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Strain Name:
C57BL/6J-MtgxR8701Btlr/Mmmh
Stock Number:
068555-MU
Citation ID:
RRID:MMRRC_068555-MU
Other Names:
R8701 (G1)
Major Collection:

Strain Information

Sphk2
Name: sphingosine kinase 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56632
Homologene: 32456
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66743
Homologene: 10036
Tead4
Name: TEA domain family member 4
Synonyms: Tefr1a, TEAD-4, Tcf13r1, TEF-3, ETFR-2a, Etfr2, Tefr, Tef3, Rtef1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21679
Homologene: 74463
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Ncaph
Name: non-SMC condensin I complex, subunit H
Synonyms: HCAP-H, A730011O11Rik, Brrn1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215387
HGNC: HGNC:1112
Homologene: 133986
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Mak-v, Bstk1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 26,685,445 bp
  • A to G, chromosome 1 at 40,539,341 bp
  • A to G, chromosome 1 at 66,638,032 bp
  • A to T, chromosome 1 at 150,755,257 bp
  • A to G, chromosome 2 at 88,652,487 bp
  • T to C, chromosome 2 at 127,106,138 bp
  • T to A, chromosome 2 at 156,161,587 bp
  • G to T, chromosome 2 at 163,828,866 bp
  • C to T, chromosome 2 at 164,833,134 bp
  • A to T, chromosome 3 at 20,316,092 bp
  • A to T, chromosome 3 at 35,995,784 bp
  • C to T, chromosome 3 at 90,087,680 bp
  • T to C, chromosome 3 at 90,122,814 bp
  • C to T, chromosome 3 at 95,493,765 bp
  • T to A, chromosome 3 at 95,684,966 bp
  • C to T, chromosome 4 at 21,678,615 bp
  • A to G, chromosome 4 at 33,944,739 bp
  • A to G, chromosome 4 at 41,520,283 bp
  • T to A, chromosome 4 at 96,121,573 bp
  • T to C, chromosome 4 at 117,489,993 bp
  • A to T, chromosome 4 at 118,430,510 bp
  • T to C, chromosome 4 at 132,830,642 bp
  • C to T, chromosome 4 at 152,279,101 bp
  • C to T, chromosome 4 at 155,861,046 bp
  • T to C, chromosome 5 at 97,391,958 bp
  • G to A, chromosome 5 at 109,047,690 bp
  • T to A, chromosome 5 at 124,726,847 bp
  • T to A, chromosome 5 at 134,216,235 bp
  • T to C, chromosome 5 at 135,107,191 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • C to G, chromosome 6 at 52,163,450 bp
  • T to C, chromosome 6 at 71,885,511 bp
  • T to A, chromosome 6 at 116,413,826 bp
  • T to A, chromosome 6 at 128,242,566 bp
  • T to A, chromosome 7 at 12,481,098 bp
  • G to T, chromosome 7 at 16,885,276 bp
  • A to G, chromosome 7 at 24,125,740 bp
  • A to G, chromosome 7 at 43,694,142 bp
  • A to T, chromosome 7 at 45,710,825 bp
  • A to T, chromosome 7 at 102,578,692 bp
  • A to G, chromosome 7 at 112,093,195 bp
  • A to G, chromosome 7 at 141,695,607 bp
  • C to T, chromosome 8 at 3,945,892 bp
  • T to A, chromosome 8 at 27,345,124 bp
  • A to T, chromosome 8 at 75,052,168 bp
  • T to C, chromosome 8 at 85,095,153 bp
  • T to A, chromosome 8 at 117,581,677 bp
  • A to T, chromosome 9 at 38,309,438 bp
  • A to T, chromosome 9 at 39,750,914 bp
  • A to G, chromosome 9 at 40,022,519 bp
  • A to G, chromosome 9 at 107,948,041 bp
  • G to A, chromosome 10 at 5,205,026 bp
  • T to A, chromosome 10 at 59,467,653 bp
  • A to G, chromosome 11 at 73,278,936 bp
  • A to T, chromosome 11 at 97,022,264 bp
  • A to G, chromosome 14 at 8,298,755 bp
  • G to A, chromosome 14 at 24,176,700 bp
  • A to T, chromosome 14 at 56,260,360 bp
  • A to T, chromosome 14 at 88,468,413 bp
  • T to C, chromosome 14 at 118,599,373 bp
  • A to G, chromosome 15 at 44,574,683 bp
  • T to A, chromosome 16 at 49,007,141 bp
  • T to A, chromosome 16 at 90,386,610 bp
  • A to T, chromosome 18 at 20,107,682 bp
  • A to G, chromosome 19 at 3,978,448 bp
  • T to C, chromosome 19 at 56,851,484 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8701 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068555-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.