Strain Name:
C57BL/6J-MtgxR8701Btlr/Mmmh
Stock Number:
068555-MU
Citation ID:
RRID:MMRRC_068555-MU
Other Names:
R8701 (G1)
Major Collection:

Strain Information

Sphk2
Name: sphingosine kinase 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56632
Homologene: 32456
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66743
Homologene: 10036
Tead4
Name: TEA domain family member 4
Synonyms: Tefr1a, TEAD-4, Tcf13r1, TEF-3, ETFR-2a, Etfr2, Tefr, Tef3, Rtef1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21679
Homologene: 74463
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Ncaph
Name: non-SMC condensin I complex, subunit H
Synonyms: HCAP-H, A730011O11Rik, Brrn1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215387
HGNC: HGNC:1112
Homologene: 133986
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Mak-v, Bstk1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Abcc4
Name: ATP-binding cassette, sub-family C member 4
Synonyms: D630049P08Rik, MOAT-B, MRP4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239273
VEGA: 14
HGNC: HGNC:55
Homologene: 74563
Plcg2
Name: phospholipase C, gamma 2
Synonyms: Plcg-2, PLCgamma2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Ppp1r8
Name: protein phosphatase 1, regulatory subunit 8
Synonyms: 6330548N22Rik, NIPP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100336
HGNC: HGNC:9296
Homologene: 8555
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: Cip2a, C330027C09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224171
Homologene: 10842
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ptcd3
Name: pentatricopeptide repeat domain 3
Synonyms: 2610034F17Rik, 2810422B04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69956
Homologene: 41211
Cnr1
Name: cannabinoid receptor 1
Synonyms: CB1, CB1R
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12801
HGNC: HGNC:2159
Homologene: 7273
Rbm39
Name: RNA binding motif protein 39
Synonyms: caper, 2310040E03Rik, 1500012C14Rik, Rnpc2, B330012G18Rik, Caper alpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170791
Homologene: 136465
Tpm3
Name: tropomyosin 3, gamma
Synonyms: hTMnm, hTM30nm, gamma-TM, skalphaTM.2, Tpm-5, Trop-5, Tpm5, Tm5NM
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59069
Homologene: 81889
Camkv
Name: CaM kinase-like vesicle-associated
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235604
Homologene: 56983
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Pcdh20
Name: protocadherin 20
Synonyms: PCDH13, C630015B17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219257
Homologene: 11277
Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Synonyms: Hif1b, ESTM42, D3Ertd557e, bHLHe2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11863
HGNC: HGNC:700
Homologene: 1261
Tom1
Name: target of myb1 trafficking protein
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21968
Homologene: 88453
Fam219a
Name: family with sequence similarity 219, member A
Synonyms: 2310028H24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71901
Homologene: 51830
Tas1r3
Name: taste receptor, type 1, member 3
Synonyms: T1r3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83771
Homologene: 12890
Mcu
Name: mitochondrial calcium uniporter
Synonyms: 2010012O16Rik, D130073L02Rik, Ccdc109a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215999
Homologene: 9916
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: MCCalpha, MCCA, 1810045E08Rik, 2310058B18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Mlxipl
Name: MLX interacting protein-like
Synonyms: WS-bHLH, ChREBP, Wbscr14, bHLHd14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58805
Homologene: 32507
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Spata31e2
Name: spermatogenesis associated 31 subfamily E member 2
Synonyms: 4931408C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210940
Homologene: 86827
Gtf2ird2
