Strain Name:
C57BL/6J-MtgxR8983Btlr/Mmmh
Stock Number:
068816-MU
Citation ID:
RRID:MMRRC_068816-MU
Other Names:
R8983 (G1)
Major Collection:

Strain Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Smco3
Name: single-pass membrane protein with coiled-coil domains 3
Synonyms: C030030A07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 654818
Homologene: 79087
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, nmf335, mnd-2, nmf58, ataxia 3, nmf2, motor end-plate disease, NaCh6, mnd2, C630029C19Rik, seal, NMF335, Nav1.6, nur14
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Faf2
Name: Fas associated factor family member 2
Synonyms: 2210404D11Rik, Ubxd8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76577
Homologene: 8753
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Sfmbt2
Name: Scm-like with four mbt domains 2
Synonyms: D2Wsu23e, D330030P06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 353282
Homologene: 82485
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Atxn2
Name: ataxin 2
Synonyms: Sca2, ATX2, 9630045M23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20239
Homologene: 2234
Epha8
Name: Eph receptor A8
Synonyms: Eek, EphA8, Hek3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64898
Homologene: 8769
Ccdc80
Name: coiled-coil domain containing 80
Synonyms: Ssg1, DRO1, Urb, 2610001E17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67896
Homologene: 12206
Spag9
Name: sperm associated antigen 9
Synonyms: JLP, syd1, 4733401I23Rik, JIP4, Mapk8ip4, 3110018C07Rik, 4831406C20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
Megf9
Name: multiple EGF-like-domains 9
Synonyms: 4933405H16Rik, Egfl5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230316
HGNC: HGNC:3234
Homologene: 18209
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Mrpl48
Name: mitochondrial ribosomal protein L48
Synonyms: 1810030E20Rik, CGI-118, D4Ertd786e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52443
Homologene: 32294
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99003
Homologene: 11710
Cnot3
Name: CCR4-NOT transcription complex, subunit 3
Synonyms: A930039N10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232791
HGNC: HGNC:7879
Homologene: 133900
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, A430109M19Rik, ZFYVE2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Rdx
Name: radixin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19684
VEGA: 9
HGNC: HGNC:9944
Homologene: 37707
Tmprss7
Name: transmembrane serine protease 7
Synonyms: LOC385645, matriptase-3, B230219I23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208171
Homologene: 18178
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Zfp646
Name: zinc finger protein 646
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233905
Homologene: 8802
Ccr6
Name: C-C motif chemokine receptor 6
Synonyms: Cmkbr6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12458
VEGA: 17
HGNC: HGNC:1607
Homologene: 3214
Astn1
Name: astrotactin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Eif3m
Name: eukaryotic translation initiation factor 3, subunit M
Synonyms: Tango7, Pcid1, Ga17
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98221
Homologene: 4639
Prss59
Name: serine protease 59
Synonyms: Tryx5, 1700074P13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73481
Homologene: 49905
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Arhgef11
Name: Rho guanine nucleotide exchange factor 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213498
Homologene: 11409
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: LOC381522, E230008N13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381522
Homologene: 117988
Adcy5
Name: adenylate cyclase 5
Synonyms: AC5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224129
VEGA: 16
HGNC: HGNC:236
Homologene: 11213
Ahnak
Name: AHNAK nucleoprotein
Synonyms: 2310047C17Rik, 1110004P15Rik, DY6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Ablim1
Name: actin-binding LIM protein 1
Synonyms: 2210411C18Rik, 9330196J19Rik, 4833406P10Rik, 2610209L21Rik, Limab1, abLIM-L, abLIM-M, abLIM-S
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Vmn2r83
Name: vomeronasal 2, receptor 83
Synonyms: EG625029
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625029
Homologene: 83669
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Fam83b
Name: family with sequence similarity 83, member B
Synonyms: C530008M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208994
Homologene: 19478
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Zfp777
Name: zinc finger protein 777
Synonyms: 2500002G23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72306
Homologene: 56721
4921509C19Rik
Name: RIKEN cDNA 4921509C19 gene
Synonyms: LOC381389
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381393
Homologene: 72396
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
5730522E02Rik
Name: RIKEN cDNA 5730522E02 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70626
Or9g3
Name: olfactory receptor family 9 subfamily G member 3
Synonyms: GA_x6K02T2Q125-47239120-47238185, Olfr1012, MOR213-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258561
Homologene: 64889
Klra6
