Strain Name:
C57BL/6J-MtgxR8824Btlr/Mmmh
Stock Number:
068657-MU
Citation ID:
RRID:MMRRC_068657-MU
Other Names:
R8824 (G1)
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: flail, MyoVA, 9630007J19Rik, Dbv, MVa, Myo5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Adora2a
Name: adenosine A2a receptor
Synonyms: A2aR, ARA2A, A2AAR, A2a, Rs, AA2AR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Dnmbp
Name: dynamin binding protein
Synonyms: Tuba, 2410003M15Rik, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: aldosterone synthase, Cyp11b-2, steroid-11-beta-hydroxylase, Cyp11b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Prgs, Gaps
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Dusp16
Name: dual specificity phosphatase 16
Synonyms: D6Ertd213e, 3830417M17Rik, MKP7, MKP-7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70686
Homologene: 15604
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: [delta]EF1, AREB6, Zfx1a, Zfhx1a, Nil2, ZEB, Tcf18, Tcf8, MEB1, 3110032K11Rik, Tw, Zfhep
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21417
Homologene: 31779
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Ptprc
Name: protein tyrosine phosphatase receptor type C
Synonyms: CD45, Lyt-4, Ly-5, B220, T200
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, C330002D13Rik, Coh1, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Rreb1
Name: ras responsive element binding protein 1
Synonyms: sao, 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68750
Homologene: 2218
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: TIF2/GRIP-1, KAT13C, TIF2, Grip1, D1Ertd433e, SRC-2, glucocorticoid receptor-interacting protein 1, TIF-2, bHLHe75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Slc38a9
Name: solute carrier family 38, member 9
Synonyms: 9130023D20Rik, 4833412L08Rik, 9430067K09Rik, 6720411P22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268706
VEGA: 13
Homologene: 18139
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217351
Homologene: 23137
Ehbp1
Name: EH domain binding protein 1
Synonyms: Flj21950, KIAA0903-like
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216565
Homologene: 22880
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: Flk-2, CD135, Flk2, wmfl, Flt-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Rapgef3
Name: Rap guanine nucleotide exchange factor (GEF) 3
Synonyms: 9330170P05Rik, 2310016P22Rik, Epac1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223864
Homologene: 21231
Peg10
Name: paternally expressed 10
Synonyms: MyEF-3, Rtl2, Mar2, Mart2, MEF3L, Edr, HB-1, MyEF-3 like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Usf3
Name: upstream transcription factor family member 3
Synonyms: 5530400K22Rik, Gm608, LOC207806, LOC385650
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207806
Homologene: 19504
Ubxn10
Name: UBX domain protein 10
Synonyms: 5730509E04Rik, Ubxd3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212190
Homologene: 17568
Rsph1
Name: radial spoke head 1 homolog (Chlamydomonas)
Synonyms: Tsga2, meichroacidin, MCA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22092
VEGA: 17
Homologene: 11905
Trim55
Name: tripartite motif-containing 55
Synonyms: D830041C10Rik, Murf2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381485
Homologene: 13205
Prkg2
Name: protein kinase, cGMP-dependent, type II
Synonyms: Prkgr2, cGK-II
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19092
HGNC: HGNC:9416
Homologene: 4556
Or5p76
Name: olfactory receptor family 5 subfamily P member 76
Synonyms: Olfr502, MOR204-8, GA_x6K02T2PBJ9-10853935-10852991
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258734
Homologene: 72021
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211936
Homologene: 52235
Zhx2
Name: zinc fingers and homeoboxes 2
Synonyms: Raf, Afr-1, Afr1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 387609
Homologene: 8968
