Strain Name:
C57BL/6J-MtgxR8754Btlr/Mmmh
Stock Number:
068620-MU
Citation ID:
RRID:MMRRC_068620-MU
Other Names:
R8754 (G1)
Major Collection:

Strain Information

Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: alpha6 nAChR, Acra6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11440
Homologene: 20888
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22771
Homologene: 2562
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224650
Homologene: 9068
Plxdc1
Name: plexin domain containing 1
Synonyms: Tem7, 2410003I07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72324
Homologene: 10700
Brix1
Name: BRX1, biogenesis of ribosomes
Synonyms: 1110064N10Rik, Bxdc2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67832
Homologene: 10133
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: 9230110M18Rik, MommeD8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109263
Homologene: 8243
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: CHAK1, 5033407O22Rik, Ltpr7, 4833414K03Rik, 2310022G15Rik, TRP-PLIK, LTRPC7, CHAK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, Ascc3l1, A330064G03Rik, HELIC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Ythdf3
Name: YTH N6-methyladenosine RNA binding protein 3
Synonyms: 9130022A11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229096
Homologene: 34991
Ss18
Name: SS18, subunit of BAF chromatin remodeling complex
Synonyms: Ssxt
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 268996
VEGA: 18
Homologene: 38080
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208628
Homologene: 32227
Cdc40
Name: cell division cycle 40
Synonyms: 1200003H23Rik, EHB3, PRP17
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71713
VEGA: 10
Homologene: 5716
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84585
Homologene: 11112
Nckap5l
Name: NCK-associated protein 5-like
Synonyms: C230021P08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380969
Homologene: 18924
Zik1
Name: zinc finger protein interacting with K protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22775
Homologene: 32076
Rpl4
Name: ribosomal protein L4
Synonyms: 2010004J23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67891
VEGA: 9
Homologene: 748
Platr25
Name: pluripotency associated transcript 25
Synonyms: Gm5665, 6720490N10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435366
Pxk
Name: PX domain containing serine/threonine kinase
Synonyms: D14Ertd813e, C230080L11Rik, MONaKA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218699
VEGA: 14
Homologene: 9828
Pdia4
Name: protein disulfide isomerase associated 4
Synonyms: ERp72, Cai, U48620, Erp72
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12304
Homologene: 21020
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68187
Homologene: 32665
Amotl2
Name: angiomotin-like 2
Synonyms: Lccp, MASCOT
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56332
Homologene: 9420
Patl1
Name: protein associated with topoisomerase II homolog 1 (yeast)
Synonyms: Pat1b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225929
VEGA: 19
Homologene: 82269
Ubqln4
Name: ubiquilin 4
Synonyms: UBIN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94232
HGNC: HGNC:1237
Homologene: 41346
Dlat
Name: dihydrolipoamide S-acetyltransferase
Synonyms: 6332404G05Rik, PDC-E2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Nr1h2
Name: nuclear receptor subfamily 1, group H, member 2
Synonyms: Unr2, RIP15, LXRbeta, LXRB
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22260
HGNC: HGNC:7965
Homologene: 21397
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Med17
Name: mediator complex subunit 17
Synonyms: C330002H14Rik, Trap80, Crsp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234959
VEGA: 9
HGNC: HGNC:2375
Homologene: 3151
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Pigo
Name: phosphatidylinositol glycan anchor biosynthesis, class O
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56703
Homologene: 31761
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Ush2a
Name: usherin
Synonyms: MUSH2A, A930037M10Rik, LOC381317, LOC269160, Ushrn, A930011D15Rik, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Kdm5d
Name: lysine demethylase 5D
Synonyms: Jarid1d, Smcy, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Trim16
Name: tripartite motif-containing 16
Synonyms: EBBP, 9130006M08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94092
Homologene: 4726
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Rnf185
Name: ring finger protein 185
Synonyms: 1700022N24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193670
Homologene: 34298
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Dusp26
Name: dual specificity phosphatase 26
Synonyms: 2310043K02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66959
Homologene: 11421
Il17ra
Name: interleukin 17 receptor A
Synonyms: Il17r, VDw217
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16172
HGNC: HGNC:5985
Homologene: 7378
Tnxb
Name: tenascin XB
Synonyms: TN-MHC, Tnx
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108151
Homologene: 23664
Lipe
Name: lipase, hormone sensitive
Synonyms: 4933403G17Rik, HSL
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241263
Homologene: 19381
Mrpl37
Name: mitochondrial ribosomal protein L37
Synonyms: 2300004O14Rik, MRP-L2, Rpml2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56280
Homologene: 9536
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Actn3
Name: actinin alpha 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11474
HGNC: HGNC:165
Homologene: 862
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18080
Homologene: 40632
Klk1b21
