Strain Name:
C57BL/6J-MtgxR8975Btlr/Mmmh
Stock Number:
068809-MU
Citation ID:
RRID:MMRRC_068809-MU
Other Names:
R8975 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Dpagt1
Name: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Synonyms: GPT, Dpagt2, Gnpta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13478
VEGA: 9
HGNC: HGNC:2995
Homologene: 1058
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2d, Bat2l2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Larp4b
Name: La ribonucleoprotein 4B
Synonyms: D13Wsu64e, Larp5, A130023E24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217980
Homologene: 18195
Tbcd
Name: tubulin-specific chaperone d
Synonyms: A030005L14Rik, 2310057L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108903
Homologene: 4368
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Depdc1b
Name: DEP domain containing 1B
Synonyms: XTP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218581
Homologene: 10157
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Atg2b
Name: autophagy related 2B
Synonyms: C630028L02Rik, C030004M05Rik, 2410024A21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52397
Homologene: 12971
Ctps1
Name: cytidine 5'-triphosphate synthase 1
Synonyms: Ctps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 51797
HGNC: HGNC:2519
Homologene: 20446
Med23
Name: mediator complex subunit 23
Synonyms: ESTM7, 3000002A17Rik, X83317, Crsp3, Sur2, sno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Bmt2
Name: base methyltransferase of 25S rRNA 2
Synonyms: B630005N14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101148
Homologene: 34695
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Map1lc3a
Name: microtubule-associated protein 1 light chain 3 alpha
Synonyms: 4922501H04Rik, 1010001H21Rik, LC3a, LC3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66734
HGNC: HGNC:6838
Homologene: 12021
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Peg10
Name: paternally expressed 10
Synonyms: MEF3L, HB-1, MyEF-3, MyEF-3 like, Edr, Mart2, Mar2, Rtl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Frmd4b
Name: FERM domain containing 4B
Synonyms: 6030440G05Rik, GRSP1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232288
Homologene: 14916
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, Ptpri, PTPL1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Mep1b
Name: meprin 1 beta
Synonyms: meprin beta, Mep-1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Proser3
Name: proline and serine rich 3
Synonyms: BC053749
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333193
Homologene: 116064
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Ifngr1
Name: interferon gamma receptor 1
Synonyms: CD119, Nktar, Ifgr, Ifngr, IFN-gamma R, IFN-gammaR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15979
HGNC: HGNC:5439
Homologene: 359
Dynap
Name: dynactin associated protein
Synonyms: 2310002L13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75577
VEGA: 18
Homologene: 82463
Stk33
Name: serine/threonine kinase 33
Synonyms: 4921505G21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 117229
Homologene: 75307
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Dpy19l1
Name: dpy-19 like C-mannosyltransferase 1
Synonyms: 1100001I19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244745
Homologene: 14762
Myo15b
Name: myosin XVB
Synonyms: LOC217328, LOC380737, E330039G21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Dhh
Name: desert hedgehog
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13363
VEGA: 15
HGNC: HGNC:2865
Homologene: 22431
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21881
Homologene: 68154
Plagl2
Name: pleiomorphic adenoma gene-like 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54711
HGNC: HGNC:9047
Homologene: 1994
Mapk8ip1
Name: mitogen-activated protein kinase 8 interacting protein 1
Synonyms: JIP-1, MAPK8IP1, IB1, Prkm8ip, mjip-2a, Skip, Jip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19099
HGNC: HGNC:6882
Homologene: 31314
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: SNS2, NaN, NaT, NSS2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
4930550C14Rik
Name: RIKEN cDNA 4930550C14 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75311
VEGA: 9
Homologene: 12595
Uqcrc1
Name: ubiquinol-cytochrome c reductase core protein 1
Synonyms: 1110032G10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22273
Homologene: 2525
Pdha2
Name: pyruvate dehydrogenase E1 alpha 2
Synonyms: Pdhal
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18598
HGNC: HGNC:8807
Homologene: 137212
1700018F24Rik
Name: RIKEN cDNA 1700018F24 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69396
Homologene: 86127
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Hhat
Name: hedgehog acyltransferase
Synonyms: Skn, 2810432O22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226861
Homologene: 41232
Mup3
Name: major urinary protein 3
Synonyms: Mup-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17842
Homologene: 74304
Lilra5
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
Synonyms: Gm4878
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232801
Homologene: 83297
Or4d2
Name: olfactory receptor family 4 subfamily D member 2
Synonyms: GA_x6K02T2PAEV-9540823-9539888, MOR240-1, Olfr463
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258408
HGNC: HGNC:8294
Homologene: 64870
Tpra1
Name: transmembrane protein, adipocyte asscociated 1
Synonyms: Tpra40, 40kDa, Gpr175