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Clrn1
Name: clarin 1
Synonyms: A130002D11Rik, clarin-1, USH3, Ush3a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229320
Homologene: 17738
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14918
Homologene: 71540
Krt4
Name: keratin 4
Synonyms: Krt2-4, Krt-2.4, K4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16682
VEGA: 15
HGNC: HGNC:6441
Homologene: 20523
Golgb1
Name: golgin B1
Synonyms: Giantin, Gm6840, C130074L01Rik, 6330407A06Rik, F730017E11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Trim30b
Name: tripartite motif-containing 30B
Synonyms: Trim30-1, A530023O14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244183
Lipn
Name: lipase, family member N
Synonyms: Lipl4, 2210418G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70166
Homologene: 66969
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Shc2
Name: SHC (Src homology 2 domain containing) transforming protein 2
Synonyms: ShcB, Sli
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216148
Homologene: 19127
Or1j18
Name: olfactory receptor family 1 subfamily J member 18
Synonyms: Olfr347, GA_x6K02T2NLDC-33428755-33429693, MOR136-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258945
Homologene: 51790
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: 5730550L01Rik, argonaute 4, Eif2c4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76850
Homologene: 41184
Cd248
Name: CD248 antigen, endosialin
Synonyms: Cd164l1, 2610111G01Rik, Tem1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70445
VEGA: 19
Homologene: 10699
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: mGluR8, Gprc1h
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Smarca5
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Synonyms: Snf2h, D030040M08Rik, D330027N15Rik, 4933427E24Rik, MommeD4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93762
Homologene: 55764
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: Trs4, 4932408B21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)-like
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381411
Homologene: 86007
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Or4b1b
Name: olfactory receptor family 4 subfamily B member 1B
Synonyms: Olfr1272, MOR227-3, GA_x6K02T2Q125-51636504-51635578
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258982
HGNC: HGNC:8290
Homologene: 133649
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Dip2, 4931420H10Rik, Kiaa0184-hp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64451
Homologene: 41012
Krtap26-1
Name: keratin associated protein 26-1
Synonyms: 2310002B14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69533
VEGA: 16
Homologene: 88911
Mrgpra9
Name: MAS-related GPR, member A9
Synonyms: MrgA9, EG668725
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668725
Homologene: 79615
Prkcz
Name: protein kinase C, zeta
Synonyms: zetaPKC, Pkcz, aPKCzeta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18762
HGNC: HGNC:9412
Homologene: 55681
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: Gpr71, TR2, T1r2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83770
Homologene: 75323
Cxcr6
Name: C-X-C motif chemokine receptor 6
Synonyms: STRL33, BONZO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80901
VEGA: 9
Homologene: 38197
Zfp780b
Name: zinc finger protein 780B
Synonyms: B230208L21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 338354
Homologene: 85969
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: MIWI2, Miwi2, 9230101H05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330890
Homologene: 45122
Lrrc14b
Name: leucine rich repeat containing 14B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432779
Homologene: 47758
Or5w12
Name: olfactory receptor family 5 subfamily W member 12
Synonyms: MOR177-2, GA_x6K02T2Q125-49177531-49176599, Olfr1135
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258654
