Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8825Btlr/Mmmh
Stock Number:
068728-MU
Citation ID:
RRID:MMRRC_068728-MU
Other Names:
R8825 (G1)
Major Collection:

Strain Information

Gsta4
Name: glutathione S-transferase, alpha 4
Synonyms: GST 5.7, mGsta4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14860
VEGA: 9
Homologene: 135605
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Par-1, Emk
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Arfgap2
Name: ARF GTPase activating protein 2
Synonyms: 2310032E02Rik, Zfp289
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77038
Homologene: 8735
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Cdkal1
Name: CDK5 regulatory subunit associated protein 1-like 1
Synonyms: 6620401C13Rik, 1190005B03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68916
Homologene: 9830
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Miga1
Name: mitoguardin 1
Synonyms: C030011O14Rik, Mita1, Fam73a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 215708
Homologene: 18369
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, rjs, D7H15F37S1, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Depdc1b
Name: DEP domain containing 1B
Synonyms: XTP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218581
Homologene: 10157
Hip1
Name: huntingtin interacting protein 1
Synonyms: 2610109B09Rik, A930014B11Rik, E130315I21Rik, HIP-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Lamb2
Name: laminin, beta 2
Synonyms: Lamb-2, Lams, npht
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Lgals3
Name: lectin, galactose binding, soluble 3
Synonyms: Mac-2, galectin-3, L-34, gal3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16854
HGNC: HGNC:6563
Homologene: 37608
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Itih5
Name: inter-alpha-trypsin inhibitor, heavy chain 5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209378
Homologene: 57115
Htt
Name: huntingtin
Synonyms: huntingtin, HD, htt, IT15, C430023I11Rik, Hdh
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, PM-Scl, RRP6, p4, p3, p2, Pmscl2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Crtc2
Name: CREB regulated transcription coactivator 2
Synonyms: 4632407F12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74343
Homologene: 18765
Zng1
Name: Zn regulated GTPase metalloprotein activator 1
Synonyms: Zng1, Cbwd1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226043
VEGA: 19
Homologene: 6843
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Prkg2
Name: protein kinase, cGMP-dependent, type II
Synonyms: cGK-II, Prkgr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19092
HGNC: HGNC:9416
Homologene: 4556
Unc13b
Name: unc-13 homolog B
Synonyms: Unc13h2, Munc13-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Clcn3
Name: chloride channel, voltage-sensitive 3
Synonyms: Clc3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12725
HGNC: HGNC:2021
Homologene: 20435
Slc6a18
Name: solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms: XT2, D630001K16Rik, Xtrp2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22598
VEGA: 13
Homologene: 40785
Ints11
Name: integrator complex subunit 11
Synonyms: 2410006F12Rik, Cpsf3l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71957
Homologene: 9894
Dgkg
Name: diacylglycerol kinase, gamma
Synonyms: Dagk3, E430001K23Rik, 2900055E17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110197
HGNC: HGNC:2853
Homologene: 1029
Ufm1
Name: ubiquitin-fold modifier 1
Synonyms: 1810045K17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67890
Homologene: 9594
Ces2g
Name: carboxylesterase 2G
Synonyms: 2210023G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72361
HGNC: HGNC:1864
Homologene: 77154
Trpm5
Name: transient receptor potential cation channel, subfamily M, member 5
Synonyms: Mtr1, Ltrpc5, 9430099A16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56843
Homologene: 22818
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238455
Homologene: 18813
Ppic
Name: peptidylprolyl isomerase C
Synonyms: cyclophilin C, CyP-20c
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19038
VEGA: 18
HGNC: HGNC:9256
Homologene: 727
Or2ag19
Name: olfactory receptor family 2 subfamily AG member 19
Synonyms: GA_x6K02T2PBJ9-9222217-9223176, MOR283-7, Olfr703
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258589
Vmn2r77
Name: vomeronasal 2, receptor 77
Synonyms: EG546983
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546983
Homologene: 115466
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Rpt-1, Rpt1, Trim30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20128
Homologene: 114426
Golgb1
Name: golgin B1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Bpi
Name: bactericidal permeablility increasing protein
Synonyms: 9230105K17Rik, Bpifd1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329547
HGNC: HGNC:1095
Homologene: 37519
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Stat2
Name: signal transducer and activator of transcription 2
Synonyms: 1600010G07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20847
VEGA: 10
Homologene: 3952
Or8g4
Name: olfactory receptor family 8 subfamily G member 4
Synonyms: GA_x6K02T2PVTD-33447884-33448816, MOR171-30P, Olfr967
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258086
VEGA: 9
