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Strain Name:
C57BL/6J-MtgxR8734Btlr/Mmmh
Stock Number:
068582-MU
Citation ID:
RRID:MMRRC_068582-MU
Other Names:
R8734 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Lias
Name: lipoic acid synthetase
Synonyms: MGC7254, mLip1, 4933425M12Rik, 2900022L22Rik, 7a5ex
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79464
Homologene: 4997
Gpr37l1
Name: G protein-coupled receptor 37-like 1
Synonyms: CAG-18, D0Kist8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171469
Homologene: 3500
Sntb2
Name: syntrophin, basic 2
Synonyms: Snt2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20650
Homologene: 4911
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: D330036J23Rik, AP162, B2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 353047
Homologene: 8871
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 92,573,399 bp
  • A to T, chromosome 1 at 97,834,402 bp
  • C to T, chromosome 1 at 135,167,429 bp
  • A to T, chromosome 1 at 162,679,512 bp
  • T to C, chromosome 1 at 172,193,860 bp
  • C to A, chromosome 1 at 179,780,865 bp
  • T to C, chromosome 1 at 192,506,012 bp
  • C to T, chromosome 2 at 30,256,607 bp
  • T to A, chromosome 2 at 44,243,118 bp
  • T to C, chromosome 2 at 76,710,688 bp
  • T to A, chromosome 2 at 85,918,649 bp
  • T to A, chromosome 2 at 150,588,904 bp
  • G to A, chromosome 3 at 32,719,955 bp
  • A to T, chromosome 3 at 55,124,879 bp
  • G to A, chromosome 3 at 57,692,285 bp
  • T to A, chromosome 3 at 109,657,969 bp
  • T to A, chromosome 4 at 44,072,911 bp
  • A to G, chromosome 4 at 129,607,524 bp
  • A to G, chromosome 4 at 133,498,069 bp
  • C to T, chromosome 5 at 8,978,208 bp
  • T to C, chromosome 5 at 25,250,224 bp
  • T to A, chromosome 5 at 28,352,876 bp
  • T to C, chromosome 5 at 65,404,209 bp
  • T to A, chromosome 5 at 135,784,129 bp
  • A to G, chromosome 5 at 137,611,288 bp
  • A to G, chromosome 5 at 138,311,788 bp
  • A to T, chromosome 6 at 25,688,202 bp
  • G to T, chromosome 6 at 41,373,893 bp
  • A to G, chromosome 6 at 59,210,199 bp
  • A to T, chromosome 6 at 101,151,606 bp
  • T to A, chromosome 6 at 121,871,381 bp
  • A to G, chromosome 7 at 26,198,610 bp
  • A to T, chromosome 7 at 29,259,410 bp
  • T to C, chromosome 7 at 65,931,733 bp
  • T to A, chromosome 7 at 139,216,599 bp
  • A to G, chromosome 8 at 48,349,356 bp
  • G to A, chromosome 8 at 71,693,501 bp
  • A to G, chromosome 8 at 95,328,310 bp
  • A to G, chromosome 8 at 107,001,688 bp
  • G to A, chromosome 8 at 116,954,786 bp
  • A to G, chromosome 8 at 128,480,939 bp
  • C to A, chromosome 9 at 67,272,654 bp
  • T to A, chromosome 9 at 67,973,403 bp
  • A to G, chromosome 9 at 99,520,485 bp
  • A to G, chromosome 10 at 86,833,999 bp
  • A to C, chromosome 11 at 23,444,184 bp
  • A to G, chromosome 11 at 74,903,826 bp
  • A to G, chromosome 11 at 78,500,264 bp
  • A to T, chromosome 11 at 103,394,952 bp
  • T to C, chromosome 11 at 115,416,863 bp
  • T to A, chromosome 12 at 73,585,244 bp
  • T to A, chromosome 12 at 100,940,135 bp
  • T to A, chromosome 12 at 108,854,321 bp
  • T to C, chromosome 14 at 21,010,168 bp
  • T to C, chromosome 15 at 25,968,407 bp
  • A to T, chromosome 15 at 98,313,073 bp
  • C to T, chromosome 16 at 73,967,763 bp
  • A to G, chromosome 17 at 27,438,791 bp
  • A to G, chromosome 17 at 32,416,002 bp
  • T to A, chromosome 19 at 7,574,982 bp
  • T to A, chromosome 19 at 43,782,416 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8734 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068582-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.