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Strain Name:
C57BL/6J-MtgxR8700Btlr/Mmmh
Stock Number:
068554-MU
Citation ID:
RRID:MMRRC_068554-MU
Other Names:
R8700 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Shc1
Name: src homology 2 domain-containing transforming protein C1
Synonyms: p66, ShcA, p66shc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20416
Homologene: 7934
Ccdc163
Name: coiled-coil domain containing 163
Synonyms: 4933430J04Rik, 0610037D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68394
Homologene: 12265
Dhx35
Name: DEAH-box helicase 35
Synonyms: Ddx35, 1200009D07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71715
Homologene: 6406
Ppfibp2
Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Synonyms: liprin beta 2, Cclp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19024
HGNC: HGNC:9250
Homologene: 7486
Fto
Name: FTO alpha-ketoglutarate dependent dioxygenase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26383
Homologene: 8053
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Clec16a
Name: C-type lectin domain family 16, member A
Synonyms: 4932416N17Rik, curt
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74374
Homologene: 71019
Anapc7
Name: anaphase promoting complex subunit 7
Synonyms: prediabetic NOD sera-reactive autoantigen, APC7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56317
Homologene: 10512
Neo1
Name: neogenin
Synonyms: D930014N22Rik, 2610028H22Rik, Igdcc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Pja2
Name: praja ring finger ubiquitin ligase 2
Synonyms: Neurodap1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224938
Homologene: 32233
Katnip
Name: katanin interacting protein
Synonyms: D430042O09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233865
Homologene: 45841
Rhbdf2
Name: rhomboid 5 homolog 2
Synonyms: 4732465I17Rik, Rhbdl6, iRhom2, cub, Uncv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217344
Homologene: 11612
Peg10
Name: paternally expressed 10
Synonyms: MEF3L, HB-1, MyEF-3, MyEF-3 like, Edr, Mart2, Mar2, Rtl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Cep164
Name: centrosomal protein 164
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214552
Homologene: 51110
Zfpl1
Name: zinc finger like protein 1
Synonyms: 1500015B20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 81909
Homologene: 4935
Myo16
Name: myosin XVI
Synonyms: C230040D10Rik, Nyap3, BM140241
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244281
Homologene: 34710
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Chsy3
Name: chondroitin sulfate synthase 3
Synonyms: 4833446K15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78923
VEGA: 18
Homologene: 28624
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Ptprh
Name: protein tyrosine phosphatase receptor type H
Synonyms: SAP-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545902
HGNC: HGNC:9672
Homologene: 37693
Entpd5
Name: ectonucleoside triphosphate diphosphohydrolase 5
Synonyms: mNTPase, NTPDase-5, ER-UDPase, NTPDase5, Cd39l4, Pcph
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12499
HGNC: HGNC:3367
Homologene: 37457
Or10j7
Name: olfactory receptor family 10 subfamily J member 7
Synonyms: GA_x6K02T2R7CC-664297-665229, MOR267-5, Olfr1406
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258758
Homologene: 133644
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NR2A, NMDAR2A, GluRepsilon1, GluN2A
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Ripk2
Name: receptor (TNFRSF)-interacting serine-threonine kinase 2
Synonyms: CCK, CARDIAK, RIP2, RICK, CARD3, D4Bwg0615e, 2210420D18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192656
Homologene: 37856
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Vmn1r46
Name: vomeronasal 1 receptor 46
Synonyms: V1rb8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113856
Homologene: 134021
Ppp3cc
Name: protein phosphatase 3, catalytic subunit, gamma isoform
Synonyms: PP2BA gamma, Calnc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19057
VEGA: 14
HGNC: HGNC:9316
Homologene: 68475
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Abtb2
Name: ankyrin repeat and BTB domain containing 2
Synonyms: BPOZ-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99382
Homologene: 15904
Pcdhb14
Name: protocadherin beta 14
Synonyms: Pcdhb17, PcdhbN, 2210006M07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93885
Homologene: 70876
Srms
Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Synonyms: srm, A230069J08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20811
Homologene: 7957
Sirpb1a
Name: signal-regulatory protein beta 1A
Synonyms: 9930027N05Rik, Sirpb1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320832
Homologene: 82993
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 338365
Homologene: 9870
Psg18
Name: pregnancy specific beta-1-glycoprotein 18
Synonyms: mmCGM6, Cea-3, Cea3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26438
HGNC: HGNC:9524
Homologene: 110989
Atxn7l3
Name: ataxin 7-like 3
Synonyms: E030022H21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217218
Homologene: 35401
Tob2
Name: transducer of ERBB2, 2
