Strain Name:
C57BL/6J-MtgxR8806Btlr/Mmmh
Stock Number:
068612-MU
Citation ID:
RRID:MMRRC_068612-MU
Other Names:
R8806 (G1)
Major Collection:

Strain Information

Cbx1
Name: chromobox 1
Synonyms: MOD1, M31, E430007M08Rik, Cbx-rs2, HP1B, Hp1beta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12412
HGNC: HGNC:1551
Homologene: 89116
Ece1
Name: endothelin converting enzyme 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230857
HGNC: HGNC:3146
Homologene: 1068
Mcm7
Name: minichromosome maintenance complex component 7
Synonyms: Mcmd7, mCDC47
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17220
HGNC: HGNC:6950
Homologene: 4323
Ubtd1
Name: ubiquitin domain containing 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226122
VEGA: 19
Homologene: 11799
Dmtn
Name: dematin actin binding protein
Synonyms: dematin, Epb4.9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13829
VEGA: 14
HGNC: HGNC:3382
Homologene: 1496
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF-kappaB, NF-kappaB p50, p50, nuclear factor kappaB p50, p50/p105, NF kappaB1, p50 subunit of NF kappaB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Sik3
Name: SIK family kinase 3
Synonyms: 5730525O22Rik, 9030204A07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70661
Homologene: 57023
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Mcpr, 2610021O03Rik, Apc1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17847
Homologene: 40978
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116873
Homologene: 32490
N4bp2
Name: NEDD4 binding protein 2
Synonyms: B3bp, LOC386488, LOC333789
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333789
Homologene: 32396
Cops7b
Name: COP9 signalosome subunit 7B
Synonyms: COP9 complex S7b, D1Wsu66e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26895
Homologene: 8068
Tmem135
Name: transmembrane protein 135
Synonyms: 2810439K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72759
Homologene: 11295
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: C330002D13Rik, Coh1, 1810042B05Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Zfp931
Name: zinc finger protein 931
Synonyms: 2810021G02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 353208
Homologene: 136272
Runx2
Name: runt related transcription factor 2
Synonyms: Cbfa1, Pebpa2a, AML3, polyomavirus enhancer binding factor 2 (PEBP2), PEBP2 alpha A, Osf2, SL3-3 enhancer factor 1, PEBP2aA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Nup88
Name: nucleoporin 88
Synonyms: Prei2, Nup84
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Nop16
Name: NOP16 nucleolar protein
Synonyms: D13Wsu177e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 28126
Homologene: 16887
Kif13a
Name: kinesin family member 13A
Synonyms: N-3 kinesin, 4930505I07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Bcl7b
Name: B cell CLL/lymphoma 7B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12054
HGNC: HGNC:1005
Homologene: 1290
Tox4
Name: TOX high mobility group box family member 4
Synonyms: 5730589K01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268741
Homologene: 8889
Nolc1
Name: nucleolar and coiled-body phosphoprotein 1
Synonyms: 3230402K17Rik, P130, NOPP140
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70769
VEGA: 19
Afg3l1
Name: AFG3-like AAA ATPase 1
Synonyms: 3110061K15Rik, 1700047G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114896
HGNC: HGNC:314
Homologene: 134198
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: ZNF-U69274, 9230110G02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 271377
Homologene: 8678
Prl
Name: prolactin
Synonyms: Prl1a1, Prl
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19109
HGNC: HGNC:9445
Homologene: 732
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: mineralocorticoid receptor, Mlr, aldosterone receptor, MR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270066
