Strain Name:
C57BL/6J-MtgxR8873Btlr/Mmmh
Stock Number:
068686-MU
Citation ID:
RRID:MMRRC_068686-MU
Other Names:
R8873 (G1)
Major Collection:

Strain Information

Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269400
Homologene: 13168
Fam110b
Name: family with sequence similarity 110, member B
Synonyms: 1700012H17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242297
Homologene: 17518
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Asah2
Name: N-acylsphingosine amidohydrolase 2
Synonyms: neutral/alkaline ceramidase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54447
VEGA: 19
Homologene: 10310
Phf3
Name: PHD finger protein 3
Synonyms: AU020177, 2310061N19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Auts2
Name: autism susceptibility candidate 2
Synonyms: A730011F23Rik, D830032G16Rik, 2700063G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319974
Homologene: 22907
Cstf3
Name: cleavage stimulation factor, 3' pre-RNA, subunit 3
Synonyms: 4732468G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228410
HGNC: HGNC:2485
Homologene: 1014
Skil
Name: SKI-like
Synonyms: SnoN, Skir, sno-dE3, SnoN2, 9130011J04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20482
Homologene: 3948
Arhgap35
Name: Rho GTPase activating protein 35
Synonyms: Grlf1, p190RhoGAP, p190A, P190 RhoGAP, 6430596G11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232906
HGNC: HGNC:4591
Homologene: 35136
Fbxl17
Name: F-box and leucine-rich repeat protein 17
Synonyms: C130023C01Rik, 6330576B01Rik, Fbxo13, Fbx13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50758
Homologene: 79859
Nsmce4a
Name: NSE4 homolog A, SMC5-SMC6 complex component
Synonyms: 2410003A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67872
Homologene: 9745
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Npnt
Name: nephronectin
Synonyms: 1110009H02Rik, POEM
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114249
Homologene: 14138
Ganab
Name: alpha glucosidase 2 alpha neutral subunit
Synonyms: G2an, GluII
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14376
VEGA: 19
HGNC: HGNC:4138
Homologene: 5426
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: LH2, D530025C14Rik, Plod-2, lysyl hydroxylase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Cmip
Name: c-Maf inducing protein
Synonyms: 4933407C03Rik, 5830471E12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74440
Homologene: 18869
Siglecg
Name: sialic acid binding Ig-like lectin G
Synonyms: mSiglec-G, A630096C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243958
Homologene: 13228
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 544678
Homologene: 129584
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Fam124a
Name: family with sequence similarity 124, member A
Synonyms: EG629059
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 629059
Homologene: 86241
Or2t6
Name: olfactory receptor family 2 subfamily T member 6
Synonyms: Olfr720, GA_x6K02T2PLTE-6544896-6543946, MOR274-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258387
Homologene: 74036
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: 9430031G15Rik, LTBP-1, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Fyb2
Name: FYN binding protein 2
Synonyms: 1700024P16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242594
Homologene: 52981
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243083
Homologene: 65356
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), 1700062G21Rik, neurexin I alpha, 9330127H16Rik, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I beta, A230068P09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Fbxw24
Name: F-box and WD-40 domain protein 24
Synonyms: Gm5162
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382106
Homologene: 110776
Asb2
Name: ankyrin repeat and SOCS box-containing 2
Synonyms: 1110008E15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 65256
Homologene: 69202
Pramel15
Name: PRAME like 15
Synonyms: Gm13125, Pramef20, EG627009
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627009
Homologene: 133194
Ehhadh
Name: enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
