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Strain Name:
C57BL/6J-MtgxR8992Btlr/Mmmh
Stock Number:
068823-MU
Citation ID:
RRID:MMRRC_068823-MU
Other Names:
R8992 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Vcp
Name: valosin containing protein
Synonyms: CDC48, p97, p97/VCP, AAA ATPase p97
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269523
Homologene: 5168
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Top1
Name: topoisomerase (DNA) I
Synonyms: Top-1, D130064I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Ptrh2
Name: peptidyl-tRNA hydrolase 2
Synonyms: A230072I16Rik, Bit1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217057
Homologene: 5330
Atp5if1
Name: ATP synthase inhibitory factor subunit 1
Synonyms: If1, Atpif1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11983
HGNC: HGNC:871
Homologene: 40581
Neurl4
Name: neuralized E3 ubiquitin protein ligase 4
Synonyms: 0610025P10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216860
Homologene: 13029
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,819,781 bp
  • T to C, chromosome 1 at 65,082,141 bp
  • T to A, chromosome 1 at 107,047,177 bp
  • T to A, chromosome 1 at 128,300,562 bp
  • A to T, chromosome 1 at 134,187,924 bp
  • A to G, chromosome 2 at 65,763,898 bp
  • A to T, chromosome 2 at 75,979,907 bp
  • G to A, chromosome 2 at 76,884,471 bp
  • A to T, chromosome 2 at 77,014,395 bp
  • A to G, chromosome 2 at 119,379,578 bp
  • A to T, chromosome 2 at 122,344,705 bp
  • A to G, chromosome 2 at 131,313,277 bp
  • A to G, chromosome 2 at 158,454,277 bp
  • A to G, chromosome 2 at 160,721,001 bp
  • T to C, chromosome 3 at 89,092,058 bp
  • A to G, chromosome 3 at 89,236,385 bp
  • A to T, chromosome 3 at 142,610,969 bp
  • G to T, chromosome 3 at 146,586,962 bp
  • A to G, chromosome 4 at 8,839,589 bp
  • A to G, chromosome 4 at 12,058,559 bp
  • T to C, chromosome 4 at 42,980,828 bp
  • T to A, chromosome 4 at 106,377,565 bp
  • G to T, chromosome 4 at 118,382,788 bp
  • T to C, chromosome 4 at 132,533,374 bp
  • G to A, chromosome 4 at 134,202,667 bp
  • A to C, chromosome 4 at 154,158,433 bp
  • C to T, chromosome 5 at 14,669,311 bp
  • A to G, chromosome 5 at 24,331,870 bp
  • T to G, chromosome 5 at 25,264,985 bp
  • A to G, chromosome 5 at 37,117,538 bp
  • T to C, chromosome 5 at 73,629,884 bp
  • A to T, chromosome 5 at 110,323,622 bp
  • G to A, chromosome 5 at 130,269,224 bp
  • G to T, chromosome 5 at 138,986,222 bp
  • C to A, chromosome 6 at 13,602,850 bp
  • C to T, chromosome 6 at 41,613,359 bp
  • G to A, chromosome 6 at 91,500,974 bp
  • G to A, chromosome 6 at 121,336,942 bp
  • A to T, chromosome 7 at 16,907,295 bp
  • A to G, chromosome 7 at 25,925,390 bp
  • A to G, chromosome 8 at 46,581,562 bp
  • CT to C, chromosome 8 at 104,182,032 bp
  • C to T, chromosome 9 at 20,349,599 bp
  • A to G, chromosome 9 at 106,451,618 bp
  • T to C, chromosome 10 at 5,185,508 bp
  • T to C, chromosome 10 at 75,131,572 bp
  • A to G, chromosome 10 at 81,080,138 bp
  • A to G, chromosome 11 at 58,580,912 bp
  • A to T, chromosome 11 at 67,205,781 bp
  • T to C, chromosome 11 at 69,908,132 bp
  • A to G, chromosome 11 at 86,690,081 bp
  • A to C, chromosome 11 at 86,776,756 bp
  • T to G, chromosome 11 at 106,261,961 bp
  • A to T, chromosome 12 at 4,871,490 bp
  • G to T, chromosome 12 at 79,075,533 bp
  • T to C, chromosome 12 at 100,500,174 bp
  • A to T, chromosome 12 at 108,358,107 bp
  • T to C, chromosome 13 at 12,401,114 bp
  • C to A, chromosome 13 at 37,930,376 bp
  • T to A, chromosome 14 at 8,028,282 bp
  • T to A, chromosome 14 at 12,154,170 bp
  • C to T, chromosome 14 at 44,858,724 bp
  • T to C, chromosome 14 at 55,745,981 bp
  • A to T, chromosome 15 at 33,594,235 bp
  • A to G, chromosome 15 at 89,548,685 bp
  • T to A, chromosome 16 at 18,584,187 bp
  • A to T, chromosome 16 at 20,712,330 bp
  • T to A, chromosome 16 at 97,476,394 bp
  • A to T, chromosome 18 at 14,670,323 bp
  • G to T, chromosome 18 at 37,449,178 bp
  • T to A, chromosome 18 at 52,476,320 bp
  • A to C, chromosome 18 at 76,970,670 bp
  • A to G, chromosome 18 at 88,977,708 bp
  • C to A, chromosome 19 at 6,542,484 bp
  • T to A, chromosome 19 at 46,306,865 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8992 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068823-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.