Strain Name:
C57BL/6J-MtgxR8934Btlr/Mmmh
Stock Number:
068777-MU
Citation ID:
RRID:MMRRC_068777-MU
Other Names:
R8934 (G1)
Major Collection:

Strain Information

Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191
Lhx3
Name: LIM homeobox protein 3
Synonyms: Lim3, mLim-3, P-LIM
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16871
HGNC: HGNC:6595
Homologene: 7814
Slamf6
Name: SLAM family member 6
Synonyms: SF2000, NTB-A, KAL1b, KAL1, Ly108
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30925
Homologene: 49945
Abce1
Name: ATP-binding cassette, sub-family E member 1
Synonyms: RNS4l (Eye), Oabp, Rnaseli
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24015
HGNC: HGNC:69
Homologene: 2205
Dusp16
Name: dual specificity phosphatase 16
Synonyms: MKP7, MKP-7, D6Ertd213e, 3830417M17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70686
Homologene: 15604
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, Shrm, D5Ertd287e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Zfp609
Name: zinc finger protein 609
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214812
Homologene: 72220
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: A730023M06Rik, 1190005L06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68925
Homologene: 32269
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229681
Homologene: 14910
Ubtf
Name: upstream binding transcription factor, RNA polymerase I
Synonyms: A930005G04Rik, UBF1, UBF, Tcfubf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21429
Homologene: 7970
Brat1
Name: BRCA1-associated ATM activator 1
Synonyms: Baat1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231841
Homologene: 16776
Ppp2r5a
Name: protein phosphatase 2, regulatory subunit B', alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226849
HGNC: HGNC:9309
Homologene: 55961
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Lca5
Name: Leber congenital amaurosis 5 (human)
Synonyms: ORF64, 4930431B11Rik, 5730406O13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75782
Homologene: 32718
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Ifrd2
Name: interferon-related developmental regulator 2
Synonyms: 1810034A24Rik, SKMc15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15983
HGNC: HGNC:5457
Homologene: 21341
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKK-2, IKK[b], IKK2, IKKbeta, IKK-beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Ddx17
Name: DEAD box helicase 17
Synonyms: p72, DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, 2610007K22Rik, LOC381024, A430025E01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67040
VEGA: 15
HGNC: HGNC:2740
Homologene: 101101
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Mettl8
Name: methyltransferase 8, methylcytidine
Synonyms: TIP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228019
Homologene: 11706
Rufy1
Name: RUN and FYVE domain containing 1
Synonyms: 3000002E04Rik, ZFYVE12, Rabip4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216724
Homologene: 23522
Hjv
Name: hemojuvelin BMP co-receptor
Synonyms: HJV, Hfe2, Rgmc, hemojuvelin, 2310035L15Rik, 5230400G09Rik, DL-M
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69585
HGNC: HGNC:4887
Homologene: 17060
Rundc1
Name: RUN domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217201
Homologene: 15095
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, Dnahc14, LOC381311, A230079K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Cfap126
Name: cilia and flagella associated protein 126
Synonyms: Fltp, 1700009P17Rik, Flattop
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75472
Homologene: 23682
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 670940
Homologene: 115466
Or51ah3
Name: olfactory receptor family 51 subfamily AH member 3
Synonyms: MOR19-2, Olfr615, GA_x6K02T2PBJ9-6284902-6285843
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259084
Homologene: 17494
C4b
Name: complement C4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12268
Homologene: 36030
Irf6
Name: interferon regulatory factor 6
Synonyms: E230028I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54139
HGNC: HGNC:6121
Homologene: 4479
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223658
Homologene: 44882
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: MP-1, 2310012C15Rik, PreP, Ntup1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69617
VEGA: 13
Homologene: 5742
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Adamts18
Name: ADAM metallopeptidase with thrombospondin type 1 motif 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 208936
Homologene: 65241
C5ar1
Name: complement component 5a receptor 1
Synonyms: Cd88, D7Msu1, C5r1, C5aR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12273
HGNC: HGNC:1338
Homologene: 20413
Nemp2
Name: nuclear envelope integral membrane protein 2
Synonyms: Tmem194b, 5330401P04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227094
