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Strain Name:
C57BL/6J-MtgxR8814Btlr/Mmmh
Stock Number:
068649-MU
Citation ID:
RRID:MMRRC_068649-MU
Other Names:
R8814 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: D5Ertd460e, Srb1, Cd36l1, Cla-1, SRBI, SR-BI, Hlb398, Hdlq1, Chohd1, Chohd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Lcat
Name: lecithin cholesterol acyltransferase
Synonyms: D8Wsu61e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16816
HGNC: HGNC:6522
Homologene: 68042
Brd7
Name: bromodomain containing 7
Synonyms: bromodomain protein 75 kDa, BP75, CELTIX1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26992
Homologene: 8085
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: nucling, 2700059D02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Sub1
Name: SUB1 homolog, transcriptional regulator
Synonyms: P15, Pc4, Rpo2tc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20024
Homologene: 38218
Psma3
Name: proteasome subunit alpha 3
Synonyms: Lmpc8
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19167
HGNC: HGNC:9532
Homologene: 2082
Zfp26
Name: zinc finger protein 26
Synonyms: mkr-3, Zfp-26, 5033428C05Rik, Zfp70, KRAB15, Zfp81-rs1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22688
Homologene: 52318
Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13078
VEGA: 17
HGNC: HGNC:2597
Homologene: 68035
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239250
VEGA: 14
Homologene: 12986
Cpsf4
Name: cleavage and polyadenylation specific factor 4
Synonyms: 30kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54188
HGNC: HGNC:2327
Homologene: 38216
Trappc10
Name: trafficking protein particle complex 10
Synonyms: LOC380642, B230307C21Rik, Tmem1, b2b2613Clo, b2b2416Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209018
Homologene: 44592
Ift74
Name: intraflagellar transport 74
Synonyms: 1700029H06Rik, Cmg1, Ccdc2, b2b796Clo
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67694
Homologene: 11831
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Crispld2
Name: cysteine-rich secretory protein LCCL domain containing 2
Synonyms: 1810049K24Rik, coffeecrisp, Lgl1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78892
Homologene: 41792
Hhip
Name: Hedgehog-interacting protein
Synonyms: Hip, Hip1, Hhip1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15245
Homologene: 32469
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269224
Homologene: 9038
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: Bromi, C6orf170, D630037F22Rik, b2b2284Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Mtcl2
Name: microtubule crosslinking factor 2
Synonyms: D430036N24Rik, 9830001H06Rik, Soga1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320706
Homologene: 52382
Msh4
Name: mutS homolog 4
Synonyms: mMsh4, 4930485C04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: CD169, Siglec-1, Sn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20612
Homologene: 124458
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80797
HGNC: HGNC:2017
Homologene: 77224
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 670940
Homologene: 115466
Tspan15
Name: tetraspanin 15
Synonyms: 2700063A19Rik, Tm4sf15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70423
VEGA: 10
Homologene: 22716
Pcdh8
Name: protocadherin 8
Synonyms: Papc, 1700080P15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18530
HGNC: HGNC:8660
Homologene: 1943
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 621430
Homologene: 115466
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Trim28
Name: tripartite motif-containing 28
Synonyms: KRIP-1, KAP-1, Tif1b, MommeD9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21849
Homologene: 21175
Lmntd2
Name: lamin tail domain containing 2
Synonyms: 1600016N20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72000
Homologene: 104159
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), neurexin I beta, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I alpha, 1700062G21Rik, A230068P09Rik, 9330127H16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Clec2m
Name: C-type lectin domain family 2, member m
Synonyms: 4922502D21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381816
Homologene: 77865
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319217
Homologene: 129754
Or5d37
Name: olfactory receptor family 5 subfamily D member 37
Synonyms: GA_x6K02T2Q125-49585842-49584862, MOR174-11, Olfr1164