Name: GTF2I repeat domain containing 2
Synonyms: 1700012P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114674
Homologene: 24941
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83561
Homologene: 12850
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229595
Homologene: 23141
Or8g4
Name: olfactory receptor family 8 subfamily G member 4
Synonyms: GA_x6K02T2PVTD-33447884-33448816, MOR171-30P, Olfr967
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258086
VEGA: 9
HGNC: HGNC:8484
Homologene: 115535
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: 1110036I10Rik, VRL3, Nh
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246788
Homologene: 17040
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Agtr1b
Name: angiotensin II receptor, type 1b
Synonyms: Agtr-1b, AT1B, Angtr-1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11608
HGNC: HGNC:336
Homologene: 84871
Il18rap
Name: interleukin 18 receptor accessory protein
Synonyms: AcPL accessory protein-like)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16174
HGNC: HGNC:5989
Homologene: 2859
Vmn2r11
Name: vomeronasal 2, receptor 11
Synonyms: EG384219
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384219
Homologene: 129606
Aldh3b2
Name: aldehyde dehydrogenase 3 family, member B2
Synonyms: C130048D07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 621603
HGNC: HGNC:411
Homologene: 84430
Cyp2j12
Name: cytochrome P450, family 2, subfamily j, polypeptide 12
Synonyms: OTTMUSG00000007939, Cyp2j12-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242546
HGNC: HGNC:2634
Homologene: 133195
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LO, 5-LOX, 5LX
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Sp6
Name: trans-acting transcription factor 6
Synonyms: Klf14, 1110025J03Rik, epiprofin, Epfn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83395
Homologene: 19879
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Ccn5
Name: cellular communication network factor 5
Synonyms: rCop1, Crgr4, CCN5, Wisp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22403
Homologene: 2882
Prdm13
Name: PR domain containing 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230025
Homologene: 11000
Repin1
Name: replication initiator 1
Synonyms: Zfp464, AP4, E430037F08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Dsc1
Name: desmocollin 1
Synonyms: Dsc1b, Dsc1a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
Tex24
Name: testis expressed gene 24
Synonyms: TESF-1, 1700108N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 541463
Fam107a
Name: family with sequence similarity 107, member A
Synonyms: DRR1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268709
Homologene: 48509
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Or10g6
Name: olfactory receptor family 10 subfamily G member 6
Synonyms: GA_x6K02T2PVTD-33720892-33721824, MOR223-8, Olfr981
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258283
VEGA: 9
Homologene: 64849
Gpr153
Name: G protein-coupled receptor 153
Synonyms: 1110065N12Rik, PGR1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100129
Homologene: 18662
Cd209c
Name: CD209c antigen
Synonyms: SIGNR2, mSIGNR2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170776
HGNC: HGNC:1641
Homologene: 87186
Elovl1
Name: ELOVL fatty acid elongase 1
Synonyms: Ssc1, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54325
Homologene: 41322
Neurl2
Name: neuralized E3 ubiquitin protein ligase 2
Synonyms: Ozz-E3, Ozz
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 415115
Homologene: 15435
Zfp606
Name: zinc finger protein 606
Synonyms: 2410022M24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67370
Homologene: 23514
Gzmb
Name: granzyme B
Synonyms: CCP1, CCP-1/C11, Ctla-1, Ctla1, GZB
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14939
VEGA: 14
HGNC: HGNC:4709
Naa11
Name: N(alpha)-acetyltransferase 11, NatA catalytic subunit
