Strain Name:
C57BL/6J-MtgxR8734Btlr/Mmmh
Stock Number:
068582-MU
Citation ID:
RRID:MMRRC_068582-MU
Other Names:
R8734 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Gpr37
Name: G protein-coupled receptor 37
Synonyms: parkin-associated endothelin B-like receptor, Pael-R
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Lias
Name: lipoic acid synthetase
Synonyms: 2900022L22Rik, mLip1, 4933425M12Rik, MGC7254, 7a5ex
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79464
Homologene: 4997
Gpr37l1
Name: G protein-coupled receptor 37-like 1
Synonyms: D0Kist8, CAG-18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171469
Homologene: 3500
Sntb2
Name: syntrophin, basic 2
Synonyms: Snt2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20650
Homologene: 4911
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: 0610010D24Rik, Daple
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: B2, AP162, D330036J23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 353047
Homologene: 8871
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: Elys, 6230412P20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226747
Homologene: 9142
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: Bat2d, Bat2l2, 9630039I18Rik, 1810043M20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Armc8
Name: armadillo repeat containing 8
Synonyms: 1200015K23Rik, Gid5, HSPC056
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74125
Homologene: 9121
Dcaf8
Name: DDB1 and CUL4 associated factor 8
Synonyms: Wdr42a, D1Ucla4, D1Dau35e, H326
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98193
Homologene: 56725
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17847
Homologene: 40978
Crot
Name: carnitine O-octanoyltransferase
Synonyms: 1200003H03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74114
HGNC: HGNC:2366
Homologene: 10899
Atp5pd
Name: ATP synthase peripheral stalk subunit d
Synonyms: Atp5h, 0610009D10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71679
HGNC: HGNC:845
Homologene: 130552
Grm4
Name: glutamate receptor, metabotropic 4
Synonyms: Gprc1d, mGluR4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268934
HGNC: HGNC:4596
Homologene: 20230
B3gnt3
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Synonyms: 2210008L19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72297
Homologene: 113516
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, 2600013A04Rik, D230004I22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Tsr1
Name: TSR1 20S rRNA accumulation
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104662
Homologene: 5576
Tmem234
Name: transmembrane protein 234
Synonyms: 2510006D16Rik, 1500002D11Rik, 4933407D05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76799
Homologene: 41314
Rbm33
Name: RNA binding motif protein 33
Synonyms: 3200001K10Rik, 6430512A10Rik, Prr8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381626
Homologene: 137386
Lrrc8a
Name: leucine rich repeat containing 8A VRAC subunit A
Synonyms: ebo, SWELL1, Lrrc8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241296
Homologene: 18617
Mdh2
Name: malate dehydrogenase 2, NAD (mitochondrial)
Synonyms: Mor-1, Mdh-2, Mor1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17448
HGNC: HGNC:6971
Homologene: 55938
Spint2
Name: serine protease inhibitor, Kunitz type 2
Synonyms: HAI-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20733
Homologene: 7955
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Odz3, Ten-m3, 2610100B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Actl6a
Name: actin-like 6A
Synonyms: Baf53a, ARP4, 2810432C06Rik, Actl6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56456
Homologene: 55811
Pglyrp2
Name: peptidoglycan recognition protein 2
Synonyms: PGRP-L, tagl-beta, Pglyrpl, tagL-alpha, C730002N09Rik, tagL
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57757
VEGA: 17
Homologene: 49671
Stag3
Name: STAG3 cohesin complex component
Synonyms: stromalin 3, SA-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50878
Homologene: 40844
Trnp1
Name: TMF1-regulated nuclear protein 1
Synonyms: 2300002D11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69539
Homologene: 19492
Slc25a47
Name: solute carrier family 25, member 47
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104910
VEGA: 12
Homologene: 64441
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Atmin
Name: ATM interactor
Synonyms: gpg6, Asciz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234776
Homologene: 35321
Or9s23
Name: olfactory receptor family 9 subfamily S member 23
Synonyms: GA_x6K02T2R7CC-81180849-81179878, Olfr1413, MOR208-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 259039
Homologene: 128165
Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms: Cyp2b, phenobarbitol inducible, type a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13094
HGNC: HGNC:2615
Homologene: 74933
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: E430002F06Rik, A430075I06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231050
Homologene: 11126
Pcsk6
Name: proprotein convertase subtilisin/kexin type 6
Synonyms: b2b2830Clo, SPC4, PACE4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18553
HGNC: HGNC:8569
Homologene: 20569
Nrp1
Name: neuropilin 1
Synonyms: NP-1, Npn1, NPN-1, Neuropilin-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Tigd2
Name: tigger transposable element derived 2
Synonyms: 3632410O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68140
Homologene: 129603
Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms: 2310066H07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50798