Homologene: 49075
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
D130043K22Rik
Name: RIKEN cDNA D130043K22 gene
Synonyms: Kiaa0319
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210108
Homologene: 8878
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Cdkl3
Name: cyclin dependent kinase like 3
Synonyms: B230379H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213084
Homologene: 49467
Rnf135
Name: ring finger protein 135
Synonyms: 0610037N03Rik, MGC13061, U 2-3-0, 2410006N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71956
Homologene: 12427
Gm7298
Name: predicted gene 7298
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 640530
HGNC: HGNC:9750
Spata31g1
Name: SPATA31 subfamily G member 1
Synonyms: 1700022I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67317
Homologene: 52406
Trim34b
Name: tripartite motif-containing 34B
Synonyms: Gm15134, Trim34-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434218
Homologene: 128238
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Birc1f, Naip-rs4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212892
Homologene: 71779
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Tektl1
Name: tektin like 1
Synonyms: Ccdc105, 4931413A09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Gucy2e
Name: guanylate cyclase 2e
Synonyms: ROS-GC1, GC1, GC-E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14919
HGNC: HGNC:4689
Homologene: 55442
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Vmn1r56
Name: vomeronasal 1 receptor 56
Synonyms: V1rd3, V3R3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81015
Homologene: 41799
Or8k1
Name: olfactory receptor family 8 subfamily K member 1
Synonyms: Olfr1046, GA_x6K02T2Q125-47692494-47691544, MOR194-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258575
Homologene: 17301
Or1i2
Name: olfactory receptor family 1 subfamily I member 1
Synonyms: MOR128-3, MOR128-4, Olfr1357, GA_x6K02T2QGN0-3196801-3197742
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257883
HGNC: HGNC:8207
Homologene: 72920
Plxnc1
Name: plexin C1
Synonyms: vespr, CD232, 2510048K12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238405
Homologene: 128362
Zfp956
Name: zinc finger protein 956
Synonyms: AI894139
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101197
Homologene: 128449
Or4s2b
Name: olfactory receptor family 4 subfamily S member 2B
Synonyms: MOR226-1, GA_x6K02T2Q125-50154044-50154826, GA_x6K02T2Q125-50158288-50158818, Olfr1193, Olfr1194-ps1, MOR230-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329460
Homologene: 27297
Exo5
Name: exonuclease 5
Synonyms: Dem1, 3110037I16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73172
Homologene: 41497
Decr1
Name: 2,4-dienoyl CoA reductase 1, mitochondrial
Synonyms: 1200012F07Rik, Decr, Nadph
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67460
HGNC: HGNC:2753
Homologene: 68178
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: 6530401L14Rik, GAP (1-12)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
Or4n4
Name: olfactory receptor family 4 subfamily N member 4
Synonyms: MOR241-1, Olfr732, GA_x6K02T2PMLR-5975274-5974348
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258659
Homologene: 72012
Or4k6
Name: olfactory receptor family 4 subfamily K member 6
Synonyms: GA_x6K02T2PMLR-5936117-5935137, MOR246-5, Olfr731
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258360
Homologene: 84579
Mrgprb8
Name: MAS-related GPR, member B8
Synonyms: MrgB8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404240
Homologene: 83620
Rrp8
Name: ribosomal RNA processing 8
Synonyms: 1500003O22Rik, 2900001K19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101867
Homologene: 5621
Snx31
Name: sorting nexin 31
Synonyms: 4631426E05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66696
Homologene: 23551
