Strain Name:
C57BL/6J-MtgxR8917Btlr/Mmmh
Stock Number:
068704-MU
Citation ID:
RRID:MMRRC_068704-MU
Other Names:
R8917 (G1)
Major Collection:

Strain Information

Kif3c
Name: kinesin family member 3C
Synonyms: N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16570
VEGA: 12
HGNC: HGNC:6321
Homologene: 55640
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Exoc6
Name: exocyst complex component 6
Synonyms: Sec15l1, msec15, 4833405E05Rik, hbd, Sec15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, pet, hypothroid
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Axin2
Name: axin 2
Synonyms: Conductin, Axil
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12006
HGNC: HGNC:904
Homologene: 3420
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 4632407J06Rik, 2810487N22Rik, B130055D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Tbc1d14
Name: TBC1 domain family, member 14
Synonyms: 2810413P16Rik, D5Ertd110e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100855
Homologene: 10809
Furin
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: Fur, SPC1, PACE, 9130404I01Rik, Pcsk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: D330024H06Rik, A930031B09Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Erh
Name: ERH mRNA splicing and mitosis factor
Synonyms: Prei1, Mer
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13877
HGNC: HGNC:3447
Homologene: 3274
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Ankrd26
Name: ankyrin repeat domain 26
Synonyms: 5730521P14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232339
Homologene: 45968
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 3110031A07Rik, 2410140K03Rik, D5Ertd591e, A630018G05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Klhl26
Name: kelch-like 26
Synonyms: C630013N10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234378
Homologene: 41247
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, 0910001L17Rik, Ugcgl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Rtn3
Name: reticulon 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20168
VEGA: 19
Homologene: 24934
Skor2
Name: SKI family transcriptional corepressor 2
Synonyms: Fussel18, Corl2, Gm7348
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 664805
VEGA: 18
Homologene: 64797
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: Fam75d1c, 4932441B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Ano4
Name: anoctamin 4
Synonyms: Tmem16d, A330096O15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320091
Homologene: 66599
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: Adgrc2, mfmi1, flamingo, EGFL2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Cracdl
Name: capping protein inhibiting regulator of actin like
Synonyms: 2010300C02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72097
Homologene: 19208
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: LOC380660, 8430416H19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380660
Homologene: 11587
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Zxdc
Name: ZXD family zinc finger C
Synonyms: B930086F11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 80292
Homologene: 82340
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap-1, Mtap1, 6330416M19Rik, Mtap1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
2610528J11Rik
Name: RIKEN cDNA 2610528J11 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66451
Homologene: 11971
Myo1a
Name: myosin IA
Synonyms: BBM-I, brush border myosin 1, Myhl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78816
Homologene: 9570
Cts8
Name: cathepsin 8
Synonyms: Epcs70, Epcs68, CTS2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56094
VEGA: 13
Homologene: 129897
Zfp518a
Name: zinc finger protein 518A
Synonyms: 6330417C12Rik, 2810401C22Rik, Zfp518
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Poldip2
Name: polymerase (DNA-directed), delta interacting protein 2
Synonyms: 1300003F06Rik, mitogenin 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67811
Homologene: 9201
Fmo1
Name: flavin containing monooxygenase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14261
HGNC: HGNC:3769
Homologene: 55520
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383258
Homologene: 129687
Tekt3
Name: tektin 3
Synonyms: 4933407G07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71062
Homologene: 12896
Thnsl2
Name: threonine synthase-like 2 (bacterial)
Synonyms: TSH2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232078
Homologene: 5489
Selenov
Name: selenoprotein V
Synonyms: BC089491
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 280621
Homologene: 35357
Or9m1
Name: olfactory receptor family 9 subfamily M member 1
Synonyms: GA_x6K02T2Q125-49403456-49402524, MOR173-2, Olfr1154
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258641
