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Strain Name:
C57BL/6J-MtgxR8917Btlr/Mmmh
Stock Number:
068704-MU
Citation ID:
RRID:MMRRC_068704-MU
Other Names:
R8917 (G1)
Major Collection:

Strain Information

Kif3c
Name: kinesin family member 3C
Synonyms: N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16570
VEGA: 12
HGNC: HGNC:6321
Homologene: 55640
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Exoc6
Name: exocyst complex component 6
Synonyms: msec15, 4833405E05Rik, Sec15, Sec15l1, hbd
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,146,654 bp
  • A to G, chromosome 1 at 37,637,912 bp
  • A to T, chromosome 1 at 159,874,122 bp
  • A to G, chromosome 1 at 162,836,204 bp
  • A to T, chromosome 2 at 87,902,963 bp
  • A to G, chromosome 2 at 118,457,136 bp
  • A to G, chromosome 2 at 121,301,310 bp
  • A to G, chromosome 3 at 5,399,099 bp
  • T to A, chromosome 3 at 59,319,467 bp
  • T to C, chromosome 3 at 87,810,969 bp
  • C to A, chromosome 3 at 92,806,790 bp
  • A to T, chromosome 3 at 108,396,566 bp
  • G to A, chromosome 4 at 101,911,738 bp
  • C to A, chromosome 4 at 115,454,465 bp
  • A to G, chromosome 4 at 118,529,293 bp
  • A to T, chromosome 5 at 36,519,338 bp
  • C to T, chromosome 5 at 121,519,082 bp
  • T to C, chromosome 5 at 143,715,940 bp
  • T to C, chromosome 6 at 24,734,104 bp
  • T to C, chromosome 6 at 71,139,943 bp
  • A to G, chromosome 6 at 90,382,323 bp
  • G to T, chromosome 6 at 118,558,941 bp
  • A to G, chromosome 7 at 28,288,303 bp
  • A to G, chromosome 7 at 34,642,083 bp
  • T to C, chromosome 7 at 43,048,009 bp
  • T to C, chromosome 7 at 80,398,689 bp
  • T to C, chromosome 7 at 128,698,557 bp
  • T to C, chromosome 8 at 3,517,637 bp
  • T to C, chromosome 8 at 24,591,507 bp
  • T to A, chromosome 8 at 69,817,778 bp
  • T to C, chromosome 8 at 70,452,805 bp
  • T to C, chromosome 9 at 27,088,001 bp
  • T to A, chromosome 9 at 44,248,844 bp
  • A to G, chromosome 9 at 98,594,110 bp
  • A to G, chromosome 10 at 88,952,298 bp
  • T to C, chromosome 10 at 106,937,263 bp
  • C to T, chromosome 10 at 127,715,665 bp
  • C to T, chromosome 11 at 54,691,566 bp
  • A to T, chromosome 11 at 63,087,226 bp
  • G to A, chromosome 11 at 78,521,841 bp
  • A to G, chromosome 11 at 101,083,376 bp
  • A to T, chromosome 11 at 108,931,515 bp
  • T to A, chromosome 12 at 3,366,690 bp
  • G to T, chromosome 12 at 80,637,508 bp
  • T to A, chromosome 12 at 91,502,055 bp
  • A to T, chromosome 13 at 60,936,040 bp
  • A to T, chromosome 13 at 61,249,068 bp
  • C to T, chromosome 13 at 65,035,615 bp
  • G to A, chromosome 13 at 96,832,704 bp
  • T to A, chromosome 15 at 44,533,007 bp
  • T to C, chromosome 15 at 66,773,483 bp
  • C to A, chromosome 16 at 17,312,446 bp
  • T to C, chromosome 17 at 55,610,216 bp
  • A to G, chromosome 18 at 37,335,378 bp
  • G to A, chromosome 18 at 76,860,809 bp
  • A to T, chromosome 19 at 7,456,740 bp
  • G to T, chromosome 19 at 25,409,564 bp
  • A to G, chromosome 19 at 37,589,912 bp
  • A to C, chromosome 19 at 40,913,426 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8917 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068704-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.