Homologene: 17331
Fgl1
Name: fibrinogen-like protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234199
HGNC: HGNC:3695
Homologene: 37927
Afg1l
Name: AFG1 like ATPase
Synonyms: Lace1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215951
Homologene: 5782
Or5d47
Name: olfactory receptor family 5 subfamily D member 47
Synonyms: mOR-EV, GA_x6K02T2Q125-49458388-49457432, MOR174-4, Olfr74
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 117005
Homologene: 74078
Ttc39c
Name: tetratricopeptide repeat domain 39C
Synonyms: 2810439F02Rik, 1700008N02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72747
Homologene: 124438
Or10u4
Name: olfactory receptor family 10 subfamily U member 4
Synonyms: Olfr819, MOR265-2_p, GA_x6K02T2PULF-11644164-11643823
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100043200
Homologene: 73929
Gm28168
Name: predicted gene 28168
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 13,177,185 bp
  • T to A, chromosome 1 at 97,128,159 bp
  • T to G, chromosome 1 at 117,947,895 bp
  • T to A, chromosome 1 at 138,113,708 bp
  • A to T, chromosome 2 at 36,735,191 bp
  • C to G, chromosome 2 at 52,216,911 bp
  • T to C, chromosome 2 at 87,671,960 bp
  • A to G, chromosome 2 at 87,974,003 bp
  • A to G, chromosome 2 at 90,296,012 bp
  • A to T, chromosome 2 at 93,862,850 bp
  • A to G, chromosome 2 at 104,991,877 bp
  • A to G, chromosome 2 at 155,630,381 bp
  • T to C, chromosome 3 at 19,672,962 bp
  • A to T, chromosome 3 at 58,884,893 bp
  • C to T, chromosome 4 at 88,557,761 bp
  • C to A, chromosome 4 at 126,507,184 bp
  • A to G, chromosome 4 at 138,735,867 bp
  • A to G, chromosome 4 at 139,653,763 bp
  • G to A, chromosome 4 at 155,344,828 bp
  • G to A, chromosome 5 at 98,942,208 bp
  • A to G, chromosome 5 at 125,118,757 bp
  • T to C, chromosome 5 at 147,334,863 bp
  • T to TCCC, chromosome 6 at 4,756,451 bp
  • C to A, chromosome 6 at 24,479,308 bp
  • A to G, chromosome 6 at 27,761,352 bp
  • A to T, chromosome 6 at 124,517,695 bp
  • A to T, chromosome 6 at 134,739,769 bp
  • T to C, chromosome 7 at 27,963,468 bp
  • A to T, chromosome 7 at 47,235,293 bp
  • C to T, chromosome 7 at 98,443,469 bp
  • T to A, chromosome 7 at 104,357,906 bp
  • T to G, chromosome 7 at 108,523,143 bp
  • A to C, chromosome 8 at 15,114,169 bp
  • A to G, chromosome 8 at 41,199,711 bp
  • A to G, chromosome 8 at 80,705,332 bp
  • C to A, chromosome 9 at 14,727,475 bp
  • A to G, chromosome 9 at 75,167,046 bp
  • A to G, chromosome 9 at 108,967,025 bp
  • A to C, chromosome 9 at 123,810,941 bp
  • G to A, chromosome 10 at 42,438,387 bp
  • G to A, chromosome 10 at 75,326,179 bp
  • A to G, chromosome 10 at 76,278,486 bp
  • A to G, chromosome 10 at 79,637,702 bp
  • C to T, chromosome 10 at 129,965,792 bp
  • A to T, chromosome 11 at 22,232,053 bp
  • T to A, chromosome 11 at 117,739,854 bp
  • C to T, chromosome 13 at 37,930,516 bp
  • A to G, chromosome 13 at 74,363,949 bp
  • G to A, chromosome 13 at 112,701,487 bp
  • A to T, chromosome 14 at 78,516,347 bp
  • T to A, chromosome 15 at 35,533,299 bp
  • C to T, chromosome 15 at 57,821,280 bp
  • T to A, chromosome 15 at 74,856,065 bp
  • C to T, chromosome 15 at 97,766,908 bp
  • T to A, chromosome 15 at 101,920,642 bp
  • A to G, chromosome 16 at 36,915,689 bp
  • A to G, chromosome 16 at 44,215,613 bp
  • A to T, chromosome 16 at 88,647,415 bp
  • T to C, chromosome 16 at 88,647,436 bp
  • T to C, chromosome 16 at 91,630,703 bp
  • A to C, chromosome 17 at 31,273,376 bp
  • T to A, chromosome 18 at 5,748,680 bp
  • T to A, chromosome 18 at 12,686,946 bp
  • A to G, chromosome 19 at 5,069,617 bp
  • T to C, chromosome 19 at 34,084,716 bp
  • A to G, chromosome 19 at 43,849,837 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8824 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068657-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.