Strain Name:
C57BL/6J-MtgxR8685Btlr/Mmmh
Stock Number:
068540-MU
Citation ID:
RRID:MMRRC_068540-MU
Other Names:
R8685 (G1)
Major Collection:

Strain Information

Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: 5430402I23Rik, Lphn3, D130075K09Rik, LEC3, lectomedin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Niban2
Name: niban apoptosis regulator 2
Synonyms: Fam129b, 9130404D14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227737
Homologene: 11269
Lamc1
Name: laminin, gamma 1
Synonyms: Lamb2, laminin B2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Hyls1
Name: HYLS1, centriolar and ciliogenesis associated
Synonyms: hydrolethalus syndrome 1, 3010015K02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76832
Homologene: 82283
Il17rb
Name: interleukin 17 receptor B
Synonyms: IL-17Rh1, IL-17ER, Evi27, IL17RH1, Il17br
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50905
Homologene: 10287
Hk1
Name: hexokinase 1
Synonyms: Hk1-s, Hk-1, mHk1-s
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Psmd2
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms: 9430095H01Rik, Tex190, TEG-190
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21762
HGNC: HGNC:9559
Homologene: 2101
Naa35
Name: N(alpha)-acetyltransferase 35, NatC auxiliary subunit
Synonyms: A330027C19Rik, C030004C14Rik, A330021G12Rik, Mak10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78689
Homologene: 5781
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104570
Homologene: 68886
Myo7a
Name: myosin VIIA
Synonyms: polka, nmf371, Myo7, USH1B, Hdb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Bbs4
Name: Bardet-Biedl syndrome 4
Synonyms: D9Ertd464e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102774
VEGA: 9
HGNC: HGNC:969
Homologene: 13197
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Ush2a
Name: usherin
Synonyms: MUSH2A, A930037M10Rik, LOC381317, LOC269160, Ushrn, A930011D15Rik, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Dlgap2
Name: DLG associated protein 2
Synonyms: 6430596N04Rik, DAP2, SAP90/PSD-95-associated protein 2, PSD-95/SAP90-binding protein 2, Sapap2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244310
HGNC: HGNC:2906
Homologene: 3484
Per2
Name: period circadian clock 2
Synonyms: mPer2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18627
HGNC: HGNC:8846
Homologene: 7885
Clstn3
Name: calsyntenin 3
Synonyms: CSTN3, Clstn3b, Cst-3, alcadein-beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232370
Homologene: 22836
Pnma8b
Name: PNMA family member 8B
Synonyms: Pnmal2, EG434128
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434128
Homologene: 35491
Tpsg1
Name: tryptase gamma 1
Synonyms: Prss31, TMT
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26945
Homologene: 74994
Atf6b
Name: activating transcription factor 6 beta
Synonyms: Crebl1, Creb-rp, ATF6beta
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
2310057J18Rik
Name: RIKEN cDNA 2310057J18 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67719
Homologene: 82613
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Smarcd3
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Synonyms: 2210409C08Rik, BAF60C, 1500001J14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66993
Homologene: 2314
Hrnr
Name: hornerin
Synonyms: A530063N20Rik, 1110033K19Rik, S100a18
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68723
Homologene: 138092
Slc6a15
Name: solute carrier family 6 (neurotransmitter transporter), member 15
Synonyms: v7-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103098
VEGA: 10
Homologene: 18163
Krtap4-23
Name: keratin associated protein 4-23
Synonyms: Gm11596
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 670464
Homologene: 124486
Cylc2
Name: cylicin, basic protein of sperm head cytoskeleton 2
Synonyms: 4930488P18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74914
HGNC: HGNC:2583
Homologene: 136270
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: B230202K19Rik, 1500001A10Rik, flopsy, fp, nSR100, bv
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68955
