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Strain Name:
C57BL/6J-MtgxR8913Btlr/Mmmh
Stock Number:
068702-MU
Citation ID:
RRID:MMRRC_068702-MU
Other Names:
R8913 (G1)
Major Collection:

Strain Information

Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Zfp207
Name: zinc finger protein 207
Synonyms: Zep, 8430401D15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22680
Homologene: 134624
Fzd8
Name: frizzled class receptor 8
Synonyms: Fz8, mFZ8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14370
VEGA: 18
HGNC: HGNC:4046
Homologene: 40606
Nmt1
Name: N-myristoyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18107
HGNC: HGNC:7857
Homologene: 69027
Nckap1
Name: NCK-associated protein 1
Synonyms: mh19, Hem-2, H19, Nap1, Hem2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 40,543,017 bp
  • A to G, chromosome 1 at 71,264,813 bp
  • C to T, chromosome 1 at 75,491,248 bp
  • A to G, chromosome 1 at 127,822,626 bp
  • T to C, chromosome 1 at 135,963,841 bp
  • T to A, chromosome 1 at 171,574,206 bp
  • A to T, chromosome 1 at 171,574,207 bp
  • A to G, chromosome 1 at 181,725,498 bp
  • C to A, chromosome 2 at 32,387,146 bp
  • A to G, chromosome 2 at 60,257,897 bp
  • G to A, chromosome 2 at 69,833,890 bp
  • A to G, chromosome 2 at 80,571,220 bp
  • A to G, chromosome 2 at 88,909,647 bp
  • T to C, chromosome 2 at 91,501,440 bp
  • A to G, chromosome 2 at 118,713,884 bp
  • A to G, chromosome 2 at 122,799,886 bp
  • A to T, chromosome 2 at 181,585,489 bp
  • T to C, chromosome 3 at 88,058,358 bp
  • A to G, chromosome 3 at 89,945,523 bp
  • A to T, chromosome 3 at 98,161,264 bp
  • A to T, chromosome 3 at 142,244,905 bp
  • A to T, chromosome 3 at 146,002,393 bp
  • T to A, chromosome 4 at 34,769,056 bp
  • A to C, chromosome 4 at 100,407,830 bp
  • C to A, chromosome 4 at 122,867,652 bp
  • C to A, chromosome 4 at 128,523,558 bp
  • C to A, chromosome 5 at 63,806,097 bp
  • G to T, chromosome 5 at 65,028,478 bp
  • T to A, chromosome 6 at 8,215,924 bp
  • T to C, chromosome 6 at 18,054,571 bp
  • C to T, chromosome 6 at 36,741,341 bp
  • A to T, chromosome 6 at 146,626,123 bp
  • T to A, chromosome 6 at 147,022,449 bp
  • G to A, chromosome 7 at 23,753,950 bp
  • A to T, chromosome 7 at 42,136,354 bp
  • G to A, chromosome 7 at 96,702,745 bp
  • GGCG to GGCGACGGCCGCG, chromosome 7 at 97,579,906 bp
  • A to T, chromosome 7 at 108,868,602 bp
  • T to C, chromosome 7 at 108,893,529 bp
  • T to G, chromosome 7 at 121,076,316 bp
  • G to A, chromosome 8 at 13,795,728 bp
  • T to C, chromosome 9 at 119,794,028 bp
  • T to C, chromosome 10 at 39,106,043 bp
  • T to A, chromosome 10 at 105,323,026 bp
  • T to C, chromosome 10 at 127,705,841 bp
  • T to A, chromosome 11 at 80,385,918 bp
  • C to T, chromosome 11 at 80,471,512 bp
  • G to T, chromosome 11 at 102,294,961 bp
  • G to T, chromosome 11 at 103,057,445 bp
  • C to T, chromosome 12 at 91,364,447 bp
  • T to C, chromosome 12 at 100,554,336 bp
  • C to T, chromosome 12 at 104,389,218 bp
  • T to C, chromosome 12 at 110,658,168 bp
  • A to G, chromosome 13 at 21,659,104 bp
  • T to C, chromosome 13 at 92,022,526 bp
  • A to T, chromosome 14 at 27,466,188 bp
  • A to G, chromosome 14 at 55,072,086 bp
  • A to G, chromosome 15 at 4,917,528 bp
  • T to C, chromosome 15 at 76,297,480 bp
  • A to C, chromosome 16 at 72,904,734 bp
  • A to G, chromosome 17 at 20,029,706 bp
  • G to A, chromosome 17 at 24,644,865 bp
  • G to T, chromosome 17 at 32,667,836 bp
  • A to T, chromosome 17 at 38,335,429 bp
  • T to C, chromosome 17 at 44,608,282 bp
  • G to A, chromosome 17 at 46,411,773 bp
  • A to G, chromosome 18 at 9,213,869 bp
  • C to T, chromosome 18 at 61,756,839 bp
  • T to A, chromosome 18 at 84,560,528 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8913 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068702-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.