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258634
Homologene: 74077
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546913
Homologene: 84037
Or52s6
Name: olfactory receptor family 52 subfamily S member 6
Synonyms: GA_x6K02T2PBJ9-6164792-6163848, MOR202-22P, MOR24-5, Olfr605
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258156
Homologene: 79414
Serpinb6b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6b
Synonyms: Spi12, NK13, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20708
HGNC: HGNC:8950
Homologene: 22633
Vmn1r84
Name: vomeronasal 1 receptor 84
Synonyms: V1rg11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171267
Homologene: 74328
Mterf1b
Name: mitochondrial transcription termination factor 1b
Synonyms: Gm9897
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208595
Homologene: 5073
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209462
Homologene: 10807
Pheta1
Name: PH domain containing endocytic trafficking adaptor 1
Synonyms: A230106M15Rik, Ses1, Fam109a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231717
Homologene: 16966
Or1s2
Name: olfactory receptor family 1 subfamily S member 1
Synonyms: GA_x6K02T2RE5P-4112771-4113718, MOR127-1, Olfr1496
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258991
Homologene: 17458
Hemgn
Name: hemogen
Synonyms: EDAG, 4921524M03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93966
Homologene: 14223
Or2d3c
Name: olfactory receptor family 2 subfamily D member 3C
Synonyms: GA_x6K02T2PBJ9-9307730-9306814, MOR260-7, Olfr709
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258146
Samd11
Name: sterile alpha motif domain containing 11
Synonyms: mr-s
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231004
VEGA: 4
Homologene: 34983
Or5p61
Name: olfactory receptor family 5 subfamily P member 61
Synonyms: GA_x6K02T2PBJ9-10489044-10488091, MOR204-40_p, MOR204-30P, Olfr485
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258041
Homologene: 110483
Gm47995
Name: predicted gene, 47995
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 93,320,585 bp
  • A to G, chromosome 1 at 151,198,988 bp
  • T to A, chromosome 2 at 88,092,971 bp
  • G to A, chromosome 2 at 131,072,744 bp
  • A to G, chromosome 2 at 156,052,243 bp
  • C to T, chromosome 2 at 157,030,531 bp
  • A to G, chromosome 3 at 64,716,563 bp
  • G to T, chromosome 3 at 144,797,764 bp
  • A to G, chromosome 3 at 153,872,320 bp
  • G to T, chromosome 4 at 46,400,717 bp
  • C to T, chromosome 4 at 94,662,636 bp
  • T to C, chromosome 4 at 156,247,884 bp
  • T to C, chromosome 5 at 4,197,456 bp
  • G to T, chromosome 5 at 121,853,045 bp
  • A to T, chromosome 5 at 125,294,092 bp
  • T to G, chromosome 5 at 145,178,868 bp
  • C to G, chromosome 6 at 123,637,830 bp
  • T to C, chromosome 6 at 129,325,604 bp
  • A to G, chromosome 7 at 12,362,458 bp
  • T to A, chromosome 7 at 13,028,527 bp
  • T to A, chromosome 7 at 85,565,961 bp
  • C to G, chromosome 7 at 87,002,506 bp
  • A to G, chromosome 7 at 103,442,913 bp
  • T to A, chromosome 7 at 106,926,818 bp
  • T to A, chromosome 7 at 108,159,065 bp
  • G to A, chromosome 7 at 141,210,084 bp
  • T to C, chromosome 8 at 80,051,472 bp
  • A to G, chromosome 8 at 88,345,154 bp
  • G to A, chromosome 8 at 105,941,970 bp
  • A to G, chromosome 8 at 120,015,345 bp
  • A to T, chromosome 9 at 20,438,434 bp
  • A to G, chromosome 9 at 60,866,398 bp
  • C to A, chromosome 9 at 67,221,411 bp
  • A to G, chromosome 10 at 45,652,701 bp
  • A to T, chromosome 10 at 53,348,969 bp
  • A to G, chromosome 10 at 56,196,592 bp
  • G to A, chromosome 10 at 62,188,056 bp
  • A to G, chromosome 10 at 78,202,919 bp
  • A to G, chromosome 11 at 83,016,679 bp
  • A to G, chromosome 12 at 70,978,806 bp
  • A to G, chromosome 13 at 32,978,304 bp
  • A to G, chromosome 14 at 7,927,409 bp
  • T to A, chromosome 14 at 29,097,815 bp
  • A to G, chromosome 14 at 79,768,897 bp
  • G to C, chromosome 14 at 110,749,938 bp
  • A to T, chromosome 15 at 4,792,784 bp
  • G to T, chromosome 15 at 4,941,625 bp
  • A to C, chromosome 15 at 11,984,231 bp
  • T to C, chromosome 16 at 21,576,650 bp
  • A to T, chromosome 16 at 23,004,011 bp
  • T to C, chromosome 17 at 79,713,359 bp
  • A to T, chromosome 17 at 90,630,101 bp
  • T to A, chromosome 19 at 13,781,533 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8814 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068649-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.