Homologene: 74192
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: 4932701A20Rik, Hyal-ps1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Nherf4
Name: NHERF family PDZ scaffold protein 4
Synonyms: sodium-phosphate cotransporter IIa C-terminal-associated protein 2, NaPi-Cap2, Pdzk2, Pdzd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 170761
VEGA: 9
Homologene: 11719
Mrps22
Name: mitochondrial ribosomal protein S22
Synonyms: 3100002P07Rik, Rpms22
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64655
Homologene: 57030
Pcdhb6
Name: protocadherin beta 6
Synonyms: Pcdhb5B, PcdhbF
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93877
HGNC: HGNC:8690
Homologene: 62177
Kctd15
Name: potassium channel tetramerisation domain containing 15
Synonyms: MGC25497
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233107
Homologene: 11450
Ido1
Name: indoleamine 2,3-dioxygenase 1
Synonyms: Ido, Indo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15930
HGNC: HGNC:6059
Homologene: 48082
Vmn2r-ps158
Name: vomeronasal 2, receptor, pseudogene 158
Synonyms: Gm9268, Vmn2r126
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668612
Homologene: 104832
Coasy
Name: Coenzyme A synthase
Synonyms: Ukr1, Dpck, 1300003G02Rik, Ppat
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71743
Homologene: 11889
Cyp4a30b
Name: cytochrome P450, family 4, subfamily a, polypeptide 30b
Synonyms: OTTMUSG00000008626, Cyp4a30b-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435802
Adam1a
Name: a disintegrin and metallopeptidase domain 1a
Synonyms: Ftna, fertilin alpha, PH-30 alpha
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280668
HGNC: HGNC:187
Homologene: 73803
Ctla2a
Name: cytotoxic T lymphocyte-associated protein 2 alpha
Synonyms: Ctla-2a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13024
VEGA: 13
Homologene: 130627
Lce1k
Name: late cornified envelope 1K
Synonyms: Sprrl6, Gm7055
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 631101
Ankrd31
Name: ankyrin repeat domain 31
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 625662
Homologene: 110355
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,146,654 bp
  • A to G, chromosome 1 at 37,637,912 bp
  • A to T, chromosome 1 at 159,874,122 bp
  • A to G, chromosome 1 at 162,836,204 bp
  • A to T, chromosome 2 at 87,902,963 bp
  • A to G, chromosome 2 at 118,457,136 bp
  • A to G, chromosome 2 at 121,301,310 bp
  • A to G, chromosome 3 at 5,399,099 bp
  • T to A, chromosome 3 at 59,319,467 bp
  • T to C, chromosome 3 at 87,810,969 bp
  • C to A, chromosome 3 at 92,806,790 bp
  • A to T, chromosome 3 at 108,396,566 bp
  • G to A, chromosome 4 at 101,911,738 bp
  • C to A, chromosome 4 at 115,454,465 bp
  • A to G, chromosome 4 at 118,529,293 bp
  • A to T, chromosome 5 at 36,519,338 bp
  • C to T, chromosome 5 at 121,519,082 bp
  • T to C, chromosome 5 at 143,715,940 bp
  • T to C, chromosome 6 at 24,734,104 bp
  • T to C, chromosome 6 at 71,139,943 bp
  • A to G, chromosome 6 at 90,382,323 bp
  • G to T, chromosome 6 at 118,558,941 bp
  • A to G, chromosome 7 at 28,288,303 bp
  • A to G, chromosome 7 at 34,642,083 bp
  • T to C, chromosome 7 at 43,048,009 bp
  • T to C, chromosome 7 at 80,398,689 bp
  • T to C, chromosome 7 at 128,698,557 bp
  • T to C, chromosome 8 at 3,517,637 bp
  • T to C, chromosome 8 at 24,591,507 bp
  • T to A, chromosome 8 at 69,817,778 bp
  • T to C, chromosome 8 at 70,452,805 bp
  • T to C, chromosome 9 at 27,088,001 bp
  • T to A, chromosome 9 at 44,248,844 bp
  • A to G, chromosome 9 at 98,594,110 bp
  • A to G, chromosome 10 at 88,952,298 bp
  • T to C, chromosome 10 at 106,937,263 bp
  • C to T, chromosome 10 at 127,715,665 bp
  • C to T, chromosome 11 at 54,691,566 bp
  • A to T, chromosome 11 at 63,087,226 bp
  • G to A, chromosome 11 at 78,521,841 bp
  • A to G, chromosome 11 at 101,083,376 bp
  • A to T, chromosome 11 at 108,931,515 bp
  • T to A, chromosome 12 at 3,366,690 bp
  • G to T, chromosome 12 at 80,637,508 bp
  • T to A, chromosome 12 at 91,502,055 bp
  • A to T, chromosome 13 at 60,936,040 bp
  • A to T, chromosome 13 at 61,249,068 bp
  • C to T, chromosome 13 at 65,035,615 bp
  • G to A, chromosome 13 at 96,832,704 bp
  • T to A, chromosome 15 at 44,533,007 bp
  • T to C, chromosome 15 at 66,773,483 bp
  • C to A, chromosome 16 at 17,312,446 bp
  • T to C, chromosome 17 at 55,610,216 bp
  • A to G, chromosome 18 at 37,335,378 bp
  • G to A, chromosome 18 at 76,860,809 bp
  • A to T, chromosome 19 at 7,456,740 bp
  • G to T, chromosome 19 at 25,409,564 bp
  • A to G, chromosome 19 at 37,589,912 bp
  • A to C, chromosome 19 at 40,913,426 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8917 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068704-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.