Strain Name:
C57BL/6J-MtgxR8961Btlr/Mmmh
Stock Number:
068795-MU
Citation ID:
RRID:MMRRC_068795-MU
Other Names:
R8961 (G1)
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Kpna4
Name: karyopherin subunit alpha 4
Synonyms: importin alpha 3, 1110058D08Rik, IPOA3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16649
HGNC: HGNC:6397
Homologene: 20521
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: Sumo-1 activating enzyme subunit 2, SAE2, UBA2, anthracycline-associated resistance, Arx, Uble1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50995
Homologene: 4018
Rps6ka1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: Rsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20111
Homologene: 55703
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Skil
Name: SKI-like
Synonyms: SnoN, Skir, sno-dE3, SnoN2, 9130011J04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20482
Homologene: 3948
Mdc1
Name: mediator of DNA damage checkpoint 1
Synonyms: NFBD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240087
Homologene: 67092
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Rtf1
Name: RTF1, Paf1/RNA polymerase II complex component
Synonyms: Gtl7, 2900005O08Rik, 6530416A09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76246
Homologene: 133868
Ccp110
Name: centriolar coiled coil protein 110
Synonyms: 6330503K22Rik, CP110
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101565
Homologene: 8810
Atp6v1b2
Name: ATPase, H+ transporting, lysosomal V1 subunit B2
Synonyms: Atp6b2, HO57
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11966
HGNC: HGNC:854
Homologene: 1279
Sqle
Name: squalene epoxidase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20775
Homologene: 2355
Crim1
Name: cysteine rich transmembrane BMP regulator 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50766
VEGA: 17
HGNC: HGNC:2359
Homologene: 9510
Angptl6
Name: angiopoietin-like 6
Synonyms: Angiopoietin-related growth factor, AGF, Arp5, 6330404E11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70726
Homologene: 88931
Dennd2a
Name: DENN domain containing 2A
Synonyms: B930096L08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209773
Homologene: 35238
Cdh6
Name: cadherin 6
Synonyms: cad6, K-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
B3gat2
Name: beta-1,3-glucuronyltransferase 2
Synonyms: GlcAT-S
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 280645
HGNC: HGNC:922
Homologene: 50574
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: D030022P06Rik, F630004O05Rik, B930091H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217463
VEGA: 12
Homologene: 41011
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Vwa7
Name: von Willebrand factor A domain containing 7
Synonyms: G7c, D17H6S56E-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27762
Homologene: 11895
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: 1700010C24Rik, A830008O07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Unc13c
Name: unc-13 homolog C
Synonyms: D9Ertd414e, Munc13-3, 1500037O19Rik, Unc13h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: E230008N13Rik, LOC381522
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381522
Homologene: 117988
Or6z5
Name: olfactory receptor family 6 subfamily Z member 5
Synonyms: MOR103-6, Olfr1346, GA_x6K02T2QGBW-3203957-3204898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258918
Homologene: 74134
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: tomosyn-2, A830015P08Rik, insulin level locus 1, LLGL4, t2md1, T2dm1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207227
Homologene: 18173
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Zcchc9
Name: zinc finger, CCHC domain containing 9
Synonyms: 1810019C21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69085
Homologene: 12999
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Or5m5
Name: olfactory receptor family 5 subfamily M member 5
Synonyms: Olfr1030, MOR196-2, GA_x6K02T2Q125-47462755-47463693
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258581
Homologene: 64892
Elfn2
Name: leucine rich repeat and fibronectin type III, extracellular 2
Synonyms: Lrrc62
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207393
VEGA: 15
Homologene: 18835
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: Card4, Nlrc1, F830007N14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107607
Homologene: 4440
