Strain Name:
C57BL/6J-MtgxR8877Btlr/Mmmh
Stock Number:
068745-MU
Citation ID:
RRID:MMRRC_068745-MU
Other Names:
R8877 (G1)
Major Collection:

Strain Information

Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Zfp704
Name: zinc finger protein 704
Synonyms: Gig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170753
Homologene: 64370
Hira
Name: histone cell cycle regulator
Synonyms: Gm15797, Tuple1, D16Ertd95e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: 3010002K18Rik, Qprs, 2410081F06Rik, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Cep104
Name: centrosomal protein 104
Synonyms: BC046331
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230967
Homologene: 44919
Larp4b
Name: La ribonucleoprotein 4B
Synonyms: Larp5, D13Wsu64e, A130023E24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217980
Homologene: 18195
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 9230102M16Rik, 4633402D15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70829
Homologene: 10393
Zfp462
Name: zinc finger protein 462
Synonyms: 9430078C22Rik, Gt4-2, Zfpip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242466
Homologene: 41430
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Ddit3
Name: DNA-damage inducible transcript 3
Synonyms: CHOP10, gadd153, CHOP-10, chop, C/EBP homoologous protein 10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13198
HGNC: HGNC:2726
Homologene: 3012
Armt1
Name: acidic residue methyltransferase 1
Synonyms: 1700052N19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73419
Homologene: 41557
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Anxa7
Name: annexin A7
Synonyms: synexin, Anx7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11750
VEGA: 14
HGNC: HGNC:545
Homologene: 36149
Kif13a
Name: kinesin family member 13A
Synonyms: 4930505I07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Stx4a
Name: syntaxin 4A (placental)
Synonyms: Stx4, Syn4, Syn-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20909
Homologene: 105435
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, A630028O16Rik, LOC380767
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Esco1
Name: establishment of sister chromatid cohesion N-acetyltransferase 1
Synonyms: A930014I12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77805
Homologene: 62166
Arid3b
Name: AT-rich interaction domain 3B
Synonyms: Bdp, Dri2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56380
Homologene: 4721
Gin1
Name: gypsy retrotransposon integrase 1
Synonyms: 4930429M06Rik, 4930429M06, Zh2c2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 252876
Homologene: 69238
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: 3110009N10Rik, BACH1, 8030460J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237911
Homologene: 32766
Mavs
Name: mitochondrial antiviral signaling protein
Synonyms: IPS-1, D430028G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228607
Homologene: 17004
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Mep1b
Name: meprin 1 beta
Synonyms: Mep-1b, meprin beta
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Mttp
Name: microsomal triglyceride transfer protein
Synonyms: MTP, 1810043K16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17777
HGNC: HGNC:7467
Homologene: 212
2900092C05Rik
Name: RIKEN cDNA 2900092C05 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73090
Homologene: 49900
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Tpo
Name: thyroid peroxidase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22018
Homologene: 461
Or10ak12
Name: olfactory receptor family 10 subfamily AK member 12
Synonyms: GA_x6K02T2QD9B-18726774-18727577, MOR259-5, Olfr1335, MOR259-12, GA_x6K02T2QD9B-18723799-18724749, Olfr1334-ps1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435804
Homologene: 138635
Nsun7
Name: NOL1/NOP2/Sun domain family, member 7
Synonyms: 4921525L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70918
Homologene: 11653
Gid8
Name: GID complex subunit 8
Synonyms: 2310003C23Rik, 4833420G11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76425
Homologene: 41207
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Smarcd3
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Synonyms: BAF60C, 2210409C08Rik, 1500001J14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66993
Homologene: 2314
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207607
Homologene: 27890
Pip5kl1
Name: phosphatidylinositol-4-phosphate 5-kinase-like 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227733
Homologene: 45457
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 435845
Homologene: 78847
Col17a1
Name: collagen, type XVII, alpha 1
Synonyms: Bpag, BP180, BPAg2, Bpag2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12821
HGNC: HGNC:2194
Homologene: 7276
Psg26
Name: pregnancy-specific beta-1-glycoprotein 26
Synonyms: cea14, EG574429
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 574429
Homologene: 110989
Or5w11
Name: olfactory receptor family 5 subfamily W member 11
Synonyms: MOR177-4, Olfr1131, GA_x6K02T2Q125-49133664-49134593
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258652
Homologene: 133019
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98733
Khnyn
Name: KH and NYN domain containing
Synonyms: 9130227C08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219094
VEGA: 14
Homologene: 23611