HGNC: HGNC:8484
Homologene: 115535
Obox3
Name: oocyte specific homeobox 3
Synonyms: Ohx
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246791
Homologene: 44937
Med10
Name: mediator complex subunit 10
Synonyms: D13Wsu50e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 28077
VEGA: 13
Homologene: 44533
Sema5a
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms: M-Sema D, semF, Semaf, 9130201M22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20356
VEGA: 15
Homologene: 2949
Nipal4
Name: NIPA-like domain containing 4
Synonyms: 9530066K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214112
Homologene: 133769
Cactin
Name: cactin, spliceosome C complex subunit
Synonyms: 2510012J08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70312
VEGA: 10
Homologene: 69553
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
A430078G23Rik
Name: RIKEN cDNA A430078G23 gene
Type: Gene
Species: Mouse
Chromosome: 8
Rnf148
Name: ring finger protein 148
Synonyms: Greul3, 4933432M07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71300
Homologene: 82404
Cd200
Name: CD200 molecule
Synonyms: MRC OX-2, OX2, Mox2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17470
HGNC: HGNC:7203
Homologene: 4344
Fem1al
Name: fem-1 homolog A like
Synonyms: 4931440F15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216622
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74419
Homologene: 69456
Trcg1
Name: taste receptor cell gene 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 541610
Homologene: 134171
Mcat
Name: malonyl CoA:ACP acyltransferase (mitochondrial)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223722
VEGA: 15
Homologene: 15511
Mad2l2
Name: MAD2 mitotic arrest deficient-like 2
Synonyms: MAD2B, REV7, 2310033C13Rik, G1-453-4, repro22
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71890
HGNC: HGNC:6764
Homologene: 4624
Prl2c2
Name: prolactin family 2, subfamily c, member 2
Synonyms: MRP-1, PLF-1, Plf, Plf1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18811
VEGA: 13
Homologene: 40763
Tgfb2
Name: transforming growth factor, beta 2
Synonyms: Tgf-beta2, Tgfb-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21808
Homologene: 2432
Erfl
Name: ETS repressor factor like
Synonyms: Gm4881
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232974
Homologene: 15125
Tcf24
Name: transcription factor 24
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100039596
Homologene: 100093
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 9,960,999 bp
  • T to A, chromosome 1 at 186,628,939 bp
  • A to G, chromosome 2 at 10,190,420 bp
  • A to G, chromosome 2 at 26,423,574 bp
  • T to A, chromosome 2 at 91,273,561 bp
  • A to G, chromosome 2 at 158,267,750 bp
  • T to C, chromosome 2 at 168,951,632 bp
  • T to A, chromosome 3 at 53,863,672 bp
  • T to A, chromosome 3 at 90,259,156 bp
  • A to T, chromosome 3 at 152,276,823 bp
  • T to A, chromosome 4 at 43,237,683 bp
  • T to C, chromosome 4 at 148,140,820 bp
  • G to A, chromosome 4 at 148,568,702 bp
  • T to A, chromosome 4 at 155,885,130 bp
  • T to C, chromosome 5 at 34,825,960 bp
  • T to C, chromosome 5 at 98,942,184 bp
  • T to C, chromosome 5 at 109,339,153 bp
  • T to G, chromosome 5 at 109,678,880 bp
  • C to T, chromosome 5 at 135,422,122 bp
  • G to C, chromosome 6 at 23,654,379 bp
  • A to T, chromosome 7 at 15,627,301 bp
  • A to G, chromosome 7 at 24,929,257 bp
  • T to A, chromosome 7 at 56,050,878 bp
  • A to T, chromosome 7 at 86,803,647 bp
  • T to A, chromosome 7 at 104,411,322 bp
  • T to A, chromosome 7 at 105,693,967 bp
  • A to T, chromosome 7 at 106,845,429 bp
  • T to C, chromosome 7 at 143,083,016 bp
  • T to A, chromosome 8 at 3,386,951 bp
  • A to T, chromosome 8 at 60,929,488 bp
  • A to C, chromosome 8 at 66,513,667 bp
  • C to T, chromosome 8 at 104,967,322 bp
  • T to C, chromosome 9 at 39,750,698 bp
  • A to G, chromosome 9 at 57,241,471 bp
  • T to G, chromosome 9 at 78,208,839 bp
  • C to T, chromosome 9 at 108,485,261 bp
  • A to G, chromosome 10 at 81,325,658 bp
  • A to T, chromosome 10 at 123,013,871 bp
  • T to A, chromosome 10 at 128,291,364 bp
  • T to C, chromosome 11 at 29,823,696 bp
  • T to C, chromosome 11 at 46,162,046 bp
  • A to G, chromosome 11 at 115,797,375 bp
  • T to A, chromosome 12 at 119,445,852 bp
  • T to A, chromosome 13 at 13,005,071 bp
  • C to T, chromosome 13 at 29,354,794 bp
  • T to G, chromosome 13 at 69,813,927 bp
  • C to A, chromosome 13 at 73,665,632 bp
  • T to G, chromosome 13 at 108,384,782 bp
  • G to T, chromosome 14 at 7,887,566 bp
  • T to A, chromosome 14 at 47,380,100 bp
  • C to A, chromosome 14 at 103,229,435 bp
  • T to C, chromosome 15 at 4,731,688 bp
  • T to G, chromosome 15 at 32,689,352 bp
  • T to C, chromosome 15 at 83,552,611 bp
  • T to A, chromosome 16 at 22,562,769 bp
  • A to G, chromosome 16 at 36,919,447 bp
  • G to A, chromosome 16 at 45,394,794 bp
  • T to A, chromosome 17 at 74,613,505 bp
  • A to T, chromosome 18 at 3,268,061 bp
  • A to G, chromosome 18 at 53,409,150 bp
  • T to C, chromosome 18 at 74,759,098 bp
  • T to C, chromosome 19 at 7,341,206 bp
  • A to G, chromosome 19 at 24,949,237 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8825 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068728-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.