Strain Name:
C57BL/6J-MtgxR8997Btlr/Mmmh
Stock Number:
068828-MU
Citation ID:
RRID:MMRRC_068828-MU
Other Names:
R8997 (G1)
Major Collection:

Strain Information

Rnf111
Name: ring finger 111
Synonyms: Arkadia
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93836
VEGA: 9
Homologene: 9741
Adra2a
Name: adrenergic receptor, alpha 2a
Synonyms: alpha2A-AR, alpha2A, alpha2A-adrenergic receptor, alpha(2A)AR, Adra-2, Adra-2a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11551
VEGA: 19
HGNC: HGNC:281
Homologene: 47944
Arid1a
Name: AT-rich interaction domain 1A
Synonyms: Smarcf1, BAF250a, Osa1, 1110030E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93760
Homologene: 21216
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Alp145, Recc1, 140kDa, RFC140
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Jhdm1b, Cxxc2, Fbxl10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 30841
Homologene: 13069
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: 6720416K24Rik, Gtl6, 1110036I07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14897
Homologene: 44226
Mdn1
Name: midasin AAA ATPase 1
Synonyms: D4Abb1e, 4833432B22Rik, LOC213784
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Tbck
Name: TBC1 domain containing kinase
Synonyms: 1700120J03Rik, C030007I09Rik, A630047E20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271981
Homologene: 13221
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Zfp846
Name: zinc finger protein 846
Synonyms: 2210010B09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244721
Homologene: 87243
Treml1
Name: triggering receptor expressed on myeloid cells-like 1
Synonyms: 5430401J17Rik, TLT-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71326
VEGA: 17
Homologene: 52257
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, Gm21044, LOC385009
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, b2b414Clo, Dnchc2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, m152Asp, m407Asp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Tent4b
Name: terminal nucleotidyltransferase 4B
Synonyms: Papd5, 5730445M16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 214627
Homologene: 64245
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 5730470G24Rik, CCCAP, 2700048G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76816
Homologene: 4839
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Shf
Name: Src homology 2 domain containing F
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 435684
Homologene: 44524
Fgf5
Name: fibroblast growth factor 5
Synonyms: Fgf-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14176
HGNC: HGNC:3683
Homologene: 3283
Slc39a5
Name: solute carrier family 39 (metal ion transporter), member 5
Synonyms: 1810013D05Rik, 2010205A06Rik, Zip5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72002
VEGA: 10
Homologene: 57083
Cntn3
Name: contactin 3
Synonyms: Pang
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18488
HGNC: HGNC:2173
Homologene: 7461
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Inhba
Name: inhibin beta-A
Synonyms: activin beta-A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16323
VEGA: 13
HGNC: HGNC:6066
Homologene: 1653
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Cntn1
Name: contactin 1
Synonyms: CNTN, usl, F3cam
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12805
HGNC: HGNC:2171
Homologene: 7274
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217718
Homologene: 13222
Zfp14
Name: zinc finger protein 14
Synonyms: Zfp-14, Krox-9, 4732429I09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243906
Homologene: 45619
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: mSlo1, Slo, 5730414M22Rik, BK channel alpha subunit, BKCa, MaxiK, Slo1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Sgcz
Name: sarcoglycan zeta
Synonyms: C230085N17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244431
Homologene: 26726
Tuba3b
Name: tubulin, alpha 3B
Synonyms: Tuba7, M[a]7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22147
Homologene: 128229
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Il6ra
Name: interleukin 6 receptor, alpha
Synonyms: CD126, Il6r, IL-6R, IL-6 receptor alpha chain
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16194
HGNC: HGNC:6019
Homologene: 474
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 1700048E19Rik, 2610014F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72137
Homologene: 17609
Ninl
Name: ninein-like
Synonyms: LOC381388, LOC381387, 4930519N13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78177
Homologene: 57024
Gtdc1
Name: glycosyltransferase-like domain containing 1
Synonyms: E330008O22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227835
Homologene: 32590
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: nmf192, 4930564O18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 260305