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4631426G04Rik, 4833425H18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78751
Homologene: 35328
Lhfpl6
Name: LHFPL tetraspan subfamily member 6
Synonyms: 2810489O06Rik, Lhfp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 108927
HGNC: HGNC:6586
Homologene: 4223
Adamts8
Name: ADAM metallopeptidase with thrombospondin type 1 motif 8
Synonyms: METH-2, METH2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30806
HGNC: HGNC:224
Homologene: 5108
Acp2
Name: acid phosphatase 2, lysosomal
Synonyms: Acp-2, LAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11432
HGNC: HGNC:123
Homologene: 1217
Cpa2
Name: carboxypeptidase A2, pancreatic
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232680
HGNC: HGNC:2297
Homologene: 37541
Creg2
Name: cellular repressor of E1A-stimulated genes 2
Synonyms: A830098L22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 263764
Homologene: 17827
Msantd5f6
Name: Myb/SANT DNA binding domain containing 5 family member 6
Synonyms: Gm11487
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433719
Homologene: 128423
Grin2d
Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Synonyms: NMDAR2D, GluRepsilon4, GluN2D, NR2D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14814
HGNC: HGNC:4588
Homologene: 648
Plekhg2
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Synonyms: Clg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101497
Homologene: 16341
Phc3
Name: polyhomeotic 3
Synonyms: EDR3, HPH3, E030046K01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241915
Homologene: 69390
Gsto2
Name: glutathione S-transferase omega 2
Synonyms: 1700020F09Rik, 4930425C18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68214
Homologene: 57057
Zfp51
Name: zinc finger protein 51
Synonyms: Zfp-51, zfec12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22709
VEGA: 17
Homologene: 134003
Gja10
Name: gap junction protein, alpha 10
Synonyms: Cx59, connexin-57, Cx-57, Cx57
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14610
Homologene: 7733
Slc11a1
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Nramp1, Lsh, Ity1, Ity, Nramp, host resistance locus Bcg/Ity/Lsh, Bcg, ity
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18173
Homologene: 73884
Larp6
Name: La ribonucleoprotein 6, translational regulator
Synonyms: acheron, Achn, 5430431G03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67557
Homologene: 32408
Trbv14
Name: T cell receptor beta, variable 14
Synonyms: Gm16910, BV13S1, Tcrb-V13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124678
Trav13-4-dv7
Name: T cell receptor alpha variable 13-4-DV7
Synonyms: Gm13934
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100113412
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 39,650,693 bp
  • T to C, chromosome 1 at 66,527,985 bp
  • A to G, chromosome 1 at 74,380,265 bp
  • G to A, chromosome 1 at 75,496,523 bp
  • A to G, chromosome 1 at 97,783,216 bp
  • A to T, chromosome 1 at 121,476,138 bp
  • G to A, chromosome 1 at 150,638,908 bp
  • C to T, chromosome 1 at 185,415,874 bp
  • T to C, chromosome 2 at 32,578,939 bp
  • T to C, chromosome 2 at 87,628,868 bp
  • G to A, chromosome 2 at 91,205,784 bp
  • T to A, chromosome 2 at 129,014,399 bp
  • A to G, chromosome 2 at 131,245,569 bp
  • C to T, chromosome 2 at 180,716,917 bp
  • C to T, chromosome 3 at 9,609,356 bp
  • C to T, chromosome 3 at 30,914,122 bp
  • A to G, chromosome 3 at 53,043,553 bp
  • A to T, chromosome 3 at 138,112,556 bp
  • G to A, chromosome 4 at 32,602,441 bp
  • T to C, chromosome 4 at 55,011,097 bp
  • T to A, chromosome 4 at 73,404,231 bp
  • A to G, chromosome 4 at 118,809,285 bp
  • G to T, chromosome 4 at 141,471,826 bp
  • T to A, chromosome 4 at 153,993,528 bp
  • A to G, chromosome 5 at 24,593,992 bp
  • A to T, chromosome 5 at 66,295,951 bp
  • G to A, chromosome 5 at 86,237,681 bp
  • T to C, chromosome 6 at 30,541,693 bp
  • G to A, chromosome 6 at 41,135,358 bp
  • T to A, chromosome 7 at 12,554,777 bp
  • C to T, chromosome 7 at 18,483,940 bp
  • G to T, chromosome 7 at 28,360,853 bp
  • T to C, chromosome 7 at 45,854,275 bp
  • T to A, chromosome 7 at 127,848,461 bp
  • T to C, chromosome 9 at 30,951,392 bp
  • T to C, chromosome 9 at 57,833,621 bp
  • T to A, chromosome 9 at 60,737,567 bp
  • A to G, chromosome 9 at 108,829,678 bp
  • G to A, chromosome 9 at 110,630,243 bp
  • A to G, chromosome 10 at 4,450,864 bp
  • T to C, chromosome 10 at 127,296,015 bp
  • A to C, chromosome 11 at 86,152,706 bp
  • C to T, chromosome 11 at 119,263,166 bp
  • T to A, chromosome 12 at 30,092,739 bp
  • T to C, chromosome 12 at 79,287,378 bp
  • T to C, chromosome 13 at 9,143,799 bp
  • T to A, chromosome 13 at 46,801,445 bp
  • A to G, chromosome 14 at 20,467,480 bp
  • C to A, chromosome 14 at 53,757,893 bp
  • T to C, chromosome 14 at 55,894,325 bp
  • T to A, chromosome 16 at 18,952,104 bp
  • T to C, chromosome 17 at 6,037,666 bp
  • T to C, chromosome 17 at 21,461,755 bp
  • A to G, chromosome 18 at 10,575,017 bp
  • T to A, chromosome 18 at 21,088,573 bp
  • A to G, chromosome 18 at 49,878,225 bp
  • C to T, chromosome 19 at 47,648,758 bp
  • C to A, chromosome 19 at 47,884,737 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8877 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068745-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.