Synonyms: 1300002P22Rik, HD, L-PBE, L-bifunctional enzyme, MFP1, MFP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74147
HGNC: HGNC:3247
Homologene: 1486
Ndufa4
Name: Ndufa4, mitochondrial complex associated
Synonyms: MLRQ
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17992
HGNC: HGNC:7687
Homologene: 37629
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Hrh4
Name: histamine receptor H4
Synonyms: H4R
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225192
VEGA: 18
Homologene: 11002
Rbm20
Name: RNA binding motif protein 20
Synonyms: 2010003H22Rik, 1110018J23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73713
Homologene: 28386
Serpine2
Name: serine (or cysteine) peptidase inhibitor, clade E, member 2
Synonyms: B230326M24Rik, protease nexin 1, PI7, PN-1, nexin, Spi4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20720
HGNC: HGNC:8951
Homologene: 21247
Recql
Name: RecQ protein-like
Synonyms: RecQ1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19691
HGNC: HGNC:9948
Homologene: 56279
Jazf1
Name: JAZF zinc finger 1
Synonyms: Tip27, Jaz1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231986
Homologene: 18291
Ifi209
Name: interferon activated gene 209
Synonyms: Ifix, Pyhin1, Pyhin-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 236312
HGNC: HGNC:5395
Homologene: 115929
Krtap4-21
Name: keratin associated protein 4-21
Synonyms: Gm11569
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 670472
Homologene: 124486
Abhd15
Name: abhydrolase domain containing 15
Synonyms: 1300007F04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67477
Homologene: 12142
Gm8237
Name: predicted gene 8237
Type: Gene
Species: Mouse
Chromosome: 14
Rps18-ps6
Name: ribosomal protein S18, pseudogene 6
Synonyms: Gm10260
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100039740
VEGA: 13
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Pcdhgb7
Name: protocadherin gamma subfamily B, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93704
HGNC: HGNC:8714
Homologene: 75102
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 30,804,692 bp
  • A to G, chromosome 1 at 79,821,550 bp
  • A to G, chromosome 1 at 173,642,590 bp
  • A to T, chromosome 2 at 104,645,010 bp
  • CAAA to CAA, chromosome 2 at 181,356,023 bp
  • T to C, chromosome 3 at 31,097,926 bp
  • G to A, chromosome 3 at 132,950,055 bp
  • C to T, chromosome 4 at 5,799,103 bp
  • T to C, chromosome 4 at 47,247,552 bp
  • A to T, chromosome 4 at 104,999,341 bp
  • G to T, chromosome 4 at 144,373,301 bp
  • T to C, chromosome 4 at 155,455,008 bp
  • C to T, chromosome 5 at 86,544,874 bp
  • A to G, chromosome 5 at 131,443,664 bp
  • A to G, chromosome 6 at 11,907,361 bp
  • T to A, chromosome 6 at 52,812,180 bp
  • G to T, chromosome 6 at 142,362,287 bp
  • T to C, chromosome 7 at 16,561,490 bp
  • A to G, chromosome 7 at 43,418,024 bp
  • G to T, chromosome 7 at 130,547,156 bp
  • T to C, chromosome 8 at 117,377,190 bp
  • T to A, chromosome 9 at 92,607,059 bp
  • C to A, chromosome 9 at 109,624,928 bp
  • C to A, chromosome 11 at 77,515,751 bp
  • G to T, chromosome 11 at 99,798,384 bp
  • T to A, chromosome 12 at 40,676,768 bp
  • T to C, chromosome 12 at 103,333,466 bp
  • A to T, chromosome 13 at 9,575,146 bp
  • A to G, chromosome 13 at 20,905,682 bp
  • T to A, chromosome 13 at 97,760,335 bp
  • G to T, chromosome 14 at 5,862,453 bp
  • A to T, chromosome 14 at 14,175,344 bp
  • A to G, chromosome 14 at 62,606,575 bp
  • A to G, chromosome 15 at 28,219,188 bp
  • C to T, chromosome 16 at 21,762,848 bp
  • C to T, chromosome 16 at 94,442,983 bp
  • A to G, chromosome 17 at 63,384,976 bp
  • A to G, chromosome 17 at 75,179,177 bp
  • G to T, chromosome 17 at 90,565,393 bp
  • T to A, chromosome 18 at 13,007,138 bp
  • T to C, chromosome 18 at 37,691,288 bp
  • C to T, chromosome 18 at 37,753,522 bp
  • G to A, chromosome 19 at 8,910,879 bp
  • A to T, chromosome 19 at 32,044,888 bp
  • G to T, chromosome 19 at 53,677,480 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8873 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068686-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.