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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR8806Btlr/Mmmh
Stock Number:
068612-MU
Citation ID:
RRID:MMRRC_068612-MU
Other Names:
R8806 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Cbx1
Name: chromobox 1
Synonyms: MOD1, M31, Cbx-rs2, HP1B, E430007M08Rik, Hp1beta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12412
HGNC: HGNC:1551
Homologene: 89116

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ClinGen
Ece1
Name: endothelin converting enzyme 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230857
HGNC: HGNC:3146
Homologene: 1068

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Mcm7
Name: minichromosome maintenance complex component 7
Synonyms: mCDC47, Mcmd7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17220
HGNC: HGNC:6950
Homologene: 4323

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Ubtd1
Name: ubiquitin domain containing 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226122
VEGA: 19
Homologene: 11799

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Dmtn
Name: dematin actin binding protein
Synonyms: dematin, Epb4.9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13829
VEGA: 14
HGNC: HGNC:3382
Homologene: 1496

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF kappaB1, p50 subunit of NF kappaB, p50/p105, p50, nuclear factor kappaB p50, NF-kappaB, NF-kappaB p50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 86,589,309 bp
  • C to A, chromosome 1 at 181,095,054 bp
  • T to C, chromosome 2 at 86,216,856 bp
  • T to C, chromosome 2 at 88,678,611 bp
  • T to C, chromosome 2 at 113,834,762 bp
  • T to A, chromosome 2 at 128,622,413 bp
  • T to C, chromosome 2 at 178,067,796 bp
  • T to C, chromosome 3 at 135,589,452 bp
  • T to A, chromosome 4 at 15,945,351 bp
  • A to G, chromosome 4 at 42,971,261 bp
  • T to C, chromosome 4 at 53,084,520 bp
  • T to C, chromosome 4 at 120,922,405 bp
  • T to A, chromosome 4 at 137,945,141 bp
  • T to A, chromosome 5 at 53,998,915 bp
  • T to A, chromosome 5 at 65,808,208 bp
  • T to G, chromosome 5 at 135,179,970 bp
  • T to C, chromosome 5 at 138,165,085 bp
  • T to C, chromosome 6 at 3,376,665 bp
  • A to G, chromosome 6 at 47,956,108 bp
  • C to A, chromosome 6 at 121,784,682 bp
  • T to C, chromosome 7 at 5,195,806 bp
  • C to T, chromosome 7 at 48,389,228 bp
  • G to C, chromosome 7 at 89,147,978 bp
  • A to T, chromosome 7 at 104,336,112 bp
  • A to G, chromosome 7 at 105,735,037 bp
  • T to A, chromosome 8 at 72,488,129 bp
  • T to C, chromosome 8 at 77,242,463 bp
  • T to C, chromosome 8 at 80,663,435 bp
  • A to G, chromosome 8 at 123,493,918 bp
  • A to T, chromosome 9 at 38,595,109 bp
  • T to C, chromosome 9 at 46,209,067 bp
  • C to A, chromosome 9 at 58,156,973 bp
  • T to C, chromosome 9 at 67,945,828 bp
  • T to A, chromosome 9 at 75,242,772 bp
  • T to C, chromosome 10 at 33,909,449 bp
  • T to A, chromosome 10 at 77,776,883 bp
  • G to T, chromosome 10 at 78,612,140 bp
  • A to G, chromosome 10 at 78,752,472 bp
  • G to A, chromosome 10 at 94,799,278 bp
  • C to T, chromosome 10 at 106,858,253 bp
  • C to A, chromosome 11 at 23,484,143 bp
  • T to C, chromosome 11 at 52,032,468 bp
  • A to G, chromosome 11 at 65,859,483 bp
  • A to G, chromosome 11 at 69,236,116 bp
  • T to G, chromosome 11 at 70,944,115 bp
  • A to G, chromosome 11 at 80,198,936 bp
  • A to G, chromosome 11 at 96,801,557 bp
  • A to T, chromosome 11 at 98,705,144 bp
  • T to A, chromosome 11 at 105,037,869 bp
  • G to A, chromosome 12 at 113,491,798 bp
  • A to G, chromosome 13 at 24,899,635 bp
  • A to G, chromosome 13 at 27,059,532 bp
  • A to T, chromosome 13 at 46,761,337 bp
  • A to C, chromosome 13 at 54,589,859 bp
  • G to A, chromosome 13 at 100,300,653 bp
  • T to A, chromosome 14 at 50,237,919 bp
  • A to G, chromosome 14 at 50,281,779 bp
  • T to C, chromosome 14 at 52,286,861 bp
  • T to C, chromosome 14 at 70,614,948 bp
  • T to C, chromosome 15 at 35,472,066 bp
  • A to G, chromosome 15 at 36,537,552 bp
  • G to A, chromosome 16 at 55,982,274 bp
  • C to A, chromosome 17 at 44,639,683 bp
  • T to C, chromosome 17 at 74,642,316 bp
  • A to G, chromosome 18 at 14,424,874 bp
  • T to C, chromosome 19 at 42,033,756 bp
  • C to A, chromosome 19 at 46,083,032 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8806 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
068612-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.