1, Ly-49Q
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170733
Papolg
Name: poly(A) polymerase gamma
Synonyms: 9630006B20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216578
Homologene: 56959
Ccng2
Name: cyclin G2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12452
HGNC: HGNC:1593
Homologene: 3208
Fggy
Name: FGGY carbohydrate kinase domain containing
Synonyms: 2310009E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75578
Homologene: 49535
Arsk
Name: arylsulfatase K
Synonyms: 4833414G15Rik, 2810429K17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77041
Homologene: 12670
Or10g1b
Name: olfactory receptor family 10 subfamily G member 1B
Synonyms: MOR223-9, GA_x6K02T2RJGY-608749-609705, Olfr1511
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258268
HGNC: HGNC:8170
Homologene: 87788
Cr2
Name: complement receptor 2
Synonyms: CD35, C3DR, Cr-1, Cr-2, Cr1, CD21
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Glipr1l2
Name: GLI pathogenesis-related 1 like 2
Synonyms: 4921508O11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67537
Homologene: 17579
Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224045
HGNC: HGNC:3261
Homologene: 2903
Or12e1
Name: olfactory receptor family 12 subfamily E member 1
Synonyms: GA_x6K02T2Q125-48676316-48677272, MOR264-6, Olfr1112
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258655
Homologene: 64901
Gpr85
Name: G protein-coupled receptor 85
Synonyms: 2900026B03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64450
HGNC: HGNC:4536
Homologene: 10355
Tmem169
Name: transmembrane protein 169
Synonyms: A830020B06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271711
Homologene: 16305
Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106648
Homologene: 80199
Mab21l1
Name: mab-21-like 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17116
HGNC: HGNC:6757
Homologene: 36183
Defa29
Name: defensin, alpha, 29
Synonyms: 2010300L12Rik, CRS1C-2, Defcr-rs1, 2010319H24Rik, Defa-rs1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13218
Homologene: 85974
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 72,301,007 bp
  • T to C, chromosome 1 at 106,392,289 bp
  • G to A, chromosome 1 at 195,163,542 bp
  • T to A, chromosome 2 at 72,938,301 bp
  • T to C, chromosome 2 at 74,692,380 bp
  • T to A, chromosome 2 at 87,192,309 bp
  • T to G, chromosome 2 at 153,320,904 bp
  • C to A, chromosome 2 at 154,130,630 bp
  • A to T, chromosome 3 at 26,133,373 bp
  • G to T, chromosome 3 at 55,783,183 bp
  • C to A, chromosome 3 at 108,080,116 bp
  • T to A, chromosome 4 at 95,902,058 bp
  • T to C, chromosome 4 at 106,746,180 bp
  • G to C, chromosome 4 at 132,773,869 bp
  • C to T, chromosome 4 at 135,479,581 bp
  • A to G, chromosome 4 at 154,341,552 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • T to A, chromosome 5 at 135,381,544 bp
  • A to G, chromosome 5 at 150,716,507 bp
  • G to A, chromosome 6 at 13,836,830 bp
  • C to T, chromosome 6 at 22,145,565 bp
  • A to G, chromosome 6 at 45,992,041 bp
  • T to C, chromosome 6 at 129,868,814 bp
  • A to G, chromosome 7 at 132,705,677 bp
  • T to A, chromosome 8 at 21,325,887 bp
  • A to C, chromosome 8 at 71,645,761 bp
  • A to G, chromosome 8 at 123,421,029 bp
  • T to C, chromosome 9 at 5,346,739 bp
  • A to G, chromosome 9 at 53,488,052 bp
  • A to T, chromosome 10 at 8,780,513 bp
  • A to G, chromosome 10 at 107,892,126 bp
  • A to C, chromosome 10 at 112,107,170 bp
  • T to A, chromosome 10 at 127,492,612 bp
  • C to T, chromosome 10 at 127,518,920 bp
  • T to C, chromosome 10 at 129,669,643 bp
  • G to A, chromosome 11 at 21,721,205 bp
  • C to T, chromosome 11 at 23,870,292 bp
  • A to G, chromosome 11 at 32,499,267 bp
  • A to G, chromosome 11 at 43,222,239 bp
  • A to G, chromosome 11 at 54,936,465 bp
  • T to C, chromosome 11 at 59,000,617 bp
  • A to C, chromosome 13 at 41,153,476 bp
  • A to T, chromosome 13 at 76,091,711 bp
  • A to G, chromosome 14 at 52,389,897 bp
  • G to A, chromosome 14 at 65,641,348 bp
  • T to A, chromosome 16 at 9,663,549 bp
  • T to C, chromosome 16 at 20,498,980 bp
  • T to A, chromosome 17 at 32,695,364 bp
  • T to C, chromosome 17 at 34,448,126 bp
  • T to A, chromosome 17 at 74,692,244 bp
  • A to G, chromosome 18 at 38,282,521 bp
  • C to T, chromosome 19 at 30,099,854 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8503 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067943-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.