Strain Name:
C57BL/6J-MtgxR8707Btlr/Mmmh
Stock Number:
068561-MU
Citation ID:
RRID:MMRRC_068561-MU
Other Names:
R8707 (G1)
Major Collection:

Strain Information

Wasf2
Name: WASP family, member 2
Synonyms: WAVE2, D4Ertd13e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242687
Homologene: 86743
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Kcnc4
Name: potassium voltage gated channel, Shaw-related subfamily, member 4
Synonyms: Kcr2-4, Kv3.4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99738
HGNC: HGNC:6236
Homologene: 68427
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67724
Homologene: 41000
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: 4833422K13Rik, C330023M02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231713
Homologene: 6891
Inppl1
Name: inositol polyphosphate phosphatase-like 1
Synonyms: SHIP2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16332
HGNC: HGNC:6080
Homologene: 1204
Dars2
Name: aspartyl-tRNA synthetase 2 (mitochondrial)
Synonyms: 5830468K18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226539
Homologene: 7093
Echdc2
Name: enoyl Coenzyme A hydratase domain containing 2
Synonyms: 2610009M20Rik, 1300017C12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52430
Homologene: 23088
Ube2d1
Name: ubiquitin-conjugating enzyme E2D 1
Synonyms: UBCH5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216080
Homologene: 20714
Fev
Name: FEV transcription factor, ETS family member
Synonyms: Pex1, Pet1, mPet-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 260298
Homologene: 9706
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: LOC382100, D030002L11Rik, Rme8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235567
Homologene: 13574
Pik3ap1
Name: phosphoinositide-3-kinase adaptor protein 1
Synonyms: BCAP, 1810044J04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83490
VEGA: 19
Homologene: 12848
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: IDPm, Idh-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Lmntd2
Name: lamin tail domain containing 2
Synonyms: 1600016N20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72000
Homologene: 104159
Tmem177
Name: transmembrane protein 177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66343
Homologene: 12732
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Trappc3l
Name: trafficking protein particle complex 3 like
Synonyms: ENSMUSG00000071340, Bet3l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 692132
VEGA: 10
Homologene: 82663
Ccdc8
Name: coiled-coil domain containing 8
Synonyms: ENSMUSG00000041117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434130
Homologene: 49977
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Lrrc14
Name: leucine rich repeat containing 14
Synonyms: E130306I01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223664
Homologene: 40970
Gm57858
Name: gene model 57858
Synonyms: Ccdc144b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241943
Homologene: 87263
Mtnr1b
Name: melatonin receptor 1B
Synonyms: Mt2, Mel1b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244701
HGNC: HGNC:7464
Homologene: 4350
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Setdb2
Name: SET domain, bifurcated 2
Synonyms: KMT1F, LOC239122
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239122
Homologene: 12903
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208372
Homologene: 16382
Fermt1
Name: fermitin family member 1
Synonyms: 5830467P10Rik, Kindlin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241639
Homologene: 9773
Igfals
Name: insulin-like growth factor binding protein, acid labile subunit
Synonyms: ALS, Albs
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16005
VEGA: 17
HGNC: HGNC:5468
Homologene: 37987
Pars2
Name: prolyl-tRNA synthetase (mitochondrial)(putative)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230577
Homologene: 5830
Cx3cl1
Name: C-X3-C motif chemokine ligand 1
Synonyms: D8Bwg0439e, CX3C, Scyd1, fractalkine, neurotactin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20312
Homologene: 2251
Ms4a12
Name: membrane-spanning 4-domains, subfamily A, member 12
Synonyms: LOC381213
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381213
Homologene: 130690
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,885,157 bp
  • A to G, chromosome 1 at 89,993,135 bp
  • G to A, chromosome 1 at 119,910,340 bp
  • A to G, chromosome 1 at 161,056,511 bp
  • G to A, chromosome 2 at 132,924,961 bp
  • T to A, chromosome 3 at 36,018,921 bp
  • A to G, chromosome 3 at 107,448,133 bp
  • C to A, chromosome 4 at 58,070,197 bp
  • T to C, chromosome 4 at 106,653,162 bp
  • G to A, chromosome 4 at 108,173,831 bp
  • A to G, chromosome 4 at 116,097,336 bp
  • C to A, chromosome 4 at 118,593,006 bp
  • T to A, chromosome 4 at 133,190,229 bp
  • A to G, chromosome 5 at 121,414,812 bp
  • C to T, chromosome 7 at 16,996,050 bp
  • C to T, chromosome 7 at 28,120,495 bp
  • GGTCCCAG to GG, chromosome 7 at 80,098,329 bp
  • G to A, chromosome 7 at 101,829,696 bp
  • G to A, chromosome 7 at 141,211,321 bp
  • A to T, chromosome 8 at 94,779,747 bp
  • C to A, chromosome 9 at 15,874,513 bp
  • T to C, chromosome 9 at 104,192,648 bp
  • A to G, chromosome 10 at 34,102,731 bp
  • T to C, chromosome 10 at 71,256,648 bp
  • A to G, chromosome 10 at 115,452,705 bp
  • G to A, chromosome 14 at 59,423,458 bp
  • C to T, chromosome 15 at 34,529,203 bp
  • T to A, chromosome 15 at 76,713,216 bp
  • A to G, chromosome 16 at 20,594,215 bp
  • G to A, chromosome 16 at 49,153,087 bp
  • T to C, chromosome 16 at 90,955,431 bp
  • C to T, chromosome 17 at 14,691,383 bp
  • C to A, chromosome 17 at 24,880,211 bp
  • A to G, chromosome 19 at 11,215,372 bp
  • G to A, chromosome 19 at 41,324,600 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8707 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068561-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.