Strain Name:
C57BL/6J-MtgxR8673Btlr/Mmmh
Stock Number:
068528-MU
Citation ID:
RRID:MMRRC_068528-MU
Other Names:
R8673 (G1)
Major Collection:

Strain Information

Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Chchd6
Name: coiled-coil-helix-coiled-coil-helix domain containing 6
Synonyms: 1700021B03Rik, 0710001P09Rik, Micos25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66098
Homologene: 11920
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Ccdc9
Name: coiled-coil domain containing 9
Synonyms: 2600011L02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243846
Homologene: 9209
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: Apaf1l, 6230400I06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: E330005K07Rik, ZWS1, peroxisome biogenesis factor 1, 5430414H02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Gabrr3
Name: gamma-aminobutyric acid type A receptor subunit rho 3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328699
VEGA: 16
Homologene: 26716
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: Ube1l2, 5730469D23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231380
Homologene: 10080
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: A930018H20Rik, 9030221A05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Psmd2
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms: TEG-190, Tex190, 9430095H01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21762
HGNC: HGNC:9559
Homologene: 2101
Cxxc1
Name: CXXC finger protein 1
Synonyms: 5830420C16Rik, Cgbp, 2410002I16Rik, Cfp1, PHF18, CXXC finger 1 (PHD domain)
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74322
VEGA: 18
Homologene: 32221
Zfp958
Name: zinc finger protein 958
Synonyms: BC003267
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 233987
Homologene: 129582
Zfp870
Name: zinc finger protein 870
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240066
VEGA: 17
Homologene: 48189
Gata4
Name: GATA binding protein 4
Synonyms: Gata-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14463
HGNC: HGNC:4173
Homologene: 1551
Phf10
Name: PHD finger protein 10
Synonyms: 1810055P05Rik, Baf45a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72057
Homologene: 10112
Rasgef1b
Name: RasGEF domain family, member 1B
Synonyms: 4732452O09Rik, Gpig4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320292
Homologene: 14860
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, A130095G14Rik, 5830472H07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Anxa9
Name: annexin A9
Synonyms: 2310069F17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71790
HGNC: HGNC:547
Homologene: 2643
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: IDPm, Idh-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Slc7a2
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms: Atrc2, Tea, Cat2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11988
Homologene: 20659
Nell1
Name: NEL-like 1
Synonyms: l7R6, B230343H07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: 2900022L05Rik, Dnhd3, Dnahc2, D330014H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Irak3
Name: interleukin-1 receptor-associated kinase 3
Synonyms: IRAK-M, 4833428C18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73914
Homologene: 36215
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75820
Homologene: 51634
Mybph
Name: myosin binding protein H
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53311
HGNC: HGNC:7552
Homologene: 3661
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66898
Homologene: 23123
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620928
Homologene: 115466
Or4c105
Name: olfactory receptor family 4 subfamily C member 105
Synonyms: MOR232-7, Olfr1202, GA_x6K02T2Q125-50290367-50291296
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258454
Homologene: 133021
Spire2
Name: spire type actin nucleation factor 2
Synonyms: Spir-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234857
Homologene: 72212
Bpifb6
Name: BPI fold containing family B, member 6
Synonyms: Bpil3, LOC228796
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228796
Homologene: 18375
Rad21l
Name: RAD21-like (S. pombe)
Synonyms: Gm14160
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668929
Homologene: 82650
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: SKIP, A930009L15Rik, 4930544G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Gcnt4
Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
Synonyms: C2GNT3, LOC218476, LOC238786, Gm73
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218476
VEGA: 13
Homologene: 41144
Thoc5
Name: THO complex 5
Synonyms: Fmip, 1700060C24Rik, PK1.3, A430085L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107829