Synonyms: Ard1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 97243
Homologene: 39206
Or51r1
Name: olfactory receptor family 51 subfamily R member 1
Synonyms: GA_x6K02T2PBJ9-5297243-5298193, MOR16-1, Olfr550
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259108
Homologene: 17507
Dact3
Name: dishevelled-binding antagonist of beta-catenin 3
Synonyms: EG666671
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 629378
Homologene: 77340
Gm28308
Name: predicted gene 28308
Type: Gene
Species: Mouse
Chromosome: 6
Or8c19-ps1
Name: olfactory receptor family 8 subfamily C member 19, pseudogene1
Synonyms: GA_x6K02T2PVTD-31999710-32000653, MOR170-7, Olfr897-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258473
VEGA: 9
Or4p4
Name: olfactory receptor family 4 subfamily P member 4
Synonyms: GA_x6K02T2Q125-50131417-50131917, MOR225-11, Olfr1192
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257937
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 26,685,445 bp
  • A to G, chromosome 1 at 40,539,341 bp
  • A to G, chromosome 1 at 66,638,032 bp
  • A to T, chromosome 1 at 150,755,257 bp
  • A to G, chromosome 2 at 88,652,487 bp
  • T to C, chromosome 2 at 127,106,138 bp
  • T to A, chromosome 2 at 156,161,587 bp
  • G to T, chromosome 2 at 163,828,866 bp
  • C to T, chromosome 2 at 164,833,134 bp
  • A to T, chromosome 3 at 20,316,092 bp
  • A to T, chromosome 3 at 35,995,784 bp
  • C to T, chromosome 3 at 90,087,680 bp
  • T to C, chromosome 3 at 90,122,814 bp
  • C to T, chromosome 3 at 95,493,765 bp
  • T to A, chromosome 3 at 95,684,966 bp
  • C to T, chromosome 4 at 21,678,615 bp
  • A to G, chromosome 4 at 33,944,739 bp
  • A to G, chromosome 4 at 41,520,283 bp
  • T to A, chromosome 4 at 96,121,573 bp
  • T to C, chromosome 4 at 117,489,993 bp
  • A to T, chromosome 4 at 118,430,510 bp
  • T to C, chromosome 4 at 132,830,642 bp
  • C to T, chromosome 4 at 152,279,101 bp
  • C to T, chromosome 4 at 155,861,046 bp
  • T to C, chromosome 5 at 97,391,958 bp
  • G to A, chromosome 5 at 109,047,690 bp
  • T to A, chromosome 5 at 124,726,847 bp
  • T to A, chromosome 5 at 134,216,235 bp
  • T to C, chromosome 5 at 135,107,191 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • C to G, chromosome 6 at 52,163,450 bp
  • T to C, chromosome 6 at 71,885,511 bp
  • T to A, chromosome 6 at 116,413,826 bp
  • T to A, chromosome 6 at 128,242,566 bp
  • T to A, chromosome 7 at 12,481,098 bp
  • G to T, chromosome 7 at 16,885,276 bp
  • A to G, chromosome 7 at 24,125,740 bp
  • A to G, chromosome 7 at 43,694,142 bp
  • A to T, chromosome 7 at 45,710,825 bp
  • A to T, chromosome 7 at 102,578,692 bp
  • A to G, chromosome 7 at 112,093,195 bp
  • A to G, chromosome 7 at 141,695,607 bp
  • C to T, chromosome 8 at 3,945,892 bp
  • T to A, chromosome 8 at 27,345,124 bp
  • A to T, chromosome 8 at 75,052,168 bp
  • T to C, chromosome 8 at 85,095,153 bp
  • T to A, chromosome 8 at 117,581,677 bp
  • A to T, chromosome 9 at 38,309,438 bp
  • A to T, chromosome 9 at 39,750,914 bp
  • A to G, chromosome 9 at 40,022,519 bp
  • A to G, chromosome 9 at 107,948,041 bp
  • G to A, chromosome 10 at 5,205,026 bp
  • T to A, chromosome 10 at 59,467,653 bp
  • A to G, chromosome 11 at 73,278,936 bp
  • A to T, chromosome 11 at 97,022,264 bp
  • A to G, chromosome 14 at 8,298,755 bp
  • G to A, chromosome 14 at 24,176,700 bp
  • A to T, chromosome 14 at 56,260,360 bp
  • A to T, chromosome 14 at 88,468,413 bp
  • T to C, chromosome 14 at 118,599,373 bp
  • A to G, chromosome 15 at 44,574,683 bp
  • T to A, chromosome 16 at 49,007,141 bp
  • T to A, chromosome 16 at 90,386,610 bp
  • A to T, chromosome 18 at 20,107,682 bp
  • A to G, chromosome 19 at 3,978,448 bp
  • T to C, chromosome 19 at 56,851,484 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8701 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068555-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.