Strain Name:
C57BL/6J-MtgxR8965Btlr/Mmmh
Stock Number:
068799-MU
Citation ID:
RRID:MMRRC_068799-MU
Other Names:
R8965 (G1)
Major Collection:

Strain Information

Zbtb25
Name: zinc finger and BTB domain containing 25
Synonyms: Kup, Zfp-50, 2810462M08Rik, Zfp50, 2900064P18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109929
Homologene: 5070
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: 5830453M24Rik, Pdzgef1, RA-GEF-1, CNRasGEF, nRapGEP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Psma5
Name: proteasome subunit alpha 5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26442
HGNC: HGNC:9534
Homologene: 2084
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Synonyms: PTP2C, PTP1D, SH-PTP2, SHP-2, Syp, Shp2, SH2 domain-containing protein tyrosine phosphatase-2, 2700084A17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19247
HGNC: HGNC:9644
Homologene: 2122
Patz1
Name: POZ (BTB) and AT hook containing zinc finger 1
Synonyms: MAZR, 8430401L15Rik, POZ-AT hook-zinc finger protein, Zfp278
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56218
Homologene: 8636
Epha8
Name: Eph receptor A8
Synonyms: EphA8, Hek3, Eek
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Wipf2
Name: WAS/WASL interacting protein family, member 2
Synonyms: 1110014J05Rik, 5730509C05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68524
Homologene: 15777
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, 1700015F03Rik, D10Bwg0629e, Jouberin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
E4f1
Name: E4F transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13560
VEGA: 17
HGNC: HGNC:3121
Homologene: 3259
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: KCC1, K-Cl Co-transporter-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20498
Homologene: 21056
Peli1
Name: pellino 1
Synonyms: 2810468L03Rik, D11Ertd676e, A930031K15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67245
HGNC: HGNC:8827
Homologene: 23243
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Spaca6
Name: sperm acrosome associated 6
Synonyms: B230206P06Rik, 4930546H06Rik, Ncrna00085
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75202
Homologene: 53443
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170571
Homologene: 24912
Spata6
Name: spermatogenesis associated 6
Synonyms: Hash, 1700062C23Rik, KRP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67946
Homologene: 10410
Erich6
Name: glutamate rich 6
Synonyms: 4932431H17Rik, Fam194a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 545527
Homologene: 65043
Or5p52
Name: olfactory receptor family 5 subfamily P member 52
Synonyms: GA_x6K02T2PBJ9-10231953-10232885, MOR204-5, Olfr472
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258770
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Usp20
Name: ubiquitin specific peptidase 20
Synonyms: 1700055M05Rik, Vdu2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74270
Homologene: 4861
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: GluRdelta2, tpr, B230104L07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Or10ag53
Name: olfactory receptor family 10 subfamily AG member 53
Synonyms: GA_x6K02T2Q125-48736906-48737886, MOR273-4P, MOR273-4P, MOR264-20, Olfr1530-ps1, Olfr1115
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258294
Homologene: 27114
P2rx1
Name: purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms: P2x, RP-2, P2X1 receptor, Pdcd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18436
HGNC: HGNC:8533
Homologene: 1921
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Svop
Name: SV2 related protein
Synonyms: 1110030H18Rik, msvop
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68666
Homologene: 41283
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: CD106, Vcam-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22329
Homologene: 838
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210530
Homologene: 10062
Lztr1
Name: leucine-zipper-like transcriptional regulator, 1
Synonyms: TCFL2, 1200003E21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66863
HGNC: HGNC:6742
Homologene: 4925
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380997
VEGA: 15
Homologene: 86099
Or2w2
Name: olfactory receptor family 2 subfamily W member 2
Synonyms: GA_x6K02T2QHY8-11663090-11664010, MOR256-13, Olfr1364
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258533
Homologene: 64885
Zfp677
Name: zinc finger protein 677
Synonyms: A830058L05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210503
Homologene: 138402
Trim38
Name: tripartite motif-containing 38
Synonyms: LOC214158
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214158
Homologene: 48427
Pcna
Name: proliferating cell nuclear antigen
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18538
HGNC: HGNC:8729
Homologene: 1945
Vwa1
Name: von Willebrand factor A domain containing 1
Synonyms: WARP, 4932416A11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246228
Homologene: 11270
Ttc12
Name: tetratricopeptide repeat domain 12
Synonyms: E330017O07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235330
Homologene: 32375
Herpud1
Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms: Herp, Mifl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64209
Homologene: 40973
Ace3
Name: angiotensin I converting enzyme 3
Synonyms: EG217246
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217246
Homologene: 80337
Igkv2-109
Name: immunoglobulin kappa variable 2-109
Synonyms: ENSMUSG00000060986
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 628268
Nicn1
Name: nicolin 1
Synonyms: 1500032A17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66257
Homologene: 11936
Trgv3
Name: T cell receptor gamma, variable 3
Synonyms: vgamma3, Tcrg-V3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21637
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 172,280,045 bp
  • T to A, chromosome 2 at 31,011,785 bp
  • A to T, chromosome 2 at 87,252,557 bp
  • T to C, chromosome 2 at 132,252,849 bp
  • A to T, chromosome 3 at 58,624,317 bp
  • A to G, chromosome 3 at 79,092,544 bp
  • T to A, chromosome 3 at 108,265,194 bp
  • T to A, chromosome 3 at 116,128,773 bp
  • A to C, chromosome 4 at 70,266,805 bp
  • T to A, chromosome 4 at 111,822,812 bp
  • G to T, chromosome 4 at 136,938,586 bp
  • A to T, chromosome 4 at 155,772,983 bp
  • A to G, chromosome 5 at 114,035,210 bp
  • G to A, chromosome 5 at 121,163,166 bp
  • A to G, chromosome 6 at 64,320,006 bp
  • A to T, chromosome 6 at 68,303,128 bp
  • T to C, chromosome 7 at 107,903,107 bp
  • T to C, chromosome 8 at 94,391,841 bp
  • A to G, chromosome 8 at 105,945,350 bp
  • T to A, chromosome 8 at 112,753,014 bp
  • G to A, chromosome 8 at 125,759,114 bp
  • A to G, chromosome 9 at 49,438,418 bp
  • C to T, chromosome 9 at 108,294,509 bp
  • A to G, chromosome 10 at 20,963,862 bp
  • T to C, chromosome 11 at 3,307,815 bp
  • T to C, chromosome 11 at 21,148,488 bp
  • A to T, chromosome 11 at 67,364,606 bp
  • T to C, chromosome 11 at 73,009,225 bp
  • A to G, chromosome 11 at 98,892,671 bp
  • G to T, chromosome 11 at 106,005,349 bp
  • T to G, chromosome 11 at 118,024,666 bp
  • A to C, chromosome 12 at 76,349,803 bp
  • T to A, chromosome 13 at 19,243,010 bp
  • T to C, chromosome 13 at 21,574,217 bp
  • T to C, chromosome 13 at 23,791,023 bp
  • T to A, chromosome 13 at 77,612,604 bp
  • T to C, chromosome 15 at 82,558,985 bp
  • T to C, chromosome 16 at 17,509,432 bp
  • A to G, chromosome 16 at 20,596,326 bp
  • T to C, chromosome 16 at 25,972,384 bp
  • A to G, chromosome 17 at 17,838,456 bp
  • T to C, chromosome 17 at 21,396,893 bp
  • C to T, chromosome 17 at 24,445,530 bp
  • C to A, chromosome 18 at 7,905,936 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8965 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068799-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.