Strain Name:
C57BL/6J-MtgxR8811Btlr/Mmmh
Stock Number:
068646-MU
Citation ID:
RRID:MMRRC_068646-MU
Other Names:
R8811 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: PTPzeta, DSD-1-PG, phosphacan, RPTPz, Ptprz, Ptpz, Rptpbeta, PTPbeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd1, Edd, 4432411E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CaMKIgamma, CLICK-III
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215303
Homologene: 48706
Mib1
Name: MIB E3 ubiquitin protein ligase 1
Synonyms: E430019M12Rik, mindbomb, Mib, mind bomb-1, skeletrophin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225164
Homologene: 10810
Slc37a3
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 3
Synonyms: 2610507O21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72144
Homologene: 41740
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbb2ip, Erbin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59079
Homologene: 41282
Nup133
Name: nucleoporin 133
Synonyms: mermaid, 4832420O05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234865
Homologene: 32402
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Ddx39b
Name: DEAD box helicase 39b
Synonyms: Bat1, D17H6S81E-1, Bat-1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B, 0610030D10Rik, Bat1a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53817
Homologene: 48376
Smoc2
Name: SPARC related modular calcium binding 2
Synonyms: Smoc2l, 1700056C05Rik, 5430426J21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64074
VEGA: 17
Homologene: 11150
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Htr1a
Name: 5-hydroxytryptamine (serotonin) receptor 1A
Synonyms: 5-HT1A receptor, Gpcr18
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15550
VEGA: 13
HGNC: HGNC:5286
Homologene: 20148
Zbtb20
Name: zinc finger and BTB domain containing 20
Synonyms: A930017C21Rik, 7330412A13Rik, HOF, D16Wsu73e, 1300017A20Rik, Zfp288
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56490
Homologene: 9226
Sox4
Name: SRY (sex determining region Y)-box 4
Synonyms: Sox-4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20677
Homologene: 2338
Tbr1
Name: T-box brain transcription factor 1
Synonyms: T-box brain gene 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21375
Homologene: 4807
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Atf7
Name: activating transcription factor 7
Synonyms: 1110012F10Rik, 9430065F09Rik, C130020M04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223922
HGNC: HGNC:792
Homologene: 4994
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Fam3b
Name: FAM3 metabolism regulating signaling molecule B
Synonyms: 9030624C24Rik, Pander, ORF9, D16Jhu19e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52793
HGNC: HGNC:1253
Homologene: 10766
Cenpe
Name: centromere protein E
Synonyms: Kif10, 312kDa, CENP-E, N-7 kinesin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Nhlrc2
Name: NHL repeat containing 2
Synonyms: 1200003G01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66866
VEGA: 19
Homologene: 12048
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: 2410002L19Rik, Centd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69710
Homologene: 12326
Arl16
Name: ADP-ribosylation factor-like 16
Synonyms: 2600005N12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70317
Homologene: 53461
Dnaja3
Name: DnaJ heat shock protein family (Hsp40) member A3
Synonyms: 1200003J13Rik, Tid-1, 1810053A11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 83945
Homologene: 36170
Foxn3
Name: forkhead box N3
Synonyms: 5430426H20Rik, Ches1l, Ches1, HTLFL1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71375
HGNC: HGNC:1928
Homologene: 135955
Gipc1
Name: GIPC PDZ domain containing family, member 1
Synonyms: Glut1CIP, TaxIP2, synectin, Rgs19ip1, Semcap1, neurophilin1-IP, TIP-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67903
HGNC: HGNC:1226
Homologene: 21167
Nutm2
Name: NUT family member 2
Synonyms: LOC328250, Gm806
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328250
Homologene: 128615
Tspear
Name: thrombospondin type laminin G domain and EAR repeats
Synonyms: ORF65, C330046G03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 252974
HGNC: HGNC:1268
Homologene: 36972
Stxbp2
Name: syntaxin binding protein 2
Synonyms: Munc-18-2, Munc18b, muSec1, C79054, Sxtp2, Munc-18b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20911
Homologene: 55530
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78250
Homologene: 11258
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: FOAP-10, basilin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Tro
Name: trophinin
Synonyms: Maged3, magphinin-gamma, Maged3l, magphinin-beta 2, magphinin, Trol, necdin and trophinin like, magphinin-alpha, Tnn, trophinin-2
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 56191
Homologene: 75113
Abcc12
Name: ATP-binding cassette, sub-family C member 12
Synonyms: 4930467B22Rik, MRP9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244562
Homologene: 57211
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Atp6v0d2
Name: ATPase, H+ transporting, lysosomal V0 subunit D2
