Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8803Btlr/Mmmh
Stock Number:
068640-MU
Citation ID:
RRID:MMRRC_068640-MU
Other Names:
R8803 (G1)
Major Collection:

Strain Information

Cops3
Name: COP9 signalosome subunit 3
Synonyms: Sgn3, COP9 complex S3, Csn3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26572
HGNC: HGNC:2239
Homologene: 2710
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Acot7
Name: acyl-CoA thioesterase 7
Synonyms: 2410041A17Rik, Bach, AU014716
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70025
Homologene: 15780
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Cct2
Name: chaperonin containing TCP1 subunit 2
Synonyms: Cctb
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12461
VEGA: 10
HGNC: HGNC:1615
Homologene: 4696
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 65,927,989 bp
  • G to T, chromosome 1 at 134,405,958 bp
  • A to C, chromosome 1 at 134,890,754 bp
  • A to G, chromosome 1 at 150,734,497 bp
  • G to A, chromosome 1 at 167,001,591 bp
  • A to T, chromosome 1 at 188,944,801 bp
  • T to C, chromosome 2 at 32,633,478 bp
  • T to C, chromosome 2 at 70,252,994 bp
  • T to A, chromosome 2 at 85,353,734 bp
  • T to A, chromosome 2 at 85,438,637 bp
  • A to T, chromosome 2 at 87,490,061 bp
  • T to C, chromosome 2 at 112,130,082 bp
  • A to G, chromosome 2 at 143,795,950 bp
  • C to T, chromosome 2 at 164,909,370 bp
  • G to T, chromosome 2 at 181,001,338 bp
  • T to C, chromosome 3 at 87,996,692 bp
  • C to A, chromosome 3 at 94,944,510 bp
  • T to C, chromosome 4 at 92,145,073 bp
  • T to G, chromosome 4 at 108,831,887 bp
  • T to A, chromosome 4 at 128,546,684 bp
  • T to G, chromosome 4 at 152,217,815 bp
  • T to G, chromosome 5 at 31,069,564 bp
  • T to C, chromosome 5 at 87,336,530 bp
  • T to C, chromosome 5 at 99,221,410 bp
  • A to T, chromosome 5 at 110,107,320 bp
  • T to C, chromosome 5 at 114,634,755 bp
  • A to T, chromosome 5 at 121,323,931 bp
  • G to T, chromosome 5 at 129,598,709 bp
  • T to A, chromosome 5 at 137,779,469 bp
  • T to A, chromosome 6 at 60,988,287 bp
  • G to T, chromosome 6 at 68,542,386 bp
  • C to T, chromosome 6 at 83,547,230 bp
  • C to T, chromosome 6 at 132,571,985 bp
  • T to C, chromosome 6 at 132,893,141 bp
  • A to G, chromosome 7 at 35,463,718 bp
  • A to G, chromosome 7 at 45,416,061 bp
  • A to C, chromosome 7 at 121,997,779 bp
  • A to G, chromosome 7 at 134,874,087 bp
  • C to T, chromosome 8 at 4,255,558 bp
  • T to C, chromosome 8 at 12,825,721 bp
  • T to C, chromosome 8 at 24,647,862 bp
  • T to A, chromosome 8 at 60,545,256 bp
  • A to T, chromosome 9 at 19,846,166 bp
  • T to C, chromosome 10 at 5,361,535 bp
  • G to T, chromosome 10 at 43,907,846 bp
  • A to G, chromosome 10 at 80,137,142 bp
  • A to T, chromosome 10 at 96,023,991 bp
  • T to C, chromosome 10 at 115,411,895 bp
  • A to C, chromosome 10 at 117,058,185 bp
  • T to A, chromosome 10 at 127,710,987 bp
  • T to C, chromosome 11 at 5,194,981 bp
  • T to A, chromosome 11 at 59,054,403 bp
  • A to G, chromosome 11 at 59,827,976 bp
  • A to G, chromosome 11 at 61,248,930 bp
  • T to C, chromosome 11 at 79,146,056 bp
  • T to A, chromosome 11 at 104,584,577 bp
  • T to C, chromosome 12 at 70,195,616 bp
  • T to C, chromosome 12 at 81,993,151 bp
  • T to C, chromosome 13 at 93,041,483 bp
  • T to C, chromosome 15 at 79,794,454 bp
  • T to A, chromosome 15 at 89,186,180 bp
  • T to C, chromosome 15 at 94,581,255 bp
  • A to T, chromosome 16 at 17,802,831 bp
  • G to A, chromosome 16 at 33,812,917 bp
  • A to G, chromosome 16 at 45,239,067 bp
  • A to G, chromosome 17 at 74,652,038 bp
  • A to G, chromosome 18 at 35,616,220 bp
  • T to C, chromosome 19 at 4,864,663 bp
  • T to C, chromosome 19 at 12,088,105 bp
  • A to T, chromosome 19 at 13,410,673 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8803 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068640-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.