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 24100
Homologene: 40799
Ppp1r3e
Name: protein phosphatase 1, regulatory subunit 3E
Synonyms: LOC382898, A630071A11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105651
Homologene: 34797
Spmip4
Name: sperm microtubule inner protein 4
Synonyms: 4921507P07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70821
Homologene: 69433
Slc10a5
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 5
Synonyms: LOC241877
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241877
Homologene: 78106
Phtf2
Name: putative homeodomain transcription factor 2
Synonyms: 9530062N20Rik, 1110054G21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68770
Homologene: 10713
Dyrk4
Name: dual-specificity tyrosine phosphorylation regulated kinase 4
Synonyms: Dyrk4b, Dyrk4a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101320
HGNC: HGNC:3095
Homologene: 37858
Vmn1r32
Name: vomeronasal 1 receptor 32
Synonyms: V1rc15
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171188
Homologene: 115644
Slc2a5
Name: solute carrier family 2 (facilitated glucose transporter), member 5
Synonyms: GLUT5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56485
Homologene: 74459
Msantd5f6
Name: Myb/SANT DNA binding domain containing 5 family member 6
Synonyms: Gm11487
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433719
Homologene: 128423
Or2a57
Name: olfactory receptor family 2 subfamily A member 57
Synonyms: IB12, MOR261-9, GA_x6K02T2P3E9-4322325-4321360, Olfr47
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18346
Homologene: 133700
Vmn1r223
Name: vomeronasal 1 receptor 223
Synonyms: Gm11330
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100036518
Homologene: 110880
Spmap1
Name: sperm microtubule associated protein 1
Synonyms: 1700001P01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72215
Homologene: 19140
Or2d2b
Name: olfactory receptor family 2 subfamily D member 2B
Synonyms: EG384732, Gm10081, Olfr715b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384732
HGNC: HGNC:8244
Homologene: 81541
Abhd16b
Name: abhydrolase domain containing 16B
Synonyms: BC050777
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241850
Homologene: 15422
Ctsz
Name: cathepsin Z
Synonyms: CTSX, cathepsin X, D2Wsu143e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64138
HGNC: HGNC:2547
Homologene: 1022
Fer1l5
Name: fer-1 like family member 5
Synonyms: 4930533C12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100534273
Homologene: 85232
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,417,816 bp
  • A to G, chromosome 1 at 162,706,061 bp
  • A to T, chromosome 1 at 181,130,436 bp
  • T to C, chromosome 1 at 192,748,942 bp
  • T to C, chromosome 2 at 69,922,307 bp
  • A to G, chromosome 2 at 92,384,821 bp
  • C to T, chromosome 2 at 153,232,426 bp
  • A to G, chromosome 2 at 155,277,006 bp
  • C to T, chromosome 2 at 155,970,122 bp
  • A to T, chromosome 2 at 174,433,628 bp
  • A to G, chromosome 2 at 181,494,013 bp
  • G to C, chromosome 3 at 10,334,610 bp
  • C to A, chromosome 3 at 141,211,888 bp
  • A to T, chromosome 4 at 62,085,235 bp
  • A to G, chromosome 4 at 73,401,930 bp
  • C to T, chromosome 4 at 120,549,546 bp
  • A to C, chromosome 4 at 150,139,813 bp
  • A to C, chromosome 5 at 20,764,251 bp
  • A to G, chromosome 5 at 103,501,400 bp
  • G to T, chromosome 5 at 106,637,601 bp
  • A to G, chromosome 5 at 145,043,382 bp
  • GC to GCTCC, chromosome 6 at 4,756,452 bp
  • A to T, chromosome 6 at 13,630,612 bp
  • T to A, chromosome 6 at 43,236,122 bp
  • C to T, chromosome 6 at 50,584,411 bp
  • C to A, chromosome 6 at 66,553,205 bp
  • A to T, chromosome 6 at 88,911,744 bp
  • G to A, chromosome 6 at 97,306,516 bp
  • T to C, chromosome 6 at 126,894,820 bp
  • T to C, chromosome 7 at 4,238,637 bp
  • A to G, chromosome 7 at 30,540,033 bp
  • CG to CGTCGGCGGGG, chromosome 7 at 97,579,908 bp
  • T to A, chromosome 7 at 107,106,457 bp
  • T to A, chromosome 7 at 109,336,073 bp
  • C to A, chromosome 7 at 135,695,635 bp
  • T to C, chromosome 7 at 135,698,400 bp
  • T to C, chromosome 9 at 24,447,806 bp
  • T to C, chromosome 9 at 44,326,149 bp
  • A to T, chromosome 9 at 53,422,958 bp
  • T to C, chromosome 9 at 108,947,653 bp
  • T to C, chromosome 9 at 119,758,499 bp
  • G to A, chromosome 10 at 5,211,945 bp
  • A to G, chromosome 10 at 19,609,612 bp
  • A to G, chromosome 10 at 24,904,436 bp
  • A to G, chromosome 10 at 100,513,920 bp
  • T to C, chromosome 11 at 30,123,869 bp
  • T to A, chromosome 11 at 65,178,461 bp
  • T to A, chromosome 11 at 87,893,819 bp
  • A to T, chromosome 11 at 97,772,746 bp
  • A to G, chromosome 11 at 105,063,589 bp
  • A to T, chromosome 11 at 115,890,954 bp
  • G to C, chromosome 11 at 121,496,853 bp
  • T to A, chromosome 12 at 82,432,838 bp
  • T to A, chromosome 12 at 98,810,570 bp
  • A to T, chromosome 12 at 105,636,466 bp
  • T to G, chromosome 13 at 9,145,501 bp
  • T to C, chromosome 13 at 23,250,078 bp
  • A to G, chromosome 13 at 108,388,560 bp
  • T to A, chromosome 14 at 30,566,927 bp
  • A to G, chromosome 14 at 54,876,489 bp
  • T to C, chromosome 15 at 98,898,095 bp
  • T to A, chromosome 17 at 27,116,654 bp
  • A to T, chromosome 18 at 21,075,657 bp
  • C to T, chromosome 18 at 58,153,856 bp
  • T to C, chromosome 18 at 70,242,022 bp
  • T to G, chromosome 19 at 9,012,737 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8975 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068809-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.