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Strain Name:
C57BL/6J-MtgxR8905Btlr/Mmmh
Stock Number:
068762-MU
Citation ID:
RRID:MMRRC_068762-MU
Other Names:
R8905 (G1)
Major Collection:

Strain Information

Nlgn3
Name: neuroligin 3
Synonyms: HNL3, A230085M13Rik, NL3, NLG3
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 245537
Homologene: 23133
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Zfp930
Name: zinc finger protein 930
Synonyms: zinc finger protein, D10627
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234358
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Smg7
Name: SMG7 nonsense mediated mRNA decay factor
Synonyms: 9430023P16Rik, Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226517
Homologene: 32235
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 26,682,814 bp
  • A to C, chromosome 1 at 46,253,374 bp
  • A to G, chromosome 1 at 87,709,626 bp
  • A to G, chromosome 1 at 93,629,207 bp
  • A to T, chromosome 1 at 97,125,666 bp
  • A to T, chromosome 1 at 140,507,729 bp
  • T to A, chromosome 1 at 152,840,066 bp
  • A to G, chromosome 1 at 162,537,278 bp
  • A to G, chromosome 2 at 14,044,950 bp
  • T to A, chromosome 2 at 37,436,915 bp
  • A to G, chromosome 2 at 69,781,760 bp
  • A to T, chromosome 2 at 89,296,457 bp
  • A to G, chromosome 2 at 131,282,726 bp
  • A to T, chromosome 2 at 156,128,583 bp
  • A to G, chromosome 2 at 167,511,214 bp
  • T to C, chromosome 3 at 19,579,020 bp
  • T to C, chromosome 3 at 32,881,423 bp
  • T to A, chromosome 3 at 59,217,576 bp
  • T to A, chromosome 3 at 64,259,274 bp
  • T to C, chromosome 3 at 84,965,327 bp
  • A to G, chromosome 4 at 6,424,951 bp
  • T to A, chromosome 4 at 20,028,435 bp
  • A to G, chromosome 4 at 21,982,398 bp
  • A to T, chromosome 4 at 98,497,175 bp
  • T to C, chromosome 4 at 137,455,242 bp
  • T to C, chromosome 4 at 148,620,636 bp
  • T to C, chromosome 5 at 31,204,093 bp
  • A to T, chromosome 5 at 74,595,963 bp
  • C to T, chromosome 5 at 113,273,629 bp
  • A to G, chromosome 5 at 130,248,284 bp
  • T to C, chromosome 5 at 136,912,891 bp
  • T to A, chromosome 6 at 68,271,086 bp
  • T to A, chromosome 6 at 90,612,141 bp
  • T to A, chromosome 7 at 28,086,509 bp
  • C to T, chromosome 7 at 75,117,711 bp
  • T to C, chromosome 7 at 100,424,925 bp
  • A to T, chromosome 7 at 120,361,548 bp
  • T to C, chromosome 7 at 127,866,426 bp
  • T to C, chromosome 7 at 139,875,847 bp
  • C to T, chromosome 7 at 141,693,400 bp
  • A to G, chromosome 7 at 143,586,459 bp
  • A to G, chromosome 8 at 69,228,699 bp
  • A to T, chromosome 8 at 80,713,948 bp
  • T to C, chromosome 8 at 111,158,036 bp
  • A to G, chromosome 9 at 18,988,198 bp
  • A to G, chromosome 9 at 23,406,786 bp
  • T to A, chromosome 9 at 57,445,386 bp
  • C to T, chromosome 9 at 108,841,302 bp
  • T to C, chromosome 10 at 80,019,736 bp
  • A to T, chromosome 10 at 115,423,478 bp
  • T to G, chromosome 11 at 6,396,840 bp
  • T to C, chromosome 11 at 42,147,225 bp
  • A to G, chromosome 11 at 59,069,958 bp
  • T to G, chromosome 11 at 87,731,125 bp
  • T to C, chromosome 12 at 65,133,627 bp
  • T to A, chromosome 12 at 72,619,657 bp
  • A to G, chromosome 13 at 15,726,531 bp
  • T to A, chromosome 13 at 54,092,414 bp
  • A to G, chromosome 13 at 92,357,959 bp
  • A to G, chromosome 13 at 95,046,485 bp
  • A to T, chromosome 13 at 118,386,943 bp
  • T to C, chromosome 15 at 82,390,901 bp
  • A to T, chromosome 15 at 85,904,068 bp
  • A to G, chromosome 16 at 5,176,500 bp
  • A to G, chromosome 16 at 14,920,411 bp
  • A to G, chromosome 16 at 20,190,394 bp
  • A to T, chromosome 16 at 72,742,285 bp
  • G to A, chromosome 17 at 32,978,481 bp
  • A to T, chromosome 17 at 81,441,655 bp
  • T to C, chromosome 17 at 86,001,462 bp
  • T to A, chromosome 18 at 25,340,149 bp
  • T to G, chromosome 18 at 32,265,718 bp
  • C to A, chromosome 18 at 39,774,651 bp
  • T to A, chromosome 19 at 7,782,966 bp
  • T to C, chromosome 19 at 10,865,283 bp
  • C to A, chromosome 19 at 40,914,336 bp
  • T to C, chromosome 19 at 56,482,596 bp
  • T to C, chromosome X at 101,308,784 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8905 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068762-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.