Strain Name:
C57BL/6J-MtgxR8556Btlr/Mmmh
Stock Number:
068519-MU
Citation ID:
RRID:MMRRC_068519-MU
Other Names:
R8556 (G1)
Major Collection:

Strain Information

Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: BB001228, 2510010B09Rik, Cxxc6, D10Ertd17e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: Aprin, AS3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Lcor
Name: ligand dependent nuclear receptor corepressor
Synonyms: 3110023F06Rik, LOC381224, Gm340, A630025C20Rik, Mlr2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 212391
VEGA: 19
Homologene: 18153
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: 3010002K18Rik, Qprs, 2410081F06Rik, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: 2700059D02Rik, nucling
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: SCAN1, Gm40556, 2810481F14Rik, 4921509N21Rik, E430034L06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104884
Homologene: 5424
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Ptprj
Name: protein tyrosine phosphatase receptor type J
Synonyms: Byp, CD148, Scc1, DEP-1, Scc-1, RPTPJ
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Acadvl
Name: acyl-Coenzyme A dehydrogenase, very long chain
Synonyms: VLCAD
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11370
HGNC: HGNC:92
Homologene: 5
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: EGF-TM7 receptor, 1110033N21Rik, Etl, Eltd1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Cdan1
Name: codanin 1
Synonyms: CDA-I, 1500015A01Rik, codanin-1, CDA1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Crk
Name: v-crk avian sarcoma virus CT10 oncogene homolog
Synonyms: Crk-I, Crk-III, Crk-II, Crko, proto-oncogene c-crk
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12928
HGNC: HGNC:2362
Homologene: 81850
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Elavl1
Name: ELAV like RNA binding protein 1
Synonyms: HuR, ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R), Hua, W91709, 2410055N02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15568
HGNC: HGNC:3312
Homologene: 20367
Edem3
Name: ER degradation enhancer, mannosidase alpha-like 3
Synonyms: 2310050N11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66967
Homologene: 11866
Tsc22d4
Name: Tsc22 domain family, member 4
Synonyms: 0610009M14Rik, Spacdr, 1700023B23Rik, Tsc22d4, Thg-1pit
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78829
Homologene: 11390
Rrbp1
Name: ribosome binding protein 1
Synonyms: ES/130, 1700087N07Rik, mRRp47, mRRp41, mRRp15a, 5730465C04Rik, mRRp15b, mRRp16.8, mRRp10, mRRp5.4, mRRp2, mRRp1.8, p180, mRRp0
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 81910
Homologene: 68138
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: CED-5, MBC, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Zbtb7b
Name: zinc finger and BTB domain containing 7B
Synonyms: Zfp67, c-Krox, Thpok
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22724
Homologene: 7605
Ret
Name: ret proto-oncogene
Synonyms: c-Ret, RET51, RET9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19713
HGNC: HGNC:9967
Homologene: 7517
Hoxb6
Name: homeobox B6
Synonyms: Hox-2.2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15414
HGNC: HGNC:5117
Homologene: 7366
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20259
Homologene: 36296
Dennd5b
Name: DENN domain containing 5B
Synonyms: 9330160C06Rik, D030011O10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320560
Homologene: 44911
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: Tmem76, 9430010M12Rik, D8Ertd354e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52120
Homologene: 15586
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTPL1, PTP-BL, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Mylk3
Name: myosin light chain kinase 3
Synonyms: D830007F02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 213435
Homologene: 35278
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Mdh1b
Name: malate dehydrogenase 1B, NAD (soluble)
Synonyms: 1700124B08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76668
Homologene: 57110
Plppr5
Name: phospholipid phosphatase related 5
Synonyms: 4833424O15Rik, Lppr5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75769
Homologene: 25279
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Serpina1a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1A