Name: killer cell lectin-like receptor, subfamily A, member 6
Synonyms: Ly49f, Ly49F
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16637
Homologene: 110821
Top6bl
Name: TOP6B like initiator of meiotic double strand breaks
Synonyms: Top6bl, Gm960
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381196
VEGA: 19
Homologene: 69381
Ncald
Name: neurocalcin delta
Synonyms: D030020D09Rik, D15Ertd412e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52589
HGNC: HGNC:7655
Homologene: 49978
Potefam1
Name: POTE ankyrin domain family member 1
Synonyms: Pote1, A26c3, 4930430A15Rik, Potea
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67575
Homologene: 69410
Dok3
Name: docking protein 3
Synonyms: p62Dok-like protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27261
VEGA: 13
Homologene: 8448
Mipep
Name: mitochondrial intermediate peptidase
Synonyms: 5730405E07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70478
VEGA: 14
HGNC: HGNC:7104
Homologene: 4337
Fgl1
Name: fibrinogen-like protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234199
HGNC: HGNC:3695
Homologene: 37927
Utp14b
Name: UTP14B small subunit processome component
Synonyms: jsd, 4932411L21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 195434
Homologene: 78703
Lpxn
Name: leupaxin
Synonyms: A530083L21Rik, 4933402K05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107321
VEGA: 19
Homologene: 3536
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Sbpl
Name: spermine binding protein-like
Synonyms: 2310068J22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 638345
VEGA: 17
Homologene: 117464
Pals1
Name: protein associated with LIN7 1, MAGUK family member
Synonyms: Mpp5, Pals1, 3830420B02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56217
VEGA: 12
Homologene: 9512
Cdca7l
Name: cell division cycle associated 7 like
Synonyms: JPO2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217946
Homologene: 10285
Slc35f3
Name: solute carrier family 35, member F3
Synonyms: B230375D17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 210027
Homologene: 62481
Epn3
Name: epsin 3
Synonyms: 2310022G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71889
Homologene: 56791
Loricrin
Name: loricrin cornified envelope precursor protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16939
HGNC: HGNC:6663
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 78,665,286 bp
  • T to A, chromosome 1 at 158,664,130 bp
  • A to G, chromosome 2 at 10,404,456 bp
  • T to C, chromosome 2 at 85,753,907 bp
  • T to C, chromosome 2 at 104,787,357 bp
  • T to C, chromosome 2 at 104,999,794 bp
  • A to G, chromosome 2 at 111,200,356 bp
  • A to T, chromosome 2 at 151,471,352 bp
  • A to G, chromosome 3 at 87,733,201 bp
  • T to C, chromosome 3 at 92,081,139 bp
  • T to A, chromosome 4 at 45,909,359 bp
  • A to G, chromosome 4 at 70,435,397 bp
  • G to T, chromosome 4 at 136,938,586 bp
  • A to G, chromosome 5 at 121,778,000 bp
  • A to T, chromosome 6 at 22,138,687 bp
  • A to G, chromosome 6 at 40,921,000 bp
  • A to T, chromosome 6 at 48,029,224 bp
  • C to T, chromosome 6 at 60,976,058 bp
  • T to C, chromosome 6 at 130,022,610 bp
  • C to T, chromosome 6 at 136,831,732 bp
  • T to C, chromosome 7 at 3,651,329 bp
  • T to C, chromosome 7 at 100,574,495 bp
  • A to T, chromosome 7 at 127,881,605 bp
  • A to T, chromosome 8 at 41,200,459 bp
  • A to G, chromosome 8 at 80,669,246 bp
  • G to A, chromosome 8 at 95,106,476 bp
  • CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC to CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC, chromosome 8 at 126,389,036 bp
  • G to A, chromosome 9 at 52,063,605 bp
  • A to G, chromosome 9 at 76,493,075 bp
  • A to G, chromosome 9 at 88,582,351 bp
  • A to G, chromosome 9 at 119,128,351 bp
  • T to G, chromosome 10 at 79,491,526 bp
  • C to T, chromosome 10 at 96,019,879 bp
  • T to C, chromosome 11 at 25,769,069 bp
  • T to C, chromosome 11 at 94,067,989 bp
  • T to C, chromosome 11 at 94,496,088 bp
  • A to G, chromosome 11 at 103,071,266 bp
  • A to G, chromosome 11 at 119,430,349 bp
  • A to G, chromosome 12 at 51,744,627 bp
  • G to A, chromosome 12 at 78,837,524 bp
  • A to G, chromosome 12 at 117,865,167 bp
  • A to G, chromosome 13 at 54,621,913 bp
  • G to T, chromosome 13 at 55,523,722 bp
  • A to T, chromosome 14 at 55,516,254 bp
  • G to A, chromosome 14 at 60,843,253 bp
  • T to A, chromosome 14 at 115,092,686 bp
  • A to G, chromosome 15 at 37,397,268 bp
  • C to A, chromosome 15 at 101,002,149 bp
  • T to G, chromosome 16 at 35,156,862 bp
  • T to C, chromosome 16 at 45,104,417 bp
  • T to C, chromosome 16 at 45,660,900 bp
  • T to G, chromosome 17 at 8,256,046 bp
  • T to C, chromosome 17 at 23,953,279 bp
  • T to A, chromosome 17 at 30,851,654 bp
  • C to T, chromosome 17 at 71,246,967 bp
  • T to C, chromosome 17 at 84,231,087 bp
  • A to G, chromosome 18 at 78,859,244 bp
  • T to C, chromosome 19 at 4,645,686 bp
  • C to A, chromosome 19 at 9,004,113 bp
  • A to G, chromosome 19 at 12,833,158 bp
  • A to T, chromosome 19 at 57,239,212 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8983 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068816-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.