Homologene: 67089
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Ptpru
Name: protein tyrosine phosphatase receptor type U
Synonyms: RPTPlambda, Ptprl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Il1rap
Name: interleukin 1 receptor accessory protein
Synonyms: IL-1R AcP, 6430709H04Rik, IL-1RAcP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16180
HGNC: HGNC:5995
Homologene: 1643
Tmem237
Name: transmembrane protein 237
Synonyms: Als2cr4, LOC381259
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381259
Homologene: 17570
Pgbd5
Name: piggyBac transposable element derived 5
Synonyms: 2900019M05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209966
Homologene: 11583
Or4b1b
Name: olfactory receptor family 4 subfamily B member 1B
Synonyms: GA_x6K02T2Q125-51636504-51635578, MOR227-3, Olfr1272
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258982
HGNC: HGNC:8290
Homologene: 133649
Tyk2
Name: tyrosine kinase 2
Synonyms: JTK1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54721
VEGA: 9
Homologene: 20712
Cyp3a44
Name: cytochrome P450, family 3, subfamily a, polypeptide 44
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 337924
HGNC: HGNC:2638
Homologene: 133568
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Epdr1
Name: ependymin related 1
Synonyms: MERP2, Epdr2, Epdr1, Ucc1, MERP-2, MERP-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105298
VEGA: 13
Homologene: 9714
Adad2
Name: adenosine deaminase domain containing 2
Synonyms: 4930403J07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75773
Homologene: 16392
Dipk1b
Name: divergent protein kinase domain 1B
Synonyms: PIP49, B230317C12Rik, Fam69b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56279
Homologene: 10516
Zfp663
Name: zinc finger protein 663
Synonyms: Gm1008, LOC381405
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381405
Homologene: 128277
Rptn
Name: repetin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20129
Homologene: 84780
Prss30
Name: serine protease 30
Synonyms: Disp1, Tmprss8, 2010015P21Rik, Disp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30943
Homologene: 88826
Erv3
Name: endogenous retroviral sequence 3
Synonyms: 1600014E20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71995
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,392,010 bp
  • T to A, chromosome 1 at 52,649,709 bp
  • T to C, chromosome 1 at 59,114,179 bp
  • A to G, chromosome 1 at 171,126,121 bp
  • C to T, chromosome 1 at 171,917,771 bp
  • T to C, chromosome 1 at 181,622,723 bp
  • T to A, chromosome 1 at 191,368,638 bp
  • T to C, chromosome 1 at 193,162,725 bp
  • T to C, chromosome 1 at 193,338,860 bp
  • C to A, chromosome 2 at 26,202,246 bp
  • G to A, chromosome 2 at 26,634,854 bp
  • T to C, chromosome 2 at 71,051,718 bp
  • T to A, chromosome 2 at 90,282,012 bp
  • C to T, chromosome 2 at 119,769,249 bp
  • T to C, chromosome 2 at 131,856,181 bp
  • A to T, chromosome 2 at 165,352,794 bp
  • A to G, chromosome 3 at 93,395,912 bp
  • T to G, chromosome 3 at 96,526,593 bp
  • A to G, chromosome 3 at 104,889,318 bp
  • C to T, chromosome 4 at 131,818,986 bp
  • C to T, chromosome 4 at 144,363,775 bp
  • T to C, chromosome 5 at 41,819,601 bp
  • T to A, chromosome 5 at 92,941,725 bp
  • T to C, chromosome 5 at 140,710,249 bp
  • A to T, chromosome 5 at 145,794,976 bp
  • A to T, chromosome 6 at 134,741,676 bp
  • A to T, chromosome 7 at 16,248,477 bp
  • G to A, chromosome 7 at 19,179,813 bp
  • A to G, chromosome 7 at 39,411,129 bp
  • T to A, chromosome 7 at 44,657,428 bp
  • T to A, chromosome 7 at 85,561,980 bp
  • T to C, chromosome 7 at 103,561,083 bp
  • T to C, chromosome 8 at 22,660,391 bp
  • A to G, chromosome 8 at 79,703,032 bp
  • A to T, chromosome 8 at 95,765,067 bp
  • T to A, chromosome 8 at 113,736,878 bp
  • G to A, chromosome 8 at 119,614,796 bp
  • A to C, chromosome 8 at 124,384,259 bp
  • T to C, chromosome 9 at 21,127,120 bp
  • C to T, chromosome 9 at 65,703,279 bp
  • T to C, chromosome 9 at 83,391,856 bp
  • T to C, chromosome 9 at 107,592,270 bp
  • T to A, chromosome 11 at 50,407,878 bp
  • A to G, chromosome 11 at 58,998,259 bp
  • A to G, chromosome 11 at 101,431,501 bp
  • G to T, chromosome 11 at 102,314,029 bp
  • T to C, chromosome 13 at 6,556,630 bp
  • T to C, chromosome 13 at 19,593,180 bp
  • G to A, chromosome 14 at 32,660,657 bp
  • G to A, chromosome 14 at 35,321,707 bp
  • A to G, chromosome 15 at 11,299,929 bp
  • T to C, chromosome 15 at 76,450,186 bp
  • T to C, chromosome 15 at 79,536,016 bp
  • T to C, chromosome 15 at 98,861,886 bp
  • T to C, chromosome 16 at 26,676,984 bp
  • C to T, chromosome 17 at 23,973,654 bp
  • G to A, chromosome 17 at 34,732,984 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8934 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068777-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.