Synonyms: 1620401A02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242341
Homologene: 72090
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, 4732433M03Rik, CPSase I, D1Ucla3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Polg2
Name: polymerase (DNA directed), gamma 2, accessory subunit
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50776
HGNC: HGNC:9180
Homologene: 5221
Ubtfl1
Name: upstream binding transcription factor, RNA polymerase I-like 1
Synonyms: B020006M18Rik, Hmgpi
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546118
Homologene: 110115
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Prss28
Name: serine protease 28
Synonyms: Isp1, mIsp-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 114661
Homologene: 130906
Mcrip1
Name: MAPK regulated corepressor interacting protein 1
Synonyms: BC003940, Fam195b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192173
Homologene: 19571
Or6f1
Name: olfactory receptor family 6 subfamily F member 1
Synonyms: GA_x6K02T2NHDJ-9786435-9787361, MOR104-1, Olfr308
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258614
Homologene: 27225
Slc24a4
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Synonyms: NCKX4, A930002M03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238384
Homologene: 17798
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Calhm4
Name: calcium homeostasis modulator family member 4
Synonyms: LOC270711, 4732454E20Rik, Fam26d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270711
VEGA: 10
Homologene: 19551
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: BC026439, OAT-PG
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210463
Homologene: 18166
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620672
Homologene: 115466
Lat2
Name: linker for activation of T cells family, member 2
Synonyms: Wbscr5, Wbscr15
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56743
Homologene: 11297
Dusp7
Name: dual specificity phosphatase 7
Synonyms: PYST2, MKP-X
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235584
HGNC: HGNC:3073
Homologene: 1468
Trim31
Name: tripartite motif-containing 31
Synonyms: HCG1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224762
Homologene: 17137
Kdelr3
Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105785
VEGA: 15
HGNC: HGNC:6306
Homologene: 68533
Aldoc
Name: aldolase C, fructose-bisphosphate
Synonyms: Aldolase C, Aldo3, Scrg2, zebrin II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11676
HGNC: HGNC:418
Homologene: 21073
Grpel2
Name: GrpE-like 2, mitochondrial
Synonyms: mt-GrpE#2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17714
VEGA: 18
Homologene: 41432
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 67,214,087 bp
  • C to G, chromosome 1 at 193,362,100 bp
  • C to A, chromosome 2 at 61,811,852 bp
  • A to G, chromosome 3 at 135,223,240 bp
  • A to T, chromosome 4 at 19,922,397 bp
  • C to T, chromosome 5 at 134,606,699 bp
  • G to A, chromosome 6 at 23,030,662 bp
  • A to G, chromosome 6 at 39,345,340 bp
  • A to G, chromosome 7 at 8,471,882 bp
  • T to C, chromosome 7 at 85,150,687 bp
  • G to A, chromosome 7 at 86,321,781 bp
  • C to T, chromosome 7 at 101,387,196 bp
  • A to T, chromosome 8 at 3,639,541 bp
  • T to G, chromosome 8 at 47,883,544 bp
  • T to A, chromosome 8 at 83,662,290 bp
  • T to C, chromosome 8 at 86,018,527 bp
  • G to T, chromosome 8 at 86,553,394 bp
  • AAGAGA to AAGA, chromosome 8 at 123,911,888 bp
  • A to G, chromosome 9 at 18,410,163 bp
  • A to T, chromosome 9 at 63,544,913 bp
  • C to G, chromosome 9 at 106,371,042 bp
  • T to A, chromosome 10 at 34,041,665 bp
  • T to C, chromosome 10 at 77,829,629 bp
  • T to A, chromosome 11 at 78,324,784 bp
  • T to G, chromosome 11 at 84,019,584 bp
  • A to T, chromosome 11 at 106,779,382 bp
  • A to T, chromosome 11 at 120,466,700 bp
  • A to G, chromosome 11 at 120,544,779 bp
  • T to C, chromosome 12 at 99,196,692 bp
  • T to C, chromosome 12 at 102,213,874 bp
  • T to A, chromosome 13 at 20,999,951 bp
  • A to G, chromosome 13 at 28,952,928 bp
  • A to T, chromosome 13 at 50,469,953 bp
  • C to T, chromosome 13 at 103,886,316 bp
  • G to C, chromosome 13 at 105,444,593 bp
  • T to C, chromosome 14 at 55,772,764 bp
  • C to A, chromosome 15 at 38,040,879 bp
  • T to C, chromosome 15 at 47,696,743 bp
  • A to T, chromosome 15 at 57,244,841 bp
  • T to C, chromosome 15 at 79,525,851 bp
  • T to C, chromosome 15 at 102,593,709 bp
  • C to A, chromosome 16 at 4,696,519 bp
  • T to C, chromosome 16 at 43,610,494 bp
  • T to C, chromosome 16 at 97,512,515 bp
  • T to C, chromosome 17 at 14,325,634 bp
  • T to G, chromosome 17 at 24,317,238 bp
  • T to A, chromosome 17 at 25,309,653 bp
  • T to A, chromosome 17 at 35,244,459 bp
  • T to C, chromosome 17 at 36,899,983 bp
  • T to A, chromosome 17 at 71,275,287 bp
  • C to T, chromosome 18 at 10,755,643 bp
  • A to C, chromosome 18 at 61,718,752 bp
  • T to C, chromosome 19 at 41,206,573 bp
  • T to A, chromosome 19 at 56,594,912 bp
  • G to A, chromosome X at 150,655,559 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8811 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068646-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.