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Or1j11
Name: olfactory receptor family 1 subfamily E member 1
Synonyms: Olfr339, MOR136-3, GA_x6K02T2NLDC-33116096-33117025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258951
Homologene: 133615
Tmc3
Name: transmembrane channel-like gene family 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233424
Homologene: 45588
Flot2
Name: flotillin 2
Synonyms: reggie-2, Esa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: 2410012C07Rik, very-kind, VKIND, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Or6c5c
Name: olfactory receptor family 6 subfamily C member 5C
Synonyms: MOR111-10, GA_x6K02T2PULF-11141498-11142436, Olfr787
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258069
Homologene: 105326
Dnajc25
Name: DnaJ heat shock protein family (Hsp40) member C25
Synonyms: 2010109C08Rik, 2010203O07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72429
Homologene: 37883
Krt39
Name: keratin 39
Synonyms: 4732494G06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237934
Homologene: 19078
Or52l1
Name: olfactory receptor family 52 subfamily L member 1
Synonyms: MOR37-1, GA_x6K02T2PBJ9-7810071-7809121, Olfr685
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258160
Homologene: 66455
Misp
Name: mitotic spindle positioning
Synonyms: 9130017N09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78906
VEGA: 10
Homologene: 49933
Dnajb3
Name: DnaJ heat shock protein family (Hsp40) member B3
Synonyms: MSJ-1, Msj1, Hsj3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15504
Homologene: 56409
Mogs
Name: mannosyl-oligosaccharide glucosidase
Synonyms: Gcs1, 1810017N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57377
Homologene: 4593
Gm10277
Name: predicted gene 10277
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 791303
Vmn1r21
Name: vomeronasal 1 receptor 21
Synonyms: V1rc28
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171201
Homologene: 74363
1700064H15Rik
Name: RIKEN cDNA 1700064H15 gene
Type: Gene
Species: Mouse
Chromosome: 3
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 23,762,819 bp
  • T to A, chromosome 1 at 88,205,276 bp
  • A to T, chromosome 2 at 36,422,165 bp
  • T to A, chromosome 2 at 85,984,266 bp
  • T to A, chromosome 2 at 119,726,896 bp
  • T to A, chromosome 3 at 19,610,469 bp
  • T to C, chromosome 3 at 31,113,580 bp
  • T to C, chromosome 3 at 69,079,488 bp
  • A to G, chromosome 4 at 45,929,573 bp
  • T to A, chromosome 4 at 59,020,438 bp
  • A to G, chromosome 4 at 133,860,051 bp
  • A to T, chromosome 4 at 148,043,642 bp
  • A to G, chromosome 4 at 152,383,032 bp
  • A to G, chromosome 5 at 77,268,635 bp
  • T to C, chromosome 6 at 39,485,621 bp
  • C to T, chromosome 6 at 41,613,359 bp
  • C to T, chromosome 6 at 54,949,476 bp
  • T to A, chromosome 6 at 57,843,844 bp
  • C to A, chromosome 6 at 83,115,739 bp
  • T to C, chromosome 6 at 108,493,705 bp
  • T to C, chromosome 7 at 6,474,764 bp
  • A to T, chromosome 7 at 34,156,217 bp
  • T to C, chromosome 7 at 83,607,762 bp
  • A to G, chromosome 7 at 105,181,169 bp
  • T to G, chromosome 7 at 118,722,887 bp
  • C to G, chromosome 7 at 127,541,929 bp
  • T to A, chromosome 7 at 139,924,061 bp
  • C to T, chromosome 7 at 139,927,795 bp
  • A to G, chromosome 8 at 69,102,762 bp
  • A to G, chromosome 8 at 116,999,978 bp
  • T to C, chromosome 9 at 20,878,171 bp
  • G to T, chromosome 9 at 73,932,242 bp
  • A to G, chromosome 10 at 79,827,989 bp
  • A to G, chromosome 10 at 83,573,793 bp
  • C to T, chromosome 10 at 129,463,356 bp
  • T to A, chromosome 11 at 77,787,000 bp
  • G to A, chromosome 11 at 78,054,806 bp
  • T to C, chromosome 11 at 99,519,105 bp
  • T to C, chromosome 12 at 35,105,286 bp
  • C to A, chromosome 13 at 91,805,836 bp
  • T to A, chromosome 15 at 9,647,328 bp
  • A to T, chromosome 15 at 13,041,361 bp
  • T to A, chromosome 15 at 59,315,846 bp
  • T to A, chromosome 15 at 71,532,963 bp
  • T to C, chromosome 15 at 78,673,178 bp
  • ATTTT to ATTTTT, chromosome 16 at 37,216,052 bp
  • C to T, chromosome 17 at 35,019,110 bp
  • T to C, chromosome 17 at 35,848,515 bp
  • T to C, chromosome 17 at 78,372,688 bp
  • T to C, chromosome 18 at 11,732,205 bp
  • C to T, chromosome 18 at 77,385,069 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8961 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068795-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.