Homologene: 37836
Spata1
Name: spermatogenesis associated 1
Synonyms: 4921536I21Rik, SP-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70951
Homologene: 23356
1700067P10Rik
Name: RIKEN cDNA 1700067P10 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68224
VEGA: 17
Homologene: 87035
Dlgap1
Name: DLG associated protein 1
Synonyms: Sapap1, 4933422O14Rik, DAP-1 beta, SAPAP1, D17Bwg0511e, Gkap, GKAP/SAPAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Vmn1r62
Name: vomeronasal 1 receptor 62
Synonyms: V1rd8, V3R2, V1rd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81016
Homologene: 41799
Col4a6
Name: collagen, type IV, alpha 6
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 94216
HGNC: HGNC:2208
Homologene: 48050
Esd
Name: esterase D/formylglutathione hydrolase
Synonyms: Es10, Es-10, Esd
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13885
HGNC: HGNC:3465
Homologene: 55623
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: IP, prostacyclin receptor
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Etnk2
Name: ethanolamine kinase 2
Synonyms: 4933417N20Rik, Eki2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214253
Homologene: 10072
Ttll2
Name: tubulin tyrosine ligase-like family, member 2
Synonyms: EG625850
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100216474
VEGA: 17
Homologene: 12917
Vegfb
Name: vascular endothelial growth factor B
Synonyms: VEGF-B, Vrf
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22340
Homologene: 87131
Igkv1-99
Name: immunoglobulin kappa variable 1-99
Synonyms: Gm16800
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434028
Tdpoz2
Name: TD and POZ domain containing 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 399673
Homologene: 133956
Or5b114-ps1
Name: olfactory receptor family 5 subfamily B member 114, pseudogene 1
Synonyms: GA_x6K02T2RE5P-3706029-3706953, Olfr1468-ps1, MOR202-21
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258192
Or10ag55-ps1
Name: olfactory receptor family 10 subfamily AG member 55, pseudogene 1
Synonyms: MOR264-10P, GA_x6K02T2Q125-48769330-48770299, Olfr1117-ps1, MOR264-27_p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258110
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 83,275,840 bp
  • T to C, chromosome 1 at 133,374,562 bp
  • T to A, chromosome 1 at 134,198,404 bp
  • A to G, chromosome 1 at 175,806,018 bp
  • T to C, chromosome 2 at 69,472,460 bp
  • A to T, chromosome 2 at 87,284,314 bp
  • T to C, chromosome 2 at 88,817,246 bp
  • A to G, chromosome 2 at 151,660,798 bp
  • G to T, chromosome 2 at 153,905,292 bp
  • G to A, chromosome 2 at 158,450,213 bp
  • A to T, chromosome 3 at 93,651,611 bp
  • C to T, chromosome 3 at 95,300,346 bp
  • T to A, chromosome 3 at 146,475,324 bp
  • C to T, chromosome 4 at 141,470,370 bp
  • A to C, chromosome 5 at 3,635,886 bp
  • A to G, chromosome 5 at 36,672,807 bp
  • A to G, chromosome 5 at 86,136,319 bp
  • G to T, chromosome 5 at 99,222,985 bp
  • T to A, chromosome 5 at 144,276,042 bp
  • C to A, chromosome 5 at 150,395,111 bp
  • C to T, chromosome 6 at 68,542,403 bp
  • T to A, chromosome 6 at 89,569,398 bp
  • A to G, chromosome 7 at 5,675,278 bp
  • A to T, chromosome 7 at 16,284,361 bp
  • G to T, chromosome 7 at 16,907,362 bp
  • A to G, chromosome 7 at 50,219,595 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • T to A, chromosome 7 at 85,872,694 bp
  • A to T, chromosome 7 at 131,243,117 bp
  • A to T, chromosome 8 at 4,628,268 bp
  • G to T, chromosome 8 at 40,912,409 bp
  • A to G, chromosome 8 at 123,360,128 bp
  • A to G, chromosome 10 at 90,995,668 bp
  • G to T, chromosome 10 at 120,146,588 bp
  • G to A, chromosome 11 at 4,926,061 bp
  • A to T, chromosome 11 at 69,514,697 bp
  • G to A, chromosome 11 at 86,757,375 bp
  • G to A, chromosome 13 at 96,946,489 bp
  • T to C, chromosome 14 at 63,240,809 bp
  • T to C, chromosome 14 at 74,732,512 bp
  • C to T, chromosome 15 at 89,549,776 bp
  • T to C, chromosome 16 at 20,656,888 bp
  • T to G, chromosome 16 at 59,415,270 bp
  • C to T, chromosome 17 at 7,351,941 bp
  • T to C, chromosome 17 at 14,950,606 bp
  • C to T, chromosome 17 at 32,882,930 bp
  • G to T, chromosome 17 at 48,090,329 bp
  • T to A, chromosome 17 at 70,815,298 bp
  • C to T, chromosome 18 at 74,218,844 bp
  • G to A, chromosome 19 at 6,985,444 bp
  • T to C, chromosome 19 at 13,375,217 bp
  • G to A, chromosome 19 at 25,183,503 bp
  • G to A, chromosome X at 141,234,177 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8673 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068528-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.