Homologene: 3996
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Prkch
Name: protein kinase C, eta
Synonyms: Pkch
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18755
HGNC: HGNC:9403
Homologene: 84384
Or5m13
Name: olfactory receptor family 5 subfamily M member 13
Synonyms: MOR196-5P, Olfr1025, MOR196-6_p, GA_x6K02T2Q125-47397266-47398205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258083
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Pdzrn3
Name: PDZ domain containing RING finger 3
Synonyms: LNX3, Semcap3, semaphorin cytoplasmic domain-associated protein 3A, 1110020C07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 55983
Homologene: 10328
Arhgap15
Name: Rho GTPase activating protein 15
Synonyms: 5830480G12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76117
Homologene: 41271
Spart
Name: spartin
Synonyms: Spg20, TAHCCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229285
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt2, Astt-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: Mrp2, multidrug resistance protein 2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: Kv10.1, Eag1, ether a go-go
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Prss3
Name: serine protease 3
Synonyms: Try3, TRY4, MTG, mesotrypsin, Tb
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22073
Homologene: 88408
Lrrc27
Name: leucine rich repeat containing 27
Synonyms: 1700071K18Rik, 2310044E02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76612
Homologene: 19268
Nt5dc3
Name: 5'-nucleotidase domain containing 3
Synonyms: Gnn, C630002B14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103466
VEGA: 10
Homologene: 9571
Ankub1
Name: ankyrin repeat and ubiquitin domain containing 1
Synonyms: LOC242037, Gm410
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242037
Homologene: 54680
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Plaat3
Name: phospholipase A and acyltransferase 3
Synonyms: Pla2g16, Hrasls3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225845
Homologene: 5136
Vtn
Name: vitronectin
Synonyms: Vn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22370
Homologene: 532
Retreg1
Name: reticulophagy regulator 1
Synonyms: 1810015C04Rik, Fam134b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66270
VEGA: 15
Homologene: 10368
Zfp319
Name: zinc finger protein 319
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 79233
Homologene: 11548
Apmap
Name: adipocyte plasma membrane associated protein
Synonyms: 2310001A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71881
Homologene: 41380
Or8s16
Name: olfactory receptor family 8 subfamily S member 16
Synonyms: MOR160-3, Olfr257, Olfr285, GA_x6K02T2N22H-3824-2865, GA_x6K02T2NBG7-5440777-5441736
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 257943
Homologene: 66175
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 92,573,399 bp
  • A to T, chromosome 1 at 97,834,402 bp
  • C to T, chromosome 1 at 135,167,429 bp
  • A to T, chromosome 1 at 162,679,512 bp
  • T to C, chromosome 1 at 172,193,860 bp
  • C to A, chromosome 1 at 179,780,865 bp
  • T to C, chromosome 1 at 192,506,012 bp
  • C to T, chromosome 2 at 30,256,607 bp
  • T to A, chromosome 2 at 44,243,118 bp
  • T to C, chromosome 2 at 76,710,688 bp
  • T to A, chromosome 2 at 85,918,649 bp
  • T to A, chromosome 2 at 150,588,904 bp
  • G to A, chromosome 3 at 32,719,955 bp
  • A to T, chromosome 3 at 55,124,879 bp
  • G to A, chromosome 3 at 57,692,285 bp
  • T to A, chromosome 3 at 109,657,969 bp
  • T to A, chromosome 4 at 44,072,911 bp
  • A to G, chromosome 4 at 129,607,524 bp
  • A to G, chromosome 4 at 133,498,069 bp
  • C to T, chromosome 5 at 8,978,208 bp
  • T to C, chromosome 5 at 25,250,224 bp
  • T to A, chromosome 5 at 28,352,876 bp
  • T to C, chromosome 5 at 65,404,209 bp
  • T to A, chromosome 5 at 135,784,129 bp
  • A to G, chromosome 5 at 137,611,288 bp
  • A to G, chromosome 5 at 138,311,788 bp
  • A to T, chromosome 6 at 25,688,202 bp
  • G to T, chromosome 6 at 41,373,893 bp
  • A to G, chromosome 6 at 59,210,199 bp
  • A to T, chromosome 6 at 101,151,606 bp
  • T to A, chromosome 6 at 121,871,381 bp
  • A to G, chromosome 7 at 26,198,610 bp
  • A to T, chromosome 7 at 29,259,410 bp
  • T to C, chromosome 7 at 65,931,733 bp
  • T to A, chromosome 7 at 139,216,599 bp
  • A to G, chromosome 8 at 48,349,356 bp
  • G to A, chromosome 8 at 71,693,501 bp
  • A to G, chromosome 8 at 95,328,310 bp
  • A to G, chromosome 8 at 107,001,688 bp
  • G to A, chromosome 8 at 116,954,786 bp
  • A to G, chromosome 8 at 128,480,939 bp
  • C to A, chromosome 9 at 67,272,654 bp
  • T to A, chromosome 9 at 67,973,403 bp
  • A to G, chromosome 9 at 99,520,485 bp
  • A to G, chromosome 10 at 86,833,999 bp
  • A to C, chromosome 11 at 23,444,184 bp
  • A to G, chromosome 11 at 74,903,826 bp
  • A to G, chromosome 11 at 78,500,264 bp
  • A to T, chromosome 11 at 103,394,952 bp
  • T to C, chromosome 11 at 115,416,863 bp
  • T to A, chromosome 12 at 73,585,244 bp
  • T to A, chromosome 12 at 100,940,135 bp
  • T to A, chromosome 12 at 108,854,321 bp
  • T to C, chromosome 14 at 21,010,168 bp
  • T to C, chromosome 15 at 25,968,407 bp
  • A to T, chromosome 15 at 98,313,073 bp
  • C to T, chromosome 16 at 73,967,763 bp
  • A to G, chromosome 17 at 27,438,791 bp
  • A to G, chromosome 17 at 32,416,002 bp
  • T to A, chromosome 19 at 7,574,982 bp
  • T to A, chromosome 19 at 43,782,416 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8734 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068582-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.