Islr
Name: immunoglobulin superfamily containing leucine-rich repeat
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26968
VEGA: 9
HGNC: HGNC:6133
Homologene: 4050
Med24
Name: mediator complex subunit 24
Synonyms: D11Ertd307e, 100kDa, Trap100, Pparb2, R75526, Gse2, Thrap4, DRIP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Krtap10-26
Name: keratin associated protein 10-26
Synonyms: Gm7138
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102640500
VEGA: 10
Homologene: 115744
Or8b49
Name: olfactory receptor family 8 subfamily B member 49
Synonyms: MOR165-9P, Olfr913, GA_x6K02T2PVTD-32296575-32297513, MOR165-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258225
VEGA: 9
Homologene: 79398
Gm5160
Name: predicted gene 5160
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 382096
VEGA: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 86,589,309 bp
  • C to A, chromosome 1 at 181,095,054 bp
  • T to C, chromosome 2 at 86,216,856 bp
  • T to C, chromosome 2 at 88,678,611 bp
  • T to C, chromosome 2 at 113,834,762 bp
  • T to A, chromosome 2 at 128,622,413 bp
  • T to C, chromosome 2 at 178,067,796 bp
  • T to C, chromosome 3 at 135,589,452 bp
  • T to A, chromosome 4 at 15,945,351 bp
  • A to G, chromosome 4 at 42,971,261 bp
  • T to C, chromosome 4 at 53,084,520 bp
  • T to C, chromosome 4 at 120,922,405 bp
  • T to A, chromosome 4 at 137,945,141 bp
  • T to A, chromosome 5 at 53,998,915 bp
  • T to A, chromosome 5 at 65,808,208 bp
  • T to G, chromosome 5 at 135,179,970 bp
  • T to C, chromosome 5 at 138,165,085 bp
  • T to C, chromosome 6 at 3,376,665 bp
  • A to G, chromosome 6 at 47,956,108 bp
  • C to A, chromosome 6 at 121,784,682 bp
  • T to C, chromosome 7 at 5,195,806 bp
  • C to T, chromosome 7 at 48,389,228 bp
  • G to C, chromosome 7 at 89,147,978 bp
  • A to T, chromosome 7 at 104,336,112 bp
  • A to G, chromosome 7 at 105,735,037 bp
  • T to A, chromosome 8 at 72,488,129 bp
  • T to C, chromosome 8 at 77,242,463 bp
  • T to C, chromosome 8 at 80,663,435 bp
  • A to G, chromosome 8 at 123,493,918 bp
  • A to T, chromosome 9 at 38,595,109 bp
  • T to C, chromosome 9 at 46,209,067 bp
  • C to A, chromosome 9 at 58,156,973 bp
  • T to C, chromosome 9 at 67,945,828 bp
  • T to A, chromosome 9 at 75,242,772 bp
  • T to C, chromosome 10 at 33,909,449 bp
  • T to A, chromosome 10 at 77,776,883 bp
  • G to T, chromosome 10 at 78,612,140 bp
  • A to G, chromosome 10 at 78,752,472 bp
  • G to A, chromosome 10 at 94,799,278 bp
  • C to T, chromosome 10 at 106,858,253 bp
  • C to A, chromosome 11 at 23,484,143 bp
  • T to C, chromosome 11 at 52,032,468 bp
  • A to G, chromosome 11 at 65,859,483 bp
  • A to G, chromosome 11 at 69,236,116 bp
  • T to G, chromosome 11 at 70,944,115 bp
  • A to G, chromosome 11 at 80,198,936 bp
  • A to G, chromosome 11 at 96,801,557 bp
  • A to T, chromosome 11 at 98,705,144 bp
  • T to A, chromosome 11 at 105,037,869 bp
  • G to A, chromosome 12 at 113,491,798 bp
  • A to G, chromosome 13 at 24,899,635 bp
  • A to G, chromosome 13 at 27,059,532 bp
  • A to T, chromosome 13 at 46,761,337 bp
  • A to C, chromosome 13 at 54,589,859 bp
  • G to A, chromosome 13 at 100,300,653 bp
  • T to A, chromosome 14 at 50,237,919 bp
  • A to G, chromosome 14 at 50,281,779 bp
  • T to C, chromosome 14 at 52,286,861 bp
  • T to C, chromosome 14 at 70,614,948 bp
  • T to C, chromosome 15 at 35,472,066 bp
  • A to G, chromosome 15 at 36,537,552 bp
  • G to A, chromosome 16 at 55,982,274 bp
  • C to A, chromosome 17 at 44,639,683 bp
  • T to C, chromosome 17 at 74,642,316 bp
  • A to G, chromosome 18 at 14,424,874 bp
  • T to C, chromosome 19 at 42,033,756 bp
  • C to A, chromosome 19 at 46,083,032 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8806 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068612-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.