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Strain Name:
C57BL/6J-MtgxR8691Btlr/Mmmh
Stock Number:
068545-MU
Citation ID:
RRID:MMRRC_068545-MU
Other Names:
R8691 (G1)
Major Collection:

Strain Information

Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 6720481N21Rik, C230047C07Rik, 8030492O04Rik, AIP4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16396
Homologene: 88442
Cbfa2t2
Name: CBFA2/RUNX1 translocation partner 2
Synonyms: MTGR1, C330013D05Rik, Cbfa2t2h
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12396
HGNC: HGNC:1536
Homologene: 3733
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Fgfr1
Name: fibroblast growth factor receptor 1
Synonyms: Flt-2, Fgfr-1, Hspy, Eask, FGFR-I, Fr1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14182
HGNC: HGNC:3688
Homologene: 69065
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Ppfibp2
Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Synonyms: liprin beta 2, Cclp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19024
HGNC: HGNC:9250
Homologene: 7486
Dhx40
Name: DEAH-box helicase 40
Synonyms: ARG147, DDX40, 2410016C14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67487
Homologene: 57000
Camkmt
Name: calmodulin-lysine N-methyltransferase
Synonyms: 1700106N22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73582
VEGA: 17
Homologene: 11704
Utp25
Name: UTP25 small subunit processome component
Synonyms: AA408296, Diexf, mDef
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215193
Homologene: 6170
Card6
Name: caspase recruitment domain family, member 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239319
Homologene: 13067
Furin
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: Fur, PACE, SPC1, Pcsk3, 9130404I01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Tnc
Name: tenascin C
Synonyms: Hxb, TN-C, TN, C130033P17Rik, tenascin-C, cytotactin, hexabrachion
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
C1qtnf9
Name: C1q and tumor necrosis factor related protein 9
Synonyms: 9130217G22Rik, CTRP9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239126
Homologene: 18679
Bach1
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms: 6230421P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12013
HGNC: HGNC:935
Homologene: 916
Rnf41
Name: ring finger protein 41
Synonyms: 4930511A05Rik, FLRF, 4933415P08Rik, 2210404G21Rik, D10Ertd722e, Nrdp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67588
VEGA: 10
Homologene: 4226
Deptor
Name: DEP domain containing MTOR-interacting protein
Synonyms: 4731402B04Rik, D15Ertd336e, 9130412E02Rik, D15Ertd597e, Depdc6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 97998
Homologene: 32551
Hspa1b
Name: heat shock protein 1B
Synonyms: hsp68, Hsp70.1, Hsp70-1, HSP70B1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15511
HGNC: HGNC:5233
Homologene: 133785
Adamts6
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6
Synonyms: ADAM-TS6, A930019D11Rik, b2b2228Clo, b2b2187.1Clo, b2b2182Clo, b2b2029Clo, b2b1879.1Clo
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108154
VEGA: 13
HGNC: HGNC:222
Homologene: 82573
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: LOC208169, spermNHE, Slc9a10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208169
Homologene: 19505
Colec10
Name: collectin sub-family member 10
Synonyms: CL-L1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239447
VEGA: 15
HGNC: HGNC:2220
Homologene: 31381
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224582
Homologene: 129678
Or11g27
Name: olfactory receptor family 11 subfamily G member 27
Synonyms: GA_x6K02T2N6FY-3870-3385, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, MOR106-14, Olfr265, Olfr743-ps1, Olfr264, Olfr743
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219019
Homologene: 74163
Atosa
Name: atos homolog A
Synonyms: 6330415I01Rik, C130047D21Rik, BC031353, Fam214a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235493
VEGA: 9
Homologene: 35065
Klhl5
Name: kelch-like 5
Synonyms: 1300013C10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71778
HGNC: HGNC:6356
Homologene: 56736
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, AN2, 4732461B14Rik, Cspg4a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: D030049F17Rik, Nedl2, A730039N16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329152
Homologene: 66192
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22313
Homologene: 129751
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216859
Homologene: 22835
Actl6b
Name: actin-like 6B
Synonyms: Baf53b, ArpNa, Actl6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83766
HGNC: HGNC:160
Homologene: 81844
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: GluRdelta2, tpr, B230104L07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Or4e1
Name: olfactory receptor family 4 subfamily E member 1
Synonyms: GA_x6K02T2RJGY-520647-521579, MOR244-2, MOR244-4, MOR10, Olfr1508
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57270
HGNC: HGNC:8296
Homologene: 10737
Fam98c
Name: family with sequence similarity 98, member C
