Strain Name:
C57BL/6J-MtgxR8864Btlr/Mmmh
Stock Number:
068680-MU
Citation ID:
RRID:MMRRC_068680-MU
Other Names:
R8864 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Nfia
Name: nuclear factor I/A
Synonyms: 9430022M17Rik, NF1A, NF1-A, 1110047K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18027
HGNC: HGNC:7784
Homologene: 4086
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: Zfp403, D330017P12Rik, DIF-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217039
Homologene: 11750
Rangap1
Name: RAN GTPase activating protein 1
Synonyms: Fug1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19387
VEGA: 15
HGNC: HGNC:9854
Homologene: 55700
Wapl
Name: WAPL cohesin release factor
Synonyms: Wapal, A530089A20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218914
Homologene: 41002
Eif3b
Name: eukaryotic translation initiation factor 3, subunit B
Synonyms: D5Wsu45e, Eif3s9, EIF3-P116
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27979
HGNC: HGNC:3280
Homologene: 2780
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 2610040L17Rik, 9330187F13Rik, D3Bwg1534e, Ten-m2, Odz2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Mtch2
Name: mitochondrial carrier 2
Synonyms: 2310034D24Rik, HSPC032, 4930539J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56428
Homologene: 8645
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Npas4
Name: neuronal PAS domain protein 4
Synonyms: LE-PAS, Nxf, Npas4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225872
VEGA: 19
Homologene: 15333
Rgs5
Name: regulator of G-protein signaling 5
Synonyms: 1110070A02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19737
Homologene: 2682
Zfp74
Name: zinc finger protein 74
Synonyms: Zfp66, 2810054M15Rik, KRAB8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72723
Homologene: 51861
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Gfpt1
Name: glutamine fructose-6-phosphate transaminase 1
Synonyms: 2810423A18Rik, GFAT1, GFAT, GFA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14583
HGNC: HGNC:4241
Homologene: 68220
Tnc
Name: tenascin C
Synonyms: C130033P17Rik, TN, hexabrachion, Hxb, cytotactin, tenascin-C, TN-C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: Syd2, Jip3, JNK-interacting protein 3, JUN/SAPK-associated protein 1, JSAP1d, JSAP1c, JSAP1b, JSAP1a, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, JSAP1, sunday driver 2, D17Wsu15e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: C6orf170, b2b2284Clo, D630037F22Rik, Bromi
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Cachd1
Name: cache domain containing 1
Synonyms: Vwcd1, 1190007F10Rik, B430218L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320508
Homologene: 10854
Grn
Name: granulin
Synonyms: epithelin, acrogranulin, PC cell-derived growth factor, Pgrn, progranulin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14824
HGNC: HGNC:4601
Homologene: 1577
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Adamts3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Rwdd4a
Name: RWD domain containing 4A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 192174
Homologene: 16059
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Adamts19
Name: ADAM metallopeptidase with thrombospondin type 1 motif 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: 1200014I03Rik, Factor XIIIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Tas2r104
Name: taste receptor, type 2, member 104
Synonyms: Tas2r4, mGR04, T2R04, mt2r45
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387340
Homologene: 130072
Loxl3
Name: lysyl oxidase-like 3
Synonyms: Lor2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16950
Homologene: 56591
Rnf19a
Name: ring finger protein 19A
Synonyms: XY body protein, Dorfin, Rnf19, XYbp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 30945
VEGA: 15
Homologene: 8501
Cyp2j12
Name: cytochrome P450, family 2, subfamily j, polypeptide 12
Synonyms: Cyp2j12-ps, OTTMUSG00000007939
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242546
HGNC: HGNC:2634
Homologene: 133195
Ergic2
Name: ERGIC and golgi 2
Synonyms: 4930572C01Rik, 1200009B18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67456
Homologene: 6574
Majin
Name: membrane anchored junction protein
Synonyms: 1700123I01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 622554
Homologene: 78163
Lrriq3
Name: leucine-rich repeats and IQ motif containing 3
Synonyms: 4930438B07Rik, 4930511J15Rik, 4933403H06Rik, Lrrc44
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74435
Homologene: 23668
Rab3gap1
Name: RAB3 GTPase activating protein subunit 1
Synonyms: p130, 1700003B17Rik, 4732493F09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226407
Homologene: 45617
Best2
Name: bestrophin 2
Synonyms: Vmd2l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212989
Homologene: 41187
Jrkl
Name: Jrk-like
Synonyms: C030035D04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77532
VEGA: 9
HGNC: HGNC:6200
Homologene: 2797
Spata31e1
Name: spermatogenesis associated 31 subfamily E member 1
Synonyms: Gm30302
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102632152
VEGA: 13
Homologene: 141176
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 127,909,893 bp
  • T to A, chromosome 1 at 169,690,421 bp
  • C to T, chromosome 2 at 41,112,706 bp
  • C to T, chromosome 2 at 90,854,930 bp
  • T to A, chromosome 3 at 155,187,938 bp
  • T to C, chromosome 4 at 43,174,724 bp
  • C to T, chromosome 4 at 63,993,059 bp
  • T to C, chromosome 4 at 96,121,513 bp
  • T to C, chromosome 4 at 98,063,145 bp
  • T to A, chromosome 4 at 100,994,829 bp
  • T to C, chromosome 5 at 89,707,122 bp
  • T to C, chromosome 5 at 140,426,532 bp
  • A to G, chromosome 6 at 83,035,758 bp
  • T to A, chromosome 6 at 87,054,623 bp
  • G to A, chromosome 6 at 113,111,508 bp
  • A to G, chromosome 6 at 131,685,669 bp
  • A to G, chromosome 6 at 148,181,895 bp
  • T to C, chromosome 7 at 29,934,810 bp
  • A to T, chromosome 8 at 47,547,841 bp
  • T to A, chromosome 8 at 85,009,313 bp
  • T to C, chromosome 9 at 13,244,321 bp
  • G to T, chromosome 9 at 67,330,552 bp
  • T to C, chromosome 10 at 5,420,473 bp
  • T to A, chromosome 10 at 56,087,559 bp
  • A to C, chromosome 11 at 36,027,195 bp
  • G to A, chromosome 11 at 84,840,076 bp
  • T to C, chromosome 11 at 102,436,385 bp
  • C to T, chromosome 12 at 114,665,999 bp
  • C to T, chromosome 13 at 36,877,779 bp
  • T to C, chromosome 13 at 49,787,512 bp
  • T to C, chromosome 13 at 100,426,320 bp
  • G to T, chromosome 14 at 29,333,778 bp
  • T to A, chromosome 14 at 34,692,202 bp
  • T to C, chromosome 15 at 9,599,747 bp
  • T to C, chromosome 15 at 36,265,306 bp
  • C to G, chromosome 15 at 81,726,069 bp
  • A to T, chromosome 17 at 24,899,518 bp
  • T to C, chromosome 17 at 29,931,321 bp
  • T to C, chromosome 17 at 30,762,642 bp
  • T to A, chromosome 18 at 58,890,425 bp
  • C to A, chromosome 19 at 4,988,528 bp
  • T to C, chromosome 19 at 6,211,620 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8864 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068680-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.