Strain Name:
C57BL/6J-MtgxR8714Btlr/Mmmh
Stock Number:
068568-MU
Citation ID:
RRID:MMRRC_068568-MU
Other Names:
R8714 (G1)
Major Collection:

Strain Information

S1pr1
Name: sphingosine-1-phosphate receptor 1
Synonyms: Edg1, S1P1, S1P
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13609
HGNC: HGNC:3165
Homologene: 1071
Casp8
Name: caspase 8
Synonyms: MACH, FLICE, Caspase-8, Mch5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12370
HGNC: HGNC:1509
Homologene: 7657
Card11
Name: caspase recruitment domain family, member 11
Synonyms: BIMP3, 2410011D02Rik, CARMA1, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240725
Homologene: 49408
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: KPI-2, KPI2, A330101P12Rik, 2900041G10Rik, BREK, AATYK2, cprk
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231876
Homologene: 8948
Bard1
Name: BRCA1 associated RING domain 1
Synonyms: ENSMUSG00000060893, ENSMUSG00000073653
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12021
HGNC: HGNC:952
Homologene: 400
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Rab7
Name: RAB7, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19349
HGNC: HGNC:9788
Homologene: 3408
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Ten-m4, l7Rn3, Odz4, l(7)-3Rn, ELM2, Doc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Alb
Name: albumin
Synonyms: Alb-1, Alb1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Ddx41
Name: DEAD box helicase 41
Synonyms: 2900024F02Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72935
VEGA: 13
Homologene: 9431
Morc2a
Name: microrchidia 2A
Synonyms: 8430403M08Rik, Zcwcc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74522
Homologene: 8966
Ubxn7
Name: UBX domain protein 7
Synonyms: Ubxd7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224111
VEGA: 16
Homologene: 45585
Cd209d
Name: CD209d antigen
Synonyms: SIGNR3, mSIGNR3, SIGN-R3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170779
HGNC: HGNC:1641
Homologene: 8603
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Rnf157
Name: ring finger protein 157
Synonyms: A130073L17Rik, 2610036E23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217340
Homologene: 28235
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, D430003I15Rik, Abc10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207618
Homologene: 52304
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17076
Homologene: 31085
Asb17
Name: ankyrin repeat and SOCS box-containing 17
Synonyms: 4933436O18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66772
Homologene: 12031
Micall1
Name: microtubule associated monooxygenase, calponin and LIM domain containing -like 1
Synonyms: Mus EST 820961, D15N2e, D15Mit260
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27008
VEGA: 15
Homologene: 24911
Dmrta1
Name: doublesex and mab-3 related transcription factor like family A1
Synonyms: Dmrt4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242523
Homologene: 18477
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: A530052M23Rik, [a]1 (XVI) collagen, 2700007F12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Ogfod3
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 3
Synonyms: 1110031I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66179
Homologene: 11640
H2-Q2
Name: histocompatibility 2, Q region locus 2
Synonyms: Gm11132, H-2Q2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15013
Homologene: 128352
D3Ertd751e
Name: DNA segment, Chr 3, ERATO Doi 751, expressed
Synonyms: 4930415G15Rik, 2810009O15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73852
Homologene: 12520
Plscr3
Name: phospholipid scramblase 3
Synonyms: 2610037N06Rik, 2210403O21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70310
Homologene: 23219
Cacnb3
Name: calcium channel, voltage-dependent, beta 3 subunit
Synonyms: Cchb3, Beta3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12297
VEGA: 15
HGNC: HGNC:1403
Homologene: 20187
Fbxw13
Name: F-box and WD-40 domain protein 13
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 211305
Homologene: 110776
Prb1c
Name: proline-rich protein BstNI subfamily 1C
Synonyms: Gm8882
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667929
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70941
Homologene: 52843
Or51a43