Synonyms: B230110F21Rik, 1110006G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73833
Homologene: 45483
Ivl
Name: involucrin
Synonyms: 1110019C06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16447
HGNC: HGNC:6187
Homologene: 137207
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4930578N11Rik, 4931433A01Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Ttll11
Name: tubulin tyrosine ligase-like family, member 11
Synonyms: 4932702F08Rik, D2Ertd624e, 4933424A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74410
Homologene: 77534
Or7e176
Name: olfactory receptor family 7 subfamily E member 176
Synonyms: GA_x6K02T2PVTD-13999915-14000844, MOR145-3, Olfr872
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258553
HGNC: HGNC:8396
Homologene: 138312
Pou3f1
Name: POU domain, class 3, transcription factor 1
Synonyms: Scip, Tst-1, Test1, Otf6, Oct-6, Tst1, Oct6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18991
HGNC: HGNC:9214
Homologene: 20590
Actr3b
Name: ARP3 actin-related protein 3B
Synonyms: ARP11, Arp3b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242894
Homologene: 4180
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
Pskh1
Name: protein serine kinase H1
Synonyms: E130013P03Rik, b2b1230Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244631
HGNC: HGNC:9529
Homologene: 48461
Or51d1
Name: olfactory receptor family 51 subfamily D member 1
Synonyms: GA_x6K02T2PBJ9-5414934-5415902, MOR18-3, Olfr557
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258358
Homologene: 123803
Esp31
Name: exocrine gland secreted peptide 31
Synonyms: Gm20516
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126768
Malsu1
Name: mitochondrial assembly of ribosomal large subunit 1
Synonyms: 2410003K15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75593
Homologene: 16317
Eif1ad16
Name: eukaryotic translation initiation factor 1A domain containing 16
Synonyms: Gm6803
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 627873
VEGA: 12
Ighv6-7
Name: immunoglobulin heavy variable V6-7
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 432701
HGNC: HGNC:5623
Gm17078
Name: predicted gene 17078
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102631639
Homologene: 128452
Phlda2
Name: pleckstrin homology like domain, family A, member 2
Synonyms: Ipl, Tssc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22113
Homologene: 2482
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,865,064 bp
  • A to T, chromosome 1 at 139,042,036 bp
  • T to C, chromosome 1 at 193,113,802 bp
  • T to A, chromosome 2 at 35,784,149 bp
  • C to A, chromosome 2 at 154,500,483 bp
  • G to T, chromosome 2 at 155,210,558 bp
  • G to A, chromosome 3 at 92,571,516 bp
  • A to G, chromosome 4 at 63,962,076 bp
  • G to T, chromosome 4 at 111,662,959 bp
  • G to A, chromosome 4 at 124,657,756 bp
  • A to G, chromosome 5 at 14,521,692 bp
  • G to T, chromosome 5 at 25,825,204 bp
  • G to T, chromosome 5 at 30,105,289 bp
  • A to G, chromosome 5 at 65,149,538 bp
  • G to A, chromosome 5 at 137,567,323 bp
  • C to A, chromosome 6 at 49,075,237 bp
  • G to T, chromosome 6 at 63,503,337 bp
  • G to A, chromosome 6 at 73,168,867 bp
  • A to T, chromosome 7 at 28,153,839 bp
  • A to T, chromosome 7 at 29,153,464 bp
  • C to T, chromosome 7 at 80,392,027 bp
  • C to T, chromosome 7 at 96,905,941 bp
  • C to T, chromosome 7 at 102,698,570 bp
  • A to G, chromosome 7 at 107,747,578 bp
  • A to C, chromosome 7 at 143,502,469 bp
  • A to T, chromosome 8 at 25,562,237 bp
  • T to C, chromosome 8 at 105,913,201 bp
  • T to A, chromosome 9 at 20,260,451 bp
  • T to C, chromosome 9 at 56,892,996 bp
  • A to T, chromosome 9 at 75,010,053 bp
  • T to C, chromosome 10 at 128,438,208 bp
  • A to G, chromosome 11 at 69,890,177 bp
  • T to C, chromosome 11 at 86,799,593 bp
  • C to T, chromosome 12 at 16,573,659 bp
  • T to G, chromosome 12 at 88,018,508 bp
  • A to G, chromosome 12 at 114,455,684 bp
  • A to C, chromosome 13 at 100,161,168 bp
  • A to G, chromosome 13 at 104,314,331 bp
  • A to G, chromosome 14 at 50,533,453 bp
  • A to T, chromosome 14 at 51,611,236 bp
  • A to T, chromosome 14 at 52,463,901 bp
  • C to T, chromosome 14 at 55,872,649 bp
  • G to A, chromosome 14 at 60,779,692 bp
  • T to C, chromosome 14 at 121,640,105 bp
  • A to T, chromosome 15 at 5,099,596 bp
  • A to G, chromosome 15 at 6,787,032 bp
  • A to T, chromosome 15 at 9,601,919 bp
  • A to C, chromosome 15 at 54,435,024 bp
  • A to C, chromosome 15 at 55,220,200 bp
  • A to G, chromosome 15 at 82,618,270 bp
  • T to A, chromosome 16 at 45,606,819 bp
  • T to C, chromosome 16 at 87,719,629 bp
  • A to G, chromosome 17 at 20,041,848 bp
  • G to T, chromosome 17 at 20,583,142 bp
  • T to C, chromosome 17 at 34,957,096 bp
  • G to T, chromosome 17 at 38,644,701 bp
  • A to T, chromosome 17 at 85,113,832 bp
  • T to A, chromosome 18 at 6,225,787 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8691 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068545-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.