Strain Name:
C57BL/6J-MtgxR8733Btlr/Mmmh
Stock Number:
068581-MU
Citation ID:
RRID:MMRRC_068581-MU
Other Names:
R8733 (G1)
Major Collection:

Strain Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: tn, Hrs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: Nedd4a, Nedd4-1, Nedd4, E430025J12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Tsk2, Col3a-1, Tsk-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Ints6
Name: integrator complex subunit 6
Synonyms: 2900075H24Rik, Notch2l, Ddx26, DICE1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212281
Homologene: 133713
Lima1
Name: LIM domain and actin binding 1
Synonyms: epithelial protein lost in neoplasm, EPLIN, 1110021C24Rik, 3526402A12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 65970
Homologene: 9484
Cep85
Name: centrosomal protein 85
Synonyms: Ccdc21, 2410030J07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70012
Homologene: 11254
Slu7
Name: SLU7 splicing factor homolog (S. cerevisiae)
Synonyms: D11Ertd730e, D3Bwg0878e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193116
Homologene: 4690
Dhx16
Name: DEAH-box helicase 16
Synonyms: 2410006N22Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 16, DBP2, Ddx16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Slc41a3
Name: solute carrier family 41, member 3
Synonyms: SLC41A1-L2, 1010001P06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71699
Homologene: 23052
Sphk1
Name: sphingosine kinase 1
Synonyms: 1110006G24Rik, SK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20698
Homologene: 39748
Bbs9
Name: Bardet-Biedl syndrome 9
Synonyms: E130103I17Rik, EST 3159894
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319845
Homologene: 44480
Rbm18
Name: RNA binding motif protein 18
Synonyms: 2010004P11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67889
Homologene: 12204
Rcc1
Name: regulator of chromosome condensation 1
Synonyms: 4931417M11Rik, Chc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100088
HGNC: HGNC:1913
Homologene: 55567
Sqstm1
Name: sequestosome 1
Synonyms: A170, p62, OSF-6, STAP, Osi
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18412
Homologene: 31202
Zc2hc1a
Name: zinc finger, C2HC-type containing 1A
Synonyms: 3110050N22Rik, Fam164a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67306
Homologene: 9338
Psmd11
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Synonyms: S9, 1810019E17Rik, 2610024G20Rik, P44.5, 2810055C24Rik, C78232, 1700089D09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69077
HGNC: HGNC:9556
Homologene: 2108
Dync1li1
Name: dynein cytoplasmic 1 light intermediate chain 1
Synonyms: Dlic1, LIC-1, 1110053F02Rik, Dnclic1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235661
VEGA: 9
Homologene: 9403
Dgcr8
Name: DGCR8, microprocessor complex subunit
Synonyms: Vo59c07, DiGeorge syndrome critical region gene 8, Gy1, D16H22S788E, D16Wis2, D16H22S1742E, N41
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 94223
HGNC: HGNC:2847
Homologene: 11223
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Chrne
Name: cholinergic receptor, nicotinic, epsilon polypeptide
Synonyms: AChrepsilon, Acre
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11448
HGNC: HGNC:1966
Homologene: 60
Otop1
Name: otopetrin 1
Synonyms: A530025J20Rik, tlt
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21906
Homologene: 35244
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Alx3
Name: aristaless-like homeobox 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11694
HGNC: HGNC:449
Homologene: 4737
Ralgps1
Name: Ral GEF with PH domain and SH3 binding motif 1
Synonyms: RALGEF2, 5830418G11Rik, RALGPS1A
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241308
Homologene: 65163
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320714
Homologene: 11076
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: AS250, RGC2, A230067G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: 2300002I04Rik, MUC5, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Parp3
Name: poly (ADP-ribose) polymerase family, member 3
Synonyms: A930002C11Rik, Adprt3, Adprtl3, PARP-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235587
HGNC: HGNC:273
Homologene: 4005
Serac1
Name: serine active site containing 1
Synonyms: 4930511N22Rik, D17Ertd141e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 321007
Homologene: 41900
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: 4930532L22Rik, B230399N07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Or8d23
Name: olfactory receptor family 8 subfamily D member 23
Synonyms: Olfr930, GA_x6K02T2PVTD-32626123-32627049, MOR171-46
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258269
VEGA: 9
HGNC: HGNC:8481
Homologene: 138304
Rgma
Name: repulsive guidance molecule family member A
Synonyms: RGM domain family, member A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244058
Homologene: 10626
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Dnm1
Name: dynamin 1
Synonyms: dynamin 1, Ftfl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13429
HGNC: HGNC:2972
Homologene: 123905