Name: olfactory receptor family 51 subfamily A member 43
Synonyms: GA_x6K02T2PBJ9-6803062-6802118, MOR13-1, Olfr644
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259125
Homologene: 17491
Vmn1r62
Name: vomeronasal 1 receptor 62
Synonyms: V1rd8, V1rd2, V3R2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81016
Homologene: 41799
Cfap161
Name: cilia and flagella associated protein 161
Synonyms: 1700026D08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75556
Homologene: 12605
Ttc29
Name: tetratricopeptide repeat domain 29
Synonyms: 1700031F13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73301
Homologene: 12918
4930474N05Rik
Name: RIKEN cDNA 4930474N05 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218921
Homologene: 138428
Apol9a
Name: apolipoprotein L 9a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223672
VEGA: 15
Homologene: 77567
Dhrs13
Name: dehydrogenase/reductase 13
Synonyms: dehydrogenase/reductase (SDR family) member 13, 2610209N15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70451
Homologene: 64807
Muc1
Name: mucin 1, transmembrane
Synonyms: CD227, EMA, Muc-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Chid1
Name: chitinase domain containing 1
Synonyms: 3110023E09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68038
Homologene: 12229
Plat
Name: plasminogen activator, tissue
Synonyms: tPA, D8Ertd2e, t-PA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Hemgn
Name: hemogen
Synonyms: EDAG, 4921524M03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93966
Homologene: 14223
Asb14
Name: ankyrin repeat and SOCS box-containing 14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 142687
Homologene: 15445
Acat3
Name: acetyl-Coenzyme A acetyltransferase 3
Synonyms: ACTL
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224530
HGNC: HGNC:94
Homologene: 55855
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 12,807,917 bp
  • A to T, chromosome 1 at 58,833,653 bp
  • T to C, chromosome 1 at 71,030,827 bp
  • T to C, chromosome 1 at 155,860,731 bp
  • T to C, chromosome 2 at 60,334,485 bp
  • T to C, chromosome 2 at 118,462,284 bp
  • G to T, chromosome 3 at 41,746,563 bp
  • G to A, chromosome 3 at 89,231,514 bp
  • A to T, chromosome 3 at 115,711,821 bp
  • A to G, chromosome 3 at 122,148,879 bp
  • A to G, chromosome 3 at 153,850,676 bp
  • C to T, chromosome 4 at 46,395,904 bp
  • A to T, chromosome 4 at 89,691,445 bp
  • C to T, chromosome 4 at 103,242,896 bp
  • T to A, chromosome 4 at 130,054,168 bp
  • T to C, chromosome 4 at 141,488,003 bp
  • C to A, chromosome 4 at 148,041,818 bp
  • A to T, chromosome 5 at 6,772,378 bp
  • T to C, chromosome 5 at 90,461,015 bp
  • G to A, chromosome 5 at 130,269,224 bp
  • T to A, chromosome 5 at 140,913,392 bp
  • A to G, chromosome 5 at 144,176,058 bp
  • T to A, chromosome 6 at 32,163,444 bp
  • T to C, chromosome 6 at 88,012,387 bp
  • C to T, chromosome 6 at 121,882,722 bp
  • G to A, chromosome 6 at 132,364,088 bp
  • C to A, chromosome 7 at 5,675,630 bp
  • T to A, chromosome 7 at 30,720,588 bp
  • T to C, chromosome 7 at 83,793,274 bp
  • C to T, chromosome 7 at 96,905,941 bp
  • T to A, chromosome 7 at 104,068,276 bp
  • T to A, chromosome 7 at 141,513,765 bp
  • CAT to C, chromosome 8 at 3,873,772 bp
  • G to T, chromosome 8 at 22,772,232 bp
  • A to G, chromosome 8 at 78,333,702 bp
  • C to T, chromosome 8 at 125,773,807 bp
  • C to T, chromosome 9 at 109,194,764 bp
  • C to T, chromosome 11 at 3,675,877 bp
  • G to T, chromosome 11 at 69,848,012 bp
  • G to C, chromosome 11 at 78,032,666 bp
  • C to A, chromosome 11 at 116,347,065 bp
  • C to T, chromosome 11 at 119,468,894 bp
  • T to A, chromosome 11 at 121,196,782 bp
  • T to C, chromosome 13 at 55,534,437 bp
  • C to T, chromosome 14 at 26,901,075 bp
  • T to A, chromosome 14 at 36,096,499 bp
  • A to G, chromosome 15 at 66,684,042 bp
  • T to C, chromosome 15 at 77,404,742 bp
  • G to A, chromosome 15 at 79,127,310 bp
  • G to A, chromosome 15 at 98,632,381 bp
  • T to A, chromosome 16 at 32,367,411 bp
  • A to T, chromosome 17 at 12,928,629 bp
  • T to C, chromosome 17 at 35,343,362 bp
  • T to C, chromosome 19 at 6,855,845 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8714 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068568-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.