Synonyms: Aat2, Spi1-1, PI1, Aat-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20700
HGNC: HGNC:8941
Homologene: 20103
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: Nh, VRL3, 1110036I10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246788
Homologene: 17040
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: mWAKE, LOC382543, nmf9, 4932411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 382543
Homologene: 34996
Rbm12
Name: RNA binding motif protein 12
Synonyms: SWAN, 9430070C08Rik, 5730420G12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75710
HGNC: HGNC:9898
Homologene: 34993
Gm6370
Name: predicted gene 6370
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622924
Homologene: 86127
Eya4
Name: EYA transcriptional coactivator and phosphatase 4
Synonyms: B130023L16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14051
VEGA: 10
HGNC: HGNC:3522
Homologene: 3025
Wdr20rt
Name: WD repeat domain 20, retrogene
Synonyms: Wdr20b, 4921538B03Rik, 4930427E19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70948
VEGA: 12
Snx20
Name: sorting nexin 20
Synonyms: 9130017C17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71607
Homologene: 12399
Svs6
Name: seminal vesicle secretory protein 6
Synonyms: Svp6, MSVSP99, SVS VI
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20945
Homologene: 49347
Or4p8
Name: olfactory receptor family 4 subfamily P member 8
Synonyms: MOR225-4, GA_x6K02T2Q125-50372411-50371485, Olfr1208
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258774
Homologene: 74190
Otop3
Name: otopetrin 3
Synonyms: 2310011E08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69602
Homologene: 26091
Esp31
Name: exocrine gland secreted peptide 31
Synonyms: Gm20516
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126768
Trgc4
Name: T cell receptor gamma, constant 4
Synonyms: Tcrg-C4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107576
Igkv6-17
Name: immunoglobulin kappa variable 6-17
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667865
HGNC: HGNC:5834
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 63,710,982 bp
  • G to A, chromosome 1 at 151,784,835 bp
  • G to A, chromosome 1 at 185,420,288 bp
  • A to T, chromosome 2 at 88,897,038 bp
  • A to G, chromosome 2 at 90,440,700 bp
  • C to T, chromosome 2 at 120,722,990 bp
  • A to T, chromosome 2 at 143,989,125 bp
  • T to C, chromosome 2 at 156,096,561 bp
  • T to C, chromosome 2 at 164,317,565 bp
  • A to G, chromosome 2 at 181,229,557 bp
  • A to G, chromosome 3 at 55,647,386 bp
  • T to C, chromosome 3 at 89,393,137 bp
  • T to A, chromosome 3 at 117,672,030 bp
  • T to C, chromosome 3 at 151,510,665 bp
  • A to G, chromosome 4 at 123,488,343 bp
  • G to A, chromosome 5 at 103,559,172 bp
  • T to C, chromosome 5 at 137,747,587 bp
  • T to C, chromosome 5 at 144,825,937 bp
  • T to C, chromosome 5 at 146,493,892 bp
  • G to A, chromosome 5 at 150,792,608 bp
  • T to C, chromosome 6 at 70,371,762 bp
  • A to G, chromosome 6 at 118,169,188 bp
  • A to G, chromosome 6 at 148,993,770 bp
  • G to A, chromosome 7 at 80,726,039 bp
  • A to G, chromosome 8 at 4,295,388 bp
  • C to T, chromosome 8 at 25,953,280 bp
  • T to C, chromosome 8 at 85,327,273 bp
  • T to A, chromosome 8 at 88,630,033 bp
  • T to C, chromosome 9 at 7,113,198 bp
  • T to A, chromosome 9 at 18,640,937 bp
  • A to T, chromosome 9 at 60,870,641 bp
  • A to G, chromosome 9 at 106,067,053 bp
  • A to G, chromosome 9 at 119,126,221 bp
  • G to A, chromosome 10 at 23,106,258 bp
  • T to C, chromosome 10 at 62,840,206 bp
  • T to C, chromosome 11 at 34,262,457 bp
  • A to T, chromosome 11 at 70,013,550 bp
  • A to G, chromosome 11 at 73,287,465 bp
  • A to G, chromosome 11 at 75,692,521 bp
  • A to T, chromosome 11 at 89,441,442 bp
  • G to T, chromosome 11 at 96,300,717 bp
  • T to A, chromosome 11 at 115,344,956 bp
  • T to C, chromosome 12 at 40,077,594 bp
  • G to A, chromosome 12 at 65,226,965 bp
  • T to C, chromosome 12 at 99,891,268 bp
  • T to A, chromosome 12 at 103,855,970 bp
  • A to G, chromosome 13 at 19,344,782 bp
  • T to C, chromosome 13 at 68,630,975 bp
  • A to T, chromosome 17 at 38,641,051 bp
  • T to G, chromosome 17 at 74,557,954 bp
  • TCA to T, chromosome 19 at 41,558,424 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8556 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068519-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.