Homologene: 9024
Fbxo39
Name: F-box protein 39
Synonyms: 1700010H23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 628100
Homologene: 15156
Sgip1
Name: SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms: 3110007P09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73094
Homologene: 13001
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: Vcam-1, CD106
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22329
Homologene: 838
A830018L16Rik
Name: RIKEN cDNA A830018L16 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320492
Homologene: 14194
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: C330017E21Rik, SLC21A20, PRO2176, OATP4C1, OATP-M1, OATP-H
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227394
Homologene: 62654
Cma2
Name: chymase 2, mast cell
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545055
VEGA: 14
Homologene: 115745
Pik3c2b
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms: PI3K-C2beta, C330011J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240752
HGNC: HGNC:8972
Homologene: 20582
Dlgap1
Name: DLG associated protein 1
Synonyms: Sapap1, 4933422O14Rik, DAP-1 beta, SAPAP1, D17Bwg0511e, Gkap, GKAP/SAPAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Negr1
Name: neuronal growth regulator 1
Synonyms: neurotractin, Ntra, 5330422G01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320840
Homologene: 41447
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: Cd26, THAM, Dpp-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Zfp873
Name: zinc finger protein 873
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 408062
Homologene: 134319
Abhd17a
Name: abhydrolase domain containing 17A
Synonyms: Fam108a, 1700013O15Rik, D10Bwg1364e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216169
Homologene: 50272
Nphp1
Name: nephronophthisis 1 (juvenile) homolog (human)
Synonyms: nephrocystin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53885
HGNC: HGNC:7905
Homologene: 229
Pcdhgb1
Name: protocadherin gamma subfamily B, 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93699
HGNC: HGNC:8708
Homologene: 81867
Tcstv7b
Name: Tcstv family member 7B
Synonyms: Gm21731
Type: Gene
Species: Mouse
Chromosome: 13
Teddm3
Name: transmembrane epididymal family member 3
Synonyms: 2310042E22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66561
Homologene: 83314
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 11,545,267 bp
  • G to T, chromosome 1 at 84,793,875 bp
  • T to A, chromosome 1 at 96,867,947 bp
  • A to G, chromosome 1 at 133,090,779 bp
  • C to A, chromosome 1 at 176,955,808 bp
  • C to T, chromosome 2 at 37,800,485 bp
  • A to T, chromosome 2 at 44,825,374 bp
  • A to C, chromosome 2 at 59,858,633 bp
  • A to C, chromosome 2 at 62,334,614 bp
  • C to T, chromosome 2 at 118,786,986 bp
  • A to G, chromosome 2 at 122,357,247 bp
  • A to T, chromosome 2 at 127,754,062 bp
  • C to T, chromosome 2 at 150,959,896 bp
  • T to C, chromosome 3 at 89,887,111 bp
  • T to C, chromosome 3 at 116,117,328 bp
  • A to T, chromosome 3 at 132,734,345 bp
  • T to A, chromosome 3 at 157,016,281 bp
  • T to C, chromosome 4 at 32,773,275 bp
  • T to A, chromosome 4 at 102,933,584 bp
  • T to A, chromosome 4 at 133,694,032 bp
  • G to A, chromosome 4 at 152,538,888 bp
  • A to T, chromosome 5 at 65,275,721 bp
  • A to T, chromosome 5 at 98,275,552 bp
  • C to A, chromosome 5 at 122,880,173 bp
  • A to G, chromosome 6 at 102,204,062 bp
  • G to T, chromosome 6 at 145,621,228 bp
  • A to T, chromosome 7 at 30,038,175 bp
  • G to T, chromosome 8 at 38,660,740 bp
  • T to A, chromosome 8 at 88,252,395 bp
  • A to T, chromosome 9 at 7,129,003 bp
  • T to C, chromosome 9 at 18,607,467 bp
  • G to A, chromosome 9 at 20,594,430 bp
  • T to C, chromosome 9 at 27,048,281 bp
  • A to T, chromosome 9 at 70,476,263 bp
  • T to C, chromosome 10 at 80,586,636 bp
  • A to G, chromosome 10 at 82,061,156 bp
  • T to C, chromosome 10 at 111,255,714 bp
  • G to A, chromosome 10 at 128,396,479 bp
  • C to T, chromosome 11 at 59,043,803 bp
  • T to A, chromosome 11 at 72,317,640 bp
  • A to G, chromosome 12 at 64,473,984 bp
  • A to T, chromosome 12 at 85,320,791 bp
  • T to G, chromosome 13 at 16,026,522 bp
  • GTT to GT, chromosome 13 at 81,405,338 bp
  • A to T, chromosome 13 at 120,240,979 bp
  • T to C, chromosome 14 at 23,462,969 bp
  • T to A, chromosome 14 at 55,972,744 bp
  • G to A, chromosome 15 at 92,234,466 bp
  • A to T, chromosome 16 at 21,152,937 bp
  • A to T, chromosome 17 at 48,360,438 bp
  • A to G, chromosome 17 at 70,516,533 bp
  • A to T, chromosome 18 at 10,510,747 bp
  • C to A, chromosome 18 at 37,681,080 bp
  • T to C, chromosome 19 at 54,047,298 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8997 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068828-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.