Name: kallikrein 1-related peptidase b21
Synonyms: Klk21, mGk-21
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16616
Homologene: 68141
Cttnbp2
Name: cortactin binding protein 2
Synonyms: 3010022N24Rik, Cortbp2, 9130022E09Rik, 4732477G22Rik, ORF4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106763
VEGA: 17
Homologene: 50342
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231147
Homologene: 10360
Txk
Name: TXK tyrosine kinase
Synonyms: Btkl, PTK4, A130089B16Rik, Rlk
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22165
Homologene: 2497
Or8c16
Name: olfactory receptor family 8 subfamily C member 16
Synonyms: Olfr894, GA_x6K02T2PVTD-31898993-31899934, MOR170-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258868
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: GLUT-12, Glut12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353169
Homologene: 59263
Pbxip1
Name: pre B cell leukemia transcription factor interacting protein 1
Synonyms: 4732463H20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229534
Homologene: 10740
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 9530055J05Rik, 0610006A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Telo2
Name: telomere maintenance 2
Synonyms: 1200003M09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71718
Homologene: 41107
Tox2
Name: TOX high mobility group box family member 2
Synonyms: LOC269389, RxHMG1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269389
Homologene: 13155
Rsl1d1
Name: ribosomal L1 domain containing 1
Synonyms: 2410005K20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66409
Homologene: 41052
Serhl
Name: serine hydrolase-like
Synonyms: 1110019M09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68607
Homologene: 65196
Gtf2h5
Name: general transcription factor IIH, polypeptide 5
Synonyms: 2810432H05Rik, 2700017P07Rik, D17Wsu155e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66467
Homologene: 45635
Krtap4-7
Name: keratin associated protein 4-7
Synonyms: 2310037K05Rik, KRTAP4.7, KAP4.7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76444
Homologene: 137394
Zfp367
Name: zinc finger protein 367
Synonyms: 8030486J21Rik, ZFF29b, ZFF29a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238673
Homologene: 17802
Eif1ad13
Name: eukaryotic translation initiation factor 1A domain containing 13
Synonyms: Gm21936
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100861898
Homologene: 103865
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 11,545,248 bp
  • G to A, chromosome 1 at 24,028,488 bp
  • C to G, chromosome 1 at 90,767,606 bp
  • C to T, chromosome 1 at 172,108,359 bp
  • C to T, chromosome 1 at 188,848,965 bp
  • G to A, chromosome 2 at 21,576,882 bp
  • A to G, chromosome 2 at 126,822,703 bp
  • A to G, chromosome 2 at 127,226,085 bp
  • A to G, chromosome 2 at 163,321,440 bp
  • A to T, chromosome 3 at 16,203,974 bp
  • T to A, chromosome 3 at 88,565,783 bp
  • T to C, chromosome 3 at 89,447,928 bp
  • T to C, chromosome 3 at 138,066,037 bp
  • T to A, chromosome 4 at 43,024,724 bp
  • T to C, chromosome 4 at 107,064,414 bp
  • T to C, chromosome 4 at 121,146,813 bp
  • T to C, chromosome 4 at 135,925,578 bp
  • T to C, chromosome 5 at 12,553,224 bp
  • A to T, chromosome 5 at 32,979,537 bp
  • C to A, chromosome 5 at 35,706,458 bp
  • T to C, chromosome 5 at 72,731,779 bp
  • T to A, chromosome 5 at 123,759,052 bp
  • A to C, chromosome 6 at 18,434,038 bp
  • A to C, chromosome 6 at 47,796,530 bp
  • A to G, chromosome 6 at 120,481,456 bp
  • A to G, chromosome 7 at 10,489,899 bp
  • T to A, chromosome 7 at 25,388,582 bp
  • T to A, chromosome 7 at 44,106,488 bp
  • C to T, chromosome 7 at 44,551,344 bp
  • T to A, chromosome 7 at 114,416,043 bp
  • C to T, chromosome 7 at 141,800,271 bp
  • T to C, chromosome 8 at 27,407,201 bp
  • C to T, chromosome 8 at 31,091,777 bp
  • A to T, chromosome 8 at 95,102,396 bp
  • A to G, chromosome 9 at 15,277,600 bp
  • A to T, chromosome 9 at 38,219,569 bp
  • G to T, chromosome 9 at 50,649,667 bp
  • A to T, chromosome 9 at 64,174,960 bp
  • T to C, chromosome 9 at 91,362,648 bp
  • A to G, chromosome 9 at 102,720,159 bp
  • T to A, chromosome 9 at 108,071,164 bp
  • A to T, chromosome 10 at 22,645,217 bp
  • C to T, chromosome 10 at 27,001,151 bp
  • C to T, chromosome 10 at 40,841,484 bp
  • A to T, chromosome 11 at 3,418,052 bp
  • G to A, chromosome 11 at 62,840,937 bp
  • A to G, chromosome 11 at 73,712,174 bp
  • A to T, chromosome 11 at 97,955,511 bp
  • G to T, chromosome 11 at 99,643,841 bp
  • A to T, chromosome 12 at 70,031,013 bp
  • T to A, chromosome 12 at 87,795,799 bp
  • T to A, chromosome 13 at 12,413,294 bp
  • A to T, chromosome 13 at 62,700,110 bp
  • A to T, chromosome 13 at 64,144,255 bp
  • T to C, chromosome 14 at 8,151,496 bp
  • A to T, chromosome 15 at 10,476,578 bp
  • G to A, chromosome 15 at 45,114,469 bp
  • A to G, chromosome 15 at 83,101,925 bp
  • A to G, chromosome 15 at 99,429,409 bp
  • A to T, chromosome 16 at 11,199,648 bp
  • A to T, chromosome 16 at 32,781,986 bp
  • C to CA, chromosome 17 at 6,084,558 bp
  • G to A, chromosome 17 at 25,102,067 bp
  • C to A, chromosome 17 at 27,996,010 bp
  • A to G, chromosome 17 at 34,715,908 bp
  • G to T, chromosome 17 at 46,445,201 bp
  • G to C, chromosome 18 at 14,640,959 bp
  • A to G, chromosome 19 at 4,863,460 bp
  • T to C, chromosome 19 at 6,855,845 bp
  • A to G, chromosome 19 at 11,922,534 bp
  • T to C, chromosome Y at 941,594 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8754 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068620-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.