Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8712Btlr/Mmmh
Stock Number:
068566-MU
Citation ID:
RRID:MMRRC_068566-MU
Other Names:
R8712 (G1)
Major Collection:

Strain Information

Otx2
Name: orthodenticle homeobox 2
Synonyms: E130306E05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18424
HGNC: HGNC:8522
Homologene: 11026
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Tti1
Name: TELO2 interacting protein 1
Synonyms: 2610036D13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75425
Homologene: 40969
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70797
Homologene: 19076
Esrrb
Name: estrogen related receptor, beta
Synonyms: Estrrb, ERRb, ERR2, Err2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26380
HGNC: HGNC:3473
Homologene: 69108
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: WBSCR11, Cream1, GTF3, MusTRD1, binding factor for early enhancer, BEN, ESTM9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 164,298,290 bp
  • T to A, chromosome 1 at 172,275,980 bp
  • A to T, chromosome 1 at 173,480,508 bp
  • T to A, chromosome 1 at 173,527,920 bp
  • A to G, chromosome 2 at 76,737,338 bp
  • A to T, chromosome 2 at 90,138,770 bp
  • A to T, chromosome 2 at 112,156,589 bp
  • A to G, chromosome 2 at 114,118,877 bp
  • A to C, chromosome 2 at 122,289,345 bp
  • G to A, chromosome 2 at 155,024,174 bp
  • A to C, chromosome 2 at 157,993,010 bp
  • G to A, chromosome 3 at 84,952,377 bp
  • A to T, chromosome 4 at 45,920,842 bp
  • C to A, chromosome 5 at 3,772,643 bp
  • T to C, chromosome 5 at 91,089,154 bp
  • C to T, chromosome 5 at 134,415,210 bp
  • C to T, chromosome 5 at 137,327,654 bp
  • T to C, chromosome 6 at 8,013,133 bp
  • C to T, chromosome 6 at 18,274,697 bp
  • G to A, chromosome 6 at 57,036,680 bp
  • A to C, chromosome 6 at 83,102,252 bp
  • T to C, chromosome 6 at 112,384,438 bp
  • G to T, chromosome 7 at 12,635,950 bp
  • T to C, chromosome 7 at 28,546,344 bp
  • T to A, chromosome 7 at 45,361,705 bp
  • C to T, chromosome 7 at 75,865,672 bp
  • T to C, chromosome 7 at 86,443,715 bp
  • T to A, chromosome 7 at 104,129,115 bp
  • T to C, chromosome 7 at 104,179,818 bp
  • C to A, chromosome 7 at 105,092,601 bp
  • T to C, chromosome 7 at 115,597,508 bp
  • T to A, chromosome 7 at 123,001,753 bp
  • C to T, chromosome 7 at 140,668,139 bp
  • A to G, chromosome 8 at 27,344,624 bp
  • A to G, chromosome 8 at 66,468,348 bp
  • A to G, chromosome 8 at 109,538,677 bp
  • C to A, chromosome 9 at 21,933,755 bp
  • T to C, chromosome 9 at 22,013,079 bp
  • T to C, chromosome 9 at 38,209,803 bp
  • T to C, chromosome 9 at 39,942,595 bp
  • A to T, chromosome 10 at 10,689,552 bp
  • A to G, chromosome 10 at 57,811,430 bp
  • T to A, chromosome 10 at 69,270,757 bp
  • G to A, chromosome 10 at 80,530,089 bp
  • A to G, chromosome 10 at 103,389,251 bp
  • C to T, chromosome 11 at 32,237,334 bp
  • T to C, chromosome 11 at 49,160,470 bp
  • T to A, chromosome 11 at 49,494,844 bp
  • T to A, chromosome 11 at 78,179,644 bp
  • T to C, chromosome 11 at 107,881,684 bp
  • T to C, chromosome 11 at 114,784,773 bp
  • A to G, chromosome 12 at 13,243,858 bp
  • T to C, chromosome 12 at 37,357,674 bp
  • T to C, chromosome 12 at 84,806,350 bp
  • T to A, chromosome 12 at 86,518,950 bp
  • T to C, chromosome 12 at 112,786,252 bp
  • T to C, chromosome 12 at 112,787,089 bp
  • A to G, chromosome 13 at 24,918,541 bp
  • T to C, chromosome 13 at 55,805,844 bp
  • T to G, chromosome 13 at 76,056,523 bp
  • T to C, chromosome 13 at 100,223,096 bp
  • A to G, chromosome 14 at 48,659,064 bp
  • T to C, chromosome 14 at 56,018,713 bp
  • T to A, chromosome 15 at 89,386,822 bp
  • C to T, chromosome 15 at 100,694,620 bp
  • A to G, chromosome 16 at 45,560,283 bp
  • A to T, chromosome 16 at 85,798,008 bp
  • T to A, chromosome 17 at 19,591,135 bp
  • A to G, chromosome 17 at 25,231,715 bp
  • A to G, chromosome 17 at 78,921,652 bp
  • T to A, chromosome 17 at 88,714,923 bp
  • A to T, chromosome 18 at 80,130,970 bp
  • T to C, chromosome 18 at 80,974,021 bp
  • C to A, chromosome 19 at 10,215,070 bp
  • T to C, chromosome 19 at 39,321,694 bp
  • T to C, chromosome 19 at 40,611,726 bp
  • T to C, chromosome 19 at 46,313,336 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8712 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068566-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.