Icosl
Name: icos ligand
Synonyms: ICOS-L, B7h, GL50-B, GL50, LICOS, B7RP-1, B7-H2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50723
VEGA: 10
Homologene: 49412
Lrfn2
Name: leucine rich repeat and fibronectin type III domain containing 2
Synonyms: 5730420O05Rik, SALM1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70530
Homologene: 19182
Catsperg1
Name: cation channel sperm associated auxiliary subunit gamma 1
Synonyms: Catsperg, A230107C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320225
Homologene: 10915
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Mrvi1, Ris1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Slc22a16
Name: solute carrier family 22 (organic cation transporter), member 16
Synonyms: OKB1, CT2, FLIPT2, OCT6, 4921504E14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70840
Homologene: 41957
Polr2k
Name: polymerase (RNA) II (DNA directed) polypeptide K
Synonyms: RPB12, Mt1a, ABC10-alpha, MafY, RPB10alpha, RPB7.0, RPABC4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17749
HGNC: HGNC:9198
Homologene: 86049
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: Semai, M-Sema F, Semacl1, Semaf, Semacl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20353
Homologene: 23047
Cpsf4l
Name: cleavage and polyadenylation specific factor 4-like
Synonyms: 0610010C04Rik, 1500000C01Rik, D11Ertd636e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52670
Homologene: 32669
Pcdhb20
Name: protocadherin beta 20
Synonyms: Pcdhb14, PcdhbT
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93891
HGNC: HGNC:8685
Homologene: 134303
Grap
Name: GRB2-related adaptor protein
Synonyms: 8430435N19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71520
Homologene: 4822
Trav6-1
Name: T cell receptor alpha variable 6-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667449
Mup4
Name: major urinary protein 4
Synonyms: Mup-4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17843
Homologene: 74304
Or6c88
Name: olfactory receptor family 6 subfamily C member 88
Synonyms: GA_x6K02T2PULF-11248702-11249664, Olfr794, MOR114-11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258375
Homologene: 45066
Esp31
Name: exocrine gland secreted peptide 31
Synonyms: Gm20516
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126768
Trav9-2
Name: T cell receptor alpha variable 9-2
Synonyms: Gm16979
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 436479
Or10ag55-ps1
Name: olfactory receptor family 10 subfamily AG member 55, pseudogene 1
Synonyms: MOR264-10P, GA_x6K02T2Q125-48769330-48770299, Olfr1117-ps1, MOR264-27_p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258110
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,552,873 bp
  • A to G, chromosome 1 at 45,340,312 bp
  • G to T, chromosome 2 at 32,316,975 bp
  • C to A, chromosome 2 at 33,284,824 bp
  • A to G, chromosome 2 at 36,134,199 bp
  • T to A, chromosome 2 at 66,324,600 bp
  • A to T, chromosome 2 at 87,284,772 bp
  • G to A, chromosome 2 at 146,424,763 bp
  • A to G, chromosome 3 at 7,528,108 bp
  • C to G, chromosome 3 at 107,604,819 bp
  • A to T, chromosome 4 at 59,958,587 bp
  • C to A, chromosome 4 at 132,338,204 bp
  • T to C, chromosome 4 at 134,148,161 bp
  • A to T, chromosome 4 at 152,379,466 bp
  • G to A, chromosome 5 at 38,299,773 bp
  • T to A, chromosome 5 at 38,300,453 bp
  • A to T, chromosome 6 at 90,633,728 bp
  • C to T, chromosome 6 at 139,768,700 bp
  • A to T, chromosome 7 at 29,191,686 bp
  • T to C, chromosome 7 at 73,409,288 bp
  • C to T, chromosome 7 at 110,878,218 bp
  • A to G, chromosome 7 at 141,863,795 bp
  • A to T, chromosome 8 at 47,501,848 bp
  • A to G, chromosome 9 at 22,670,832 bp
  • A to G, chromosome 9 at 38,930,689 bp
  • T to C, chromosome 9 at 72,726,484 bp
  • C to T, chromosome 9 at 106,475,951 bp
  • T to A, chromosome 9 at 114,705,110 bp
  • A to G, chromosome 10 at 40,574,065 bp
  • A to T, chromosome 10 at 78,073,863 bp
  • T to A, chromosome 10 at 129,570,710 bp
  • A to T, chromosome 11 at 8,933,657 bp
  • G to A, chromosome 11 at 43,443,340 bp
  • G to T, chromosome 11 at 50,210,666 bp
  • G to T, chromosome 11 at 61,671,691 bp
  • A to G, chromosome 11 at 70,617,030 bp
  • A to G, chromosome 11 at 80,434,516 bp
  • A to G, chromosome 11 at 94,358,801 bp
  • A to G, chromosome 11 at 113,709,453 bp
  • A to G, chromosome 11 at 116,535,625 bp
  • G to A, chromosome 11 at 120,470,128 bp
  • A to G, chromosome 13 at 67,620,985 bp
  • T to A, chromosome 14 at 52,638,756 bp
  • T to A, chromosome 14 at 53,591,298 bp
  • G to A, chromosome 14 at 62,696,848 bp
  • T to A, chromosome 15 at 36,176,767 bp
  • A to G, chromosome 15 at 99,780,818 bp
  • T to C, chromosome 16 at 18,259,961 bp
  • A to G, chromosome 17 at 6,050,028 bp
  • A to G, chromosome 17 at 35,881,375 bp
  • A to G, chromosome 17 at 38,644,618 bp
  • G to A, chromosome 17 at 49,096,796 bp
  • C to T, chromosome 18 at 37,505,384 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8733 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068581-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.