Synonyms: 2900090N22Rik, 4930545K18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 57259
VEGA: 15
Homologene: 9447
Ano7
Name: anoctamin 7
Synonyms: IPCA-5, NGEP, NGEP-L, Pcanap5, Tmem16g
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 404545
Homologene: 45787
Zfp974
Name: zinc finger protein 974
Synonyms: 1700049G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73430
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, EC1-VR2, V2rf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Arhgef39
Name: Rho guanine nucleotide exchange factor 39
Synonyms: E130306D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230098
Homologene: 19225
Setdb2
Name: SET domain, bifurcated 2
Synonyms: LOC239122, KMT1F
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239122
Homologene: 12903
Zfp365
Name: zinc finger protein 365
Synonyms: Su48, DBZ
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216049
Homologene: 8975
Akr1c14
Name: aldo-keto reductase family 1, member C14
Synonyms: 9030611N15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105387
Homologene: 138093
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: acid ceramidase, 2310081N20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Art5
Name: ADP-ribosyltransferase 5
Synonyms: Yac-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11875
Homologene: 7231
Calcoco2
Name: calcium binding and coiled-coil domain 2
Synonyms: 2410154J16Rik, Ndp52l1, Ndp52
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76815
Gabrr2
Name: gamma-aminobutyric acid type A receptor subunit rho 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14409
HGNC: HGNC:4091
Homologene: 20471
Unc119
Name: unc-119 lipid binding chaperone
Synonyms: Rg4, HRG4, UNC119, Unc119h, MRG4, Rtg4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22248
Homologene: 3778
4933414I15Rik
Name: RIKEN cDNA 4933414I15 gene
Synonyms: ENSMUSG00000051192
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74408
Gm9195
Name: predicted gene 9195
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 675947
Homologene: 139067
Gm5565
Name: predicted gene 5565
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433961
Homologene: 86127
Or7e171-ps1
Name: olfactory receptor family 7 subfamily E member 171, pseudogene 1
Synonyms: GA_x6K02T2PVTD-13682249-13681321, MOR146-5P, MOR146-11_p, Olfr863-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258070
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 53,495,929 bp
  • T to G, chromosome 1 at 93,388,607 bp
  • G to T, chromosome 1 at 173,183,862 bp
  • C to A, chromosome 2 at 103,566,944 bp
  • T to A, chromosome 2 at 118,789,859 bp
  • T to A, chromosome 2 at 158,840,632 bp
  • C to A, chromosome 2 at 181,206,728 bp
  • T to C, chromosome 3 at 15,411,359 bp
  • A to G, chromosome 3 at 89,427,433 bp
  • T to A, chromosome 4 at 8,833,892 bp
  • T to A, chromosome 4 at 16,158,422 bp
  • T to C, chromosome 4 at 33,095,488 bp
  • T to A, chromosome 4 at 43,496,715 bp
  • T to C, chromosome 4 at 116,714,151 bp
  • T to A, chromosome 4 at 143,949,131 bp
  • T to A, chromosome 5 at 122,422,606 bp
  • T to A, chromosome 5 at 146,160,426 bp
  • T to TCCA, chromosome 6 at 4,756,451 bp
  • T to A, chromosome 6 at 73,075,890 bp
  • C to T, chromosome 6 at 89,976,343 bp
  • A to G, chromosome 6 at 119,281,693 bp
  • A to G, chromosome 7 at 4,564,191 bp
  • A to T, chromosome 7 at 18,353,625 bp
  • G to T, chromosome 7 at 27,910,047 bp
  • T to C, chromosome 7 at 102,099,655 bp
  • A to G, chromosome 7 at 107,746,395 bp
  • A to G, chromosome 7 at 125,829,870 bp
  • T to C, chromosome 7 at 135,705,707 bp
  • T to C, chromosome 8 at 10,413,172 bp
  • T to C, chromosome 8 at 41,360,275 bp
  • T to A, chromosome 8 at 91,522,833 bp
  • A to C, chromosome 9 at 19,941,700 bp
  • T to C, chromosome 9 at 45,775,369 bp
  • A to G, chromosome 9 at 58,918,630 bp
  • T to C, chromosome 9 at 73,572,397 bp
  • A to G, chromosome 9 at 79,620,089 bp
  • T to C, chromosome 10 at 67,909,705 bp
  • G to T, chromosome 10 at 79,293,683 bp
  • A to T, chromosome 10 at 82,292,025 bp
  • T to C, chromosome 10 at 83,316,233 bp
  • T to A, chromosome 11 at 50,942,517 bp
  • T to C, chromosome 11 at 78,347,311 bp
  • A to T, chromosome 11 at 95,510,880 bp
  • T to A, chromosome 11 at 96,103,504 bp
  • A to T, chromosome 11 at 102,293,921 bp
  • G to A, chromosome 11 at 116,607,404 bp
  • A to T, chromosome 12 at 84,396,734 bp
  • T to C, chromosome 13 at 4,081,157 bp
  • T to C, chromosome 14 at 59,417,439 bp
  • C to A, chromosome 14 at 70,236,552 bp
  • C to T, chromosome 14 at 72,482,731 bp
  • G to T, chromosome 15 at 81,851,601 bp
  • T to C, chromosome 16 at 9,579,548 bp
  • A to G, chromosome 16 at 10,688,558 bp
  • T to A, chromosome 17 at 49,496,152 bp
  • C to T, chromosome 17 at 64,292,954 bp
  • T to C, chromosome 18 at 37,449,599 bp
  • T to C, chromosome 18 at 59,176,415 bp
  • T to C, chromosome 18 at 80,753,146 bp
  • T to C, chromosome 19 at 6,082,434 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8700 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068554-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.