Homologene: 49869
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22351
Homologene: 22650
Elmo1
Name: engulfment and cell motility 1
Synonyms: C230095H21Rik, 6330578D22Rik, CED-12
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 140580
Homologene: 56685
Plekhg6
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 6
Synonyms: LOC213522
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213522
Homologene: 32395
Dcpp3
Name: demilune cell and parotid protein 3
Synonyms: EG620253
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620253
VEGA: 17
Homologene: 103921
Cdh10
Name: cadherin 10
Synonyms: C030011H18Rik, A830016G23Rik, C030003B10Rik, T2-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320873
HGNC: HGNC:1749
Homologene: 68530
Plau
Name: plasminogen activator, urokinase
Synonyms: urokinase-type plasminogen activator, u-PA, uPA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18792
VEGA: 14
HGNC: HGNC:9052
Homologene: 55670
Aoc3
Name: amine oxidase, copper containing 3
Synonyms: SSAO, VAP1, semicarbazide-sensitive amine oxidase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11754
HGNC: HGNC:550
Homologene: 2770
Cbx2
Name: chromobox 2
Synonyms: M33
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12416
HGNC: HGNC:1552
Homologene: 7256
Or1f19
Name: olfactory receptor family 1 subfamily F member 19
Synonyms: MOR131-1, GA_x54KRFPKG5P-112942-113883, Olfr161
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258859
Homologene: 51784
Pcdha8
Name: protocadherin alpha 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353235
HGNC: HGNC:8675
Homologene: 129614
Larp6
Name: La ribonucleoprotein 6, translational regulator
Synonyms: acheron, Achn, 5430431G03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67557
Homologene: 32408
Gm38394
Name: predicted gene, 38394
Type: Gene
Species: Mouse
Chromosome: 1
Trbv26
Name: T cell receptor beta, variable 26
Synonyms: Gm16909, Tcrb-V3.1, Tcrb-V3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110315
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 91,450,680 bp
  • A to T, chromosome 1 at 133,657,016 bp
  • G to T, chromosome 1 at 153,233,542 bp
  • T to A, chromosome 1 at 188,466,204 bp
  • T to G, chromosome 2 at 32,919,089 bp
  • T to A, chromosome 3 at 93,322,898 bp
  • C to T, chromosome 4 at 51,229,651 bp
  • G to A, chromosome 5 at 24,595,990 bp
  • G to T, chromosome 5 at 81,726,861 bp
  • T to C, chromosome 5 at 116,447,321 bp
  • C to A, chromosome 6 at 41,227,759 bp
  • C to T, chromosome 6 at 124,456,908 bp
  • T to A, chromosome 6 at 125,375,792 bp
  • T to A, chromosome 7 at 16,946,040 bp
  • T to C, chromosome 7 at 98,097,127 bp
  • A to G, chromosome 8 at 14,831,628 bp
  • A to G, chromosome 9 at 35,561,428 bp
  • T to C, chromosome 9 at 59,339,855 bp
  • A to T, chromosome 9 at 60,724,212 bp
  • A to G, chromosome 9 at 75,284,947 bp
  • A to T, chromosome 9 at 119,066,727 bp
  • T to C, chromosome 10 at 28,986,144 bp
  • T to C, chromosome 10 at 62,296,674 bp
  • T to C, chromosome 10 at 103,409,695 bp
  • T to C, chromosome 11 at 29,209,436 bp
  • A to G, chromosome 11 at 77,854,694 bp
  • C to A, chromosome 11 at 99,792,990 bp
  • G to A, chromosome 11 at 101,332,216 bp
  • T to C, chromosome 11 at 101,489,846 bp
  • T to A, chromosome 11 at 119,027,920 bp
  • A to G, chromosome 13 at 9,637,125 bp
  • T to A, chromosome 13 at 20,290,424 bp
  • T to A, chromosome 13 at 59,586,222 bp
  • G to A, chromosome 14 at 20,839,559 bp
  • T to A, chromosome 14 at 30,004,340 bp
  • T to A, chromosome 15 at 18,899,765 bp
  • A to T, chromosome 16 at 3,593,040 bp
  • T to C, chromosome 16 at 20,655,411 bp
  • C to G, chromosome 16 at 32,753,930 bp
  • T to C, chromosome 17 at 23,919,122 bp
  • A to T, chromosome 17 at 25,373,267 bp
  • A to G, chromosome 17 at 34,650,346 bp
  • T to A, chromosome 18 at 36,993,950 bp
  • C to T, chromosome 19 at 12,469,631 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8685 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068540-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.