Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8872Btlr/Mmmh
Stock Number:
068743-MU
Citation ID:
RRID:MMRRC_068743-MU
Other Names:
R8872 (G1)
Major Collection:

Strain Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Gfap
Name: glial fibrillary acidic protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14580
HGNC: HGNC:4235
Homologene: 1554
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Nos2
Name: nitric oxide synthase 2, inducible
Synonyms: iNOS, Nos-2, NOS-II, Nos2a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18126
HGNC: HGNC:7873
Homologene: 55473
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Crlf3
Name: cytokine receptor-like factor 3
Synonyms: cytor4, Creme9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54394
Homologene: 9327
Lrrfip2
Name: leucine rich repeat (in FLII) interacting protein 2
Synonyms: 5133400F20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71268
HGNC: HGNC:6703
Homologene: 22476
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 87,380,003 bp
  • T to C, chromosome 1 at 162,647,444 bp
  • T to A, chromosome 2 at 37,436,901 bp
  • C to T, chromosome 2 at 73,367,592 bp
  • T to A, chromosome 2 at 76,788,403 bp
  • T to C, chromosome 2 at 125,752,972 bp
  • T to C, chromosome 2 at 129,115,693 bp
  • T to A, chromosome 2 at 132,849,899 bp
  • T to A, chromosome 3 at 82,108,742 bp
  • T to C, chromosome 3 at 84,594,240 bp
  • A to G, chromosome 3 at 100,963,328 bp
  • A to T, chromosome 3 at 115,946,668 bp
  • T to A, chromosome 3 at 123,354,936 bp
  • C to T, chromosome 3 at 126,997,876 bp
  • T to C, chromosome 4 at 125,126,619 bp
  • A to T, chromosome 4 at 138,578,645 bp
  • A to G, chromosome 5 at 87,887,938 bp
  • A to T, chromosome 5 at 108,099,185 bp
  • G to T, chromosome 5 at 143,202,060 bp
  • G to A, chromosome 6 at 112,380,995 bp
  • A to T, chromosome 6 at 113,704,209 bp
  • A to C, chromosome 6 at 120,388,140 bp
  • A to G, chromosome 7 at 5,053,217 bp
  • A to G, chromosome 7 at 29,139,096 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • T to C, chromosome 7 at 120,133,802 bp
  • A to C, chromosome 7 at 126,591,022 bp
  • C to T, chromosome 8 at 94,386,585 bp
  • T to A, chromosome 8 at 111,057,152 bp
  • A to T, chromosome 8 at 112,859,127 bp
  • A to G, chromosome 9 at 13,826,684 bp
  • A to T, chromosome 9 at 20,499,979 bp
  • A to G, chromosome 9 at 50,703,153 bp
  • A to G, chromosome 9 at 111,205,756 bp
  • T to C, chromosome 10 at 61,626,015 bp
  • A to T, chromosome 10 at 82,292,785 bp
  • A to T, chromosome 10 at 88,466,526 bp
  • T to A, chromosome 10 at 102,388,285 bp
  • A to T, chromosome 10 at 128,204,666 bp
  • A to G, chromosome 11 at 29,708,633 bp
  • T to G, chromosome 11 at 74,269,294 bp
  • T to A, chromosome 11 at 78,949,123 bp
  • T to C, chromosome 11 at 80,047,614 bp
  • A to T, chromosome 11 at 97,032,135 bp
  • T to A, chromosome 11 at 102,895,794 bp
  • T to G, chromosome 11 at 104,870,054 bp
  • C to A, chromosome 11 at 106,261,920 bp
  • A to G, chromosome 12 at 76,612,039 bp
  • A to G, chromosome 13 at 27,162,341 bp
  • T to A, chromosome 13 at 30,226,414 bp
  • T to C, chromosome 13 at 44,902,508 bp
  • T to C, chromosome 13 at 49,057,484 bp
  • C to T, chromosome 13 at 50,432,264 bp
  • T to C, chromosome 13 at 55,348,384 bp
  • A to G, chromosome 13 at 67,541,795 bp
  • T to C, chromosome 13 at 76,185,207 bp
  • A to G, chromosome 14 at 52,174,087 bp
  • G to T, chromosome 14 at 80,021,503 bp
  • T to A, chromosome 14 at 103,688,405 bp
  • T to C, chromosome 15 at 39,105,944 bp
  • A to G, chromosome 15 at 80,918,089 bp
  • T to A, chromosome 15 at 99,711,094 bp
  • C to A, chromosome 16 at 17,652,741 bp
  • C to A, chromosome 16 at 18,426,489 bp
  • A to T, chromosome 17 at 20,268,139 bp
  • T to A, chromosome 17 at 36,165,401 bp
  • A to G, chromosome 17 at 48,090,644 bp
  • C to T, chromosome 17 at 49,071,249 bp
  • A to T, chromosome 18 at 10,529,684 bp
  • T to C, chromosome 18 at 19,989,622 bp
  • A to T, chromosome 18 at 65,280,906 bp
  • A to G, chromosome 19 at 8,160,567 bp
  • T to C, chromosome 19 at 11,552,887 bp
  • T to C, chromosome 19 at 56,320,195 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8872 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068743-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.