Strain Name:
C57BL/6J-MtgxR8840Btlr/Mmmh
Stock Number:
068668-MU
Citation ID:
RRID:MMRRC_068668-MU
Other Names:
R8840 (G1)
Major Collection:

Strain Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: NPR-C, Nppc receptor, B430320C24Rik, lgj, longjohn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 2610510B01Rik, 0610038M01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Ccdc163
Name: coiled-coil domain containing 163
Synonyms: 4933430J04Rik, 0610037D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68394
Homologene: 12265
Kdm1a
Name: lysine (K)-specific demethylase 1A
Synonyms: LSD1, 1810043O07Rik, Aof2, Kdm1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 99982
Homologene: 32240
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Prgs, Gaps
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4921507G06Rik, 4930435C18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Suclg2
Name: succinate-Coenzyme A ligase, GDP-forming, beta subunit
Synonyms: D6Wsu120e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20917
Homologene: 2854
Ccz1
Name: CCZ1 vacuolar protein trafficking and biogenesis associated
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231874
Homologene: 56717
Sbno2
Name: strawberry notch 2
Synonyms: Stno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216161
VEGA: 10
Homologene: 8981
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, ALL-1, Mll1, Cxxc7, Mll, HTRX1, All1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22722
Homologene: 7604
Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269470
Homologene: 4937
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsp, Sh2bp1, Tsbp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22083
Homologene: 40668
Robo2
Name: roundabout guidance receptor 2
Synonyms: D230004I22Rik, 2600013A04Rik, 9430089E08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Rbm15
Name: RNA binding motif protein 15
Synonyms: C230088J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229700
Homologene: 23383
Ibsp
Name: integrin binding sialoprotein
Synonyms: Bsp, BSP, bone sialoprotein, Bsp2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15891
HGNC: HGNC:5341
Homologene: 3644
Atp6v1b1
Name: ATPase, H+ transporting, lysosomal V1 subunit B1
Synonyms: lysosomal 56/58kDa, Vpp-3, D630030L16Rik, Atp6b1, Vpp3, D630039P21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110935
HGNC: HGNC:853
Homologene: 68198
Cldn1
Name: claudin 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12737
HGNC: HGNC:2032
Homologene: 9620
Fam151a
Name: family with sequence simliarity 151, member A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230579
Homologene: 17143
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76608
Homologene: 18426
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212168
Homologene: 18183
Ythdc2
Name: YTH domain containing 2
Synonyms: 3010002F02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240255
Homologene: 11265
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: D5Ertd249e, APC4, 2610306D21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52206
Homologene: 40873
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 408022
Homologene: 14065
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Antxr2
Name: anthrax toxin receptor 2
Synonyms: CMG-2, cI-35, CMG2, 2310046B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71914
Homologene: 43236
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Spaca6
Name: sperm acrosome associated 6
Synonyms: Ncrna00085, 4930546H06Rik, B230206P06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75202
Homologene: 53443
Btnl1
Name: butyrophilin-like 1
Synonyms: NG10, LOC240074, LOC240074, Btnl3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100038862
Homologene: 103816
Pramel25
Name: PRAME like 25
Synonyms: MGC:91194, Gm13023
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194227
Homologene: 103830
Xab2
Name: XPA binding protein 2
Synonyms: 0610041O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67439
Homologene: 5738
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Arhgap9
Name: Rho GTPase activating protein 9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216445
VEGA: 10
Homologene: 13041
Ccdc8
Name: coiled-coil domain containing 8
Synonyms: ENSMUSG00000041117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434130
Homologene: 49977
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Card15, Nlrc2, F830032C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 328505
Homologene: 106613
Trhr2
Name: thyrotropin releasing hormone receptor 2
Synonyms: TRH-R2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170732
Homologene: 44052
Gnl1
Name: guanine nucleotide binding protein-like 1
Synonyms: Gna-rs1, Gnal1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14670
HGNC: HGNC:4413
Homologene: 3862
Meltf
Name: melanotransferrin
Synonyms: MTf, melanotransferrin, CD228, Mfi2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30060
VEGA: 16
HGNC: HGNC:7037
Homologene: 4335
Rpl3l
Name: ribosomal protein L3-like
Synonyms: 1110057H16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66211
Homologene: 68434
Eppk1
Name: epiplakin 1
Synonyms: EPPK, EPIPL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Or8g29-ps1
Name: olfactory receptor family 8 subfamily G member 29, pseudogene 1
Synonyms: MOR171-43, GA_x6K02T2PVTD-32987171-32986232, Olfr947-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257924
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 2 at 76,776,027 bp
  • A to G, chromosome 2 at 82,991,262 bp
  • T to C, chromosome 2 at 127,808,007 bp
  • A to T, chromosome 2 at 168,926,715 bp
  • G to A, chromosome 3 at 100,149,937 bp
  • A to G, chromosome 3 at 107,332,989 bp
  • T to C, chromosome 4 at 106,745,622 bp
  • T to C, chromosome 4 at 111,987,986 bp
  • T to A, chromosome 4 at 116,710,286 bp
  • T to C, chromosome 4 at 116,998,407 bp
  • T to C, chromosome 4 at 136,560,405 bp
  • C to A, chromosome 4 at 143,795,068 bp
  • G to A, chromosome 5 at 52,859,131 bp
  • T to A, chromosome 5 at 98,004,910 bp
  • C to T, chromosome 5 at 104,310,140 bp
  • T to C, chromosome 5 at 144,004,164 bp
  • A to T, chromosome 6 at 83,756,863 bp
  • T to A, chromosome 6 at 95,569,634 bp
  • T to A, chromosome 7 at 16,994,717 bp
  • A to G, chromosome 7 at 111,043,030 bp
  • A to G, chromosome 8 at 3,613,254 bp
  • A to T, chromosome 8 at 46,593,696 bp
  • C to T, chromosome 8 at 84,214,070 bp
  • T to C, chromosome 8 at 88,672,751 bp
  • T to C, chromosome 8 at 109,623,210 bp
  • T to C, chromosome 8 at 122,358,882 bp
  • G to A, chromosome 9 at 39,289,722 bp
  • A to T, chromosome 9 at 44,809,719 bp
  • A to G, chromosome 9 at 45,723,420 bp
  • T to C, chromosome 9 at 54,401,855 bp
  • A to G, chromosome 10 at 80,057,526 bp
  • A to G, chromosome 10 at 127,325,140 bp
  • A to G, chromosome 11 at 77,976,487 bp
  • A to G, chromosome 14 at 61,191,728 bp
  • A to T, chromosome 15 at 11,905,243 bp
  • T to A, chromosome 15 at 76,109,894 bp
  • T to C, chromosome 16 at 26,371,536 bp
  • T to C, chromosome 16 at 31,897,202 bp
  • T to A, chromosome 16 at 73,985,682 bp
  • A to T, chromosome 16 at 91,636,122 bp
  • A to G, chromosome 16 at 93,810,117 bp
  • A to T, chromosome 17 at 17,831,103 bp
  • A to G, chromosome 17 at 24,733,737 bp
  • A to G, chromosome 17 at 34,385,603 bp
  • T to G, chromosome 17 at 35,982,594 bp
  • A to G, chromosome 18 at 44,860,624 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8840 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068668-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.